Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies

Ahmed ElkamhawyChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon, South Korea,

Jung-eun ParkChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea,

Nam-Chul ChoCenter of Neuromedicine, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biotechnology, Yonsei University, Seoul, South Korea, and

Taebo SimChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon, South Korea, ;KU-KIST Graduate School of Converging Science and Technology, Seoul, South Korea

Ae Nim PaeCenter of Neuromedicine, Korea Institute of Science and Technology (KIST), Seoul, South Korea,

Eun Joo RohChemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea, ;Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon, South Korea, Correspondence[email protected]

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies

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Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies

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