Biomarkers of Fruit and Vegetable Intake in Human Intervention Studies: A Systematic Review

REFERENCES

• Abbey , M. , Noakes , M. and Nestel , P. J. 1995 . Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidized low-density lipoproteins . J. Am. Diet. Assoc. , 95 : 671 – 675 .
   PubMedGoogle Scholar
• Al-Delaimy , W. K. , Ferrari , P. , Slimani , N. , Pala , V. , Johansson , I. , Nilsson , S. , Mattisson , I. , Wirfalt , E. , Galaso , R. , Palli , D. , Vineis , P. , Tumino , R. , Dorronsoro , M. , Pera , G. , Ocke , M. , Bueno-de-Mesquita , H. B. , Overvad , K. , Chirlaque , M. D. , Trichopoulou , A. , Naska , A. , Tjonneland , A. , Olsen , A. , Lund , E. , Alsaker , H. E.R. , Barricarte , A. , Kesse , E. , Boutron-Ruault , M-C. , Clavel-Chapelton , F. , Key , T. J. , Spencer , E. , Bingham , S. , Welch , A. A. , Sanchez-Perez , M-J. , Nagel , G. , Linseisen , J. , Quiros , J. R. , Peeters , P. H.M. , van Gils , C. H. , Boeing , H. , van Kappel , A. L. , Steghens , J-P. and Riboli , E. 2005 . Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC) . Eur. J. Clin. Nutr. , 59 : 1387 – 1396 .
   PubMed Web of Science ®Google Scholar
• Appel , L. J. , Moore , T. J. , Obarzanek , E. , Vollmer , W. M. , Svetkey , L. P. , Sacks , F. M. , Bray , G. A. , Vogt , T. M. , Cutler , J. A. , Windhauser , M. M. , Lin , P. H. and Karanja , N. 1997 . A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group . N. Engl. J. Med. , 336 ( 16 ) : 1117 – 1124 .
   PubMed Web of Science ®Google Scholar
• Astley , S. B. , Elliott , R. M. , Archer , D. B. and Southon , S. 2004 . Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: Repair balance in human lymphocytes . Br. J. Nutr. , 91 : 63 – 72 .
   PubMed Web of Science ®Google Scholar
• Bernstein , M. A. , Nelson , M. E. , Tucker , K. L. , Layne , J. , Johnson , E. , Nuernberger , A. , Castaneda , C. , Judge , J. O. , Buchner , D. and Singh , M. F. 2002 . A home-based nutrition intervention to increase consumption of fruits, vegetables, and calcium-rich foods in community dwelling elders . J. Am. Diet. Assoc. , 102 : 1421 – 1427 .
   PubMed Web of Science ®Google Scholar
• Bingham , S. A. , Gill , C. , Welch , A. , Cassidy , A. , Runswick , S. A. , Oakes , S. , Lubin , R. , Thurnham , D. I. , Key , T. J. , Roe , L. , Khaw , K. T. and Day , N. E . 1997 . Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and vitamin C and carotenoids as biomarkers . Int. J. Epidemiol. , 26 : S137 – S151 .
   PubMed Web of Science ®Google Scholar
• Bogaards , J. J.P. , Verhagen , H. , Willems , M. I. , van Poppel , G. and van Bladeren , P. J. 1994 . Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma . Carcinogenesis , 15 ( 5 ) : 1073 – 1075 .
   PubMed Web of Science ®Google Scholar
• Bowen , P. E. , Garg , V. , Stacewicz-Sapuntzakis , M. , Yelton , L. and Schreiner , R. S. 1993 . Variability of serum carotenoids in response to controlled six servings of fruits and vegetables per day . Ann. N. Y. Acad. Sci. , 691 : 24 – 243 .
   Web of Science ®Google Scholar
• Brevik , A. , Rasmussen , S. E. , Drevon , C. A. and Andersen , L. F. 2004a . Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables . Cancer Epidemiol. Biomarkers Prev. , 13 ( 5 ) : 843 – 849 .
   PubMed Web of Science ®Google Scholar
• Brevik , A. , Andersen , L. F. , Karlsen , A. , Trygg , K. U. , Blomhoff , R. and Drevon , C. A. 2004b . Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study . Eur. J. Clin. Nutr. , 58 : 1166 – 1173 .
   PubMed Web of Science ®Google Scholar
• Briviba , K. , Bub , A. , Moseneder , J. , Schwerdtle , T. , Hartwig , A. , Kulling , S. and Watzl , B. 2008 . No differences in DNA damage and antioxidant capacity between intervention groups of healthy, nonsmoking men receiving 2, 5, or 8 servings/day of vegetables and fruit . Nutr. Cancer. , 60 ( 2 ) : 164 – 170 .
   PubMed Web of Science ®Google Scholar
• Broekmans , W. M.R. , Klopping-Ketelaars , I. A.A. , Schuurman , C. R.W.C. , Verhagen , H. , van den Berg , H. , Kok , F. J. and van Poppel , G. 2000 . Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans . J. Nutr. , 130 : 1578 – 1583 .
   PubMed Web of Science ®Google Scholar
• Broekmans , W. M.R. , Klopping-Ketelaars , W. A.A. , Kluft , C. , van den Berg , H. , Kok , F. J. and van Poppel , G. 2001 . Fruit and vegetables and cardiovascular risk profile: A diet controlled intervention study . Eur. J. Clin. Nutr. , 55 : 636 – 642 .
   PubMed Web of Science ®Google Scholar
• Brown , M. J. , Ferruzzi , M. G. , Nguyen , M. L. , Cooper , D. A. , Eldridge , A. L. , Schwartz , S. J. and White , W. S. 2004 . Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection . Am. J. Clin. Nutr. , 80 : 396 – 403 .
   PubMed Web of Science ®Google Scholar
• Bub , A. , Watzl , B. , Abrahamse , L. , Delincee , H. , Adam , S. , Wever , J. , Muller , H. and Rechkemmer , G. 2000 . Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men . J. Nutr , 130 : 2200 – 2206 .
   PubMed Web of Science ®Google Scholar
• Bub , A. , Watzl , B. , Blockhaus , M. , Briviba , K. , Liegibel , U. , Muller , H. , Pool-Zobel , B. L. and Rechkemmer , G. 2003 . Fruit juice consumption modulates antioxidative status, immune status and DNA damage . J. Nutr. Biochem. , 14 : 90 – 98 .
   PubMed Web of Science ®Google Scholar
• Burr , M. L. , Trembeth , J. , Jones , K. B. , Geen , J. , Lynch , L. A. and Roberts , Z. E.S. 2007 . The effects of dietary advice and vouchers on the intake of fruit and fruit juice by pregnant women in a deprived area: A controlled trial . Public. Health. Nutr. , 10 ( 6 ) : 559 – 565 .
