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Resveratrol as an anti-cancer agent: A review

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References

  • Abdel-Latif, G. A., Al-Abd, A. M., Tadros, M. G., Al-Abbasi, F. A., Khalifa, A. E. and Abdel-Naim, A. B. (2015). The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Sci. Rep. 5:12054.
  • Alayev, A., Berger, S. M., Kramer, M. Y., Schwartz, N. S. and Holz, M. K. (2015). The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells. J. Cell Biochem. 116(3):450–457.
  • Alayev, A., Salamon, R. S., Schwartz, N. S., Berman, A. Y., Wiener, S. L. and Holz, M. K. (2016). Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer. J. Cell Physiol. doi: 10.1002/jcp.25443.
  • Ali, I. and Braun, D. P. (2014). Resveratrol enhances mitomycin C-mediated suppression of human colorectal cancer cell proliferation by up-regulation of p21WAF1/CIP1. Anticancer Res. 34(10):5439–5446.
  • Aluyen, J. K., Ton, Q. N., Tran, T., Yang, A. E., Gottlieb, H. B. and Bellanger, R. A. (2012). Resveratrol: Potential as anicancer agent. J. Diet. Suppl. 9(1):45–56.
  • Aquilano, K., Baldelli, S., Rotilio, G. and Ciriolo, M. R. (2009). Trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis. Biochem. Pharmacol. 77(3):337–347.
  • Atten, M. J., Godoy-Romero, E., Attar, B. M., Milson, T., Zopel, M. and Holian, O. (2005). Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. Invest. New Drugs. 23(2):111–119.
  • Aziz, M. H., Afaq, F. and Ahmad, N. (2005). Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem. Photobiol. 81(1):25–31.
  • Back, J. H., Zhu, Y., Calabro, A., Queenan, C., Kim, A. S., Arbesman, J. and Kim, A. L. (2012). Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesis. Photochem. Photobiol. 88(5):1165–1172.
  • Baek, S. H., Ko, J. H., Lee, H., Jung, J., Kong, M., Lee, J. W., Lee, J., Chinnathambi, A., Zayed, M. E., Alharbi, S. A. et al. (2016). Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine 23(5):566–577.
  • Bai, Y., Mao, Q. Q., Qin, J., Zheng, X. Y., Wang, Y. B., Yang, K., Shen, H. F. and Xie, L. P. (2010). Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. 101(2):488–493.
  • Baribeau, S., Chaudhry, P., Parent, S. and Asselin, É. (2014). Resveratrol inhibits cisplatin-induced epithelial-to-mesenchymal transition in ovarian cancer cell lines. PLoS One 9(1):e86987.
  • Baur, J. A. and Sinclair, D. A. (2006). Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. 5:493–506.
  • Berta, G. N., Salamone, P., Sprio, A. E., Di Scipio, F., Marinos, L. M., Sapino, S., Carlotti, M. E., Cavalli, R. and Di Carlo, F. (2010). Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-beta-cyclodextrin. Oral Oncol. 46(1):42–48.
  • Bhat, K. P. and Pezzuto, J. M. (2001). Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res. 61(16):6137–6144.
  • Bielsalski, H. K. (2007). Polyphenols and inflammation: Basic interactions. Curr. Opin. Clin. Nutr. Metab. Care 10:724–728.
  • Buhrmann, C., Shayan, P., Kraehe, P, Popper, B., Goel, A. and Shakibaei, M. (2015). Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochem. Pharmacol. 98(1):51–68.
  • Cai, Y., Zhao, L., Qin, Y., Zhang, M. and He, Y. (2015). Resveratrol inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line C666-1 through AMPK activation. Pharmazie 70(6):399–403.
  • Chang, H. J., Chou, C. T., Chang, H. T., Liang, W. Z., Hung, T. Y., Li, Y. D., Fang, Y. C., Kuo, C. C., Kuo, D. H., Shieh, P. and Jan, C. R. (2015). Mechanisms of resveratrol-induced changes in cytosolic free calcium ion concentrations and cell viability in OC2 human oral cancer cells. Hum. Exp. Toxicol. 34(3):289–299.
