Exploring precision-cut liver slices for comparative xenobiotic metabolism profiling in swine and cattle

References

• Acorda JA, Yamada H, Ghamsari SM. 1995. Comparative evaluation oh hydropic degeneration of the liver in dairy cattle through biochemistry, ultrasonography and digital analysis. Vet Radiology Ultrasound. 36(4):322–326. doi: 10.1080/01652176.1995.9694522.
   Web of Science ®Google Scholar
• Álvarez L, Chiappetta V, Cantón L, Domínguez P, Cantón C, Lanusse C, Ceballos L. 2023. Feeding management and albendazole pharmacokinetics in pigs. Animals (Basel). 13(3):474. doi: 10.3390/ani13030474.
   PubMedGoogle Scholar
• Álvarez LI, Saumell CA, Sanchez SF, Lanusse CE. 1996. Plasma disposition kinetics of albendazole metabolites in pigs fed different diets. Res Vet Sci. 60(2):152–156. doi: 10.1016/s0034-5288(96)90010-7.
   PubMed Web of Science ®Google Scholar
• Benoit E, Besse S, Delatour P. 1992. Effect of repeated doses of albendazole on enantiomerism of its sulfoxide metabolite in goats. Am J Vet Res. 53(9):1663–1665. doi: 10.2460/ajvr.1992.53.09.1663.
   PubMed Web of Science ®Google Scholar
• Burke MD, Orrenius S. 1978. The effect of albumin on the metabolism of ethoxyresorufin through O-deethylation and sulphate-conjugation using isolated rat hepatocytes. Biochem Pharmacol. 27(11):1533–1538. doi: 10.1016/0006-2952(78)90481-1.
   PubMed Web of Science ®Google Scholar
• Capolongo F, Santi A, Anfossi P, Montesissa C. 2010. Benzydamine as a useful substrate of hepatic flavin-containing monooxygenase activity in veterinary species. J Vet Pharmacol Ther. 33(4):341–346. doi: 10.1111/j.1365-2885.2009.01145.x.
   PubMed Web of Science ®Google Scholar
• da Silva JS, Rosa AF, Moncau CT, Silva-Vignato B, Pugine SMP, de Melo MP, Sanchez JMD, Zanetti MA. 2021. Effect of different selenium sources and concentrations on glutathione peroxidase activity and cholesterol metabolism of beef cattle. J Anim Sci. 99(12):skab321. doi: 10.1093/jas/skab321.
   PubMed Web of Science ®Google Scholar
• D’Alessandro AM, Kalayoglu M, Sollinger HW, Hoffmann RM, Reed A, Knechtle SJ, Pirsch JD, Hafez GR, Lorentzen D, Belzer FO. 1991. The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation. Transplantation. 51(1):157–163. doi: 10.1097/00007890-199101000-00024.
   PubMed Web of Science ®Google Scholar
• de Graaf IAM, Groothuis GMM, Olinga P. 2007. Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opin Drug Metab Toxicol. 3(6):879–898. doi: 10.1517/17425255.3.6.879.
   PubMed Web of Science ®Google Scholar
• Dewyse L, Reynaert H, van Grunsven LA. 2021. Best practices and progress in precision-cut liver slice cultures. Int J Mol Sci. 22(13):7137. doi: 10.3390/ijms22137137.
   PubMed Web of Science ®Google Scholar
• Ekins S. 1996. Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism. Drug Metab Rev. 28(4):591–623. doi: 10.3109/03602539608994019.
   PubMed Web of Science ®Google Scholar
• El Amri HS, Fargetton X, Delatour P, Batt AM. 1987. Sulphoxidation of albendazole by the FAD-containing and cytochrome P-450 dependent monooxygenases from pig liver microsomes. Xenobiotica. 17(10):1159–1168. doi: 10.3109/00498258709167408.
   Google Scholar
• Fink-Gremmels J. 2008. Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences. Eur J Pharmacol. 585(2–3):502–509. doi: 10.1016/j.ejphar.2008.03.013.
   PubMed Web of Science ®Google Scholar
• Fisher RL, Judith U, Paul N, Klaus B. 2001. Histological and biochemical evaluation of precision-cut liver slices. Toxicol Methods. 11(2):59–79. doi: 10.1080/105172301300128871.
