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Original Article

Differential expression pattern of genes encoding for anti-microbial peptides in the fetal membranes of patients with spontaneous preterm labor and intact membranes and those with preterm prelabor rupture of the membranes

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Pages 1103-1115 | Received 02 Mar 2009, Accepted 20 Mar 2009, Published online: 16 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Ondrej Soucek, Marian Kacerovsky, Ivana Kacerovska Musilova, Jaroslav Stranik, Rudolf Kukla, Radka Bolehovska & Ctirad Andrys. (2023) Amniotic fluid CD36 in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study. The Journal of Maternal-Fetal & Neonatal Medicine 36:1.
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Robert Para, Roberto Romero, Derek Miller, Bogdan Panaitescu, Aneesha Varrey, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2020) Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine 33:24, pages 4117-4132.
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Joon-Seok Hong, Roberto Romero, Deug-Chan Lee, Nandor Gabor Than, Lami Yeo, Piya Chaemsaithong, Soyeon Ahn, Jung-Sun Kim, Chong Jai Kim & Yeon Mee Kim. (2016) Umbilical cord prostaglandins in term and preterm parturition. The Journal of Maternal-Fetal & Neonatal Medicine 29:4, pages 523-531.
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Heejeong Jeong, Su-jin Han, Ha-Na Yoo, Suk-Joo Choi, Soo-Young Oh, Yae-Jean Kim, Cheong-Rae Roh & Jong-Hwa Kim. (2015) Comparison of changes in etiologic microorganisms causing early-onset neonatal sepsis between preterm labor and preterm premature rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine 28:16, pages 1923-1928.
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Sun Min Kim, Roberto Romero, Jeong Woo Park, Kyung Joon Oh, Jong Kwan Jun & Bo Hyun Yoon. (2015) The relationship between the intensity of intra-amniotic inflammation and the presence and severity of acute histologic chorioamnionitis in preterm gestation. The Journal of Maternal-Fetal & Neonatal Medicine 28:13, pages 1500-1509.
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Roberto Romero, Eleazar Soto, Stanley M. Berry, Sonia S. Hassan, Juan Pedro Kusanovic, Bo Hyun Yoon, Samuel Edwin, Moshe Mazor & Tinnakorn Chaiworapongsa. (2012) Blood pH and gases in fetuses in preterm labor with and without systemic inflammatory response syndrome. The Journal of Maternal-Fetal & Neonatal Medicine 25:7, pages 1160-1170.
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Veronica Zaga-Clavellina, Guadalupe Garcia-Lopez & Pilar Flores-Espinosa. (2012) Evidence of in vitro differential secretion of human beta-defensins-1, -2, and -3 after selective exposure to Streptococcus agalactiae in human fetal membranes. The Journal of Maternal-Fetal & Neonatal Medicine 25:4, pages 358-363.
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Kyung A Lee, Seung Mi lee, Hye Jin Yang, Chan-Wook Park, Shali Mazaki-Tovi, Bo Hyun Yoon & Roberto Romero. (2011) The frequency of meconium-stained amniotic fluid increases as a function of the duration of labor. The Journal of Maternal-Fetal & Neonatal Medicine 24:7, pages 880-885.
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Articles from other publishers (31)

Marian Kacerovsky, Ivana Musilova, Simona Baresova, Klara Kolarova, Jana Matulova, Johanna Wiik, Verena Sengpiel & Bo Jacobsson. (2023) Cervical excisional treatment increases the risk of intraamniotic infection in subsequent pregnancy complicated by preterm prelabor rupture of membranes. American Journal of Obstetrics and Gynecology 229:1, pages 51.e1-51.e13.
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Eleni Agakidou, Charalampos Agakidis, Angeliki Kontou, William Chotas & Kosmas Sarafidis. (2022) Antimicrobial Peptides in Early-Life Host Defense, Perinatal Infections, and Necrotizing Enterocolitis—An Update. Journal of Clinical Medicine 11:17, pages 5074.
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Chidinma Iweha, Amanda Graham, Wei Cui, Courtney Marsh & Warren B. Nothnick. (2022) The uterine natural killer cell, cytotoxic T lymphocyte, and granulysin levels are elevated in the endometrium of women with nonstructural abnormal uterine bleeding. F&S Science 3:3, pages 246-254.
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Ramkumar Menon. (2022) Fetal inflammatory response at the fetomaternal interface: A requirement for labor at term and preterm*. Immunological Reviews 308:1, pages 149-167.
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Suhita Gayen nee' Betal, Pedro Urday, Huda B. Al-Kouatly, Kolawole Solarin, Joanna S. Y. Chan, Sankar Addya, Rupsa C. Boelig & Zubair H. Aghai. (2022) COVID-19 Infection During Pregnancy Induces Differential Gene Expression in Human Cord Blood Cells From Term Neonates. Frontiers in Pediatrics 10.
