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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 6
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Research Article

Tissue distribution of CYP3A29 mRNA expression in Bama miniature pig by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)

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Pages 423-429 | Received 04 Dec 2008, Accepted 16 Feb 2009, Published online: 20 Mar 2009

References

  • Anzenbacher P, Soucek P, Anzenbacherova E, Gut I, Hruby K, Svoboda Z, Kvetina J. (1998). Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples. Drug Metab Disposit 26:56–9.
  • Anzenbacherova E, Baranova J, Zuber R, Pechova A, Anzenbacher P, Soucek P, Martinkova J. (2005). Model systems based on experimental animals for studies on drug metabolism in man: (mini)pig cytochromes P450 3A29 and 2E1. Basic Clin Pharmacol Toxicol 96:244–5.
  • Bieche I, Narjoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune P, de Waziers I. (2007). Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Pharmacogenet Genom 17:731–42.
  • Cotreau MM, Von Moltke LL, Greenblatt DJ. (2005). The influence of age and sex on the clearance of cytochrome P450 3A substrates. Clin Pharmacokinet 44:33–60.
  • Ding X, Kaminsky LS. (2003). Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43:149–73.
  • Enayetallah AE, French RA, Thibodeau MS, Grant DF. (2004). Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues. J Histochem Cytochem 52:447–54.
  • Girault I, Rougier N, Chesne C, Lidereau R, Beaune P, Bieche I, de Waziers I. (2005). Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction. Drug Metab Disposit 33:1803–10.
  • Koch I, Weil R, Wolbold R, Brockmoller J, Hustert E, Burk O, Nuessler A, Neuhaus P, Eichelbaum M, Zanger U, Wojnowski L. (2002). Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. Drug Metab Disposit 30:1108–14.
  • Komura H, Iwaki M. (2008). Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates. J Pharmaceut Sci 97:1775–800.
  • Krishna DR, Klotz U. (1994). Extrahepatic metabolism of drugs in humans. Clin Pharmacokinet 26:144–60.
  • Li AP, Rasmussen A, Xu L, Kaminski DL. (1995). Rifampicin induction of lidocaine metabolism in cultured human hepatocytes. J Pharmacol Exp Ther 274:673–7.
  • Li J, Liu Y, Zhang JW, Wei H, Yang L. (2006). Characterization of hepatic drug-metabolizing activities of Bama miniature pigs (Sus scrofa domestica): comparison with human enzyme analogs. Comparat Med 56:286–90.
  • Mealey KL, Jabbes M, Spencer E, Akey JM. (2008). Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine. Xenobiotica 38:1305–12.
  • Nannelli A, Chirulli V, Longo V, Gervasi PG. (2008). Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. Toxicology 252:105–12.
  • Nishimura M, Yaguti H, Yoshitsugu H, Naito S, Satoh T. (2003). Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi 123:369–75.
  • Nygard AB, Jorgensen CB, Cirera S, Fredholm M. (2007). Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. BMC Mol Biol 8:67.
  • Patki KC, Von Moltke LL, Harmatz JS, Hesse LM, Court MH, Greenblatt DJ. (2004). Effect of age on in vitro triazolam biotransformation in male human liver microsomes. J Pharmacol Exp Ther 308:874–9.
  • Schuetz EG, Schuetz JD, Strom SC, Thompson MT, Fisher RA, Molowa DT, Li D, Guzelian PS. (1993). Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology 18:1254–62.
  • Shang H, Niu R, Wei H, Huang Z, Gan S, Wang A, Zeng Y. (2001). Genetic analysis of 35 microsatellite loci in three miniature pig breeds. Yi Chuan 23:17–20.
  • Skaanild MT. (2006). Porcine cytochrome P450 and metabolism. Curr Pharmaceut Design 12:1421–7.
  • Skaanild MT, Friis C. (1997). Characterization of the P450 system in Gottingen minipigs. Pharmacol Toxicol 80 Suppl. 2:28–33.
  • Soucek P, Zuber R, Anzenbacherova E, Anzenbacher P, Guengerich FP. (2001). Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs. BMC Pharmacol 1:11.
  • Stevens JC. (2006). New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology. Drug Disc Today 11:440–5.
  • Strayhorn VA, Baciewicz AM, Self TH. (1997). Update on rifampin drug interactions, III. Arch Int Med 157:2453–8.
  • Telhada MB, Pereira TM, Lechner MC. (1992). Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development. Arch Biochem Biophys 298:715–25.
  • Thummel KE, Wilkinson GR. (1998). In vitro and in vivo drug interactions involving human CYP3A. Ann Rev Pharmacol Toxicol 38:389–430.
  • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: research0034.1–research0034.11.
  • Woodland C, Huang TT, Gryz E, Bendayan R, Fawcett JP. (2008). Expression, activity and regulation of CYP3A in human and rodent brain. Drug Metab Rev 40:149–68.
  • Wrighton SA, Stevens JC. (1992). The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 22:1–21.
  • Yengi LG, Xiang Q, Pan J, Scatina J, Kao J, Ball SE, Fruncillo R, Ferron G, Roland Wolf C. (2003). Quantitation of cytochrome P450 mRNA levels in human skin. Analyt Biochem 316:103–10.
  • Zuber R, Anzenbacherova E, Anzenbacher P. (2002). Cytochromes P450 and experimental models of drug metabolism. J Cell Mol Med 6(2):189–98.

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