   Google Scholar
• Fisher RL, Vickers AEM. 2013. Preparation and culture of precision-cut organ slices from human and animal. Xenobiotica. 43(1):8–14. doi: 10.3109/00498254.2012.728013.
   PubMed Web of Science ®Google Scholar
• Fokkelman K, Haase E, Stevens J, Idikio H, Korbutt G, Bigam D, Cheung PY. 2007. Tissue-specific changes in glutathione content of hypoxic newborn pigs reoxygenated with 21% or 100% oxygen. Eur J Pharmacol. 562(1–2):132–137. doi: 10.1016/j.ejphar.2007.01.057.
   PubMed Web of Science ®Google Scholar
• Gramignoli R, Tahan V, Dorko K, Skvorak KJ, Hansel MC, Zhao W, Venkataramanan R, Ellis EC, Jorns C, Ericzon BG, et al. 2013. New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants. Stem Cell Res. 11(1):563–573. doi: 10.1016/j.scr.2013.03.002.
   PubMed Web of Science ®Google Scholar
• Hasuda AL, Person E, Khoshal AK, Bruel S, Puel S, Oswald IP, Bracarense A, Pinton P. 2022. Deoxynivalenol induces apoptosis and inflammation in the liver: analysis using precision-cut liver slices. Food Chem Toxicol. 163:112930. doi: 10.1016/j.fct.2022.112930.
   PubMed Web of Science ®Google Scholar
• Hissin PJ, Hilf R. 1976. A fluorimetric method for determination of oxidised and reduced glutathione in tissues. Anal Biochem. 74(1):214–226. doi: 10.1016/0003-2697(76)90326-2.
   PubMed Web of Science ®Google Scholar
• Ichinose P, Miró MV, Larsen K, Lanusse C, Lifschitz A, Virkel G. 2023. Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine. Vet Res Commun. 47(2):803–815. doi: 10.1007/s11259-022-10041-6.
   PubMed Web of Science ®Google Scholar
• Ioannides C. 2006. Cytochrome P450 expression in the liver of food-producing animals. Curr Drug Metab. 7(4):335–348. doi: 10.2174/138920006776873544.
   PubMed Web of Science ®Google Scholar
• Ioannides C. 2013. Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices. Xenobiotica. 43(1):15–28. doi: 10.3109/00498254.2012.698766.
   PubMed Web of Science ®Google Scholar
• Knox MR, Steel JW. 1997. Effects of diet and species on the pharmacokinetics of fenbendazole in cattle. Vet Res Commun. 21(1):37–43. doi: 10.1023/b:verc.0000009699.60051.e1.
   PubMed Web of Science ®Google Scholar
• Lake BG, Price RJ. 2013. Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica. 43(1):41–53. doi: 10.3109/00498254.2012.734643.
   PubMed Web of Science ®Google Scholar
• Lanusse C, Prichard R. 1993. Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants. Drug Metab Rev. 25(3):235–279. doi: 10.3109/03602539308993977.
   PubMed Web of Science ®Google Scholar
• Larsen K, Ichinose P, Fernández-San Juan R, Lifschitz A, Virkel G. 2023. Effects of acaricides on the activities of monooxygenases in bovine liver microsomes. J Vet Pharmacol Ther. 46(6):375–384. doi: 10.1111/jvp.13395.
   PubMed Web of Science ®Google Scholar
• Lerche-Langrand C, Toutain HJ. 2000. Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology. 153(1–3):221–253. doi: 10.1016/s0300-483x(00)00316-4.
   PubMed Web of Science ®Google Scholar
• Maté L, Giantin M, Viviani P, Ballent M, Tolosi R, Lifschitz A, Lanusse C, Dacasto M, Virkel G. 2019. Effects of fenbendazole and triclabendazole on the expression of cytochrome P450 1A and flavin-monooxygenase isozymes in bovine precision-cut liver slices. Vet J. 245:61–69. doi: 10.1016/j.tvjl.2019.01.001.
   PubMed Web of Science ®Google Scholar
• Montesissa C, Stracciari JM, Fadini L, Beretta C. 1989. Comparative microsomal oxidation of febantel and its metabolite fenbendazole in various animal species. Xenobiotica. 19(1):97–100. doi: 10.3109/00498258909034681.