   PubMed Web of Science ®Google Scholar
• Campbell , D. R. , Gross , M. D. , Martini , M. C. , Grandits , G. A. , Slavin , J. L. and Potter , J. D. 1994 . Plasma carotenoids as biomarkers of vegetable and fruit intake . Cancer Epidemiol. Biomarkers Prev. , 3 ( 6 ) : 493 – 500 .
   PubMed Web of Science ®Google Scholar
• Cartmel , B. , Bowen , D. , Ross , D. , Johnson , E. and Mayne , S. T. 2005 . A Randomized Trial of an Intervention to increase fruit and vegetable intake in curatively treated patients with early-stage head and neck cancer . Cancer Epidemiol. Biomarkers Prev. , 14 ( 12 ) : 2848 – 2854 .
   PubMed Web of Science ®Google Scholar
• Castenmiller , J. J.M. , West , C. E. , Linssen , J. P.H. , van het Hof , K. H. and Voragen , A. G.J. 1999 . The food matrix of spinach is a limiting factor in determining the bioavailability of β-carotene and to a lesser extent of lutein in humans . J. Nutr. , 129 : 349 – 355 .
   PubMed Web of Science ®Google Scholar
• Chopra , M. , O’Neill , M. E. , Keogh , N. , Wortley , G. , Southon , S. and Thurnham , D. I. 2000 . Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers . Clin. Chem. , 46 ( 11 ) : 1818 – 1829 .
   PubMed Web of Science ®Google Scholar
• Crews , H. , Alink , G. , Anderson , R. , Braesco , V. , Holst , B. , Maiani , G. , Ovesen , L. , Scotter , M. , Solfrizzo , M. , van der Berg , R. , Verhagen , H. and Williamson , G. 2001 . A critical assessment of some biomarker approaches linked with dietary intake . Br. J. Nutr. , 86 ( Suppl 1 ) : S5 – S35 .
   PubMed Web of Science ®Google Scholar
• Dauchet , L. , Amouyel , P. , Hercberg , S. and Dallongeville , J. 2006 . Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies . J. Nutr. , 136 : 2588 – 2593 .
   PubMed Web of Science ®Google Scholar
• Deharveng , G. , Charrondiere , U. R. , Slimani , N. , Southgate , D. A.T. and Riboli , E. 1999 . Comparison of nutrients in the food composition tables available in the nine European countries participating in EPIC . Eur. J. Clin. Nutr. , 53 : 60 – 79 .
   PubMed Web of Science ®Google Scholar
• Dehghan , M. , Akhtar-Danesh , N. , McMillan , C. R. and Thabane , L. 2007 . Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis . Nutr. J. , 6 : 41 – 53 .
   PubMed Web of Science ®Google Scholar
• de Lorgeril , M. , Renaud , S. , Mamelle , N. , Salen , P. , Martin , J. L. , Monjaud , I. , Guidollet , J. , Touboul , P. and Delaye , J. 1994 . Mediterranean alpha-linoleic acid-ich diet in secondary prevention of coronary heart disease . Lancet. , 343 : 1454 – 1459 .
   PubMed Web of Science ®Google Scholar
• de Lorgeril , M , Salen , P. , Martin , J-L. , Monjaud , I. , Boucher , P. and Mamelle , N. 1998 . Mediterranean Dietary Pattern in a Randomized Trial: Prolonged survival and possible reduced cancer rate . Arch. Intern. Med. , 158 : 1181 – 1187 .
   PubMed Web of Science ®Google Scholar
• De Vries , J. H.M. , Hollman , P. C.H. , Meyboom , S. , Buysman , M. N.C.P. , Zock , P. L. , van Staveren , W. A. and Katan , M. B. 1998 . Plasma concentations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake . Am. J. Clin. Nutr. , 68 : 60 – 65 .
   PubMed Web of Science ®Google Scholar
• Djuric , Z. , Ren , J. , Mekhovich , O. , Venkatranamoorthy , R. and Heilbrun , L. K. 2006 . Effects of high fruit-vegetable and/or low-fat intervention on plasma micronutrient levels . J. Am. Coll. Nutr. , 25 ( 3 ) : 178 – 187 .
   PubMed Web of Science ®Google Scholar
• Dragsted , L. O. , Pedersen , A. , Hermetter , A. , Basu , S. , Hansen , M. , Haren , G. R. , Kall , M. , Breinholt , V. , Castenmiller , J. J.M. , Stagsted , J. , Jakobsen , J. , Skibsted , L. , Rasmussen , S. E. , Loft , S. and Sandstrom , B. 2004 . The 6-a-day study: Effects of fruit and vegetables on markers of oxidative stress and antioxidant defense in healthy nonsmokers . Am. J. Clin. Nutr. , 79 : 1060 – 1072 .
   PubMed Web of Science ®Google Scholar
• Drewnowski , A. , Rock , C. L. , Henderson , S. A. , Shore , A. B. , Fischler , C. , Galan , P. , Preziosi , P. and Hercberg , S . 1997 . Serum beta-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based sample of French adults . Am. J. Clin. Nutr. , 65 : 1796 – 1802 .
   PubMed Web of Science ®Google Scholar
• Duthie , S. J. , Jenkinson , McE , A. , Crozier , A. , Mullen , W. , Pirie , L. , Kyle , J. , Yap , L. S. , Christen , P. and Duthie , G. G. 2006 . The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer . Eur. J. Nutr. , 45 : 113 – 122 .
   PubMed Web of Science ®Google Scholar
• Duttaroy , A. K. and Jorgensen , A. 2004 . Effects of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers . Platelets , 15 ( 5 ) : 287 – 292 .
   PubMed Web of Science ®Google Scholar
• Edwards , A. J. , Vinyard , B. T. , Wiley , E. R. , Brown , E. D. , Collins , J. K. , Perkins-veazie , P. , Baker , R. A. and Clevidence , B. A. 2003 . Consumption of Watermelon Juice Increases Plasma Concentrations of Lycopene and β-carotene in Humans . J. Nutr. , 133 : 1043 – 1050 .
   PubMed Web of Science ®Google Scholar
• Erlund , I. , Silaste , M. L. , Alfthan , G. , Rantala , M. , Kesanieme , Y. A. and Aro , A. 2002 . Plasma concentrations of the flavonoids hespereretin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables . Eur. J. Clin. Nutr. , 56 : 891 – 898 .
