1,994
Views
22
CrossRef citations to date
0
Altmetric
Short Communication

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies

, , , , &
Pages 158-166 | Received 15 Sep 2014, Accepted 24 Dec 2014, Published online: 25 Mar 2015

References

  • Manning G, Whyte DB, Martinez R, et al. The protein kinase complement of the human genome. Science 2002;298:1912–34
  • Cohen P. The role of protein phosphorylation in human health and disease. Eur J Biochem 2001;268:5001–10
  • Khadjavi A, Barbero G, Destefanis P, et al. Evidence of abnormal tyrosine phosphorylated proteins in the urine of patients with bladder cancer: the road toward a new diagnostic tool? J Urol 2011;185:1922–9
  • Cicenas J, Urban P, Küng W, et al. Phosphorylation of tyrosine 1248-ERBB2 measured by chemiluminescence-linked immunoassay is an independent predictor of poor prognosis in primary breast cancer patients. Eur J Cancer (Oxford, England: 1990) 2006;42:636–45
  • Gavrin LK, Saiah E. Approaches to discover non-ATP site kinase inhibitors. Med Chem Comm 2013;4:41–51
  • Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nature Rev Cancer 2009;9:28–39
  • Valiathan RR, Marco M, Leitinger B, et al. Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metast Rev 2012;31:295–321
  • Yamanaka R, Arao T, Yajima N, et al. Identification of expressed genes characterizing long-term survival in malignant glioma patients. Oncogene 2006;25:5994–6002
  • Johansson FK, Goransson H, Westermark B. Expression analysis of genes involved in brain tumor progression driven by retroviral insertional mutagenesis in mice. Oncogene 2005;24:3896–905
  • Heinzelmann-Schwarz VA, Gardiner-Garden M, Henshall SM, et al. Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. Clin Cancer Res 2004;10:4427–36
  • Weiner HL, Huang H, Zagzag D, et al. Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors. Neurosurgery 2000;47:1400–9
  • Ford CE, Lau SK, Zhu CQ, et al. Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. Brit J Cancer 2007;96:808–14
  • Elkamhawy A, Lee J, Park B-G, et al. Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study. Eur J Med Chem 2014;84:466–75
  • http://www.dtp.nci.nih.gov/
  • http://www.reactionbiology.com/
  • Monks A, Scudiero D, Skehan P, et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 1991;83:757–66
  • Boyd MR, Paull KD. Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen. Drug Devel Res 1995;34:91–109
  • Richters A, Nguyen HD, Phan T, et al. Identification of Type II and III DDR2 Inhibitors. J Med Chem 2014;57:4252–62
  • http://www.schrodinger.com/Maestro
  • Canning P, Tan L, Chu K, et al. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J Molec Biol 2014;426:2457–70
  • Kim H-G, Tan L, Weisberg EL, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol 2013;8:2145–50

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.