   PubMed Web of Science ®Google Scholar
• Murray M, Hudson A, Yassa V. 1992. Hepatic microsomal metabolism of the anthelmintic benzimidazole fenbendazole: enhanced inhibition of cytochrome P450 reactions by oxidised metabolites of the drug. Chem Res Toxicol. 5(1):60–66. doi: 10.1021/tx00025a010.
   PubMed Web of Science ®Google Scholar
• Nebbia C, Dacasto M, Rossetto Giaccherino A, Giuliano Albo A, Carletti M. 2003. Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species. Vet J. 165(1):53–64. doi: 10.1016/s1090-0233(02)00174-0.
   PubMed Web of Science ®Google Scholar
• Nebbia C. 2001. Biotransformation enzymes as determinants of xenobiotic toxicity in domestic animals. Vet J. 161(3):238–252. doi: 10.1053/tvjl.2000.0561.
   PubMed Web of Science ®Google Scholar
• Palma E, Doornebal E, Chokshi S. 2019. Precision‑cut liver slices: a versatile tool to advance liver research. Hepatol Int. 13(1):51–57. doi: 10.1007/s12072-018-9913-7.
   PubMed Web of Science ®Google Scholar
• Pegolo S, Merlanti R, Giantin M, Dacasto M, Montesissa C, Capolongo F. 2010. High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes. Vet J. 183(1):81–88. doi: 10.1016/j.tvjl.2008.08.006.
   PubMed Web of Science ®Google Scholar
• Petersen MB, Friis C. 2000. Pharmacokinetics of fenbendazole following intravenous and oral administration to pigs. Am J Vet Res. 61(5):573–576. doi: 10.2460/ajvr.2000.61.573.
   PubMed Web of Science ®Google Scholar
• Price RJ, Ball SE, Renwick AB, Barton PT, Beamand JA, Lake BG. 1998. Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers. Xenobiotica. 28(4):361–371. doi: 10.1080/004982598239470.
   PubMed Web of Science ®Google Scholar
• Puccinelli E, Gervasi PG, Longo V. 2011. Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model. Curr Drug Metab. 12(6):507–525. doi: 10.2174/138920011795713698.
   PubMed Web of Science ®Google Scholar
• Punt A, Lautz L, Stoopen G, Pinckaers N, Rijkers D, Essers M, Hoogenboom R. 2021. In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver. Toxicol in Vitro. 76:105228. doi: 10.1016/j.tiv.2021.105228.
   PubMed Web of Science ®Google Scholar
• Sánchez SF, Alvarez LI, Lanusse CE. 1997. Fasting-induced changes to the pharmacokinetic behaviour of albendazole and its metabolites in calves. J Vet Pharmacol Ther. 20(1):38–47. doi: 10.1046/j.1365-2885.1997.00810.x.
   PubMed Web of Science ®Google Scholar
• Santi A, Anfossi P, Coldham NG, Capolongo F, Sauer MJ, Montesissa C. 2002. Biotransformation of benzydamine by microsomes and precision-cut slices prepared from cattle liver. Xenobiotica. 32(1):73–86. doi: 10.1080/00498250110085827.
   PubMed Web of Science ®Google Scholar
• Sauer MJ, Dave M, Lake BG, Manchee GR, Howells LC, Coldham NG. 1999. β2-agonist abuse in food-producing animals: use of in vitro liver preparations to assess biotransformation and potential target residues for surveillance. Xenobiotica. 29(5):483–497. doi: 10.1080/004982599238498.
   PubMed Web of Science ®Google Scholar
• Sivapathasundaram S, Howells LC, Sauer MJ, Ioannides C. 2004. Functional integrity of precision-cut liver slices from deer and cattle. J Vet Pharmacol Ther. 27(2):79–84. doi: 10.1111/j.1365-2885.2004.00555.x.
   Google Scholar
• Serras AS, Rodrigues JS, Cipriano M, Rodrigues AV, Oliveira NG, Miranda JP. 2021. A critical perspective on 3D liver models for drug metabolism and toxicology studies. Front Cell Dev Biol. 9:626805. doi: 10.3389/fcell.2021.626805.
   PubMed Web of Science ®Google Scholar
• Short CR, Barker SA, Hsieh LC, Ou SP, McDowell T, Davis LE, Neff-Davis CA, Koritz G, Bevill RF, Munsiff IJ. 1987. Disposition of fenbendazole in cattle. Am J Vet Res. 48(6):958–961.