  • Chen, M. C., Chang, W. W., Kuan, Y. D., Lin, S. T., Hsu, H. C. and Lee, C. H. (2012). Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model. Innate Immun. 18(5):685–693.
  • Chen, S., Zhou, N., Zhang, Z., Li, W. and Zhu, W. (2015). Resveratrol induces cell apoptosis in adipocytes via AMPK activation. Biochem. Biophys. Res. Commun. 457(4):608–613.
  • Cho, J., Rho, O., Junco, J., Carbajal, S., Siegel, D., Slaga, T. J. and DiGiovanni, J. (2015). Effect of combined treatment with ursolic acid and resveratrol on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Prev. Res. 8(9):817–825.
  • Chow, S. M. (2005). Side effects of high-dose radioactive iodine for ablation or treatment of differentiated thyroid carcinoma. Hong Kong J. Radiol. 8(3):127–135.
  • Colin, D. J., Limagne, E., Ragot, K., Lizard, G., Ghiringhelli, F., Solary, É., Chauffert, B., Latruffe, N. and Delmas, D. (2014). The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models. Cell Death Dis. 5:e1533.
  • Dai, Z., Lei, P., Xie, J. and Hu, Y. (2015). Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways. Mol. Med. Rep. 12(2):3151–3155.
  • Das, S. and Das, D. K. (2007). Anti-inflammatory responses of resveratrol. Inflamm. Allergy. Drug Targets. 6(3):168–173.
  • de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D. and Plummer, M. (2012). Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 13(6):607–615.
  • Demoulin, B., Hermant, M., Castrogiovanni, C., Staudt, C. and Dumont, P. (2015). Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis. Toxicol. In Vitro. 29(5):1156–1165.
  • DeSantis, C., Ma, J., Bryan, L. and Jemal, A. (2013). Breast cancer statistics. CA Cancer J. Clin. 64:52–62.
  • Dhandayuthapani, S., Marimuthu, P., Hörmann, V., Kumi-Diaka, J. and Rathinavelu, A. (2013). Induction of apoptosis in HeLa cells via caspase activation by resveratrol and genistein. J. Med. Food. 16(2):139–146.
  • Dhar, S., Kumar, A., Li, K., Tzivion, G. and Levenson, A. S. (2015). Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer. Biochim. Biophys. Acta. 1853(2):265–275.
  • Dhar, S., Kumar, A., Rimando, A. M., Zhang, X. and Levenson, A. S. (2015a). Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer. Oncotarget. 6(29):27214–27226.
  • Du, Q., Shen, K. P., Hu, B. and Deng, S. (2012). Effects of resveratrol on apoptosis and ROS production in Hepa 1–6 hepatocarcinoma cells. Zhong Yao Cai. 35(3):443–448.
  • Empl, M. T., Albers, M., Wang, S. and Steinberg, P. (2015). The resveratrol tetramer r-viniferin induces a cell cycle arrest followed by apoptosis in the prostate cancer cell line LNCaP. Phytother. Res. 29(10):1640–1645.
  • Fan, G. H., Wang, Z. M., Yang, X., Xu, L. P., Qin, Q., Zhang, C., Ma, J. X., Cheng, H. Y. and Sun, X. C. (2014). Resveratrol inhibits oesophageal adenocarcinoma cell proliferation via AMP-activated protein kinase signaling. Asian Pac. J. Cancer Prev. 15(2):677–682.
  • Firouzi, F., Khoei, S. and Mirzaei, H. R. (2015). Role of resveratrol on the cytotoxic effects and DNA damages of iododeoxyuridine and megavoltage radiation in spheroid culture of U87MG glioblastoma cell line. Gen. Physiol. Biophys. 34(1):43–50.
  • Gao, Q., Yuan, Y., Gan, H. Z and Peng, Q. (2015). Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis. Oncol. Lett. 9(5):2381–2387.
