Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?

REFERENCES

• AFSSA . 2006–2007 . Etude individuelle des consommations alimentaires, INCA-2, 2006–2007, rapport AFSSA .
   Google Scholar
• Ames , B. N. , McCann , J. C. , Stampfer , M. J. and Willett , W. C. 2007 . Evidence-based decision making on micronutrients and chronic disease: Long-term randomized controlled trials are not enough . Am J Clin Nutr. , 86 : 522 – 523 .
   PubMed Web of Science ®Google Scholar
• Antoniades , C. , Tousoulis , D. and Tountas , C., et al. 2004 . Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: The effects of vitamin C . Diabet Med. , 21 : 552 – 558 .
   PubMed Web of Science ®Google Scholar
• AREDS . 2001 . A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS Report No. 9 . Arch Ophthalmol. , 119 : 1439 – 1452 .
   PubMed Web of Science ®Google Scholar
• Avenell , A. , Campbell , M. K. and Cook , J. A., et al. 2005 . Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): Pragmatic, randomised, double blind, placebo controlled trial . BMJ. , 331 : 324 – 329 .
   PubMed Web of Science ®Google Scholar
• Birlouez-Aragon , I. , Fieux , B. , Potier de Courcy , G. and Hercberg , S. 2001 . “ Apports nutritionnels conseillés en vitamine C ” . In Les Apports Nutritionnels Conseillés pour la Population Française , 3rd Ed. , Edited by: Martin , A. 215 – 230 . Tec Doc : AFSSA Coordonnateur .
   Google Scholar
• Birlouez-Aragon , I. , Girard , F. , Ravelontseheno , L. , Bourgeois , C. , Belliot , J. P. and Abitbol , G. 1995 . Comparison of two levels of vitamin C supplementation on antioxidant vitamin status in elderly institutionalized subjects . Int J Vitam Nutr Res. , 65 : 261 – 266 .
   Web of Science ®Google Scholar
• Birlouez-Aragon , I. , Saavedra , G. and Tessier , F. J., et al. 2010 . A diet based on high-heat-treated foods promotes risk factors for diabetes mellitus and cardiovascular diseases . Am J Clin Nutr. , 91 : 1220 – 1226 . 121
   PubMed Web of Science ®Google Scholar
• Block , G. , Jensen , C. D. and Dalvi , T. B., et al. 2009 . Vitamin C treatment reduces elevated C-reactive protein . Free Radic Biol Med. , 46 : 70 – 77 .
   PubMed Web of Science ®Google Scholar
• Block , G. , Jensen , C. D. and Morrow , J. D., et al. 2008 . The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level . Free Rad Biol Med. , 45 : 377 – 384 .
   PubMed Web of Science ®Google Scholar
• Block , G. , Jensen , C. D. , Norkus , E. P. , Hudes , M. and Crawford , P. B. 2008 . Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women . Nutr J. , 7 : 35 – 44 .
   PubMed Web of Science ®Google Scholar
• Block , G. , Mangels , A. R. , Patterson , B. H. , Levander , O. A. , Norkus , E. P. and Taylor , P. R. 1999 . Body weight and prior depletion affect plasma ascorbate levels attained on identical vitamin C intake: A controlled-diet study . J Am Coll Nutr. , 18 : 628 – 637 .
   PubMed Web of Science ®Google Scholar
• Blot , W. J. , Li , J. Y. and Taylor , P. R., et al. 1993 . Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population . J Natl Cancer Inst. , 85 : 1483 – 1492 .
   PubMed Web of Science ®Google Scholar
• Blumberg , J. , Heaney , R. P. and Huncharek , M., et al. 2010 . Evidence-based criteria in the nutritional context . Nutr Rev. , 68 : 478 – 484 .
   PubMed Web of Science ®Google Scholar
• Boekholdt , S. M. , Meuwese , M. C. and Day , N. E. 2006 . Plasma concentrations of ascorbic acid and C-reactive protein, and risk of future coronary artery disease, in apparently healthy men and women: The EPIC-Norfolk prospective population study . Br J Nutr. , 96 : 516 – 522 .
