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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 30, 2015 - Issue 4
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Research Article

Antitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1,3-dione, 2-hydrazonobutane-1,3-dione and trifluoromethyl-1H-pyrazole analogues

Ibrahim A. Al-SuwaidanDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia,
,
Naglaa I. Abdel-AzizDepartment of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt,
,
Adel S. El-AzabDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, ;Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt, and
,
Magda A.-A. El-SayedDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
,
Amer M. AlanaziDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia,
,
Mahmoud B. El-AshmawyDepartment of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt,
&
Alaa A.-M. Abdel-AzizDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, ;Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt, Correspondence[email protected]
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Pages 679-687 | Received 11 May 2014, Accepted 29 Aug 2014, Published online: 04 Dec 2014

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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed & Claudiu T. Supuran. (2020) S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 733-743.
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Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi & Alaa A.-M. Abdel-Aziz. (2020) Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 744-758.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy & Claudiu T. Supuran. (2020) Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 598-609.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Laila A. Abou-Zeid, Walaa M. El-Husseiny, Ahmad M. El_Morsy, Manal A. El-Gendy & Magda A.-A. El-Sayed. (2018) Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 989-998.
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