   PubMed Web of Science ®Google Scholar
• Erlund , I. , Freese , R. , Marniemi , J. , Hakala , P. and Alfthan , G. 2006 . Bioavailability of quercetin from berries and the diet . Nutr. Cancer. , 54 ( 1 ) : 13 – 17 .
   PubMed Web of Science ®Google Scholar
• Erlund , I. , Koli , R. , Alfthan , G. , Marnieme , J. , Puukka , P. , Mustonen , P. , Mattila , P. and Jula , A. 2008 . Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol . Am. J. Clin. Nutr. , 87 : 323 – 331 .
   PubMed Web of Science ®Google Scholar
• Field , J. K. , Brambilla , C. , Hirsch , F. R. , Hittelman , W. , Hogan , M. , Marshall , D. , Mulshine , J. L. , Rabbitts , P. , Sutedja , T. , Watson , A. and Weiss , S. 2001 . Molecular biomarkers workshop: A European strategy for developing lung cancer molecular diagnostics in high risk populations . Lung Cancer , 31 : 339 – 345 .
   Google Scholar
• Franciose , J. L. , Askew , E. W. , Lang , J. C. and Bernstein , P. S. 2006 . Serum and macular responses to antioxidant supplementation versus a carotenoid-rich dietary intervention in the elderly . Curr. Topic Nutraceut. Res. , 4 ( 1 ) : 69 – 78 .
   Web of Science ®Google Scholar
• Freedman , J. E. , Parker , C. , Li , L. , Perlman , J. A. , Frei , B. , Ivanov , V. , Deak , L. R. , Iafrati , M. D. and Folts , J. D. 2001 . Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release . Circulation , 103 : 2792 – 2798 .
   PubMed Web of Science ®Google Scholar
• Freese , R. , Alfthan , G. , Jauhiainen , M. , Basu , S. , Erlund , I. , Salminen , I. , Aro , A. and Mutanen , M. 2002 . High intakes of vegetable, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects . Am. J. Clin. Nutr. , 76 : 950 – 960 .
   PubMed Web of Science ®Google Scholar
• Freese , R. , Vaarala , O. , Turpeinen , A. M. and Mutanen , M. 2004 . No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects . Eur. J. Nutr. , 43 : 175 – 182 .
   PubMed Web of Science ®Google Scholar
• Gill , C. I.R. , Haldar , S. , Porter , S. , Matthews , S. , Sullivan , S. , Coulter , J. , McGlynn , H. and Rowland , I. 2004 . The Effect of cruciferous and leguminous sprouts on genotoxicity, In vitro and In vivo . Cancer Epidemiol. Biomarkers Prev. , 13 ( 7 ) : 1199 – 1205 .
   PubMed Web of Science ®Google Scholar
• Gill , C. I.R. , Haldar , S. , Boyd , LA. , Bennett , R. , Whiteford , J. , Butler , M. , Pearson , J. R. , Bradbury , I. and Rowland , I. R. 2007 . Watercress supplementation in diet reduces lymphocytes DNA damage and alters blood antioxidant status in healthy adults . Am. J. Clin. Nutr. , 85 : 504 – 510 .
   PubMed Web of Science ®Google Scholar
• Granado , F. , Olmedilla , B. , Herrero , C. , Perez-Sacristan , B. , Blanco , I. and Blazquez , S. 2006 . Bioavailability of carotenoids and tocopherols from broccoli: In Vivo and In Vitro assessment . Exp. Biol. Med. , 231 : 1733 – 1738 .
   Web of Science ®Google Scholar
• Harats , D. , Chevion , S. , Nahir , M. , Norman , Y. , Sagee , O. and Berry , E. M. 1998 . Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: Presumptive evidence for an interaction between vitamins C and E in vivo . Am. J. Clin. Nutr. , 67 : 240 – 245 .
   PubMed Web of Science ®Google Scholar
• Haskell , M. J. , Jamil , K. M. , Hassan , F. , Peerson , J. M. , Hossain , M. I. , Fuchs , G. J. and Brown , K. H. 2004 . Daily consumption of Indian spinach (Basella alba) or sweet potatoes has a positive effect on total-body vitamin A stores in Bangladeshi men . Am. J. Clin. Nutr , 80 : 705 – 714 .
   PubMed Web of Science ®Google Scholar
• He , F. J. , Nowson , C. A. and MacGregor , G. A. 2006 . Fruit and vegetable consumption and stroke: meta-analysis of cohort studies . Lancet. , 367 : 320 – 326 .
   PubMed Web of Science ®Google Scholar
• Heinonen , M. I. 1990 . Carotenoids and provitamin A activity of carrot (Daucus carota L.) cultivars . J. Agric. Food Chem , 38 : 609 – 612 .
   Web of Science ®Google Scholar
• Hoelzl , C. , Glatt , H. , Meinl , W. , Sontag , G. , Haidinger , G. , Kundi , M. , Simic , T. , Chakraborty , A. , Bichler , J. , Ferk , F. , Angelis , K. , Nersesyan , A. and Knasmuller , S. 2008 . Consumption of Brussel sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and oxidative DNA-damage: Results of a controlled human intervention trial . Mol. Nutr. Food Res. , 52 : 330 – 341 .
   PubMed Web of Science ®Google Scholar
• Horner , N. K. , Patterson , R. E. , Neuhouser , M. L. , Lampe , J. W. , Beresford , S. A. and Prentice , R. L. 2002 . Participant characteristics associated with errors in self-reported energy intake from the Women's Health Initiative food-frequency questionnaire . Am. J. Clin. Nutr. , 76 : 766 – 773 .
   PubMed Web of Science ®Google Scholar
• Howe , J. A. , Valentine , A. R. , Hull , A. K. and Tanumihardjo , S. A. 2009 . 13C Natural abundance in serum retinol acts as a biomarker for increases in dietary provitamin A . Exp. Biol. Med. , 234 : 140 – 147 .
   Web of Science ®Google Scholar
• Hu , F. B. 2003 . Plant-based foods and prevention of cardiovascular disease: An overview . Am. J. Clin. Nutr. , 78 ( suppl ) : 544S – 551S .
   PubMed Web of Science ®Google Scholar
• Huang , C-J. , Tang , Y-L. , Chen , C-Y. , Chen , M-L. , Chu , C-H. and Hseu , C-T. 2000 . The bioavailability of β-carotene in stir- or deep-fried vegetables in men determined by measuring the serum response to a single ingestion . J. Nutr. , 130 : 534 – 540 .
   PubMed Web of Science ®Google Scholar
• Hunter , D. 1990 . “ Biochemical indicators of dietary intake ” . In Nutritional Epidemiology , Edited by: Willett , D. 143 – 216 . New York : Oxford University Press .