   PubMed Web of Science ®Google Scholar
• Brubacher , D. , Moser , U. and Jordan , P. 2000 . Vitamin C concentrations in plasma as a function of intake: A meta-analysis . Int J Vitam Nutr Res. , 70 : 226 – 237 .
   PubMed Web of Science ®Google Scholar
• Buettner , G. R. 1993 . The pecking order of free radicals and antioxidants: Lipid peroxidation, alpha-tocopherol, and ascorbate . Arch Biochem Biophys. , 300 : 535 – 543 .
   PubMed Web of Science ®Google Scholar
• Cahill , L. E. and El-Sohemy , A. 2010 . Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency . Am J Clin Nutr. , 92 : 1494 – 1500 .
   PubMed Web of Science ®Google Scholar
• Carr , A. C. and Frei , B. 1999 . Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans . Am J Clin Nutr. , 69 : 1086 – 1107 .
   PubMed Web of Science ®Google Scholar
• Cook , N. R. , Albert , C. M. and Gaziano , J. M., et al. 2007 . A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: Results from the Women's Antioxidant Cardiovascular Study . Arch Intern Med , 167 : 1610 – 1618 .
   PubMed Web of Science ®Google Scholar
• Correa , P. , Fontham , E. T. and Bravo , J. C., et al. 2000 . Chemoprevention of gastric dysplasia: A randomized trial of antioxidant supplements and anti-helicobacter pylori therapy . J Natl Cancer Inst. , 92 : 1881 – 1888 .
   PubMed Web of Science ®Google Scholar
• Cuervo , M. , Corbalán , M. and Baladía , E., et al. 2009 . Comparison of dietary reference intakes (DRI) between different countries of the European Union, The United States and the World Health Organization . Nutr Hosp , 24 : 384 – 414 .
   PubMed Web of Science ®Google Scholar
• Davies , H. E. , Davies , J. E. , Hughes , R. E. and Jones , E. 1984 . Studies on the absorption of L-xyloascorbic acid (vitamin C) in young and elderly subjects . Hum Nutr Clin Nutr. , 38 : 469 – 471 .
   Google Scholar
• Deutsche Gesellschaft für Ernährung (German Society of Nutrition) . 2000 . “ Referenzwerte für die Nahrstoffzufuhr (Recommended Values of Nutrient Intake) ” . 137 – 144 . Frankfurt : Umschau . Österreichische Gesellschaft für Ernährung (Austrian Society of Nutrition), Schweizerische Gesellschaft für Ernährungsforschung (Swiss Society of Nutrition Research), Schweizerische Vereinigung für Ernährung (Swiss Union of Nutrition)
   Google Scholar
• Dietrich , M. , Block , G. and Benowitz , N. L., et al. 2003 . Vitamin C supplementation decreases oxidative stress biomarker F2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smoke . Nutr Cancer. , 45 : 176 – 184 .
   PubMed Web of Science ®Google Scholar
• Drake , V. J. and Frei , B. 2011 . “ Vitamin C in human disease prevention ” . In Vitamins in the Prevention of Human Diseases , Edited by: Herrmann , W. and Obeid , R. 347 – 362 . Berlin : Walter de Gruyter .
   Google Scholar
• Duffy , S. J. , Gokce , N. and Holbrook , M., et al. 1999 . Treatment of hypertension with ascorbic acid . Lancet. , 354 : 2048 – 2049 .
   PubMed Web of Science ®Google Scholar
• EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) . 2009 . Scientific Opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non-haem iron absorption (ID 132, 147), energy-yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 . EFSA Journal , 7 ( 9 ) : 1226
   Google Scholar
• Elmadfa , I. and Weichselbaum , E. 2005 . European Nutrition and Health Report 2004 . Forum Nutr. , 2005 : 1 – 220 .
