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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 5
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Animal Pharmacokinetics and Metabolism

Effects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats

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Pages 563-568 | Received 09 Apr 2018, Accepted 15 May 2018, Published online: 04 Jun 2018

References

  • Choi JS, Choi DH. (2013). Effects of licochalcon A on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats. Pharmazie 68:882–8.
  • Eid HM, Haddad PS. (2017). The antidiabetic potential of quercetin: underlying mechanisms. Curr Med Chem 24:355–64.
  • Gruse J, Gors S, Tuchscherer A, et al. (2015). The effects of oral quercetin supplementation on splanchnic glucose metabolism in 1-week-old calves depend on diet after birth. J Nutr 145:2486–95.
  • Hatahet T, Morille M, Hommoss A, et al. (2016). Dermal quercetin smartCrystals®: formulation development, antioxidant activity and cellular safety. Eur J Pharm Biopharm 102:51–63.
  • Huang Y, Zhao J, Jian W, Wang G. (2017). Effects of verapamil on the pharmacokinetics of dihydromyricetin in rats and its potential mechanism. Xenobiotica 1–6 [Epub ahead of print].
  • Jana S, Rastogi H. (2017). Effects of caffeic acid and quercetin on in vitro permeability, metabolism and in vivo pharmacokinetics of melatonin in rats: potential for herb-drug interaction. Eur J Drug Metab Pharmacokinet 42:781–91.
  • Jia FF, Tan ZR, McLeod HL, et al. (2016). Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers. Xenobiotica 46:896–900.
  • Joyce H, McCann A, Clynes M, Larkin A. (2015). Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism. Expert Opin Drug Metab Toxicol 11:795–809.
  • Kaur G, Invally M, Chintamaneni M. (2016). Influence of piperine and quercetin on antidiabetic potential of curcumin. J Complement Integr Med 13:247–55.
  • Kim RB, Fromm MF, Wandel C, et al. (1998). The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 101:289–94.
  • Kimura O, Fujii Y, Haraguchi K, et al. (2016). Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers. J Pharm Pharmacol 68:883–9.
  • Klishadi MS, Zarei F, Hejazian SH, et al. (2015). Losartan protects the heart against ischemia reperfusion injury: sirtuin3 involvement. J Pharm Pharm Sci 18:112–23.
  • Kobayashi M, Takagi M, Fukumoto K, et al. (2008). The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan. Drug Metab Pharmacokinet 23:115–19.
  • Li H, Liu L, Xie L, et al. (2016b). Effects of berberine on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism. Pharm Biol 54:2886–94.
  • Li Z, Wang K, Zheng J, et al. (2014). Interactions of the active components of Punica granatum (pomegranate) with the essential renal and hepatic human solute carrier transporters. Pharm Biol 52:1510–17.
  • Li B, Yang M, Liu JW, Yin GT. (2016a). Protective mechanism of quercetin on acute myocardial infarction in rats. Genet Mol Res 15:15017117.
  • Li Y, Yao J, Han C, et al. (2016c). Quercetin, inflammation and immunity. Nutrients 8:167.
  • Moreno L, Puerta E, Suarez-Santiago JE, et al. (2017). Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer's disease. Int J Pharm 517:50–7.
  • Nguyen MA, Staubach P, Wolffram S, Langguth P. (2014). Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans – implications for the evaluation of transporter-mediated flavonoid-drug interactions. Eur J Pharm Sci 61:54–60.
  • Oboh G, Ademosun AO, Ogunsuyi OB. (2016). Quercetin and its role in chronic diseases. Adv Exp Med Biol 929:377–87.
  • Palle S, Neerati P. (2017). Enhancement of oral bioavailability of rivastigmine with quercetin nanoparticles by inhibiting CYP3A4 and esterases. Pharmacol Rep 69:365–70.
  • Ravikumar Reddy D, Khurana A, Bale S, et al. (2016). Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs. Springerplus 5:1618.
  • Rincon J, Correia D, Arcaya JL, et al. (2015). Role of angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension. Life Sci 124:81–90.
  • Soldner A, Benet LZ, Mutschler E, Christians U. (2000). Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol 129:1235–43.
  • Wang X, Zhang X, Liu F, et al. (2017). The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism. Pharm Biol 55:1863–7.
  • Wen F, Shi M, Bian J, et al. (2015). Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol 54:293–302.
  • Wrighton SA, Stevens JC. (1992). The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 22:1–21.
  • Xiaoyang L, Chenming N, Chengqing L, Tao L. (2015). Drug-drug interation prediction between ketoconazole and anti-liver cancer drug Gomisin G. Afr Health Sci 15:590–3.
  • Yang SH, Cho YA, Choi JS. (2011a). Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats. Acta Pharmacol Sin 32:967–72.
  • Yang SH, Choi JS, Choi DH. (2011b). Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors. Pharmacology 88:1–9.
  • Yasar U, Babaoglu MO, Bozkurt A. (2008). Disposition of a CYP2C9 phenotyping agent, losartan, is not influenced by the common 3435C > T variation of the drug transporter gene ABCB1 (MDR1). Basic Clin Pharmacol Toxicol 103:176–9.
  • Ye L, Wang T, Tang L, et al. (2011). Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. J Pharm Sci 100:5007–17.
  • Yuan Y, Zhang H, Ma W, et al. (2013). Influence of compound Danshen tablet on the pharmacokinetics of losartan and its metabolite EXP3174 by liquid chromatography coupled with mass spectrometry. Biomed Chromatogr 27:1219–24.
  • Yun CH, Lee HS, Lee H, et al. (1995). Oxidation of the angiotensin II receptor antagonist losartan (DuP 753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174. Drug Metab Dispos 23:285–9.
  • Zaidenstein R, Soback S, Gips M, et al. (2001). Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers. Ther Drug Monit 23:369–73.
  • Zhang JW, Liu Y, Cheng J, et al. (2007). Inhibition of human liver cytochrome P450 by star fruit juice. J Pharm Pharm Sci 10:496–503.

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