   Google Scholar
• Hussein , L. and El-Tohamy , M. 1990 . Vitamin A potency of carrot and spinach carotenes in human metabolic studies . Int. J. Vit. Nutr. Res. , 60 : 229 – 235 .
   PubMed Web of Science ®Google Scholar
• Huxley , R. R. , Lean , M. , Crozier , A. , John , J. H. and Neil , H. A.W. 2004 . Effect of dietary advice to increase fruit and vegetables consumption on plasma flavonol concentrations: Results from a randomized controlled intervention trial . J. Epidemiol. Community Health. , 58 : 288 – 289 .
   PubMed Web of Science ®Google Scholar
• Jacques , P. F. , Hartz , S. C. , McGandy , R. B. , Jacob , R. A. and Russell , R. M. 1987 . Ascorbic acid, HDL, and total plasma cholesterol in the elderly . J. Am. Coll. Nutr. , 6 : 169 – 74 .
   PubMed Web of Science ®Google Scholar
• Jansen , M. C.J.F. , van Kappel , A. L. , Ocke , M. C. , van't Veer , P. , Boshuizen , H. C. , Riboli , E. and Beuno-de-Mesquita , H. B. 2004 . Plasma carotenoid levels in Dutch men and women, and the relation with vegetable and fruit consumption . Eur. J. Clin. Nutr. , 58 : 1386 – 1395 .
   PubMed Web of Science ®Google Scholar
• Jenab , M. , Slimani , N. , Bictash , M. , Ferrari , P. and Bingham , S. A. 2009 . Biomarkers in nutritional epidemiology: applications, needs and new horizons. . Hum. Genet. , 125 : 5 – 6 . 507 – 525 .
   Web of Science ®Google Scholar
• John , J. H. , Ziebland , S. , Yudkin , P. , Roe , L. S. , Neil , H. A.W. and for the Oxford Fruit and Vegetable Study Group . 2002 . Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: A randomized controlled trial . Lancet , 359 : 1969 – 1974 .
   PubMed Web of Science ®Google Scholar
• Johnston , C. S. , Dancho , C. L. and Strong , G. M. 2003 . Orange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthy adult women . J. Am. Coll. Nutr. , 22 ( 6 ) : 519 – 523 .
   PubMed Web of Science ®Google Scholar
• Joshipura , K. J. , Hu , F. B. , Manson , J. E. , Stampfer , M. J. , Rimm , E. B. , Speizer , F. E. , Colditz , G. , Ascherio , A. , Rosner , B. , Spiegelman , D. and Willett , W. C. 2001 . The effect of fruit and vegetable intake on risk for coronary heart disease . Ann. Intern. Med. , 134 : 1106 – 14 .
   PubMed Web of Science ®Google Scholar
• Khan , N. C. , West , C. E. , de Pee , S. , Bosch , D. , Phuong , H. D. , Hulshof , P. J.M. , Khoi , H. H. , Verhoef , H. and Hautvast , J. G.A.J. 2007 . The contribution of plant foods to the vitamin A supply of lactating women in Vietnam: A randomized controlled trial . Am. J. Clin. Nutr. , 85 : 1112 – 1120 .
   PubMed Web of Science ®Google Scholar
• Kim , H. , Simpson , K. L. and Gerber , L. E. 1988 . Serum carotenoids and retinol of human subjects consuming carrot juice . Nutr. Res. , 8 : 1119 – 1127 .
   Web of Science ®Google Scholar
• Kirsh , V. A. , Peters , U. , Mayne , S. T. , Subar , A. F. , Chatterjee , N. , Johnson , C. C. and Hayes , R. B. 2007 . Prospective study of fruit and vegetable intake and risk of prostate cancer . J. Natl. Cancer Inst. , 99 ( 15 ) : 1200 – 1209 .
   PubMedGoogle Scholar
• Krogholm , K. S. , Haraldsdottir , J. , Knuthsen , P. and Rasmussen , S. E. 2004 . Urinary total flavonoid excretion but not 4-pyridoxic acid or potassium can be used as a biomarker for the intake of fruits and vegetables . J. Nutr. , 134 : 445 – 451 .
   PubMed Web of Science ®Google Scholar
• Kurilich , A. C. and Juvik , J. A. 1999 . Quantification of carotenoids and tocopherol antioxidants in Zea mays . J. Agric. Food Chem. , 47 : 1948 – 1955 .
   PubMed Web of Science ®Google Scholar
• Kopsell , D. A. and Lefsrud , M. G. 2006 . Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention . J. Agric. Food Chem. , 54 : 7998 – 8005 .
   PubMed Web of Science ®Google Scholar
• Lanza , E. , Schatzkin , A. , Daston , C. , Corle , D. , Freedman , L. , Ballard-Barbash , R. , Caan , B. , Lance , P. , Marshall , J. , Iber , F. , Shike , M. , Weissfeld , J. , Slattery , M. , Paskett , E. , Mateski , D. , Albert , P. and and the PPT Study Group . 2001 . Implementation of a 4-y, high-fiber, high-fruit-and-vegetable, low-fat dietary intervention: Results of dietary changes in the Polyp Prevention Trial . Am. J. Clin. Nutr. , 74 : 387 – 401 .
   PubMed Web of Science ®Google Scholar
• Lee , R. D. and Nieman , D. C. 2003 . Nutritional Assessments , 3rd Edition , New York : McGraw-Hill .
   Google Scholar
• Le Marchand , L. , Hankin , J. H. , Carter , F. S. , Essling , C. , Luffey , D. , Franke , A. A. , Wilkens , L. R. , Cooney , R. V. and Kolonel , L. N. 1994 . A pilot study on the use of plasma carotenoids and ascorbic acid as markers of compliance to a high fruit and vegetable dietary intervention . Cancer Epidemiol. Biomarkers Prev. , 3 : 245 – 251 .
   PubMed Web of Science ®Google Scholar
• Levine , M. , Wang , Y. , Padayatty , S. J. and Morrow , J. 2001 . A new recommended dietary allowance of vitamin C for healthy young women . Proc. Natl. Acad. Sci. , 98 ( 17 ) : 9842 – 9846 .
   PubMed Web of Science ®Google Scholar
• Lin , Y-J. , Chien , Y-W. , Yang , S-H. and Cheng , H-H. 2007 . Fruits and stir-fry vegetables increase plasma carotenoids in young adults . Asia Pac. J. Clin. Nutr. , 16 ( 4 ) : 616 – 623 .
   PubMed Web of Science ®Google Scholar
• Livingstone , M. B.E. and Black , A. E. 2003 . Markers of the validity of reported energy intake . J. Nutr. , 133 : 895S – 920S .