   Google Scholar
• Englard , S. and Seifter , S. 1986 . The biochemical functions of ascorbic acid . Annu Rev Nutr. , 6 : 365 – 406 .
   PubMed Web of Science ®Google Scholar
• FSA . 2003 . “ Expert Group on Vitamins and Minerals. Risk Assessment: Vitamin C. ” . 100 – 107 . Food Standards Agency, UK. Safe Upper Levels for Vitamins and Minerals
   Google Scholar
• Frei , B. 1991 . Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage . Am J Clin Nutr. , 54 : 1113S – 1118S .
   PubMed Web of Science ®Google Scholar
• Frei , B. 2004 . Efficacy of dietary antioxidants to prevent oxidative damage and inhibit chronic disease . J Nutr. , 134 : 3196S – 3198S .
   PubMed Web of Science ®Google Scholar
• Frei , B. , England , L. and Ames , B. N. 1989 . Ascorbate is an outstanding antioxidant in human blood plasma . Proc Natl Acad Sci U S A. , 86 : 6377 – 6381 .
   PubMed Web of Science ®Google Scholar
• Frikke-Schmidt , H. and Lykkesfeldt , J. 2009 . Role of marginal vitamin C deficiency in atherogenesis: In vivo models and clinical studies . Basic Clin Pharmacol Toxicol. , 104 : 419 – 433 .
   PubMed Web of Science ®Google Scholar
• FSA . 2006 . “ Nutrient and Food Based Guidelines for UK Institutions ” . UK : Food Standards Agency .
   Google Scholar
• Gale , C. R. , Martyn , C. N. , Winter , P. D. and Cooper , C. 1995 . Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people . Br Med J. , 310 : 1563 – 1566 .
   PubMed Web of Science ®Google Scholar
• Gaziano , J. M. , Glyan , R. J. , Christen , W. G. and Kurth, T., Belanger, C., MacFadyen, J., Bubes, V., Manson, J.E., Sesso, H.D. , Buring, J.E. 2009 . Vitamin E and C in the prevention of prostate and total cancer in men: the Physician's Health Study II randemized controlled trial . JAMA , 301 : 52 – 62 .
   PubMed Web of Science ®Google Scholar
• Girodon , F. , Galan , P. , Monget , A. L. , Boutron-Ruault , M. C. , Brunet-Lecomte , P. , Preziosi , P. , Arnaud , J. , Manuguerra , J. C. and Hercberg , S. 1999 . Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: A randomized controlled trial. MIN. VIT. AOX. geriatric network . Arch Intern Med. , 159 : 748 – 754 .
   PubMed Web of Science ®Google Scholar
• Gokce , N. , Keaney , J. F. Jr. and Frei , B., et al. 1999 . Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease . Circulation. , 99 : 3234 – 3240 .
   PubMed Web of Science ®Google Scholar
• Gokce , N. , Keaney , J. F. Jr. and Hunter , L. M., et al. 2003 . Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease . J Am Coll Cardiol. , 41 : 1769 – 1775 .
   PubMed Web of Science ®Google Scholar
• Graat , J. M. , Schouten , E. G. and Kok , F. J. 2002 . Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: A randomized controlled trial . JAMA , 288 : 715 – 721 .
   PubMed Web of Science ®Google Scholar
• Graumlich , J. F. , Ludden , T. M. , Conry-Cantilena , C. , Cantilena , L. R. Jr. , Wang , Y. and Levine , M. 1997 . Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion . Pharm Res. , 14 : 1133 – 1139 .
   PubMed Web of Science ®Google Scholar
• Greenberg , E. R. , Baron , J. A. and Tosteson , T. D., et al. 1994 . A clinical trial of antioxidant vitamins to prevent colorectal adenoma . Polyp Prevention Study Group. N Engl J Med. , 331 : 141 – 147 .
   PubMed Web of Science ®Google Scholar
• Halliwell , B. 1996 . Vitamin C: Antioxidant or pro-oxidant in vivo? . Free Radic Res. , 25 : 439 – 454 .
