A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies

Gargi RoyAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of AmericaCorrespondence[email protected]

Tom MartinAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Arnita BarnesAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Jihong WangAnalytical Biochemistry, MedImmune LLC, Gaithersburg, Maryland, United States of America

Rod Brian JimenezAnalytical Biochemistry, MedImmune LLC, Gaithersburg, Maryland, United States of America

Megan RiceAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Lina LiCell Culture and Fermentation Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America

Hui FengAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Shu ZhangAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Raghothama ChaerkadyAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Herren WuAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Marcello MarelliAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

Diane HattonCell Culture and Fermentation Sciences, Biopharmaceutical Development, MedImmune, Cambridge, United Kingdom

Jie ZhuCell Culture and Fermentation Sciences, MedImmune LLC, Gaithersburg, Maryland, United States of America

Michael A. BowenAntibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America

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