   PubMed Web of Science ®Google Scholar
• Mangels , A. R. , Block , G. , Frey , C. M. , Patterson , B. H. , Taylor , P. R. , Norkus , E. P. and Levander , O. A. 1993 . The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid . J. Nutr. , 123 : 1054 – 1061 .
   PubMed Web of Science ®Google Scholar
• Marniemi , J. , Hakala , P. , Maki , J. and Ahotupa , M. 2000 . Partial resistance of low density lipoprotein to oxidation in vivo after increased intake of berries . Nutr. Metab. Cardiovasc. Dis. , 10 : 331 – 337 .
   PubMed Web of Science ®Google Scholar
• Martini , M. C. , Campbell , D. R. , Gross , M. D. , Grandits , G. A. , Potter , J. D. and Slavin , J. L. 1995 . Plasma carotenoids as biomarkers of vegetable intake: The University of Minnesota Cancer Prevention Research Unit Feeding Studies . Cancer Epidemiol. Biomarkers Prev. , 4 : 491 – 496 .
   PubMed Web of Science ®Google Scholar
• McAnlis , G. T. , McEneny , J. , Pearce , J. and Young , I. S. 1999 . Absorption and antioxidant effects of quercetin from onions, in man . Eur. J. Clin. Nutr. , 53 : 92 – 96 .
   PubMed Web of Science ®Google Scholar
• McCall , D. O. , McGartland , C. P. , McKinley , M. C. , Patterson , C. C. , Sharpe , P. , McCance , D. R. , Young , I. S. and Woodside , J. V. 2009 . Dietary intake of fruits and vegetables improves microvascular function in hypertensive subjects in a dose-dependent manner . Circulation , 119 : 2153 – 2160 .
   PubMed Web of Science ®Google Scholar
• McCance and Widdowson . 2002 . The Composition of Foods, 6th Summary Edition , Cambridge : Royal Society of Chemistry .
   Google Scholar
• McEligot , A. J. , Rock , C. L. , Flatt , S. W. , Newman , V. , Faerber , S. and Pierce , J. P. 1999 . Plasma carotenoids are biomarkers of long-term high vegetable intake in women with breast cancer . J. Nutr. , 129 : 2258 – 2263 .
   PubMed Web of Science ®Google Scholar
• Mennen , L. I. , Sapinho , D. , Ito , H. , Bertrais , S. , Galan , P. , Hercberg , S. and Scalbert , A. 2006 . Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods . Br. J. Nutr. , 96 : 191 – 198 .
   PubMed Web of Science ®Google Scholar
• Micozzi , M. S. , Brown , E. D. , Edwards , B. K. , Bieri , J. G. , Taylor , P. R. , Khachik , F. , Beecher , G. R. and Smith , J. C. Jr . 1992 . Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men . Am. J. Clin. Nutr , 55 : 1120 – 1125 .
   PubMed Web of Science ®Google Scholar
• Mikkelsen , T. B. , Olsen , S. F. , Rasmussen , S. E. and Osler , M. 2007 . Relative validity of fruit and vegetable intake estimated by the food frequency questionnaire used in the Danish National Birth Cohort . Scand. J. Public Health. , 35 ( 2 ) : 172 – 179 .
   PubMed Web of Science ®Google Scholar
• Miller , E. R. III , Erlinger , T. P. , Sacks , F. M. , Svetkey , L. P. , Charleston , J. , Lin , P-H. and Appel , L. J. 2005b . A dietary pattern that lowers oxidative stress increases antivodies to oxidized LDL: Results from a randomised controlled feeding study . Athersclerosis. , 183 : 175 – 182 .
   PubMed Web of Science ®Google Scholar
• Molldrem , K. L. , Li , J. , Simon , P. W. and Tanumihardjo , S. A. 2004 . Lutein and β-carotene from lutein-containing yellow carrots are bioavailable in humans . Am. J. Clin. Nutr. , 80 : 131 – 136 .
   PubMed Web of Science ®Google Scholar
• Moller , P. , Vogel , U. , Pedersen , A. , Dragsted , L. O. , Sandstrom , B. and Loft , S. 2003 . No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers . Cancer Epidemiol. Biomarkers Prev. , 12 : 1016 – 1022 .
   PubMed Web of Science ®Google Scholar
• Moller , P. , Loft , S. , Alfthan , G. and Freese , R. 2004 . Oxidative DNA damage in circulating mononuclear blood cells after ingestion of blackcurrant juice or anthocyanin-rich drink . Mutat. Res. , 551 : 119 – 126 .
   PubMed Web of Science ®Google Scholar
• Moon , J-H. , Nakata , R. , Oshima , S. , Inakuma , T. and Terao , J. 2000 . Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women . Am. J. Physiol. Regulatory Integrative Comp. Physiol. , 279 : 461 – 467 .
   PubMed Web of Science ®Google Scholar
• Muller , H. , Bub , A. , Watzl , B. and Rechkemmer , G. 1999 . Plasma concentations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods . Eur. J. Nutr , 38 : 35 – 44 .
   PubMed Web of Science ®Google Scholar
• Nelson , J. L. , Bernstein , P. S. , Schmidt , M. C. , Von Tress , M. S. and Askew , E. W. 2003 . Dietary modification and moderate antioxidant supplementation differentially affect serum carotenoids, antioxidant levels and markers of oxidative stress in older humans . J. Nutr. , 133 : 3117 – 3123 .
   PubMed Web of Science ®Google Scholar
• Newman , V. A. , Flatt , S. W. and Pierce , J. P. 2008 . Telephone counselling promotes dietary change in healthy adults: Results of a Pilot Trial . J. Am. Diet. Assoc. , 108 : 1350 – 1354 .
   PubMed Web of Science ®Google Scholar
• Nielsen , S. E. , Freese , R. , Kleemola , P. and Mutanen , M. 2002 . Flavonoids in human urine as biomarkers for intake of fruits and vegetables . Cancer Epidemiol. Biomarkers Prev. , 11 : 459 – 466 .
   PubMed Web of Science ®Google Scholar
• Nijhoff , W. A. , Mulder , T. P.J. , Verhagen , H. , van Poppel , G. and Peters , W. H.M. 1995 . Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-α and -π in humans . Carcinogenesis. , 16 ( 4 ) : 955 – 957 .
   PubMed Web of Science ®Google Scholar
• Padayatty , S. J. and Levine , M. 2008 . Fruit and vegetables:Think variety, go ahead, eat! . Am. J. Clin. Nutr. , 87 : 5 – 7 .