   PubMed Web of Science ®Google Scholar
• Hathcock , J. N. , Azzi , A. and Blumberg , J., et al. 2005 . Vitamins E and C are safe across a broad range of intakes . Am J Clin Nutr. , 81 : 736 – 745 .
   PubMed Web of Science ®Google Scholar
• He , F. J. , Nowson , C. A. and MacGregor , G. A. 2006 . Fruit and vegetable consumption and stroke: meta-analysis of cohort studies . Lancet. , 367 : 320 – 326 .
   PubMed Web of Science ®Google Scholar
• He , F. J. , Nowson , C. A. , Lucas , M. and MacGregor , G. A. 2007 . Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: Meta-analysis of cohort studies . J Hum Hypertens. , 21 : 717 – 728 .
   PubMed Web of Science ®Google Scholar
• Heart Protection Study Collaborative Group . 2002 . MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial . Lancet. , 360 : 23 – 33 .
   PubMed Web of Science ®Google Scholar
• Henriquez-Sanchez , P. , Sanchez-Villegas , A. , Doreste-Alonso , J. , Ortiz-Andrellucchi , A. , Pfrimer , K. and Serra-Majem , L. 2009 . Dietary assessment methods for micronutrient intake: A systematic review on vitamins . Br J Nutr. , 102 : S10 – S37 .
   PubMed Web of Science ®Google Scholar
• Hercberg , S. , Galan , P. and Preziosi , P., et al. 2004 . The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals . Arch Intern Med. , 164 : 2335 – 2242 .
   PubMed Web of Science ®Google Scholar
• Hercberg , S. , Preziosi , P. and Galan , P., et al. 1994 . Vitamin status of a healthy French population: dietary intakes and biochemical markers . Int J Vitam Nutr Res. , 64 : 220 – 232 .
   PubMed Web of Science ®Google Scholar
• Higdon , J. 2003 . “ Vitamin C ” . 65 – 72 . New York : Thieme . An Evidence-Based Approach to Vitamins and Minerals: Health Benefits and Intake Recommendations
   Google Scholar
• Horska , A. , Mislanova , C. , Bonassi , S. , Ceppi , M. , Volkovova , K. and Dusinska , M. 2010 . Vitamin C levels in blood are influenced by polymorphisms in glutathione S-transferases . Eur J Nutr. , [Epub ahead of print]
   Web of Science ®Google Scholar
• Huang , A. , Vita , J. A. , Venema , R. C. and Keaney , J. F. Jr. 2000 . Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin . J Biol Chem. , 275 : 17399 – 17406 .
   PubMed Web of Science ®Google Scholar
• Huang , A. L. , Silver , A. E. and Shvenke , E., et al. 2007 . Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery . Arterioscler Thromb Vasc Biol. , 27 : 2113 – 2119 .
   PubMed Web of Science ®Google Scholar
• Huang , H. Y. , Appel , L. J. , Croft , K. D. , Miller , E. R. III , Mori , T. A. and Puddey , I. B. 2002 . Effects of vitamin C and vitamin E on in vivo lipid peroxidation: Results of a randomized controlled trial . Am J Clin Nutr. , 76 : 549 – 555 .
   PubMed Web of Science ®Google Scholar
• Huang , H. Y. , Helzlsouer , K. J. and Appel , L. J. 2000 . The effects of vitamin C and vitamin E on oxidative DNA damage: Results from a randomized controlled trial . Cancer Epidemiol Biomarkers Prev. , 9 : 647 – 652 .
   PubMed Web of Science ®Google Scholar
• Inaba , Y. , Chen , J. A. and Bergmann , S. R. 2010 . Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: A meta-analysis . Int J Cardiovasc Imaging , 26 : 631 – 640 .
   PubMed Web of Science ®Google Scholar
• Institut Scientifique de la Santé Publique . 2004 . Enquête de Consommation Aimentaire en Belgique .
   Google Scholar
• Institute of Medicine . 2000 . “ Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids ” . Washington , DC : National Academy Press .
