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mAbs Volume 10, 2018 - Issue 3
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A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies

Gargi RoyAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of AmericaCorrespondence[email protected]
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Tom MartinAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of AmericaORCID Iconhttp://orcid.org/0000-0002-7491-8274
ORCID Icon,
Arnita BarnesAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Jihong WangAnalytical Biochemistry, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Rod Brian JimenezAnalytical Biochemistry, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Megan RiceAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Lina LiCell Culture and Fermentation Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
,
Hui FengAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Shu ZhangAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Raghothama ChaerkadyAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Herren WuAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Marcello MarelliAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Diane HattonCell Culture and Fermentation Sciences, Biopharmaceutical Development, MedImmune, Cambridge, United Kingdom
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Jie ZhuCell Culture and Fermentation Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America
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Michael A. BowenAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America
 show all
Pages 416-430 | Received 09 Oct 2017, Accepted 13 Jan 2018, Published online: 22 Feb 2018

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