1,007
Views
70
CrossRef citations to date
0
Altmetric
Orginal Articles

Genotoxicity, acute oral and dermal toxicity, eye and dermal irritation and corrosion and skin sensitisation evaluation of silver nanoparticles

, , , , , , & show all
Pages 953-960 | Received 31 Dec 2011, Accepted 12 Mar 2012, Published online: 04 Apr 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Phannaphat Phromphen, Udomlak Sukatta, Prapassorn Rugthaworn, Jirachaya Boonyarit, Phitalai Phoophat, Nattadon Rungruangkitkrai, Pawarin Tuntariyanond, Nawarat Chartvivatpornchai, Thanyachol Apipatpapha & Rungsima Chollakup. (2023) Biosynthesis of Silver Nanoparticles Enhanced Antibacterial Silk Face Covering. Journal of Natural Fibers 20:2.
Read now
Luisana Di Cristo, Gemma Janer, Susan Dekkers, Matthew Boyles, Anna Giusti, Johannes G. Keller, Wendel Wohlleben, Hedwig Braakhuis, Lan Ma-Hock, Agnes G. Oomen, Andrea Haase, Vicki Stone, Fiona Murphy, Helinor J. Johnston & Stefania Sabella. (2022) Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure. Nanotoxicology 16:3, pages 310-332.
Read now
K. A. Roach, S. E. Anderson, A. B. Stefaniak, H. L. Shane, G. R. Boyce & J. R. Roberts. (2020) Evaluation of the skin-sensitizing potential of gold nanoparticles and the impact of established dermal sensitivity on the pulmonary immune response to various forms of gold. Nanotoxicology 14:8, pages 1096-1117.
Read now
Yeo Jin Kim, Md Mujibur Rahman, Sang Min Lee, Jung Min Kim, Kwangsik Park, Joo-Hyon Kang & Young Rok Seo. (2019) Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue. International Journal of Nanomedicine 14, pages 393-405.
Read now
Katherine A. Roach, Aleksandr B. Stefaniak & Jenny R. Roberts. (2019) Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease. Journal of Immunotoxicology 16:1, pages 87-124.
Read now
Aditi Jain, Shivendu Ranjan, Nandita Dasgupta & Chidambaram Ramalingam. (2018) Nanomaterials in food and agriculture: An overview on their safety concerns and regulatory issues. Critical Reviews in Food Science and Nutrition 58:2, pages 297-317.
Read now
Seyed Reza Fatemi Tabatabaie, Babak Mehdiabadi, Naghmeh Moori Bakhtiari & Mohammad Reza Tabandeh. (2017) Silver nanoparticle exposure in pregnant rats increases gene expression of tyrosine hydroxylase and monoamine oxidase in offspring brain. Drug and Chemical Toxicology 40:4, pages 440-447.
Read now
Brittany A. Weldon, Elaine M. Faustman, Günter Oberdörster, Tomomi Workman, William C. Griffith, Carsten Kneuer & Il Je Yu. (2016) Occupational exposure limit for silver nanoparticles: considerations on the derivation of a general health-based value. Nanotoxicology 10:7, pages 945-956.
Read now
Cynthia Yu-Wai-Man & Peng Tee Khaw. (2015) Developing novel anti-fibrotic therapeutics to modulate post-surgical wound healing in glaucoma: big potential for small molecules. Expert Review of Ophthalmology 10:1, pages 65-76.
Read now
Osama Mohamed M Sarhan & Rehab M Hussein. (2014) Effects of intraperitoneally injected silver nanoparticles on histological structures and blood parameters in the albino rat. International Journal of Nanomedicine 9, pages 1505-1517.
Read now
Kwangsik Park & Yeonjin Lee. (2013) The Stability of Citrate-Capped Silver Nanoparticles in Isotonic Glucose Solution for Intravenous Injection. Journal of Toxicology and Environmental Health, Part A 76:22, pages 1236-1245.
Read now

Articles from other publishers (59)

Zohaib Saeed, Muhammad Pervaiz, Anam Ejaz, Shah Hussain, Shumila Shaheen, Behram Shehzad & Umer Younas. (2023) “Garlic and ginger extracts mediated green synthesis of silver and gold nanoparticles: A review on recent advancements and prospective applications’’. Biocatalysis and Agricultural Biotechnology 53, pages 102868.
Crossref
Luz Stella Gomez-Villalba, Ciro Salcines & Rafael Fort. (2023) Application of Inorganic Nanomaterials in Cultural Heritage Conservation, Risk of Toxicity, and Preventive Measures. Nanomaterials 13:9, pages 1454.