   Google Scholar
• Jacob , R. A. 1990 . Assessment of human vitamin C status . J Nutr. , 120 : 1480 – 1485 .
   PubMed Web of Science ®Google Scholar
• Jarosz , M. , Dzieniszewski , J. , Dabrowska-Ufniarz , E. , Wartanowicz , M. , Ziemlanski , S. and Reed , P. I. 1998 . Effects of high dose vitamin C treatment on Helicobacter pylori infection and total vitamin C concentration in gastric juice . Eur J Cancer Prev. , 7 : 449 – 454 .
   PubMed Web of Science ®Google Scholar
• Jenab , M. , Riboli , E. and Ferrari , P., et al. 2006 . Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) . Carcinogenesis. , 27 : 2250 – 2257 .
   PubMed Web of Science ®Google Scholar
• Johnston , C. S. 1999 . Biomarkers for establishing a tolerable upper intake level for vitamin C . Nutr Rev. , 57 : 71 – 77 .
   Web of Science ®Google Scholar
• Juraschek , S. P. , Guallar , E. , Appel , L. J. and Miller , E. R. III . 2012 . Effects of vitamin C supplementation on blood pressure: A meta-analysis of randomized controlled trials . Am J Clin Nutr. , 95 : 1079 – 1088 .
   PubMed Web of Science ®Google Scholar
• Kallner , A. B. , Hartmann , D. and Hornig , D. H. 1981 . On the requirements of ascorbic acid in man: Steady-state turnover and body pool in smokers . Am J Clin Nutr. , 34 : 1347 – 1355 .
   PubMed Web of Science ®Google Scholar
• Khaw , K. T. , Bingham , S. and Welch , A., et al. 2001 . Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: A prospective population study. European Prospective Investigation into Cancer and Nutrition . Lancet. , 357 : 657 – 663 .
   PubMed Web of Science ®Google Scholar
• Klaunig , J. E. and Kamendulis , L. M. 2004 . The role of oxidative stress in carcinogenesis . Annu Rev Pharmacol Toxicol. , 44 : 239 – 267 .
   PubMed Web of Science ®Google Scholar
• Kuiper , C. , Molenaar , I. G. , Dachs , G. U. , Currie , M. J. , Sykes , P. H. and Vissers , M. C. 2010 . Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer . Cancer Res. , 70 : 5749 – 5758 .
   PubMed Web of Science ®Google Scholar
• Kurl , S. , Tuomainen , T. P. and Laukkanen , J. A., et al. 2002 . Plasma vitamin C modifies the association between hypertension and risk of stroke . Stroke. , 33 : 1568 – 1573 .
   PubMed Web of Science ®Google Scholar
• Langlois , M. , Duprez , D. , Delanghe , J. , De Buyzere , M. and Clement , D. L. 2001 . Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis . Circulation. , 103 : 1863 – 1868 .
   PubMed Web of Science ®Google Scholar
• Lehr , H. A. , Frei , B. and Arfors , K. E. 1994 . Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo . Proc Natl Acad Sci U S A. , 91 : 7688 – 7692 .
   PubMed Web of Science ®Google Scholar
• Lehr , H. A. , Frei , B. , Olofsson , A. M. , Carew , T. E. and Arfors , K. E. 1995 . Protection from oxidized LDL-induced leukocyte adhesion to microvascular and macrovascular endothelium in vivo by vitamin C but not by vitamin E. . Circulation. , 91 : 1525 – 1532 .
   PubMed Web of Science ®Google Scholar
• Levine , G. N. , Frei , B. , Koulouris , S. N. , Gerhard , M. D. , Keaney , J. F. Jr. and Vita , J. A. 1996 . Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease . Circulation. , 93 : 1107 – 1113 .
   PubMed Web of Science ®Google Scholar
• Levine , M. 1986 . New concepts in the biology and biochemistry of ascorbic acid . N Engl J Med. , 314 : 892 – 902 .