  • García-Zepeda, S. P., García-Villa, E., Díaz-Chávez, J., Hernández-Pando, R. and Gariglio, P. (2013). Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy. Eur. J. Cancer Prev. 22(6):577–584.
  • George, J., Singh, M., Srivastava, A. K., Bhui, K., Roy, P., Chaturvedi, P. K. and Shukla, Y. (2011). Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS One 6(8):e23395.
  • Gu, S., Chen, C., Jiang, X. and Zhang, Z. (2015). Resveratrol synergistically triggers apoptotic cell death with arsenic trioxide via oxidative stress in human lung adenocarcinoma A549 cells. Biol. Trace Elem. Res. 163(1, 2):112–123.
  • Guo, L., Peng, Y., Li Y, Yao J, Zhang G, Chen J, Wang, J., and Sui, L. (2015). Cell death pathway induced by resveratrol-bovine serum albumin nanoparticles in a human ovarian cell line. Oncol. Lett. 9(3):1359–1363.
  • Gwak, H., Haegeman, G., Tsang, B. K. and Song, Y. S. (2015). Cancer-specific interruption of glucose metabolism by resveratrol is mediated through inhibition of Akt/GLUT1 axis in ovarian cancer cells. Mol Carcinog. 54(12):1529–1540.
  • Habibie,  , Yokoyama, S., Abdelhamed, S., Awale, S., Sakurai, H., Hayakawa, Y. and Saiki, I. (2014). Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis. Int. J. Oncol. 45(2):895–901.
  • Hao, Y. Q., Huang, W. X., Feng, H. X., Zhang, G. H., Ning, X. H., Li, H. G., Hao, C. G. and Li, Z. H. (2013). Study of apoptosis related factors regulatory mechanism of resveratrol to human skin squamous cell carcinoma A431 xenograft in nude mice. Zhonghua Yi Xue Za Zhi. 93(6):464–468.
  • Hao, Y., Huang, W., Liao, M., Zhu, Y., Liu, H., Hao, C., Liu, G., Zhang, G., Feng, H., Ning, X., Li, H. and Li, Z. (2013a). The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice. Fitoterapia 86:84–91.
  • Hedayati, M., Shafaghati, N. and Hosseinimehr, S. J. (2013). Resveratrol mitigates genotoxicity induced by iodine-131 in primary human lymphocytes. Radiat. Environ. Biophys. 52(2):287–291.
  • Heiduschka, G., Lill, C., Seemann, R., Brunner, M., Schmid, R., Houben, R., Bigenzahn, J. and Thurnher, D. (2014). The effect of resveratrol in combination with irradiation and chemotherapy: study using Merkel cell carcinoma cell lines. Strahlenther Onkol. 190(1):75–80.
  • Holian, O., Wahid, S., Atten, M. J. and Attar, B. M. (2002). Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide. Am J Physiol Gastrointest Liver Physiol. 282(5):G809–16.
  • Hosseinimehr, S. J. and Hosseini, S. A. H. (2014). Resveratrol sensitizes selectively thyroid cancer cell to 131-iodine toxicity. J. Toxicol. 2014: Article ID 839597. doi.org/10.1155/2014/839597.
  • Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W. et al. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425:191–196.
  • Hsu, K. F., Wu, C. L., Huang, S. C., Wu, C. M., Hsiao, J. R., Yo, Y. T., Chen, Y. H., Shiau, A. L. and Chou, C. Y. (2009). Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy 5(4):451–460.
  • Irigaray, P., Newby, J. A., Clapp, R., Hardell, L., Howard, V., Montagnier, L., Epstein, S. and Belpomme, D. (2007). Lifestyle-related factors and environmental agents causing cancer: an overview. Biomed. Pharmacother. 61:640–658.
  • Jagdeo, J., Adams, L., Lev-Tov, H., Sieminska, J., Michl, J. and Brody, N. (2010). Dose-dependent antioxidant function of resveratrol demonstrated via modulation of reactive oxygen species in normal human skin fibroblasts in vitro. J. Drugs Dermatol. 9(12):1523–1526.
  • Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. et al. (1997). Cancer chemoprotective activity of resveratrol, a natural product derived from grapes. Science 275:218–220.
  • Ji, Q., Liu, X., Han, Z., Zhou, L., Sui, H., Yan, L., Jiang, H., Ren, J., Cai, J. and Li, Q. (2015). Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression. BMC Cancer. 15:97.
  • Jing, X., Cheng, W., Wang, S., Li, P. and He, L. (2016). Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN regulated PI3K/Akt signaling pathway. Oncol. Rep. 5(1):472–478.
  • Junco, J. J., Mancha, A., Malik, G., Wei, S. J., Kim, D. J., Liang, H. and Slaga, T. J. (2013). Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. Mol. Cancer Res. 11(12):1521–1529.
  • Kalra, N., Roy, P., Prasad, S. and Shukla, Y. (2008). Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis. Life Sci. 82(7, 8):348–358.
  • Kaneuchi, M., Sasaki, M., Tanaka, Y., Yamamoto, R., Sakuragi, N. and Dahiya, R. (2003). Resveratrol suppresses growth of Ishikawa cells through down-regulation of EGF. Int. J. Oncol. 23(4):1167–1172.
  • Khan, A., Aljarbou, A. N., Aldebasi, Y. H., Faisal, S. M. and Khan, M. A. (2014). Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway. Cancer Epidemiol. 38(6):765–772.
  • Kim, J. A., Kim, D. H., Hossain, M. A., Kim, M. Y., Sung, B., Yoon, J. H., Suh, H., Jeong, T. C., Chung, H. Y., and Kim, N. D. (2014). HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells. Int. J. Oncol. 44(2):473–480.
  • Kim, S. H., Cho, K. H., Kim, Y. N., Jeong, B. Y., Park, C. G., Hur, G. M and Lee, H. Y. (2016). Resveratrol attenuates norepinephrine-induced ovarian cancer invasiveness through downregulating hTERT expression. Arch. Pharm. Res. 39(2):240–248.
  • Kim, Y. S., Sull, J. W. and Sung, H. J. (2012). Suppressing effect of resveratrol on the migration and invasion of human metastatic lung and cervical cancer cells. Mol. Biol. Rep. 39(9):8709–8716.
  • Ko, J. C., Syu, J. J., Chen, J. C., Wang, T. J., Chang, P. Y., Chen, C. Y., Jian, Y. T., Jian, Y. J. and Lin, Y. W. (2015). Resveratrol enhances etoposide-induced cytotoxicity through down-regulating ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 (XRCC1) protein expression in human non-small-cell lung cancer cells. Basic Clin. Pharmacol. Toxicol. 7(6):383–391.
  • Ko, J. L., Tsai, C. H., Liu, T. C., Lin, M. Y., Lin, H. L. and Ou, C. C. (2016). Differential effects of grape juice on gastric emptying and renal function from cisplatin-induced acute adverse toxicity. Hum. Exp. Toxicol. 5(8):808–817.
  • Kueck, A., Opipari, A. W. Jr, Griffith, K. A., Tan, L., Choi, M., Huang, J., Wahl, H. and Liu, J. R. (2007). Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol. Oncol. 107(3):450–457.
  • Kumar, A., Dhar, S., Rimando, A. M., Lage, J. M., Lewin, J. R., Zhang, X. and Levenson A. S. (2015). Epigenetic potential of resveratrol and analogs in preclinical models of prostate cancer. Ann. N. Y. Acad. Sci. 1348(1):1–9.
  • Lang, F., Qin, Z., Li, F., Zhang, H., Fang, Z. and Hao E. (2015). Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells. PLoS One. 10(6):eo129196/1–eo129196/17.
  • Lee, M. H., Choi, B. Y., Kundu, J. K., Shin, Y. K., Na, H. K. and Surh, Y. J. (2009). Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 69(18):7449–7458.