Crossref
Maciej Noga, Justyna Milan, Adrian Frydrych & Kamil Jurowski. (2023) Toxicological Aspects, Safety Assessment, and Green Toxicology of Silver Nanoparticles (AgNPs)—Critical Review: State of the Art. International Journal of Molecular Sciences 24:6, pages 5133.
Crossref
Triveni Shelke & Monalisa Mishra. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 321 334 .
María Constanza Paz, Cristian Alan Rossetti, María Lina Formica & Santiago Daniel Palma. 2023. Nanotechnology in Ophthalmology. Nanotechnology in Ophthalmology 285 304 .
Robert Landsiedel, Daniela Hahn, Rainer Ossig, Sabrina Ritz, Lydia Sauer, Roland Buesen, Sascha Rehm, Wendel Wohlleben, Sibylle Groeters, Volker Strauss, Saskia Sperber, Haleluya Wami, Ulrich Dobrindt, Karola Prior, Dag Harmsen, Bennard van Ravenzwaay & Juergen Schnekenburger. (2022) Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects. Particle and Fibre Toxicology 19:1.
Crossref
Soham Prajapati, Sathish Kumar Malladevanahalli Huchegowda, Devaraja Hosapalya Chikkathimmaiah, Kulkarni Jayaraj Rao, Abdul Hussain Shaik, Rajani Champalli Shankara Reddy & Latha Sabikhi. (2022) Effect of ionic silver solution on Paneer (Indian cottage cheese) quality and shelf life. International Journal of Dairy Technology 75:4, pages 902-909.
Crossref
Eva M. Mateo & Misericordia Jiménez. (2022) Silver Nanoparticle-Based Therapy: Can It Be Useful to Combat Multi-Drug Resistant Bacteria?. Antibiotics 11:9, pages 1205.
Crossref
Roshani R. Pagar, Shubham R. Musale, Ganesh Pawar, Deepak Kulkarni & Prabhanjan S. Giram. (2022) Comprehensive Review on the Degradation Chemistry and Toxicity Studies of Functional Materials. ACS Biomaterials Science & Engineering 8:6, pages 2161-2195.
Crossref
K.D. Patel, L. Barrios Silva, Y. Park, T. Shakouri, Z. Keskin-Erdogan, P. Sawadkar, K.J. Cho, J.C. Knowles, D.Y.S. Chau & H.-W. Kim. (2022) Recent advances in drug delivery systems for glaucoma treatment. Materials Today Nano 18, pages 100178.
Crossref
Krista M. Cosert, Soohyun Kim, Iman Jalilian, Maggie Chang, Brooke L. Gates, Kent E. Pinkerton, Laura S. Van Winkle, Vijay Krishna Raghunathan, Brian C. Leonard & Sara M. Thomasy. (2022) Metallic Engineered Nanomaterials and Ocular Toxicity: A Current Perspective. Pharmaceutics 14:5, pages 981.
Crossref
Jiangmei Xu, Hao Chen, Zhaoyou Chu, Zhu Li, Benjin Chen, Jianan Sun, Wei Lai, Yan Ma, Yulong He, Haisheng Qian, Fei Wang & Yunsheng Xu. (2022) A multifunctional composite hydrogel as an intrinsic and extrinsic coregulator for enhanced therapeutic efficacy for psoriasis. Journal of Nanobiotechnology 20:1.
Crossref
Yolanda Hedberg & Gunnar F. Nordberg. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 773 782 .
Dong-Han Lee, Seo-Yoon Choi, Ki-Kyung Jung, Jun-Young Yang, Ja-young Jeong, Jae-Ho Oh, Sung-Hyun Kim & Jin-Hee Lee. (2021) The Research of Toxicity and Sensitization Potential of PEGylated Silver and Gold Nanomaterials. Toxics 9:12, pages 355.
Crossref
Alexander Vaneev, Victoria Tikhomirova, Natalia Chesnokova, Ekaterina Popova, Olga Beznos, Olga Kost & Natalia Klyachko. (2021) Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye. International Journal of Molecular Sciences 22:22, pages 12368.
Crossref
Ying Liu, Hairuo Wen, Xiaochun Wu, Meiyu Wu, Lin Liu, Jiahui Wang, Guitao Huo, Jianjun Lyu, Liming Xie & Mo Dan. (2021) The Bio-Persistence of Reversible Inflammatory, Histological Changes and Metabolic Profile Alterations in Rat Livers after Silver/Gold Nanorod Administration. Nanomaterials 11:10, pages 2656.