   PubMed Web of Science ®Google Scholar
• Levine , M. and Eck , P. 2009 . Vitamin C: Working on the x-axis . Am J Clin Nutr. , 90 : 1121 – 1123 .
   Web of Science ®Google Scholar
• Levine , M. , Conry-Cantilena , C. and Wang , Y., et al. 1996 . Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance . Proc Natl Acad Sci U S A. , 93 : 3704 – 3709 .
   PubMed Web of Science ®Google Scholar
• Levine , M. , Rumsey , S. C. , Daruwala , R. , Park , J. B. and Wang , Y. 1999 . Criteria and recommendations for vitamin C intake . JAMA , 281 : 1415 – 1423 .
   PubMed Web of Science ®Google Scholar
• Levine , M. , Wang , Y. , Padayatty , S. J. and Morrow , J. 2001 . A new recommended dietary allowance of vitamin C for healthy young women . Proc Natl Acad Sci U S A , 98 : 9842 – 9846 .
   PubMed Web of Science ®Google Scholar
• Li , J. Y. , Taylor , P. R. and Li , B., et al. 1993 . Nutrition intervention trials in Linxian, China: Multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia . J Natl Cancer Inst. , 85 : 1492 – 1498 .
   PubMed Web of Science ®Google Scholar
• Loria , C. M. , Klag , M. J. , Caulfield , L. E. and Whelton , P. K. 2000 . Vitamin C status and mortality in US adults . Am J Clin Nutr. , 72 : 139 – 145 .
   PubMed Web of Science ®Google Scholar
• Lykkesfeldt , J. and Poulsen , H. E. 2010 . Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials . Br J Nutr. , 103 : 1251 – 1259 .
   PubMed Web of Science ®Google Scholar
• Lykkesfeldt , J. , Christen , S. , Wallock , L. M. , Chang , H. H. , Jacob , R. A. and Ames , B. N. 2000 . Ascorbate is depleted by smoking and repleted by moderate supplementation: A study in male smokers and nonsmokers with matched dietary antioxidant intakes . Am J Clin Nutr. , 71 : 530 – 536 .
   PubMed Web of Science ®Google Scholar
• Lykkesfeldt , J. , Loft , S. , Nielsen , J. B. and Poulsen , H. E. 1997 . Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking . Am J Clin Nutr. , 65 : 959 – 963 .
   PubMed Web of Science ®Google Scholar
• Mah , E. , Matos , M. D. and Kawiecki , D., et al. 2011 . Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men . J Am Diet Assoc. , 111 : 737 – 743 .
   Web of Science ®Google Scholar
• Mayland , C. R. , Bennett , M. I. and Allan , K. 2005 . Vitamin C deficiency in cancer patients . Palliat Med. , 19 : 17 – 20 .
   PubMed Web of Science ®Google Scholar
• Michels , A. and Frei , B. 2012 . “ Vitamin C ” . Edited by: Stipanuk , M. H. and Caudill , M. A. 626 – 654 . St. Louis , MO : Saunders Elsevier . Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 3rd Ed.
   Google Scholar
• Michels , A. J. , Hagen , T. M. and Frei , B. 2010 . A new twist on an old vitamin: Human polymorphisms in the gene encoding the sodium-dependent vitamin C transporter 1 . Am J Clin Nutr. , 92 : 271 – 272 .
   Web of Science ®Google Scholar
• Mirvish , S. S. 1994 . Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers . Cancer Res. , 54 : 1948s – 1951s .
   PubMed Web of Science ®Google Scholar
• Myint , P. K. , Luben , R. N , Welch , A. A. , Bingham , S. A. , Wareham , N. J. and Khaw , K. T. 2008 . Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study . Am J Clin Nutr. , 87 : 64 – 69 .
   PubMed Web of Science ®Google Scholar
• Nakata , Y. and Maeda , N. 2002 . Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic acid . Circulation. , 105 : 1485 – 1490 .