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Meyer Gershater, Roberto Romero, Marcia Arenas-Hernandez, Jose Galaz, Kenichiro Motomura, Li Tao, Yi Xu, Derek Miller, Roger Pique-Regi, Gregorio MartinezIIIIII, Yesong Liu, Eunjung Jung, Robert Para & Nardhy Gomez-Lopez. (2022) IL-22 Plays a Dual Role in the Amniotic Cavity: Tissue Injury and Host Defense against Microbes in Preterm Labor. The Journal of Immunology 208:7, pages 1595-1615.
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Andrea Olmos-Ortiz, Mayra Hernández-Pérez, Pilar Flores-Espinosa, Gabriela Sedano, Addy Cecilia Helguera-Repetto, Óscar Villavicencio-Carrisoza, María Yolotzin Valdespino-Vazquez, Arturo Flores-Pliego, Claudine Irles, Bruno Rivas-Santiago, Elsa Romelia Moreno-Verduzco, Lorenza Díaz & Verónica Zaga-Clavellina. (2022) Compartmentalized Innate Immune Response of Human Fetal Membranes against Escherichia coli Choriodecidual Infection. International Journal of Molecular Sciences 23:6, pages 2994.
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Ji Eun Lee, Kyo Hoon Park, Hyeon Ji Kim, Yu Mi Kim, Ji-Woong Choi, Sue Shin & Kyong-No Lee. (2021) Proteomic identification of novel plasma biomarkers associated with spontaneous preterm birth in women with preterm labor without infection/inflammation. PLOS ONE 16:10, pages e0259265.
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Ga-Hyun Son, Jae-Jun Lee, Youngmi Kim & Keun-Young Lee. (2021) The Role of Antimicrobial Peptides in Preterm Birth. International Journal of Molecular Sciences 22:16, pages 8905.
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Jaroslav Stranik, Marian Kacerovsky, Ondrej Soucek, Martina Kolackova, Ivana Musilova, Lenka Pliskova, Radka Bolehovska, Pavel Bostik, Jana Matulova, Bo Jacobsson & Ctirad Andrys. (2021) IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study. Scientific Reports 11:1.
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Newton Banupriya, BallambattuVishnu Bhat, Vinayagam Vickneshwaran & MagadiGopalakrishna Sridhar. (2020) Effect of zinc supplementation on relative expression of immune response genes in neonates with sepsis: A preliminary study. Indian Journal of Medical Research 152:3, pages 296.
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Roberto Romero, Nardhy Gomez-Lopez, Andrew D. Winters, Eunjung Jung, Majid Shaman, Janine Bieda, Bogdan Panaitescu, Percy Pacora, Offer Erez, Jonathan M. Greenberg, Madison M. Ahmad, Chaur-Dong Hsu & Kevin R. Theis. (2019) Evidence that intra-amniotic infections are often the result of an ascending invasion – a molecular microbiological study. Journal of Perinatal Medicine 47:9, pages 915-931.
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Marie-Julie Allard, Antoine Giraud, Mariela Segura & Guillaume Sebire. (2019) Sex-specific maternofetal innate immune responses triggered by group B Streptococci. Scientific Reports 9:1.
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Suhita Gayen nee’ Betal, Swati Murthy, Michael Favara, Gina Fong, Joanna S. Y. Chan, Sankar Addya, Thomas H. Shaffer, Jay Greenspan, Vineet Bhandari, Irfan Rahman & Zubair H. Aghai. (2019) Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates. Scientific Reports 9:1.
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Aneesha Varrey, Roberto Romero, Bogdan Panaitescu, Derek Miller, Tinnakorn Chaiworapongsa, Manasi Patwardhan, Jonathan Faro, Percy Pacora, Sonia S. Hassan, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2018) Human β-defensin-1: A natural antimicrobial peptide present in amniotic fluid that is increased in spontaneous preterm labor with intra-amniotic infection. American Journal of Reproductive Immunology 80:4, pages e13031.
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Bhavi P. Modi, Maria E. Teves, Laurel N. Pearson, Hardik I. Parikh, Hannah Haymond-Thornburg, John L. Tucker, Piya Chaemsaithong, Nardhy Gomez-Lopez, Timothy P. York, Roberto Romero & Jerome F. StraussIIIIII. (2017) Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM). Molecular Genetics & Genomic Medicine 5:6, pages 720-729.
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Nathália Mayumi Noda-Nicolau, Jossimara Polettini, Camila Marconi, José Carlos Peraçoli, Hélio Amante Miot & Márcia Guimarães da Silva. (2017) Human Beta Defensins 1, 2 and 3 Produced by Amniochorion Membranes Is Similar in Term and Preterm Delivery. Open Journal of Obstetrics and Gynecology 07:08, pages 846-857.