Crossref
Amal I Hassan, Amer Samir, Hanan F Youssef, Sahar S Mohamed, Mohsen S Asker & Manal G Mahmoud. (2021) Effects of silver nanoparticles–polysaccharide on bleomycin-induced pulmonary fibrosis in rats. Journal of Pharmacy and Pharmacology 73:11, pages 1503-1512.
Crossref
Soohyun Kim, Brooke L. Gates, Maggie Chang, Kent E. Pinkerton, Laura Van Winkle, Christopher J. Murphy, Brian C. Leonard, Philip Demokritou & Sara M. Thomasy. (2021) Transcorneal delivery of topically applied silver nanoparticles does not delay epithelial wound healing. NanoImpact 24, pages 100352.
Crossref
Anna Grzesiakowska, Marek Jan Kasprowicz, Marta Kuchta-Gładysz, Katarzyna Rymuza & Olga Szeleszczuk. (2021) Genotoxicity of physical silver nanoparticles, produced by the HVAD method, for Chinchilla lanigera genome. Scientific Reports 11:1.
Crossref
Banita Sinha, Tamal Goswami, Satadal Paul & Anirban Misra. (2021) Spectral tuning of 11-cis retinal in conjugation with Au14 cluster and concomitant effect on isomerization: A theoretical outlook. Journal of Photochemistry and Photobiology 7, pages 100051.
Crossref
Mohamed Mohamady Ghobashy, Mohamed Abd Elkodous, Soha Hamdy Shabaka, Sherif A. Younis, Dalal Mohamed Alshangiti, Mohamed Madani, Samera Ali Al-Gahtany, Walid F. Elkhatib, Ayman M. Noreddin, Norhan Nady & Gharieb S. El-Sayyad. (2021) An overview of methods for production and detection of silver nanoparticles, with emphasis on their fate and toxicological effects on human, soil, and aquatic environment. Nanotechnology Reviews 10:1, pages 954-977.
Crossref
Asra Parveen, Vijaykumar B. Malashetty, Sushruta Marla, Shanth Reddy, Sidramappa Sirsand, Manjunath Yalagatti, Venkataraman Abbaraju & Raghunandan Deshpande. (2021) Pharmacokinetics of Bio-shell-silver-core Nanoparticles (AgNP) in Sprague-Dawley Rats - In Vivo Study. Pharmaceutical Nanotechnology 9:3, pages 191-199.
Crossref
Alfina Grasso, Margherita Ferrante, Giovanni Arena, Rossella Salemi, Pietro Zuccarello, Maria Fiore & Chiara Copat. (2021) Chemical Characterization and Quantification of Silver Nanoparticles (Ag-NPs) and Dissolved Ag in Seafood by Single Particle ICP-MS: Assessment of Dietary Exposure. International Journal of Environmental Research and Public Health 18:8, pages 4076.
Crossref
Dawin Khiev, Zeinab A. Mohamed, Riddhi Vichare, Ryan Paulson, Sofia Bhatia, Subhra Mohapatra, Glenn P. Lobo, Mallika Valapala, Nagaraj Kerur, Christopher L. Passaglia, Shyam S. Mohapatra & Manas R. Biswal. (2021) Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery. Nanomaterials 11:1, pages 173.
Crossref
Lucía Margarita Valenzuela-Salas, Alberto Blanco-Salazar, Jesús David Perrusquía-Hernández, Mario Nequiz-Avendaño, Paris A. Mier-Maldonado, Balam Ruiz-Ruiz, Verónica Campos-Gallegos, María Evarista Arellano-García, Juan Carlos García-Ramos, Alexey Pestryakov, Luis Jesús Villarreal-Gómez, Yanis Toledano-Magaña & Nina Bogdanchikova. (2021) New Protein-Coated Silver Nanoparticles: Characterization, Antitumor and Amoebicidal Activity, Antiproliferative Selectivity, Genotoxicity, and Biocompatibility Evaluation. Pharmaceutics 13:1, pages 65.
Crossref
Mou Zhou, Fang Lin, Wendan Li, Linying Shi, Yanhui Li & Guiqiu Shan. (2021) Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment. International Journal of Biological Macromolecules 166, pages 1335-1351.
Crossref
Naida Omerović, Selma Škrbo & Edina Vranić. 2021. CMBEBIH 2021. CMBEBIH 2021 703 717 .
Niels Hadrup, Anoop K. Sharma, Katrin Loeschner & Nicklas R. Jacobsen. (2020) Pulmonary toxicity of silver vapours, nanoparticles and fine dusts: A review. Regulatory Toxicology and Pharmacology 115, pages 104690.