   PubMed Web of Science ®Google Scholar
• Newton , H. M. , Morgan , D. B. , Schorah , C. J and Hullin , R. P. 1983 . Relation between intake and plasma concentration of vitamin C in elderly women . Br Med J (Clin Res Ed). , 287 : 1429
   Web of Science ®Google Scholar
• Nyyssonen , K. , Parviainen , M. T. , Salonen , R. , Tuomilehto , J. and Salonen , J. T. 1997 . Vitamin C deficiency and risk of myocardial infarction: Prospective population study of men from eastern Finland . Br Med J. , 314 : 634 – 638 .
   PubMed Web of Science ®Google Scholar
• Odermarsky , M. , Lykkesfeldt , J. and Liuba , P. 2009 . Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with Type 1 diabetes . Am J Clin Nutr. , 90 : 447 – 452 .
   Web of Science ®Google Scholar
• Osganian , S. K. , Stampfer , M. J. Rimm , E. 2003 . Vitamin C and risk of coronary heart disease in women . J Am Coll Cardiol. , 42 : 246 – 252 .
   PubMed Web of Science ®Google Scholar
• Polidori , M. C. , Mecocci , P. and Frei , B. 2001 . Plasma vitamin C levels are decreased and correlated with brain damage in patients with intracranial hemorrhage or head trauma . Stroke. , 32 : 898 – 902 .
   PubMed Web of Science ®Google Scholar
• Potier de Courcy , G. , Guilland , J-C. and Birlouez-Aragon , I. 2001 . Nutritional recommendations for the French population: Vitamins . Sciences des Aliments. , 21 : 393 – 407 .
   Google Scholar
• Publication du Conseil Supérior de la Santé No 8309 . 2009 . Recommandations Nutritionnelles pour la Belgique . Révision 2009
   Google Scholar
• Reilly , M. , Delanty , N. , Lawson , J. A. and FitzGerald , G. A. 1996 . Modulation of oxidant stress in vivo in chronic cigarette smokers . Circulation. , 94 : 19 – 25 .
   PubMed Web of Science ®Google Scholar
• Roberts , L. J. II , Traber , M. G. and Frei , B. 2009 . Vitamins E and C in the prevention of cardiovascular disease and cancer in men . Free Radic Biol Med. , 46 : 1558
   PubMed Web of Science ®Google Scholar
• Salonen , R. M. , Nyyssonen , K. and Kaikkonen , J., et al. 2003 . Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study . Circulation. , 107 : 947 – 953 .
   PubMed Web of Science ®Google Scholar
• Sasazuki , S. , Sasaki , S. , Tsubono , Y. , Okubo , S. , Hayashi , M. , Kakizoe , T. and Tsugane , S. 2003 . The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection . Cancer Sci. , 94 : 378 – 382 .
   Web of Science ®Google Scholar
• Sauberlich , H. E. 1997 . “ A history of scurvy and Vitamin C. ” . In Vitamin C in Health and Disease , 1st Ed. , Edited by: Packer , L. and Fuchs , J. 1 – 24 . New York : Marcel Dekker .
   Google Scholar
• Savini , I. , Rossi , A. , Pierro , C. , Avigliano , L. and Catani , M. V. 2008 . SVCT1 and SVCT2: Key proteins for vitamin C uptake . Amino Acids. , 34 : 347 – 355 .
   PubMed Web of Science ®Google Scholar
• Schleicher , R. L. , Carroll , M. D. , Ford , E. S. and Lacher , D. A. 2009 . Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004. National Health and Nutrition Examination Survey (NHANES) . Am J Clin Nutr. , 90 : 1252 – 1263 .
   PubMed Web of Science ®Google Scholar
• Sesso , H. D. , Buring , J. E. and Christen , W. G., et al. 2008 . Vitamins E and C in the prevention of cardiovascular disease in men: The Physicians’ Health Study II randomized controlled trial . JAMA. , 300 : 2123 – 2133 .
   PubMed Web of Science ®Google Scholar
• Sesso , H. D. , Gaziano , J. M. , VanDenburgh , M. , Hennekens , C. H. , Glynn , R. J. and Buring , J. E. 2002 . Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: The Physicians’ Health Study . Control Clin Trials. , 23 : 686 – 702 .