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Dariusz Szukiewicz, Habib Alkhalayla, Michal Pyzlak, Mateusz Watroba, Grzegorz Szewczyk & Jaroslaw Wejman. (2016) Human beta-defensin 1, 2 and 3 production by amniotic epithelial cells with respect to human papillomavirus (HPV) infection, HPV oncogenic potential and the mode of delivery. Microbial Pathogenesis 97, pages 154-165.
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Victoria L. Yarbrough, Sean Winkle & Melissa M. Herbst-Kralovetz. (2015) Antimicrobial peptides in the female reproductive tract: a critical component of the mucosal immune barrier with physiological and clinical implications. Human Reproduction Update 21:3, pages 353-377.
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Ratana Lim, Gillian Barker & Martha Lappas. (2015) Human cathelicidin antimicrobial protein 18 (hCAP18/LL-37) is increased in foetal membranes and myometrium after spontaneous labour and delivery. Journal of Reproductive Immunology 107, pages 31-42.
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Eun Ok Lee, Ji Hye Yang, Keun-A Chang, Yoo-Hun Suh & Young Hae Chong. (2013) Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes. Journal of Neuroinflammation 10:1.
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Xiucui Luo, Qingxi Shi, Yang Gu, Jing Pan, Maofang Hua, Meilin Liu, Ziqing Dong, Meijiao Zhang, Leilei Wang, Ying Gu, Julia Zhong, Xinliang Zhao, Edmund C. Jenkins, W. Ted Brown & Nanbert Zhong. (2013) LncRNA Pathway Involved in Premature Preterm Rupture of Membrane (PPROM): An Epigenomic Approach to Study the Pathogenesis of Reproductive Disorders. PLoS ONE 8:11, pages e79897.
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V. Tambor, M. Kacerovsky, J. Lenco, G. Bhat & R. Menon. (2013) Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM. Placenta 34:2, pages 155-161.
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Roberto Romero, Zeynep Alpay Savasan, Tinnakorn Chaiworapongsa, Stanley M. Berry, Juan Pedro Kusanovic, Sonia S. Hassan, Bo Hyun Yoon, Samuel Edwin & Moshe Mazor. (2012) Hematologic profile of the fetus with systemic inflammatory response syndrome. Journal of Perinatal Medicine 40:1.
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Veronica Zaga-Clavellina, Martha Ruiz, Pilar Flores-Espinosa, Rodrigo Vega-Sanchez, Arturo Flores-Pliego, Guadalupe Estrada-Gutierrez, Irma Sosa-Gonzalez, Iyari Morales-Méndez & Mauricio Osorio-Caballero. (2012) Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system. Reproductive Biology and Endocrinology 10:1, pages 70.
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Veronica Zaga‐Clavellina, Ruiz Velasco‐Muñoz Martha & Pilar Flores‐Espinosa. (2011) In Vitro Secretion Profile of Pro‐Inflammatory Cytokines IL‐1β, TNF‐α, IL‐6, and of Human Beta‐Defensins (HBD)‐1, HBD‐2, and HBD‐3 from Human Chorioamniotic Membranes After Selective Stimulation with Gardnerella vaginalis . American Journal of Reproductive Immunology 67:1, pages 34-43.
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Pooja Mittal, Roberto Romero, Adi L. Tarca, Sorin Draghici, Chia-Ling Nhan-Chang, Tinnakorn Chaiworapongsa, John Hotra, Ricardo Gomez, Juan Pedro Kusanovic, Deug-Chan Lee, Chong Jai Kim & Sonia S. Hassan. (2011) A molecular signature of an arrest of descent in human parturition. American Journal of Obstetrics and Gynecology 204:2, pages 177.e15-177.e33.
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Tinnakorn Chaiworapongsa, Roberto Romero, Stanley M. Berry, Sonia S. Hassan, Bo Hyun Yoon, Samuel Edwin & Moshe Mazor. (2011) The role of granulocyte colony-stimulating factor in the neutrophilia observed in the fetal inflammatory response syndrome. Journal of Perinatal Medicine 39:6.
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Byoung Jae Kim, Roberto Romero, Seung Mi Lee, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun & Bo Hyun Yoon. (2011) Clinical significance of oligohydramnios in patients with preterm labor and intact membranes*,**. Journal of Perinatal Medicine 39:2.
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James L. Wynn & Ofer Levy. (2010) Role of Innate Host Defenses in Susceptibility to Early-Onset Neonatal Sepsis. Clinics in Perinatology 37:2, pages 307-337.
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Pooja Mittal, Roberto Romero, Adi L. Tarca, Juan Gonzalez, Sorin Draghici, Yi Xu, Zhong Dong, Chia-Ling Nhan-Chang, Tinnakorn Chaiworapongsa, Stephen Lye, Juan Pedro Kusanovic, Leonard Lipovich, Shali Mazaki-Tovi, Sonia S. Hassan, Sam Mesiano & Chong Jai Kim. (2010) Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. Journal of Perinatal Medicine 38:6.
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