   PubMed Web of Science ®Google Scholar
• Sistare F, Mattes W, LeCluyse E. 2016. The promise of new technologies to reduce, refine, or replace animal use while reducing risks of drug induced liver injury in pharmaceutical development. ILAR J. 57(2):186–211. doi: 10.1093/ilar/ilw025.
   PubMed Web of Science ®Google Scholar
• Tafazoli S, Spehar DD, O’Brien PJ. 2005. Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab Rev. 37(2):311–325. doi: 10.1081/dmr-55227.
   PubMed Web of Science ®Google Scholar
• Velík J, Baliharová V, Fink-Gremmels J, Bull S, Lamka J, Skálová L. 2004. Benzimidazole drugs and modulation of biotransformation enzymes. Res Vet Sci. 76(2):95–108. doi: 10.1016/j.rvsc.2003.08.005.
   PubMed Web of Science ®Google Scholar
• Velík J, Baliharová V, Skálová L, Szotáková B, Wsól V, Lamka J. 2005. Liver microsomal biotransformation of albendazole in deer, cattle, sheep and pig and some related wild breeds. J Vet Pharmacol Ther. 28(4):377–384. doi: 10.1111/j.1365-2885.2005.00671.x.
   PubMed Web of Science ®Google Scholar
• Vickers A, Fisher R, Sinclair J. 2010. Glutathione modulation and oxidative stress in human liver slices. Curr Drug Discov Technol. 7(3):154–169. doi: 10.2174/157016310793180530.
   PubMedGoogle Scholar
• Vickers AE, Saulnier M, Cruz E, Merema MT, Rose K, Bentley P, Olinga P. 2004. Organ slice viability extended for pathway characterization: an in vitro model to investigate fibrosis. Toxicol Sci. 82(2):534–544. doi: 10.1093/toxsci/kfh285.
   PubMed Web of Science ®Google Scholar
• Virkel G, Imperiale F, Lifschitz A, Pis A, Alvarez A, Merino G, Prieto J, Lanusse C. 2003. Effect of amphiphilic surfactant agents on the gastrointestinal absorption of albendazole in cattle. Biopharm Drug Dispos. 24(3):95–103. doi: 10.1002/bdd.339.
   PubMed Web of Science ®Google Scholar
• Virkel G, Lifschitz A, Sallovitz J, Pis A, Lanusse C. 2004. Comparative hepatic and extrahepatic enantioselective sulfoxidation of albendazole and fenbendazole in sheep and cattle. Drug Metab Dispos. 32(5):536–544. doi: 10.1124/dmd.32.5.536.
   PubMed Web of Science ®Google Scholar
• Viviani P, Lifschitz AL, García JP, Maté ML, Quiroga MA, Lanusse CE, Virkel GL. 2017. Assessment of liver slices for research on metabolic drug-drug interactions in cattle. Xenobiotica. 47(11):933–942. doi: 10.1080/00498254.2016.1246782.
   PubMed Web of Science ®Google Scholar
• Viviani P, Lifschitz AL, Maté ML, García JP, Lanusse CE, Virkel GL. 2018. Assessment of the pharmacological interactions between the nematodicidal fenbendazole and the flukicidal triclabendazole: in vitro studies with bovine liver microsomes and slices. J Vet Pharmacol Ther. 41(3):476–484. doi: 10.1111/jvp.12492.
   PubMed Web of Science ®Google Scholar
• Wang S, Rijk JC, Riethoff-Poortman JH, Van Kuijk S, Peijnenburg AA, Bovee TF. 2010. Bovine liver slices combined with an androgen transcriptional activation assay: an in-vitro model to study the metabolism and bioactivity of steroids. Anal Bioanal Chem. 397(2):631–641. doi: 10.1007/s00216-010-3605-z.
   PubMed Web of Science ®Google Scholar
• Zimmermann M, Lampe J, Lange S, Smirnow I, Königsrainer A, Hann-von-Weyhern C, Fend F, Gregor M, Bitzer M, Lauer UM. 2009. Improved reproducibility in preparing precision-cut liver tissue slices. Cytotechnology. 61(3):145–152. doi: 10.1007/s10616-009-9246-4.
   PubMed Web of Science ®Google Scholar