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Research Article

Synthesis of 5-amino-1,3,4-thiadiazole-2-sulphonamide derivatives and their inhibition effects on human carbonic anhydrase isozymes

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Pages 231-237 | Received 08 Mar 2010, Accepted 04 May 2010, Published online: 16 Jun 2010

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Halise Inci Gul, Cem Yamali, Fatma Yesilyurt, Hiroshi Sakagami, Kaan Kucukoglu, Ilhami Gulcin, Mustafa Gul & Claudiu T. Supuran. (2017) Microwave-assisted synthesis and bioevaluation of new sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 369-374.
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Halise Inci Gul, Ebru Mete, Sakip Emre Eren, Hiroshi Sakagami, Cem Yamali & Claudiu T. Supuran. (2017) Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 169-175.
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Mehlika Dilek Altintop, Ahmet Ozdemir, Kaan Kucukoglu, Gulhan Turan-Zitouni, Hayrunnisa Nadaroglu & Zafer Asim Kaplancikli. (2015) Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II). Journal of Enzyme Inhibition and Medicinal Chemistry 30:1, pages 32-37.
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Gonçalo A. Marcelo, David Montpeyó, Joana Galhano, Ramón Martínez-Máñez, José Luis Capelo-Martínez, Julia Lorenzo, Carlos Lodeiro & Elisabete Oliveira. (2023) Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer. International Journal of Molecular Sciences 24:7, pages 6612.
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Alpaslan Bayrakdar, Samet Mert, Rahmi Kasımoğulları, Sathya Bangaru & Prasath Manivannan. (2022) Synthesis, spectroscopic (FT-IR and NMR), DFT and molecular docking studies of ethyl 1-(3-nitrophenyl)-5-phenyl-3-((4-(trifluoromethyl)phenyl)carbamoyl)-1H-pyrazole-4-carboxylate. Research on Chemical Intermediates 48:5, pages 2087-2109.
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Samet Mert, Zuhal Alım, Mehmet Mustafa İşgör, Barış Anıl, Rahmi Kasımoğulları & Şükrü Beydemir. (2019) Novel pyrazole-3,4-dicarboxamides bearing biologically active sulfonamide moiety as potential carbonic anhydrase inhibitors. Arabian Journal of Chemistry 12:8, pages 2740-2748.
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Mehlika Dilek Altıntop, Belgin Sever, Ahmet Özdemir, Kaan Kucukoglu, Hicran Onem, Hayrunnisa Nadaroglu & Zafer Asım Kaplancıklı. (2017) Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1,3,4-thiadiazole derivatives. Bioorganic & Medicinal Chemistry 25:13, pages 3547-3554.
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Samet Mert, Zuhal Alım, Mehmet Mustafa İşgör, Şükrü Beydemir & Rahmi Kasımoğulları. (2016) The synthesis of novel pyrazole-3,4-dicarboxamides bearing 5-amino-1,3,4-thiadiazole-2-sulfonamide moiety with effective inhibitory activity against the isoforms of human cytosolic carbonic anhydrase I and II. Bioorganic Chemistry 68, pages 64-71.
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Samet Mert, Rahmi Kasımoğulları, Tuba İça, Ferdağ Çolak, Ahmet Altun & Salim Ok. (2014) Synthesis, structure–activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives. European Journal of Medicinal Chemistry 78, pages 86-96.
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Samet Mert, Ayşe Şahin Yağlıoğlu, Ibrahim Demirtas & Rahmi Kasımoğulları. (2013) Synthesis and antiproliferative activities of some pyrazole-sulfonamide derivatives. Medicinal Chemistry Research 23:3, pages 1278-1289.
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Havva Balseven, M. Mustafa İşgör, Samet Mert, Zuhal Alım, Şükrü Beydemir, Salim Ok & Rahmi Kasımoğulları. (2013) Facile synthesis and characterization of novel pyrazole-sulfonamides and their inhibition effects on human carbonic anhydrase isoenzymes. Bioorganic & Medicinal Chemistry 21:1, pages 21-27.
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