   PubMed Web of Science ®Google Scholar
• Parsons , J. K. , Newman , V. , Mohle , J. L. , Pierce , J. P. , Paskett , E. and Marshall , J. 2008 . The Men's Eating and Living (MEAL) Study: A Cancer and Leukemia Group B Pilot Trial of Dietary Intervention for the Treatment of Prostate Cancer . Urology. , 72 ( 3 ) : 633 – 637 .
   PubMed Web of Science ®Google Scholar
• Paterson , E. , Gordon , M. H. , Niwat , C. , George , T. W. , Parr , L. , Waroonphan , S. and Lovegrove , J. A. 2006 . Supplementation with fruit and vegetable soups and beverages increases plasma carotenoid concentations but does not alter markers of oxidative stress or cardiovascular risk factors . J. Nutr. , 136 : 2849 – 2855 .
   PubMed Web of Science ®Google Scholar
• Pierce , J. P. , Faerber , S. , Wright , F. A. , Newman , V. , Flatt , S. W. , Kealey , S. , Rock , C. L. , Hryniuk , W. and Greenberg , E. R. 1997 . Feasibility of a randomized trial of a high-vegetable diet to prevent breast cancer recurrence . Nutr. Cancer. , 28 ( 3 ) : 282 – 288 .
   PubMed Web of Science ®Google Scholar
• Pierce , J. P. , Faerber , S. , Wright , F. A. , Rock , CL. , Newman , V. , Flatt , S. W. , Kealey , S. , Jones , V. E. , Caan , B. J. , Gold , E. B. , Haan , M. , Hollenbach , K. A. , Jones , L. , Marshall , J. R. , Ritenbaugh , C. , Stefanick , M. L. , Thompson , C. , Wasserman , L. , Natarajan , L. , Thomas , R. G. and Gilpin , E. A. 2002 . A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: The Women's Healthy Eating and Living (WHEL) Study . Control. Clin. Trials. , 23 : 728 – 756 .
   PubMedGoogle Scholar
• Pierce , J. P. , Newman , V. A. , Flatt , S. W. , Faerber , S. , Rock , C. L. , Natarajan , L. , Caan , B. J. , Gold , E. B. , Hollenbach , K. A. , Wasserman , L. , Jones , L. , Ritenbaugh , C. , Stefanick , M. L. , Thomson , C. A. and Kealey , S. 2004 . Telephone counselling intervention increases intakes of microntrient- and phytochemical-rich vegetables, fruit and fiber in breast cancer survivors . J. Nutr. , 134 : 452 – 458 .
   PubMed Web of Science ®Google Scholar
• Pierce , J. P. , Natarajan , L. , Sun , S. , Al-Delaimy , W. , Flatt , S. W. , Kealey , S. , Rock , C. L. , Thomson , C. A. , Newman , V. A. , Ritenbaugh , C. , Gold , E. B. , Caan , B. J. and for the Women's Healthy Eating and Living Study Group . 2006 . Increases in plasma carotenoid concentrations in response to a major dietary change in the Women's Healthy Eating and Living Study . Cancer Epidemiol. Biomarkers Prev. , 12 ( 10 ) : 1886 – 1892 .
   Google Scholar
• Polidori , M. C. , Carrillo , J-C. , Verde , P. E. , Sies , H. , Siegrist , J. and Stahl , W. 2009 . Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels . Nutr. J. , 8 : 10 – 13 .
   PubMed Web of Science ®Google Scholar
• Prentice , R. L. , Caan , B. , Chlebowski , R. T. , Patterson , R. , Kuller , L. H. , Ockene , J. K. , Margolis , K. L. , Limacher , M. C. , Manson , J. E. , Parker , L. M. , Paskett , E. , Phillips , L. , Robbins , J. , Rossouw , J. E. , Sarto , G. E. , Shikany , J. M. , Stefanick , M. L. , Thomson , C. A. , Van Horn , L. , Vitolins , M. Z. , Wactawski-Wende , J. , Wallace , R. B. , Wassertheil-Smoller , S. , Whitlock , E. , Yano , K. , Adams-Campbell , L. , Anderson , G. L. , Assaf , A. R. , Beresford , S. A. , Black , H. R. , Brunner , R. L. , Brzyski , R. G. , Ford , L. , Gass , M. , Hays , J , Heber , D. , Heiss , G. , Hendrix , S. L. , Hsia , J. , Hubbell , F. A. , Jackson , R. D. , Johnson , K. C. , Kotchen , J. M. , LaCroix , A. Z. , Lane , D. S. , Langer , R. D. , Lasser , N. L. and Henderson , M. M. 2006 . Low-fat dietary pattern and risk of invasive breast cancer: The Women's Health Initiative Randomised Controlled Dietary Modification Trial . JAMA. , 295 : 629 – 642 .
   PubMed Web of Science ®Google Scholar
• Record , I. R. , Dreosti , I. E. and McInerney , J. K. 2001 . Changes in plasma antioxidant status following consumption of diets high or low in fruit and vegetables or following dietary supplementation with an antioxidant mixture . Br. J. Nutr. , 85 : 459 – 464 .
   PubMed Web of Science ®Google Scholar
• Riboli , E. and Norat , T. 2003 . Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk . Am. J. Clin. Nutr. , 78 ( suppl ) : 559S – 569S .
   PubMed Web of Science ®Google Scholar
• Roberts , W. G. , Gordon , M. H. and Walker , A. F. 2003 . Effects of enhanced consumption of fruit and vegetables on plasma antioxidant status and oxidative resistance of LDL in smokers supplemented with fish oil . Eur. J. Clin. Nutr. , 57 : 1303 – 1310 .
   PubMed Web of Science ®Google Scholar
• Rock , C. L. , Flatt , S. W. , Wright , F. A. , Faerber , S. , Newman , V. , Kealey , S. and Pierce , J. P. 1997 . Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence . Cancer Epidemiol. Biomarkers Prev. , 6 : 617 – 623 .
   PubMed Web of Science ®Google Scholar
• Rock , C. L. , Lavalvo , J. L. , Emenhiser , C. , Ruffin , M. T. , Flatt , S. W. and Schwartz , S. J. 1998 . Bioavailability of β-carotene is lower in raw than in processed carrots and spinach in women . J. Nutr. , 128 : 913 – 916 .
   PubMed Web of Science ®Google Scholar
• Rock , C. L. , Moskowitz , A. , Huizar , B. , Saenz , C. C. , Clark , J. T. , Daly , T. L. , Chin , H. , Behling , C. and Ruffin , M. T. 2001 . High vegetables and fruit diet intervention in premenopausal women with cervical intraepithelial neoplasia . J. Am. Diet. Assoc. , 101 : 1167 – 1174 .
