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Research Articles

Biochemical and immunological basis of silymarin effect, a milk thistle (Silybum marianum) against ethanol-induced oxidative damage

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Pages 409-413 | Received 25 Nov 2011, Accepted 03 Mar 2012, Published online: 04 Apr 2012

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Farrell Frankel, Matthew Priven, Elizabeth Richard, Chloe Schweinshault, Oni Tongo, Abrielle Webster, Elizabeth Barth, Kristen Slejzer & Sari Edelstein. (2016) Health Functionality of Organosulfides: A Review. International Journal of Food Properties 19:3, pages 537-548.
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Articles from other publishers (27)

Deepshi Arora, Yugam Taneja, Ashwani K. Dhingra, Kumar Guarve, Muskan Chauhan & Kajal Nagpal. (2024) Solubility Enhancement and Antioxidant Potential of Silymarin: A Poorly Water-soluble Drug. Current Drug Therapy 19:1, pages 103-115.
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Mahdi Banaee, Federica Impellitteri, Cristiana Roberta Multisanti, Antoni Sureda, Francesca Arfuso, Giuseppe Piccione & Caterina Faggio. (2023) Evaluating Silymarin Extract as a Potent Antioxidant Supplement in Diazinon-Exposed Rainbow Trout: Oxidative Stress and Biochemical Parameter Analysis. Toxics 11:9, pages 737.
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Magdalena Kachel, Marta Krajewska, Małgorzata Stryjecka, Lidia Ślusarczyk, Arkadiusz Matwijczuk, Stanisław Rudy & Marek Domin. (2023) Comparative Analysis of Phytochemicals and Antioxidant Properties of Borage Oil (Borago officinalis L.) and Milk Thistle (Silybum marianum Gaertn). Applied Sciences 13:4, pages 2560.
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Hissah Ahmed Alturki, Hany Amin Elsawy & Ademola Clement Famurewa. (2022) Silymarin abrogates acrylamide‐induced oxidative stress‐mediated testicular toxicity via modulation of antioxidant mechanism, DNA damage, endocrine deficit and sperm quality in rats . Andrologia 54:9.
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Aliaa Abdelmoniem Bedeir Eita. (2022) Milk thistle (Silybum marianum (L.)Gaertn.): An overview about its pharmacology and medicinal uses with an emphasis on oral diseases. Journal of Oral Biosciences 64:1, pages 71-76.
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Razieh Dowran, Seyed Younes Hosseini, Mohammad Reza Fattahi & Jamal Sarvari. (2021) The Effect of Silibinin on the Expression of TLR7, ISG15, and SOCS1 in Peripheral Blood Mononuclear Cells of Hepatitis C Infected Patients in Comparison with Interferon-α. Journal of Medical Microbiology and Infectious Diseases 9:1, pages 12-16.
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Yu. I. Poltavets, S. L. Kuznetsov, I. A. Tubasheva, A. I. Murav’eva & N. V. Gukasova. (2021) Nano- and Microsized Forms of Silymarin and Silybin. Nanobiotechnology Reports 16:2, pages 115-137.
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Xiao-Yu Song, Rong-Hua Li, Wei-Wei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki & Takashi Ikejima. (2021) Effect of silibinin on ethanol- or acetaldehyde-induced damge of mouse primary hepatocytes in vitro. Toxicology in Vitro 70, pages 105047.
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Jihyun Je, Hwajin Kim, Eun Jung Park, So Ra Kim, Theodomir Dusabimana, Kyuho Jeong, Seung Phil Yun, Hye Jung Kim, Kye Man Cho & Sang Won Park. (2020) Fermentation of Sprouted Ginseng ( Panax ginseng ) Increases Flavonoid and Phenolic Contents to Attenuate Alcoholic Hangover and Acute Liver Injury in Mice . The American Journal of Chinese Medicine 49:01, pages 131-146.
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Laxman Singh, Tanuj Joshi, Devesh Tewari, Javier Echeverría, Andrei Mocan, Archana N. Sah, Emil Parvanov, Nikolay T. Tzvetkov, Zheng Feei Ma, Yeong Yeh Lee, Piotr Poznański, Lukasz Huminiecki, Mariusz Sacharczuk, Artur Jóźwik, Jarosław O. Horbańczuk, Joanna Feder-Kubis & Atanas G. Atanasov. (2020) Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook. Frontiers in Pharmacology 10.
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Longxin Qiu, Chang Guo & Baoyu Hua. (2019) Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview. BioMed Research International 2019, pages 1-8.
