Phytosterol supplementation does not affect plasma antioxidant capacity in patients with metabolic syndrome

Abstract

Several studies have observed decreased levels of lipophilic antioxidants after supplementation with phytosterols and stanols. The aim of this study was to examine the effect of phytosterol supplementation on plasma total antioxidant capacity in patients with metabolic syndrome. In a parallel arm, randomized placebo-controlled design, 108 patients with metabolic syndrome were assigned to consume yogurt beverage which provided 4 g of phytosterols per day or yogurt beverage without phytosterols. The duration of the study was 2 months and the patients in both groups followed their habitual westernized type diet. Blood samples were drawn at baseline and after 2 months, and the total antioxidant capacity of plasma was measured using the ferric reducing antioxidant power of plasma and oxygen radical absorbance capacity assays. After 2 months of intervention, plasma total antioxidant capacity did not differ between and within the intervention and the control groups. Phytosterol supplementation does not affect plasma antioxidant status.

Keywords::

• phytosterols
• total antioxidant capacity
• plasma
• metabolic syndrome

Acknowledgements

The authors would like to thank ELAIS-Unilever Hellas SA for generous donation of the plant sterol-enriched yogurt beverages. Warm thanks to all the participants of the study for their cooperation.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.