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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 5
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Research Article

1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition

Guzmán AlvarezGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de la República, Uruguay
,
Beatriz Aguirre-LópezDepartamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico DF., Mexico
,
Nallely CabreraDepartamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico DF., Mexico
,
Eliã B. MarinsNúcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
,
Luzineide TinocoNúcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
,
Carlos Ignacio BatthyányUnidad de Bioquímica y Proteómica Analíticas, Instituto Pasteur de Montevideo, Montevideo, Uruguay
,
Marieta Tuena de Gómez-PuyouDepartamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico DF., Mexico
,
Armando Gómez PuyouDepartamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico DF., MexicoCorrespondence[email protected] [email protected] [email protected]; Mercedes [email protected]
,
Ruy Pérez-MontfortDepartamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico DF., MexicoCorrespondence[email protected] [email protected] [email protected]; Mercedes [email protected]
,
Hugo CerecettoGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de la República, UruguayCorrespondence[email protected] [email protected] [email protected]; Mercedes [email protected]
&
Mercedes GonzálezGrupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de la República, UruguayCorrespondence[email protected] [email protected] [email protected]; Mercedes [email protected]
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Pages 981-989 | Received 29 Apr 2012, Accepted 05 Jun 2012, Published online: 18 Jul 2012

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Itzhel García-Torres, Ignacio De la Mora-De la Mora, Gabriel López-Velázquez, Nallely Cabrera, Luis Antonio Flores-López, Ingeborg Becker, Juliana Herrera-López, Roberto Hernández, Ruy Pérez-Montfort & Sergio Enríquez-Flores. (2023) Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Articles from other publishers (12)

Lenci K. Vázquez-Jiménez, Antonio Moreno-Herrera, Alfredo Juárez-Saldivar, Alonzo González-González, Eyra Ortiz-Pérez, Alma D. Paz-González, Isidro Palos, Esther Ramírez-Moreno & Gildardo Rivera. (2022) Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents. Current Medicinal Chemistry 29:14, pages 2504-2529.
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Iván Beltran-Hortelano, Verónica Alcolea, María Font & Silvia Pérez-Silanes. (2022) Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease. Bioorganic & Medicinal Chemistry 58, pages 116577.
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Florencia Ferraro, Ileana Corvo, Lucia Bergalli, Andrea Ilarraz, Mauricio Cabrera, Jorge Gil, Brian M. Susuki, Conor R. Caffrey, David J. Timson, Xavier Robert, Christophe Guillon, Teresa Freire & Guzmán Álvarez. (2020) Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity. Scientific Reports 10:1.
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Luiz Saramago, Helga Gomes, Elena Aguilera, Hugo Cerecetto, Mercedes González, Mauricio Cabrera, Maria Alzugaray, Itabajara da Silva Vaz Junior, Rodrigo Nunes da Fonseca, Beatriz Aguirre-López, Nallely Cabrera, Ruy Pérez-Montfort, Alicia Merlino, Jorge Moraes & Guzmán Álvarez. (2018) Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity. Veterinary Sciences 5:3, pages 74.
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Alejandra Vázquez-Raygoza, Lucia Cano-González, Israel Velázquez-Martínez, Pedro Trejo-Soto, Rafael Castillo, Alicia Hernández-Campos, Francisco Hernández-Luis, Jesús Oria-Hernández, Adriana Castillo-Villanueva, Claudia Avitia-Domínguez, Erick Sierra-Campos, Mónica Valdez-Solana & Alfredo Téllez-Valencia. (2017) Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies. Molecules 22:12, pages 2055.
Crossref
Hua Deng, Jayson Vedad, Ruel Z. B. Desamero & Robert Callender. (2017) Difference FTIR Studies of Substrate Distribution in Triosephosphate Isomerase. The Journal of Physical Chemistry B 121:43, pages 10036-10045.
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Dong-Jun Fu, Sai-Yang Zhang, Jian Song, Yin-Chao Liu, Li Zhang, Ruo-Han Zhao, Xiao-Lin Zi, Hong-Min Liu & Yan-Bing Zhang. (2016) Design and Antiproliferative Activity of N-Heterocycle-Chalcone Derivatives. Journal of Chemical Research 40:10, pages 620-623.
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Elena Aguilera, Javier Varela, Estefanía Birriel, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa Vera de Bilbao, Beatriz Aguirre-López, Nallely Cabrera, Selma Díaz Mazariegos, Marieta Tuena de Gómez-Puyou, Armando Gómez-Puyou, Ruy Pérez-Montfort, Lucia Minini, Alicia Merlino, Hugo Cerecetto, Mercedes González & Guzmán Alvarez. (2016) Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity . ChemMedChem 11:12, pages 1328-1338.
Crossref
Marcos Couto, Carina Sánchez, Belén Dávila, Valentina Machín, Javier Varela, Guzmán Álvarez, Mauricio Cabrera, Laura Celano, Beatriz Aguirre-López, Nallely Cabrera, Marieta de Gómez-Puyou, Armando Gómez-Puyou, Ruy Pérez-Montfort, Hugo Cerecetto & Mercedes González. (2015) 3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies. Molecules 20:8, pages 14595-14610.
Crossref
Lucía Minini, Guzmán Álvarez, Mercedes González, Hugo Cerecetto & Alicia Merlino. (2015) Molecular docking and molecular dynamics simulation studies of Trypanosoma cruzi triosephosphate isomerase inhibitors. Insights into the inhibition mechanism and selectivity. Journal of Molecular Graphics and Modelling 58, pages 40-49.
Crossref
Veronika L. Zinsser, Edward Farnell, David W. Dunne & David J. Timson. (2013) Triose phosphate isomerase from the blood fluke Schistosoma mansoni : Biochemical characterisation of a potential drug and vaccine target . FEBS Letters 587:21, pages 3422-3427.
Crossref
Peiwen Pan, Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Andrea Scozzafava, Martti E. E. Tolvanen, Seppo Parkkila, Clemente Capasso & Claudiu T. Supuran. (2013) Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-Carbonic Anhydrase from Trypanosoma cruzi , the Causative Agent of Chagas Disease . Journal of Medicinal Chemistry 56:4, pages 1761-1771.
Crossref

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