   PubMed Web of Science ®Google Scholar
• Sanchez-Moreno , C. , Cano , M. P. , de Ancos , B. , Plaza , L. , Olmedilla , B. , Granado , F. and Martin , A. 2003 . Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans . Am. J. Clin. Nutr. , 78 : 454 – 460 .
   PubMed Web of Science ®Google Scholar
• Sanchez-Moreno , C. , Cano , M. P. , de Ancos , B. , Plaza , L. , Olmedilla , B. , Granado , F. and Martin , A. 2004 . Consumption of high-pressurized vegetables soup increases plasma vitamin c and decreases oxidative stress and inflammatory biomarkers in healthy humans . J. Nutr. , 134 : 3021 – 3025 .
   PubMed Web of Science ®Google Scholar
• Sanchez-Moreno , C. , Cano , M. P. , de Ancos , B. , Plaza , L. , Olmedilla , B. , Granado , F. and Martin , A. 2006 . Mediterranean vegetable soup consumption increases plasma vitamin C and decreases F2-isoprostanes, prostaglandin E2 and monocyte chemotactic protein-1 in healthy humans . J. Nutr. Biochem. , 17 : 183 – 189 .
   PubMed Web of Science ®Google Scholar
• Shike , M. , Latkany , L. , Riedel , E. , Fleisher , M. , Schatzkin , A. , Lanza , E. , Corle , D. , Begg , C. B. and and the Polyp Prevention Trial Study Group . 2002 . Lack of effect of a low-fat, high-fruit, -vegetable, and –fiber diet on serum prostate-specific antigen of men without prostate cancer: results from a randomised trial . J. Clin. Oncol. , 20 ( 17 ) : 3592 – 3598 .
   PubMed Web of Science ®Google Scholar
• Singh , R. B. , Niaz , MA. , Agarwal , P. , Begom , R. and Rastogi , S. S. 1995 . Effect of antioxidant-rich foods on plasma ascorbic acid, cardiac enzyme, and lipid peroxide levels in patients hospitalized with acute myocardial infarction . J. Am. Diet. Assoc. , 95 : 775 – 780 .
   PubMedGoogle Scholar
• Singh , R. B. , Rastogi , S. S. , Singh , R. , Niaz , M. A. , Singh , N. K. and Madhu , S. V. 1997 . Effects on plasma ascorbic acid and coronary risk factors of adding guava fruit to the usual diet in hypertensives with mild to moderate hypercholesterolaemia . J. Nutr. Environ. Med. , 7 : 5 – 14 .
   Google Scholar
• Smith-Warner , S. A. , Elmer , P. J. , Tharp , T. M. , Fosdick , L. , Randall , B. , Gross , M. , Wood , J. and Potter , J. D. 2000 . Increasing vegetable and fruit intake: Randomized intervention and monitoring in an at-risk population . Cancer Epidemiol. Biomarkers Prev. , 9 : 307 – 317 .
   PubMed Web of Science ®Google Scholar
• Steptoe , A. , Perkins-Porras , L. , McKay , C. , Rink , E. , Hilton , S. and Cappuccio , F. P. 2003 . Behavioral counseling to increase consumption of fruit and vegetables in low income adults: Randomized trial . BMJ , 326 : 855 – 860 .
   PubMed Web of Science ®Google Scholar
• Steptoe , A. , Perkins-Porras , L. , Hilton , S. , Rink , E. and Cappuccio , F. P. 2004 . Quality of life and self-rated health in relation to changes in fruit and vegetable intake and in plasma vitamins C and E in a randomized trial of behavioral and nutritional education counseling . Br. J. Nutr. , 92 : 177 – 184 .
   PubMed Web of Science ®Google Scholar
• Stockley , R. A. 2007 . Biomarkers in COPD: Time for a deep breadth . Thorax , 62 : 657 – 660 .
   PubMed Web of Science ®Google Scholar
• Svendsen , M. , Blomhoff , R. , Holme , I. and Tonstad , S. 2007 . The effect of an increased intake of vegetables and fruit on weight loss, blood pressure and antioxidant defense in subjects with sleep related breathing disorders . Eur. J. Clin. Nutr. , 61 : 1301 – 1311 .
   PubMed Web of Science ®Google Scholar
• Takashashi , Y. , Sasaki , S. , Takahashi , M. , Okubo , S. , Hayashi , M. and Tsugane , S. 2003 . A population-based dietary intervention trial in a high-risk area for stomach cancer and stroke: Changes in intakes and related biomarkers . Prev. Med. , 37 : 432 – 441 .
   PubMed Web of Science ®Google Scholar
• Tanumihardjo , S. A. , Valentine , A. R. , Zhang , Z. , Whigham , L. D. , Lai , H. J. and Atkinson , R. L. 2009 . Strategies to increase vegetable or reduce energy and fat intake induce weight loss in adults . Exp. Biol. Med. , 234 ( 5 ) : 542 – 552 .
   Web of Science ®Google Scholar
• Tesoriere , L. , Butera , D. , Pintaudi , A. M. , Allegra , M. and Livrea , M. A. 2004 . Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: A comparative study with vitamin C . Am. J. Clin. Nutr , 80 : 391 – 395 .
   PubMed Web of Science ®Google Scholar
• Thompson , H. J. , Heimendinger , J. , Haegele , A. , Sedlacek , S. M. , Gilette , C. , O’Neill , C. , Wolfe , P. and Conry , C. 1999 . Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage . Carcinogenesis , 20 ( 12 ) : 2261 – 2266 .
   PubMed Web of Science ®Google Scholar
• Thompson , H. J. , Heimendinger , J. , Sedlacek , S. , Haegele , A. , Diker , A. , O’Neill , C. , Meinecke , B. , Wolfe , P. , Zhu , Z. and Jiang , W. 2005a . 8-Isoprostane F2α excretion is reduced in women by increased vegetable and fruit intake . Am. J. Clin. Nutr , 82 : 768 – 776 .
   PubMed Web of Science ®Google Scholar
• Thompson , H. J. , Heimendinger , J. , Gillette , C. , Sedlacek , S. M. , Haegele , A. , O’Neill , C. and Wolfe , P. 2005b . In vivo investigation of changes in biomarkers of oxidative stress induced by plant food rich diets . J. Agric. Food Chem. , 53 : 6126 – 6132 .
   PubMed Web of Science ®Google Scholar
• Thompson , H. J. , Heimendinger , J. , Diker , A. , O’Neill , C. , Haegele , A. , Meinecke , B. , Wolfe , P. , Sedlacek , S. , Zhu , Z. and Jiang , W. 2006 . Dietary botanical diversity affect the reduction of oxidative biomarkers in women due to high vegetable and fruit intake . J. Nutr , 136 : 2207 – 2212 .
