Metabonomic and transcriptomic analyses of Tripterygium glycosides tablet-induced hepatotoxicity in rats

References

• Allard, J., et al., 2019. Drug-induced liver injury in obesity and nonalcoholic fatty liver disease. Advances in Pharmacology, 85, 75–107.
   PubMedGoogle Scholar
• Becker, R.A., et al., 1981. Methylation of liver DNA guanine in hydrazine hepatotoxicity: dose-response and kinetic characteristics of 7-methylguanine and O6-methylguanine formation and persistence in rats. Carcinogenesis, 2 (11), 1181–1188.
   PubMed Web of Science ®Google Scholar
• Bi, Y., et al., 2021. Ginsenoside Rg1 and ginsenoside Rh1 prevent liver injury induced by acetaminophen in mice. Journal of Food Biochemistry, 45 (8), e13816.
   Web of Science ®Google Scholar
• Brunt, E.M., et al., 2011. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology, 53 (3), 810–820.
   PubMed Web of Science ®Google Scholar
• Chen, K., et al., 2020. CYP2E1 and miRNA-378a-3p contribute to acetaminophen- or tripterygium glycosides-induced hepatotoxicity. Basic & Clinical Pharmacology & Toxicology, 126 (2), 153–165.
   PubMed Web of Science ®Google Scholar
• Dai, M., et al., 2022. Metabolomics reveals the role of PPARα in Tripterygium wilfordii-induced liver injury. Journal of Ethnopharmacology, 289, 115090.
   PubMed Web of Science ®Google Scholar
• Danan, G., et al., 2015. RUCAM in drug and herb induced liver injury: the update. International Journal of Molecular Sciences, 17 (1), 14.
   PubMed Web of Science ®Google Scholar
• Du, J., et al., 2016. Glutamate in peripheral organs: biology and pharmacology. European Journal of Pharmacology, 784, 42–48.
   PubMed Web of Science ®Google Scholar
• Fontana, R.J., 2014. Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives. Gastroenterology, 146 (4), 914–928.
   PubMed Web of Science ®Google Scholar
• Gao, X., et al., 2018. Bioinformatics identification of crucial genes and pathways associated with hepatocellular carcinoma. Bioscience Reports, 38 (6), BSR20181441.
   PubMed Web of Science ®Google Scholar
• Gao, Y., et al., 2014. Identifying early urinary metabolic changes with long-term environmental exposure to cadmium by mass-spectrometry-based metabolomics. Environmental Science & Technology, 48 (11), 6409–6418.
   PubMed Web of Science ®Google Scholar
• Grinberg, M., et al., 2018. Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes. Archives of Toxicology, 92 (12), 3517–3533.
   PubMed Web of Science ®Google Scholar
• Haque, T., et al., 2016. Drug-induced liver injury: pattern recognition and future directions. Gut and Liver, 10 (1), 27–36.
   PubMed Web of Science ®Google Scholar
• Honma, K., et al., 2017. Insulin-induced inhibition of gluconeogenesis genes, including glutamic pyruvic transaminase 2, is associated with reduced histone acetylation in a human liver cell line. Metabolism: Clinical and Experimental, 71, 118–124.
   PubMed Web of Science ®Google Scholar
• Hoshi, M., et al., 2020. Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice. Toxicology, 438, 152458.
   PubMed Web of Science ®Google Scholar
• Hu, T., et al., 2020. A single-injection targeted metabolomics profiling method for determination of biomarkers to reflect tripterygium glycosides efficacy and toxicity. Toxicology and Applied Pharmacology, 389, 114880.
   PubMed Web of Science ®Google Scholar
• Huang, Y., et al., 2017. Maternal high-fat diet during pregnancy and lactation affects hepatic lipid metabolism in early life of offspring rat. Journal of Biosciences, 42 (2), 311–319.
   PubMed Web of Science ®Google Scholar
• Huo, T., et al., 2014. An effective assessment of valproate sodium-induced hepatotoxicity with UPLC-MS and (1)HNMR-based metabonomics approach. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 969, 109–116.
   PubMed Web of Science ®Google Scholar
• Jiang, W., et al., 2019. Identification of the pathogenic biomarkers for hepatocellular carcinoma based on RNA-seq analyses. Pathology Oncology Research, 25 (3), 1207–1213.
