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Review Series: Antioxidants and their Clinical Applications

β-Carotene and Other Carotenoids as Antioxidants

, MD, PhD & , MD
Pages 426-433 | Received 01 Mar 1999, Published online: 07 Jun 2013

REFERENCES

  • Goodwin TW: “The Biochemistry of the Carotenoids.” Vol. 1: “Plants.” New York: Chapman and Hall, p 203, 1980.
  • Beecher GR: Nutrient content of tomatoes and tomatoes products. Proc Soc Exp Biol Med 218: 98–100, 1998.
  • Gerster H: The potential role of lycopene for human health. J Am Coll Nutr 16: 109–126, 1997.
  • Bendich A: Biological functions of dietary carotenoids. Ann NY Acad Sci 691: 61–67, 1993.
  • Sies H, Stahl W: Carotenoids and intercellular communication via gap junctions. Int J Vitam Nutr Res 67: 364–367, 1997.
  • Stahl W, Sies H: Lycopene: a biologically important carotenoid for humans? Arch Biochem Biophys 336: 1–9, 1996.
  • Krinsky NI: Overview of lycopene, carotenoids, and disease prevention. Proc Soc Exp Biol Med 218: 95–97, 1998.
  • Burton GW, Ingold KU: beta-Carotene: an unusual type of lipid antioxidant. Science 224: 569–573, 1984.
  • Rice-Evans CA, Sampson J, Bramley PM, Holloway DE: Why do we expect carotenoids to be antioxidants in vivo? Free Radic Res 26: 381–398, 1997.
  • Woodall AA, Britton G, Jackson MJ: Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: Relationship between carotenoid structure and protective ability. Biochim Biophys Acta 1336: 575–586, 1997.
  • Lessin WJ, Catigani GI, Schwartz SJ: Quantification of cis-trans isomers of provitamin A carotenoids in fresh and processed fruits and vegetables. J Agric Food Chem 45: 3728–3732, 1997.
  • Erdman JW Jr, Bierer TL, Gugger ET: Absorption and transport of carotenoids. Ann NY Acad Sci 691: 76–85, 1993.
  • Rock CL, Lovalvo JL, Emenhiser C, Ruffin MT, Flatt SW, Schwartz SJ: Bioavailability of beta-carotene is lower in raw than in processed carrots and spinach in women. J Nutr 128: 913–916, 1998.
  • Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC: Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87: 1767–1776, 1995.
  • Stahl W, Sies H: Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 122: 2161–2166, 1992.
  • Khachik F, Goli MB, Beecher GR, Holden J, Lusby WR, Tenorio MD, Barrera MR: Effect of food preparation on qualitative and quantitative distribution of major carotenoid constituents of tomatoes and several green vegetables. J Agric Food Chem 40: 390–398, 1992.
  • Martin KR, Failla ML, Smith JC Jr: Beta-carotene and lutein protect HepG2 human liver cells against oxidant-induced damage. J Nutr 126: 2098–2106, 1996.
  • Palozza P, Luberto C, Calviello G, Ricci P, Bartoli GM: Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: effects of oxygen partial pressure. Free Radic Biol Med 22: 1065–1073, 1997.
  • Gaziano JM, Hatta A, Flynn M, Johnson EJ, Krinsky NI, Ridker PM, Hennekens CH, Frei B: Supplementation with beta-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis 112: 187–195, 1995.
  • Palozza P, Calviello G, Bartoli GM: Prooxidant activity of beta-carotene under 100% oxygen pressure in rat liver microsomes. Free Radic Biol Med 19: 887–892, 1995.
  • Romanchik JE, Morel DW, Harrison EH: Distributions of carotenoids and alpha-tocopherol among lipoproteins do not change when human plasma is incubated in vitro. J Nutr 125: 2610–2617, 1995.
  • Stocker R, Bowry VW, Frei B: Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA 88: 1646–1650, 1991.
  • Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G: Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am J Clin Nutr 53: 314S–321S, 1991.
  • Reaven PD, Ferguson E, Navab M, Powell FL: Susceptibility of human LDL to oxidative modification. Effects of variations in beta-carotene concentration and oxygen tension. Arterioscler Thromb 14: 1162–1169, 1994.
  • Lin Y, Burri BJ, Neidlinger TR, Muller HG, Dueker SR, Clifford AJ: Estimating the concentration of beta-carotene required for maximal protection of low-density lipoproteins in women. Am J Clin Nutr 67: 837–845, 1998.
  • Romanchik JE, Harrison EH, Morel DW: Addition of lutein, lycopene, or beta-carotene to LDL or serum in vitro: Effects on carotenoid distribution, LDL composition, and LDL oxidation. J Nutr Biochem 8: 681–688, 1997.
  • Stahl W, Junghans A, deBoer B, Driomina ES, Briviba K, Sies H: Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein. FEBS Lett 427: 305–308, 1998.
  • Palozza P, Krinsky NI: Antioxidant effects of carotenoids in vivo and in vitro: an overview. Methods Enzymol 213: 403–420, 1992.
  • Pollack J, Campbell JM, Potter SM, Erdman JW Jr: Mongolian gerbils (Meriones unguiculatus) absorb beta-carotene intact from a test meal. J Nutr 124: 869–873, 1994.
  • Moon RC, Constantinou AI: Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis. Breast Cancer Res Treat 46: 181–189, 1997.
  • Lomnitski L, Grossman S, Bergman M, Sofer Y, Sklan D: In vitro and in vivo effects of beta-carotene on rat epidermal lipoxygenases. Int J Vitam Nutr Res 67: 407–414, 1997.
  • Iyama T, Takasuga A, Azuma M: beta-Carotene accumulation in mouse tissues and a protective role against lipid peroxidation. Int J Vitam Nutr Res 66: 301–305, 1996.
  • Levin G, Yeshurun M, Mokady S: In vivo antiperoxidative effect of 9-cis beta-carotene compared with that of the all-trans isomer. Nutr Cancer 27: 293–297, 1997.
  • Shaish A, Daugherty AFOS, Schonfeld G, Heinecke JW: Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits. J Clin Invest 96: 2075–2082, 1995.
  • Conaway CC, Jiao D, Kelloff GJ, Steele VE, Rivenson A, Chung FL: Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice. Cancer Lett 124: 85–93, 1998.
  • Kim DJ, Takasuka N, Kim JM, Sekine K, Ota T, Asamoto M, Murakoshi M, Nishino H, Nir Z, Tsuda H: Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH. Cancer Lett 120: 15–22, 1997.
  • Sharoni Y, Giron E, Rise M, Levy J: Effects of lycopene-enriched tomato oleoresin on 7,12-dimethyl-benz[a]anthracene-induced rat mammary tumors. Cancer Detect Prev 21: 118–123, 1997.
  • Nagasawa H, Mitamura T, Sakamoto S, Yamamoto K: Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice. Anticancer Res 15: 1173–1178, 1995.
  • Lambert LA, Koch WH, Wamer WG, Kornhauser A: Antitumor activity in skin of Skh and Sencar mice by two dietary beta-carotene formulations. Nutr Cancer 13: 213–221, 1990.
  • Wolterbeek APM, Schoevers EJ, Bruyntjes JP, Rutten AAJJL, Feron VJ: Benzo[a]pyrene-induced respiratory tract cancer in hamsters fed a diet rich in beta-carotene. A histomorphological study. J Environ Pathol Toxicol Oncol 14: 35–43, 1995.
  • Peto R, Doll R, Buckley JD, Sporn MB: Can dietary beta-carotene materially reduce human cancer rates? Nature 290: 201–208, 1981.
  • Omaye ST, Burri BJ, Swendseid ME, Henning SM, Briggs LA, Bowen HT, Ota RB: Blood antioxidants changes in young women following beta-carotene depletion and repletion. J Am Coll Nutr 15: 469–474, 1996.