Crossref
Rossella Grande, Francesca Sisto, Valentina Puca, Simone Carradori, Maurizio Ronci, Antonio Aceto, Raffaella Muraro, Gabriella Mincione & Luca Scotti. (2020) Antimicrobial and Antibiofilm Activities of New Synthesized Silver Ultra-NanoClusters (SUNCs) Against Helicobacter pylori. Frontiers in Microbiology 11.
Crossref
Valeria De Matteis & Loris Rizzello. (2020) Noble Metals and Soft Bio-Inspired Nanoparticles in Retinal Diseases Treatment: A Perspective. Cells 9:3, pages 679.
Crossref
Tao Zhu, Dan Zhou, Zhe Zhang, Lina Long, Yujuan Liu, Qinghong Fan, Feifan Chen, Xueke Zhang, Yan Wu, Hekun Zeng, Alexei Verkhratsky, Jianhao Zhao & Hong Nie. (2020) Analgesic and antipruritic effects of oxymatrine sustained-release microgel cream in a mouse model of inflammatory itch and pain. European Journal of Pharmaceutical Sciences 141, pages 105110.
Crossref
Muniyandi Anbukkarasi, Philip A. Thomas, P. Archana Teresa, Thiraviyam Anand & Pitchairaj Geraldine. (2020) Comparison of the efficacy of a Tabernaemontana divaricata extract and of biosynthesized silver nanoparticles in preventing cataract formation in an in-vivo system of selenite-induced cataractogenesis. Biocatalysis and Agricultural Biotechnology 23, pages 101475.
Crossref
Lyudmila V. Akhaltseva, V. S. Zhurkov & F. I. Ingel. (2019) MUTAGENIC ACTIVITY OF NANOMATERIALS IN THE AMES TEST. LITERATURE REVIEW. Hygiene and sanitation 98:11, pages 1309-1320.
Crossref
Raphaël Labruère, A. J. Sona & Edward Turos. (2019) Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics. Frontiers in Pharmacology 10.
Crossref
Shuang Zhu, Linji Gong, Yijian Li, Haiwei Xu, Zhanjun Gu & Yuliang Zhao. (2019) Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue. Advanced Science 6:16.
Crossref
Handule Lee & Kwangsik Park. (2019) In Vitro Cytotoxicity of Zinc Oxide Nanoparticles in Cultured Statens Seruminstitut Rabbit Cornea Cells . Toxicological Research 35:3, pages 287-294.
Crossref
Zorawar Singh. (2018) Fish and Rat as Models to Assess Environmental Toxicity of Silver Nanoparticles. Trends Journal of Sciences Research 3:4, pages 177-182.
Crossref
Kwangsik Park, Juyoung Park, Handule Lee, Jonghye Choi, Wook-Joon Yu & Jinsoo Lee. (2018) Toxicity and tissue distribution of cerium oxide nanoparticles in rats by two different routes: single intravenous injection and single oral administration. Archives of Pharmacal Research 41:11, pages 1108-1116.
Crossref
Niels Hadrup, Anoop K. Sharma & Katrin Loeschner. (2018) Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review. Regulatory Toxicology and Pharmacology 98, pages 257-267.
Crossref
Nurdan Sarac, Tuba Baygar & Aysel Ugur. (2017) In vitro mutagenic and anti‐mutagenic properties of green synthesised silver nanoparticles . IET Nanobiotechnology 12:2, pages 230-233.
Crossref
Young-Man Cho, Yasuko Mizuta, Jun-ichi Akagi, Takeshi Toyoda, Mizuki Sone & Kumiko Ogawa. (2018) Size-dependent acute toxicity of silver nanoparticles in mice. Journal of Toxicologic Pathology 31:1, pages 73-80.
Crossref
David P. Bishop, Mandy Grossgarten, Dörthe Dietrich, Antje Vennemann, Nerida Cole, Michael Sperling, Martin Wiemann, Philip A. Doble & Uwe Karst. (2018) Quantitative imaging of translocated silver following nanoparticle exposure by laser ablation-inductively coupled plasma-mass spectrometry. Analytical Methods 10:8, pages 836-840.
Crossref
Mohd A. Saifi, Amit Khurana & Chandraiah Godugu. 2018. Nanomaterials in Chromatography. Nanomaterials in Chromatography 437 465 .
W.K. Boyes. 2018. Comprehensive Toxicology. Comprehensive Toxicology 34 43 .
Tatiana Andreani, Verónica Nogueira, Vera V. Pinto, Maria José Ferreira, Maria Graça Rasteiro, Amélia M. Silva, Ruth Pereira & Carlos M. Pereira. (2017) Influence of the stabilizers on the toxicity of metallic nanomaterials in aquatic organisms and human cell lines. Science of The Total Environment 607-608, pages 1264-1277.