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Xiaomeng Li, Yunjie Liu, Wuyang Yue, Yuefeng Tan, He Wang, Lishi Zhang & Jinyao Chen. (2019) A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF- β 1/Smad Signaling Pathway . Evidence-Based Complementary and Alternative Medicine 2019, pages 1-11.
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Heba M. MansourAbeer A.A. SalamaRania M. Abdel-SalamNaglaa A. AhmedNoha N. YassenHala F. Zaki. (2018) The anti-inflammatory and anti-fibrotic effects of tadalafil in thioacetamide-induced liver fibrosis in rats. Canadian Journal of Physiology and Pharmacology 96:12, pages 1308-1317.
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Qiang Ou, Yuanyuan Weng, Siwei Wang, Yajuan Zhao, Feng Zhang, Jianhua Zhou & Xiaolin Wu. (2018) Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway. Digestive Diseases and Sciences 63:12, pages 3398-3408.
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Zaineb Ben Barka, Konstantinos Grintzalis, Madeleine Polet, Clement Heude, Ulf Sommer, Hanène Ben Miled, Khémais Ben Rhouma, Sakly Mohsen, Olfa Tebourbi & Yves-Jacques Schneider. (2018) A combination of NMR and liquid chromatography to characterize the protective effects of Rhus tripartita extracts on ethanol-induced toxicity and inflammation on intestinal cells. Journal of Pharmaceutical and Biomedical Analysis 150, pages 347-354.
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Nafiseh Esmaeil, Sima Balouchi Anaraki, Marjan Gharagozloo & Behjat Moayedi. (2017) Silymarin impacts on immune system as an immunomodulator: One key for many locks. International Immunopharmacology 50, pages 194-201.
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Alessandro Federico, Marcello Dallio & Carmelina Loguercio. (2017) Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules 22:2, pages 191.
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Ali Kemal Onalan, Salih Tuncal, Sibel Kilicoglu, Salih Celepli, Esra Durak, Bulent Kilicoglu, Erdinc Devrim, Aziz Mutlu Barlas & Kemal Kismet. (2016) Effect of s?lymar?n on ox?dat?ve stress and l?ver h?stopathology ?n exper?mental obstruct?ve jaund?ce model. Acta Cirurgica Brasileira 31:12, pages 801-806.
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Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun & Changxiao Liu. (2016) Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive review. European Journal of Medicinal Chemistry 123, pages 577-595.
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Manish Adhikari & Rajesh Arora. (2016) The flavonolignan-silymarin protects enzymatic, hematological, and immune system against γ-radiation-induced toxicity. Environmental Toxicology 31:6, pages 641-654.
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Peter Surai. (2015) Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 4:1, pages 204-247.
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Majid Asadi-Samani, Najme Kafash-Farkhad, Nafiseh Azimi, Ali Fasihi, Ebrahim Alinia-Ahandani & Mahmoud Rafieian-Kopaei. (2015) Medicinal plants with hepatoprotective activity in Iranian folk medicine. Asian Pacific Journal of Tropical Biomedicine 5:2, pages 146-157.
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Nancy Vargas-Mendoza. (2014) Hepatoprotective effect of silymarin. World Journal of Hepatology 6:3, pages 144.
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P.A. Abhilash, R. Harikrishnan & M. Indira. (2014) Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach. Toxicology and Applied Pharmacology 274:2, pages 215-224.
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Khaled Khazim, Yves Gorin, Rita Cassia Cavaglieri, Hanna E. Abboud & Paolo Fanti. (2013) The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. American Journal of Physiology-Renal Physiology 305:5, pages F691-F700.
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Jae-Young Je, Jae-Young Cha, Young-Sook Cho, Hee-Young Ahn, Jae Hong Lee, Young-Su Cho & Chang-Bum Ahn. (2013) Hepatoprotective effect of peptic hydrolysate from salmon pectoral fin protein byproducts on ethanol-induced oxidative stress in Sprague–Dawley rats. Food Research International 51:2, pages 648-653.
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Ru-Ping Lee, Chung-Jen Lee, Yi-Maun Subeq & Bang-Gee Hsu. (2012) A model of chlorhexidine digluconate-induced peritoneal fibrosis in rats. Tzu Chi Medical Journal 24:3, pages 108-115.
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