   PubMedGoogle Scholar
• Sharma , A. , Tripathi , M. , Satyam , A. and Kumar , L. 2009 . Study of antioxidant levels in patients with multiple myeloma . Leuk Lymphoma. , 50 : 809 – 815 .
   PubMed Web of Science ®Google Scholar
• Simon , J. A. , Hudes , E. S. and Browner , W. S. 1998 . Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults . Epidemiology. , 9 : 316 – 321 .
   Web of Science ®Google Scholar
• Simon , J. A. , Hudes , E. S. and Tice , J. A. 2001 . Relation of serum ascorbic acid to mortality among US adults . J Am Coll Nutr. , 20 : 255 – 263 .
   PubMed Web of Science ®Google Scholar
• Societa Italiana di Nutrizione Umana (Italian Society of Human Nutrition) . 1996 . Livelli di assunzione giornalieri raccommandati di energia e nutrienti per la popolazione Italiana . Revisione Internet: http://www.sinu.it/larn/introduzione.asp.
   Google Scholar
• Sugamura , K. and Keaney , J. F. Jr. 2011 . Reactive oxygen species in cardiovascular disease . Free Radic Biol Med , 51 : 978 – 992 .
   PubMed Web of Science ®Google Scholar
• Tarng , D. C. , Liu , T. Y. and Huang , T. P. 2004 . Protective effect of vitamin C on 8-hydroxy-2’-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients . Kidney Int. , 66 : 820 – 831 .
   Web of Science ®Google Scholar
• Touvier , M. , Lioret , S. and Vanrullen , I., et al. 2006 . Vitamin and mineral inadequacy in the French population: Estimation and application for the optimization of food fortification . Int J Vitam Nutr Res. , 76 : 343 – 351 .
   PubMed Web of Science ®Google Scholar
• UK Office for National Statistics . 2003 . The National Diet & Nutrition Survey (NDNS): Adults Aged 19 to 64 Years . 3
   Google Scholar
• UK Office for National Statistics . 2003 . The National Diet & Nutrition Survey (NDNS): Adults aged 19 to 64 years . 5
   Google Scholar
• Waters , D. D. , Alderman , E. L. and Hsia , J., et al. 2002 . Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: A randomized controlled trial. JAMA . 288 : 2432 – 2440 .
   Google Scholar
• WHO . 2004 . Vitamin and Mineral Requirements in Human Nutrition , 2nd Ed., Geneva, Switzerland
   Google Scholar
• Willett , W. C. 2010 . Fruits, vegetables, and cancer prevention: Turmoil in the produce section . J Natl Cancer Inst. , 102 : 510 – 511 .
   PubMed Web of Science ®Google Scholar
• Wrieden , W. L. , Hannah , M. K. , Bolton-Smith , C. , Tavendale , R. , Morrison , C. and Tunstall-Pedoe , H. 2000 . Plasma vitamin C and food choice in the third Glasgow MONICA population survey . J Epidemiol Community Health. , 54 : 355 – 360 .
   PubMed Web of Science ®Google Scholar
• Yokoyama , T. , Date , C. , Kokubo , Y. , Yoshiike , N. , Matsumura , Y. and Tanaka , H. 2000 . Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study . Stroke. , 31 : 2287 – 2294 .
   PubMed Web of Science ®Google Scholar
• You , W. C. , Chang , Y. S. and Heinrich , J., et al. 2001 . An intervention trial to inhibit the progression of precancerous gastric lesions: Compliance, serum micronutrients and S-allyl cysteine levels, and toxicity . Eur J Cancer Prev. , 10 : 257 – 263 .
   PubMed Web of Science ®Google Scholar
• Zhang , Z. W. and Farthing , M. J. 2005 . The roles of vitamin C in Helicobacter pylori associated gastric carcinogenesis . Chin J Dig Dis. , 6 : 53 – 58 .
   Google Scholar