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Clinical Toxicology Volume 54, 2016 - Issue 2
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Review Article

Review of the effect of intravenous lipid emulsion on laboratory analyses

Ami M. GrunbaumDivision of Medical Biochemistry, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada; Correspondence[email protected]
,
Brian M. GilfixDivision of Medical Biochemistry, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada;
,
Robert S. HoffmanDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, USA;
,
Valéry LavergneDepartment of Medical Biology, Sacré-Coeur Hospital, University of Montréal, Montréal, Québec, Canada;
,
Martin MorrisSchulich Library of Science and Engineering, McGill University, Montréal, Québec, Canada;
,
Andrea Miller-NesbittSchulich Library of Science and Engineering, McGill University, Montréal, Québec, Canada;
&
Sophie GosselinDepartment of Emergency Medicine, McGill University Health Centre & Department of Medicine, McGill University, Montreal, Québec, Canada
 show all
Pages 92-102 | Received 24 Jul 2015, Accepted 28 Oct 2015, Published online: 01 Dec 2015

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Michael E. Mullins. (2023) Lipid emulsion in the poisoned patient – a few answers, but more questions remain. Clinical Toxicology 61:8, pages 565-566.
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Robert S. Hoffman, Sophie Gosselin, Eric Villeneuve, Bryan D. Hayes, Lotte C. G. Hoegberg & Susan C. Smolinske. (2020) Comment on Antidotal use of lipid emulsion – the pendulum swings. Clinical Toxicology 58:12, pages 1355-1356.
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Michael E. Mullins & Donna L. Seger. (2020) Antidotal use of lipid emulsion – the pendulum swings. Clinical Toxicology 58:12, pages 1281-1283.
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Susan Smolinske, Robert S. Hoffman, Eric Villeneuve, Lotte C. G. Hoegberg & Sophie Gosselin. (2019) Utilization of lipid emulsion therapy in fatal overdose cases: an observational study. Clinical Toxicology 57:3, pages 197-202.
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Rana Biary, Arye Kremer, David S. Goldfarb & Robert S. Hoffman. (2018) Falsely elevated salicylate concentration in a patient with hypertriglyceridemia. Toxicology Communications 2:1, pages 1-2.
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Daniel J. Corwin, Alexis Topjian, Brenda L. Banwell & Kevin Osterhoudt. (2017) Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity. Clinical Toxicology 55:6, pages 603-607.
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Michael E. Mullins. (2016) Advancing the science of antidotal use of lipid emulsion. Clinical Toxicology 54:10, pages 897-898.
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Sophie Gosselin, Lotte C. G. Hoegberg, Robert. S. Hoffman, Andis Graudins, Christine M. Stork, Simon H. L. Thomas, Samuel J. Stellpflug, Bryan D. Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F. Turgeon, Benoit Bailey, Diane P. Calello, Ryan Chuang, Theodore C. Bania, Bruno Mégarbane, Ashish Bhalla & Valéry Lavergne. (2016) Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clinical Toxicology 54:10, pages 899-923.
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Articles from other publishers (33)