   PubMed Web of Science ®Google Scholar
• Kullak-Ublick, G.A., et al., 2017. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut, 66 (6), 1154–1164.
   PubMed Web of Science ®Google Scholar
• Lin, N., et al., 2020. Clinical Practice Guideline for Tripterygium glycosides/Tripterygium wilfordii Tablets in the Treatment of Rheumatoid Arthritis. Frontiers in Pharmacology, 11, 608703.
   PubMed Web of Science ®Google Scholar
• Liu, L., et al., 2013. Fasting serum lipid and dehydroepiandrosterone sulfate as important metabolites for detecting isolated postchallenge diabetes: serum metabolomics via ultra-high-performance LC-MS. Clinical Chemistry, 59 (9), 1338–1348.
   PubMed Web of Science ®Google Scholar
• Livak, K.J. and Schmittgen, T.D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25 (4), 402–408.
   PubMed Web of Science ®Google Scholar
• Ma, B., et al., 2015. Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: a GC-MS based metabolomics study. Toxicology, 336, 84–95.
   PubMed Web of Science ®Google Scholar
• Ortega-Alonso, A., et al., 2016. Case characterization, clinical features and risk factors in drug-induced liver injury. International Journal of Molecular Sciences, 17 (5), 714.
   PubMed Web of Science ®Google Scholar
• Peng, W., et al., 2021. FXR activation prevents liver injury induced by Tripterygium wilfordii preparations. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 51 (6), 716–727.
   PubMed Web of Science ®Google Scholar
• Qi, L., et al., 2017. Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine. Human & Experimental Toxicology, 36 (5), 494–507.
   PubMed Web of Science ®Google Scholar
• Shi, H., et al., 2017. Metabolomics analysis of urine from rats administered with long-term, low-dose acrylamide by ultra-performance liquid chromatography-mass spectrometry. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 47 (5), 439–449.
   PubMed Web of Science ®Google Scholar
• Singh, A.P., et al., 2010. Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men. Cancer Biomarkers: Section A of Disease Markers, 8 (6), 351–359.
   PubMed Web of Science ®Google Scholar
• Stine, J.G., et al., 2016. Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review. Expert Review of Gastroenterology & Hepatology, 10 (4), 517–536.
   PubMed Web of Science ®Google Scholar
• Suto, K., et al., 1999. Decreased expression of the peroxisomal bifunctional enzyme and carbonyl reductase in human hepatocellular carcinomas. Journal of Cancer Research and Clinical Oncology, 125 (2), 83–88.
   PubMed Web of Science ®Google Scholar
• Wang, B. and Zhou, S.F., 2009. Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Current Medicinal Chemistry, 16 (31), 4066–4218.
   PubMed Web of Science ®Google Scholar
• Wang, S., et al., 2021a. Canagliflozin improves liver function in rats by upregulating asparagine synthetase. Pharmacology, 106 (11–12), 606–612.
   PubMed Web of Science ®Google Scholar
• Wang, S., et al., 2021b. CYP1A2 polymorphism may contribute to agomelatine-induced acute liver injury: case report and review of the literature. Medicine, 100 (45), e27736.
   PubMed Web of Science ®Google Scholar
• Wang, X.Y., et al., 2019. Clinical symptoms effect of Tripterygium glycosides tablets alone or combined with methotrexate in treatment of rheumatoid arthritis: a meta-analysis. China Journal of Chinese Materia Medica, 44, 3533–3541.
   Google Scholar
• Wrighton, S.A. and Stevens, J.C., 1992. The human hepatic cytochromes P450 involved in drug metabolism. Critical Reviews in Toxicology, 22 (1), 1–21.
   PubMed Web of Science ®Google Scholar
• Zhang, J., et al., 2015. Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice. Scientific Reports, 5, 8098.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., et al., 2012. Toxicogenomic analysis of the gene expression changes in rat liver after a 28-day oral Tripterygium wilfordii multiglycoside exposure. Journal of Ethnopharmacology, 141 (1), 170–177.
   PubMed Web of Science ®Google Scholar
• Zuwała-Jagiello, J., Pazgan-Simon, M., Simon, K., and Warwas, M., 2012. Picolinic acid in patients with chronic hepatitis C infection: a preliminary report. Mediators of Inflammation, 2012, 1–10.
   Web of Science ®Google Scholar