   PubMed Web of Science ®Google Scholar
• Thurmann , P. A. , Steffen , J. , Zwernemann , C. , Aebischer , C-P. , Cohn , W. , Wendt , G. and Schalch , W. 2002 . Plasma concentration response to drinks containing β-carotene as carrot juice or formulated as a water dispersible powder . Eur. J. Nutr , 41 : 228 – 235 .
   PubMed Web of Science ®Google Scholar
• Torronen , R. , Lehmusaho , M. , Hakkinen , S. , Hanninen , O. and Mykkanen , H. 1996 . Serum β-carotene response to supplementation with raw carrots, carrot juice or purified β-carotene in healthy non-smoking women . Nutr. Res. , 16 ( 4 ) : 565 – 575 .
   Web of Science ®Google Scholar
• Tuekpe , MK-N. , Todoriki , H. , Sasaki , S. , Zheng , K-C. and Ariizumi , M. 2006 . Potassium excretion in healthy Japanese women was increased by a dietary intervention utilizing home-parcel delivery of Okinawan vegetables . Hypertens. Res , 29 : 389 – 396 .
   PubMed Web of Science ®Google Scholar
• Tucker , K. L. , Chen , H. , Vogel , S. , Wilson , P. W. , Schaefer , E. J. and Lammi-Keefe , C. J. 1999 . Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population . J. Nutr. , 129 ( 2 ) : 438 – 445 .
   PubMed Web of Science ®Google Scholar
• Turban , S. , Miller , E. R. III , Ange , B. and Appel , L. J. 2008 . Racial differences in urinary potassium excretion . J. Am. Soc. Nephrol. , 19 : 1396 – 1402 .
   PubMed Web of Science ®Google Scholar
• Unlu , N. Z. , Bohn , T. , Clinton , S. K. and Schwartz , S. J. 2005 . Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil . J. Nutr. , 135 : 431 – 436 .
   PubMed Web of Science ®Google Scholar
• van den Berg , R. , van Vliet , T. , Broekmans , W. M.R. , Cnubbem , N. H.P. , Vaes , W. H.J. , Roza , L. , Haenen , G. R.M.M. , Bast , A. and van den Berg , H. 2001 . A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers . J. Nutr. , 131 : 1714 – 1722 .
   PubMed Web of Science ®Google Scholar
• van het Hof , K. H. , Brouwer , I. A. , West , C. E. , Haddeman , E. , Steegers-Theunissen , R. P.M. , van Dusseldorp , M. , Weststrate , J. A. , Eskes , T. K.A.B. and Hautvast , J. G.A.J. 1999 . Bioavailabilty of lutein from vegetables is 5 times higher than that of β-carotene . Am. J. Clin. Nutr. , 70 : 261 – 268 .
   PubMed Web of Science ®Google Scholar
• Vincent-Baudry , S. , Defoort , C. , Gerber , M. , Bernard , M-C. , Verger , P. , Helal , O. , Portugal , H. , Planells , R. , Grolier , P. , Amiot-Carlin , M-J. , Vegue , P. and Lairon , D. 2005 . The Medi-RIVAGE study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a Mediterranean-type diet or a low-fat diet . Am. J. Clin. Nutr , 82 : 964 – 971 .
   PubMed Web of Science ®Google Scholar
• Wanke , K. L. , Daston , C. , Slonim , A. , Albert , P. S. , Snyder , K. , Schatzkin , A. and Lanza , E. 2007 . Adherence to the polyp prevention trial dietary intervention is associated with a behavioral pattern of adherence to nondietary trial requirements and general health recommendations . J. Nutr , 137 : 391 – 398 .
   PubMed Web of Science ®Google Scholar
• Watzl , B. , Bub , A. , Brandstetter , B. R. and Rechkemmer , G. 1999 . Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables . Br. J. Nutr. , 82 : 383 – 389 .
   PubMed Web of Science ®Google Scholar
• Watzl , B. , Bub , A. , Briviba , K. and Rechkemmer , G. 2003 . Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men . Ann. Nutr. Metab. , 47 : 255 – 261 .
   PubMed Web of Science ®Google Scholar
• Watzl , B. , Kulling , S. E. , Moseneder , J. , Barth , S. W. and Bub , A. 2005 . A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men . Am. J. Clin. Nutr , 82 : 1052 – 1058 .
   PubMed Web of Science ®Google Scholar
• Weisel , T. , Baum , M. , Eisenbrand , G. , Dietrich , H. , Will , F. , Stockis , J-P. , Kulling , S. , Rufer , C. , Johannes , C. and Janzawski , C. 2006 . An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands . Biotechnol. J. , 1 : 388 – 397 .
   PubMedGoogle Scholar
• West , C. E. , Eilander , A. and van Lieshout , M. 2002 . Consequences of revised estimates of carotenoid bioefficacy for dietary control of vitamin A deficiency in developing countries . J. Nutr. , 132 : 2920s – 2926s .
   PubMed Web of Science ®Google Scholar
• Wilms , L. C. , Hollman , P. C.H. , Boots , A. W. and Kleinjans , J. C.S. 2005 . Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes . Mutat. Res. , 582 : 155 – 162 .
   PubMed Web of Science ®Google Scholar
• Wilms , L. C. , Boots , A. W. , de Boer , V. C.J. , Maas , L. M. , Pachen , D. M.F.A. , Gottschalk , R. W.H. , Ketelslegers , H. B. , Godschalk , R. W.L. , Haenen , G. R.M.M. , van Schooten , F. J. and Kleinjans , J. C.S. 2007 . Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers . Carcinogenesis , 28 ( 8 ) : 1800 – 1806 .
   PubMed Web of Science ®Google Scholar
• Yeum , K-J. , Booth , S. L. , Sadowski , J. A. , Liu , C. , Tang , G. , Krinsky , N. I. and Russell , R. M. 1996 . Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables . Am. J. Clin. Nutr. , 64 : 594 – 602 .
   PubMed Web of Science ®Google Scholar
• Young , J. F. , Nielsen , S. E. , Haroldsdottir , J. , Daneshvar , B. , Lauridsen , S. T. , Knuthsen , P. , Crozier , A. , Sandstrom , B. and Dragsted , L. O. 1999 . Effect of fruit juice on urinary quercetin excretion and biomarkers of antioxidative status . Am. J. Clin. Nutr. , 69 : 87 – 94 .
   PubMed Web of Science ®Google Scholar
• Zino , S. , Skeaff , M. , Williams , S. and Mann , J. 1997 . Randomised controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants . BMJ , 314 : 1787 – 1791 .
   PubMed Web of Science ®Google Scholar