  • Meydani M, Martin A, Ribaya-Mercado JD, Gong J, Blumberg JB, Russell RM: Beta-carotene supplementation increases antioxidant capacity of plasma in older women. J Nutr 124: 2397–2403, 1994.
  • Cao G, Russell RM, Lischner N, Prior RL: Increases in serum antioxidant capacity following consumption of strawberries, spinach, red wine or vitamin C in elderly subjects. J Nutr in press, 1998.
  • Borel P, Grolier P, Boirie Y, Simonet L, Verdier E, Rochette Y, AlexandreGouabau MC, Beaufrere B, Lairon D, AzaisBraesco V: Oxidative stress status and antioxidant status are apparently not related to carotenoid status in healthy subjects. J Lab Clin Med 132: 61–66, 1998.
  • van Poppel G: Epidemiological evidence for beta-carotene in prevention of cancer and cardiovascular disease. Eur J Clin Nutr 50: S57–61, 1996.
  • Kardinaal AF, van’t Veer P, Kokl FJ, Kohlmeier L, Martin-Moreno JM, Huttunen JK, Hallen M, Aro A, Delgado-Rodriguez M, Gomez-Aracena J, et al.: EURAMIC Study: antioxidants, myocardial infarction and breast cancer. Design and main hypotheses. Eur J Clin Nutr 47: S64–72, 1993.
  • Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E: Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C. Am J Clin Nutr 57: 787S–797S, 1993.
  • Morris DL, Kritchevsky SB, Davis CE: Serum carotenoids and coronary heart disease. The Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up Study. JAMA 272: 1439–1441, 1994.
  • Knekt P, Reunanen A, Jarvinen R, Seppanen R, Heliovaara M, Aromaa A: Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 139: 1180–1189, 1994.
  • Anonymous: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med 330: 1029–1035, 1994.
  • Rapola JM, Virtamo J, Haukka JK, Heinonen OP, Albanes D, Taylor PR, Huttunen JK: Effect of vitamin E and beta carotene on the incidence of angina pectoris. A randomized, double-blind, controlled trial. JAMA 275: 693–698, 1996.
  • Rapola JM, Virtamo J, Ripatti S, Huttunen JK, Albanes D, Taylor PR, Heinonen OP: Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 349: 1715–1720, 1997.
  • Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334: 1150–1155, 1996.
  • Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R: Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334: 1145–1149, 1996.
  • Albanes D, Virtamo J, Taylor PR, Rautalahti M, Pietinen P, Heinonen OP: Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Clin Nutr 66: 366–372, 1997.
  • Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, Barnhart S, Cherniack MG, Brodkin CA, Hammar S: Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 88: 1550–1559, 1996.
  • Vogel S, Contois JH, Tucker KL, Wilson PW, Schaefer EJ, Lammi-Keefe CJ: Plasma retinol and plasma and lipoprotein tocopherol and carotenoid concentrations in healthy elderly participants of the Framingham Heart Study. Am J Clin Nutr 66: 950–958, 1997.
  • Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY, et al.: Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 85: 1483–1492, 1993.
  • Franceschi S, Bidoli E, La Vecchia C, Talamini R, D Avanzo B, Negri E: Tomatoes and risk of digestive-tract cancers. Int J Cancer 59: 181–184, 1994.
  • Mills PK, Beeson WL, Phillips RL, Fraser GE: Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer 64: 598–604, 1989.
  • Kohlmeier L, Kark JD, GomezGracia E, Martin BC, Steck SE, Kardinaal AFM, Ringstad J, Thamm M, Masaev V, Riemersma R, MartinMoreno JM, Huttunen JK, Kok FJ: Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol 146: 618–626, 1997.

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