Crossref
HanGoo Kang, Seungjae Kim, Kwang Hoon Lee, Shan Jin, Seo Hyeong Kim, Kangtaek Lee, Hyungjoon Jeon, Young-Geon Song, Sang-Won Lee, Jinwon Seo, Soomin Park & In-Hong Choi. (2017) 5 nm Silver Nanoparticles Amplify Clinical Features of Atopic Dermatitis in Mice by Activating Mast Cells. Small 13:9, pages 1602363.
Crossref
Xiao He. 2016. Toxicology of Nanomaterials. Toxicology of Nanomaterials 151 198 .
Hyejin Kim, Jonghye Choi, Handule Lee, Juyoung Park, Byung-Il Yoon, Seon Mi Jin & Kwangsik Park. (2016) Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm TM . Toxicological Research 32:4, pages 311-316.
Crossref
Dávid Kovács, Nóra Igaz, Csilla Keskeny, Péter Bélteky, Tímea Tóth, Renáta Gáspár, Dániel Madarász, Zsolt Rázga, Zoltán Kónya, Imre M. Boros & Mónika Kiricsi. (2016) Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis. Scientific Reports 6:1.
Crossref
He Huang, Wenjia Lai, Menghua Cui, Ling Liang, Yuchen Lin, Qiaojun Fang, Ying Liu & Liming Xie. (2016) An Evaluation of Blood Compatibility of Silver Nanoparticles. Scientific Reports 6:1.
Crossref
Olga D. Hendrickson, Sergey G. Klochkov, Oksana V. Novikova, Irina M. Bravova, Elena F. Shevtsova, Irina V. Safenkova, Anatoly V. Zherdev, Sergey O. Bachurin & Boris B. Dzantiev. (2016) Toxicity of nanosilver in intragastric studies: Biodistribution and metabolic effects. Toxicology Letters 241, pages 184-192.
Crossref
Hao Feng, Ilmari Pyykkö & Jing Zou. (2014) Hyaluronan up-regulation is linked to renal dysfunction and hearing loss induced by silver nanoparticles. European Archives of Oto-Rhino-Laryngology 272:10, pages 2629-2642.
Crossref
Angela Ivask, Nicolas H. Voelcker, Shane A. Seabrook, Maryam Hor, Jason K. Kirby, Michael Fenech, Thomas P. Davis & Pu Chun Ke. (2015) DNA Melting and Genotoxicity Induced by Silver Nanoparticles and Graphene. Chemical Research in Toxicology 28:5, pages 1023-1035.
Crossref
Stefaan J. Soenen, Wolfgang J. Parak, Joanna Rejman & Bella Manshian. (2015) (Intra)Cellular Stability of Inorganic Nanoparticles: Effects on Cytotoxicity, Particle Functionality, and Biomedical Applications. Chemical Reviews 115:5, pages 2109-2135.
Crossref
Ellen Kim, Ji Hyun Lee, Jin Kwon Kim, Gun Ho Lee, Kangho Ahn, Jung Duck Park & Il Je Yu. (2015) Case Study on Risk Evaluation of Silver Nanoparticle Exposure from Antibacterial Sprays Containing Silver Nanoparticles. Journal of Nanomaterials 2015, pages 1-8.
Crossref
Hayley Nehoff, Neha N. Parayath, Sebastien Taurin & Khaled Greish. 2014. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology 65 86 .
Muhammad Amin, Sadaf Hameed, Asghar Ali, Farooq Anwar, Shaukat Ali Shahid, Imran Shakir, Aqdas Yaqoob, Sara Hasan, Safyan Akram Khan & Sajjad-ur-Rahman. (2014) Green Synthesis of Silver Nanoparticles: Structural Features and In Vivo and In Vitro Therapeutic Effects against Helicobacter pylori Induced Gastritis . Bioinorganic Chemistry and Applications 2014, pages 1-11.
Crossref
Karthik V. Pillai, Piper R. Hunt & Timothy V. Duncan. 2014. Toxicants in Food Packaging and Household Plastics. Toxicants in Food Packaging and Household Plastics 95 123 .
Hyun Cho, Jae Sung, Kyung Song, Jin Kim, Jun Ji, Ji Lee, Hyeon Ryu, Kangho Ahn & Il Yu. (2013) Genotoxicity of Silver Nanoparticles in Lung Cells of Sprague Dawley Rats after 12 Weeks of Inhalation Exposure. Toxics 1:1, pages 36-45.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.