Mafdy N Basta. (2023) Local anaesthetic systemic toxicity complicating intraoperative intercostal nerve blocks: What do clinicians need to know to prevent similar occurrence?. Journal of Perioperative Practice 33:12, pages 390-395.
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Şerif Ercan & Mustafa Tat. (2023) Determination of lipemia acceptance thresholds for 31 immunoassay analytes. Clinica Chimica Acta 548, pages 117508.
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Karim Jaffal, Lucie Chevillard & Bruno Mégarbane. (2023) Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies. Pharmaceutics 15:5, pages 1396.
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Briana J Negaard, Ryan Hobbs, Jared R Frye & Anna E Merrill. (2023) Propofol-induced interference with activated partial thromboplastin time–based monitoring of therapeutic heparin anticoagulation. American Journal of Health-System Pharmacy 80:7, pages 445-451.
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Alexandra Elena Lazar, Simona Gurzu, Attila Kovecsi, Marcel Perian, Bogdan Cordos, Mircea Constantin Gherghinescu & Liviu Sorin Enache. (2022) Cardio Protective Effects of Lipid Emulsion against Ropivacaine-Induced Local Anesthetic Systemic Toxicity—An Experimental Study. Journal of Clinical Medicine 11:10, pages 2784.
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Sarah Caulfield, Erica Tinson & Rachael Birkbeck. (2022) Successful treatment of local anaesthetic toxicity using intralipid 20% emulsion following intrathoracic bupivacaine overdose in a cat. Journal of Feline Medicine and Surgery Open Reports 8:1, pages 205511692211045.
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Sheila X. Soh, Tze Ping Loh, Sunil K. Sethi & Lizhen Ong. (2021) Methods to reduce lipemic interference in clinical chemistry tests: a systematic review and recommendations. Clinical Chemistry and Laboratory Medicine (CCLM) 0:0.
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Sivasenthil Arumugam, Vanja Contino & Sree Kolli. (2020) Local Anesthetic Systemic Toxicity (LAST) – a Review and Update. Current Anesthesiology Reports 10:2, pages 218-226.
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Margherita Morandini. (2020) Lipemia: un'interferenza dimenticata? Considerazioni e Raccomandazioni. GdS VEA SIPMeL. La Rivista Italiana della Medicina di Laboratorio 16:1.
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D.J. Berman. (2020) A case of local anesthetic toxicity that wasn’t: lipid rescue from self-administered benzodiazepine overdose in labor. International Journal of Obstetric Anesthesia 42, pages 109-111.
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Gabrielle L. Procopio, Ruchi Patel & Amit Gupta. (2019) Clinical Pearls in Medical Toxicology: Updates Ranging From Decontamination to Elimination. Journal of Pharmacy Practice 32:3, pages 339-346.
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Kasper M. Petersen, Niklas R. Jørgensen, Søren Bøgevig, Tonny S. Petersen, Thomas B. Jensen, Kim P. Dalhoff & Mikkel B. Christensen. (2018) Effects of high-dose, intravenous lipid emulsion on laboratory tests in humans: a randomized, placebo-controlled, double-blind, clinical crossover trial. Clinical Chemistry and Laboratory Medicine (CCLM) 56:12, pages 2047-2057.
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Rosa M. López Martínez, Raúl Rigo Bonnin, M. José Andrés Otero, Francesca Canalias Reverter, Ruth Cano Corres, Sara Esteve Poblador, F. Javier Gella Tomás, Bernardino González de la Presa & Inmaculada Pérez de Algaba Fuentes. (2018) Procedimiento para el estudio de interferencias exógenas en la medición de magnitudes biológicas. Documento técnico (2017). Revista del Laboratorio Clínico 11:3, pages 147-152.
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Nora Nikolac Gabaj, Marijana Miler, Alen Vrtarić, Marina Hemar, Petra Filipi, Marija Kocijančić, Vesna Šupak Smolčić, Ivana Ćelap & Ana-Maria Šimundić. (2018) Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers. Clinical Chemistry and Laboratory Medicine (CCLM) 56:5, pages 776-788.
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Nicola Bates. (2018) Lipid emulsion in the management of poisoning. Companion Animal 23:4, pages 188-195.
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Martyn Harvey & Grant Cave. (2017) Lipid emulsion in local anesthetic toxicity. Current Opinion in Anaesthesiology 30:5, pages 632-638.
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Daniel S Herman, Peter A Kavsak & Dina N Greene. (2017) Variability and Error in Cardiac Troponin Testing. American Journal of Clinical Pathology 148:4, pages 281-295.
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Keith A. Baker, Emily B. Austin & George Sam Wang. (2017) Antidotes: Familiar Friends and New Approaches for the Treatment of Select Pediatric Toxicological Exposures. Clinical Pediatric Emergency Medicine 18:3, pages 218-226.
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K. Jaffal, L. Chevillard & B. Megarbane. (2017) Place des émulsions lipidiques intraveineuses en toxicologieLipid resuscitation in acute poisonning. Médecine Intensive Réanimation 26:5, pages 373-382.
Crossref
Lotte C.G. Hoegberg & Sophie Gosselin. (2017) Lipid resuscitation in acute poisoning. Current Opinion in Anaesthesiology 30:4, pages 474-479.
Crossref
Sandhya Mainali, Scott R. Davis & Matthew D. Krasowski. (2017) Frequency and causes of lipemia interference of clinical chemistry laboratory tests. Practical Laboratory Medicine 8, pages 1-9.
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Sophie Gosselin, Valéry Lavergne, Christine Stork & Robert S. Hoffman. (2017) Letters to the Editor. AACN Advanced Critical Care 28:2, pages 133-134.
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M Forsberg, S Forsberg, G Edman & J Höjer. (2016) No support for lipid rescue in oral poisoning: A systematic review and analysis of 160 published cases. Human & Experimental Toxicology 36:5, pages 461-466.
Crossref
Joris Henricus Robben & Marieke Annet Dijkman. (2017) Lipid Therapy for Intoxications. Veterinary Clinics of North America: Small Animal Practice 47:2, pages 435-450.
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Jeffrey Brent & Michael Levine. 2017. Critical Care Toxicology. Critical Care Toxicology 2859 2865 .
Silas W. Smith. 2017. Critical Care Toxicology. Critical Care Toxicology 821 841 .
Jonas Höjer, Dag Jacobsen, Pertti J. Neuvonen & Per H. Rosenberg. (2016) Lipid Rescue - Efficacy and Safety Still Unproven. Basic & Clinical Pharmacology & Toxicology 119:4, pages 345-348.
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P. H. Rosenberg. (2016) Current evidence is not in support of lipid rescue therapy in local anaesthetic systemic toxicity. Acta Anaesthesiologica Scandinavica 60:8, pages 1029-1032.
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Nicola Bates. (2016) Lipid infusion in the management of poisoning: an introduction. The Veterinary Nurse 7:6, pages 346-350.
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Nicola Bates. (2016) Lipid infusion in the management of poisoning. Veterinary Record 179:1, pages 22-22.
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Nicholas A. Buckley, Andrew H. Dawson, David N. Juurlink & Geoffrey K. Isbister. (2016) Who gets antidotes? choosing the chosen few. British Journal of Clinical Pharmacology 81:3, pages 402-407.
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Jeffrey Brent & Michael Levine. 2016. Critical Care Toxicology. Critical Care Toxicology 1 7 .
Silas W. Smith. 2016. Critical Care Toxicology. Critical Care Toxicology 1 22 .

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