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Research Article

Synthesis of aminocyanopyrazoles via a multi-component reaction and anti-carbonic anhydrase inhibitory activity of their sulfamide derivatives against cytosolic and transmembrane isoforms

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Pages 343-349 | Received 06 Aug 2012, Accepted 08 Aug 2012, Published online: 27 Sep 2012

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Read on this site (10)

Stanislav Kalinin, Claudiu T. Supuran & Mikhail Krasavin. (2016) Multicomponent chemistry in the synthesis of carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 185-199.
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Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2015) N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 1010-1012.
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Ahmed M. Alafeefy, Mariangela Ceruso, Nabila A. Al-Jaber, Seppo Parkkila, Alane Beatriz Vermelho & Claudiu T. Supuran. (2015) A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi. Journal of Enzyme Inhibition and Medicinal Chemistry 30:4, pages 581-585.
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Articles from other publishers (13)

Soumaya Bellili, Nicholas J. Coltman, Nikolas J. Hodges & Fatma Allouche. (2022) Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products. Heterocyclic Communications 28:1, pages 11-17.
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Khaled M. Elattar, Başak Doğru Mert, M. Monier & Ahmed El-Mekabaty. (2020) Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6- a ]pyrimidine and pyrimido[1,6- c ]pyrimidine scaffolds . RSC Advances 10:26, pages 15461-15492.
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Hamid Beyzaei, Reza Aryan, Mohammadreza Moghaddam-Manesh, Behzad Ghasemi, Pouya Karimi, Hojat Samareh Delarami & Mahmood Sanchooli. (2017) Evaluation and structure-activity relationship analysis of a new series of 4-imino-5H-pyrazolo[3,4-d]pyrimidin-5-amines as potential antibacterial agents. Journal of Molecular Structure 1144, pages 273-279.
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Hamid Beyzaei, Mohammadreza Moghaddam-Manesh, Reza Aryan, Behzad Ghasemi & Alireza Samzadeh-Kermani. (2017) Synthesis and in vitro antibacterial evaluation of 6-substituted 4-amino-pyrazolo[3,4-d]pyrimidines. Chemical Papers 71:9, pages 1685-1691.
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Emanuela Berrino, Silvia Bua, Mattia Mori, Maurizio Botta, Vallabhaneni S. Murthy, Vijayaparthasarathi Vijayakumar, Yasinalli Tamboli, Gianluca Bartolucci, Alessandro Mugelli, Elisabetta Cerbai, Claudiu T. Supuran & Fabrizio Carta. (2017) Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors. Molecules 22:7, pages 1049.
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Hamid Beyzaei, Reza Aryan, Hadi Molashahi, Mohammad Mehdi Zahedi, Alireza Samzadeh-Kermani, Behzad Ghasemi & Mohammadreza Moghaddam-Manesh. (2017) MgO nanoparticle-catalyzed, solvent-free Hantzsch synthesis and antibacterial evaluation of new substituted thiazoles. Journal of the Iranian Chemical Society 14:5, pages 1023-1031.
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Ilija N. Cvijetić, Muhammet Tanç, Ivan O. Juranić, Tatjana Ž. Verbić, Claudiu T. Supuran & Branko J. Drakulić. (2015) 5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 23:15, pages 4649-4659.
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Nadia Touisni, Nasreddine Kanfar, Sébastien Ulrich, Pascal Dumy, Claudiu T. Supuran, Ahmad Mehdi & Jean‐Yves Winum. (2015) Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases. Chemistry – A European Journal 21:29, pages 10306-10309.
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Aiga Grandane, Muhammet Tanc, Lorenzo Di Cesare Mannelli, Fabrizio Carta, Carla Ghelardini, Raivis Žalubovskis & Claudiu T. Supuran. (2015) 6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells. Journal of Medicinal Chemistry 58:9, pages 3975-3983.
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Nicolino Pala, Roberta Cadoni & Mario Sechi. 2015. Carbonic Anhydrases as Biocatalysts. Carbonic Anhydrases as Biocatalysts 31 49 .
Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Mariangela Ceruso & Claudiu T. Supuran. (2014) Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds. Bioorganic & Medicinal Chemistry Letters 24:22, pages 5185-5189.
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Melissa D’Ascenzio, Simone Carradori, Celeste De Monte, Daniela Secci, Mariangela Ceruso & Claudiu T. Supuran. (2014) Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII. Bioorganic & Medicinal Chemistry 22:6, pages 1821-1831.
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Amine Karoui, Fatma Allouche, Monia Deghrigue, Asma Agrebi, Abderrahman Bouraoui & Fakher Chabchoub. (2013) Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: anti-inflammatory agents with gastroprotective effect in rats. Medicinal Chemistry Research 23:3, pages 1591-1598.
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