  • Lee, M. H., Kundu, J. K., Keum, Y. S., Cho, Y. Y., Surh, Y. J. and Choi, B. Y. (2014a). Resveratrol inhibits IL-6-induced transcriptional activity of AR and STAT3 in human prostate cancer LNCaP-FGC Cells. Biomol. Ther. (Seoul). 22(5):426–430.
  • Lee, S. H., Koo, B. S., Park, S. Y. and Kim, Y. M. (2015). Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells. Mol. Med. Rep. 12(2):2777–2783.
  • Lee, T. H., Seo, J. O., Baek, S. H. and Kim, S. Y. (2014a). Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin. Biomol. Ther. (Seoul). 22(1):35–40.
  • Lee, Y. J., Hwang, I. S., Lee, Y. J., Lee, C. H., Kim, S. H., Nam, H. S., Choi, Y. J. and Lee S. H. (2014). Knockdown of Bcl-xL enhances growth-inhibiting and apoptosis-inducing effects of resveratrol and clofarabine in malignant mesothelioma H-2452 cells. J. Korean Med. Sci. 29(11):1464–1472.
  • Li, Y.-G., Xia, H.-J., Tao, J.-P., Xin, P., Liu, M.-Y., Li, J.-B., Zhu, W. and Wei, M. (2015). GRIM-19-mediated Stat3 activation is a determinant for resveratrol-induced proliferation and cytotoxicity in cervical tumor-derived cell lines. Mol. Med. Rep. 11(2):1272–1277.
  • Lin, F. Y., Hsieh, Y. H., Yang, S. F., Chen, C. T., Tang, C. H. et al. (2015). Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells. J. Oral. Pathol. Med. 44(9):699–706.
  • Lin, X., Wu, G., Huo, W. Q., Zhang, Y. and Jin, F. S. (2012). Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells. Int. J. Urol. 19(8):757–764.
  • Lin, Y., Yngve, A., Lagergren, J. and Lu, Y. (2014). A dietary pattern rich in lignans, quercetin and resveratrol decreases the risk of oesophageal cancer. Br. J. Nutr. 112(12):2002–2009.
  • Liu, M. L. and Zhang, S. J. (2014). Effects of resveratrol on the protein expression of survivin and cell apoptosis in human gastric cancer cells. J. BUON. 19(3):713–717.
  • Liu, S. Y. and Zheng, P. S. (2013). High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer. Oncotarget 4(12):2462–2475.
  • Lucas, I. K. and Kolodziej, H. (2015). Trans-resveratrol induces apoptosis through ROS-triggered mitochondria-dependent pathways in A549 human lung adenocarcinoma epithelial cells. Planta Med. 81:1038–1044.
  • Ma, L., Li, W., Wang, R., Nan, Y., Wang, Q., Liu, W. and Jin, F. (2015). Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis. Int. J. Oncol. 47(4):1460–1468.
  • Martin, K. R. (2006). Targeting apoptosis with dietary bioactive agents. Exp. Biol. Med. 231:117–129.
  • Masuelli, L., Di Stefano, E., Fantini, M., Mattera, R., Benvenuto, M. et al. (2014). Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas. Oncotarget 5(21):10745–10762.
  • Mbimba, T., Awale, P., Bhatia, D., Geldenhuys, W. J., Darvesh, A. S., Carroll, R. T. and Bishayee, A. (2012). Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis. Curr. Pharm. Biotechnol. 13(1):229–234.
  • Mikuła-Pietrasik, J., Sosińska, P. and Książek, K. (2014). Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1 integrins and hyaluronic acid. Gynecol. Oncol. 134(3):624–630.
  • Mitani, T., Harada, N., Tanimori, S., Nakano, Y., Inui, H. and Yamaji, R. (2014). Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses tumor progression in castration-resistant prostate cancer. J. Nutr. Sci. Vitaminol (Tokyo). 60(4):276–282.
  • Mitani, T., Ito, Y., Harada, N., Nakano, Y., Inui, H., Ashida, H. and Yamaji, R. (2014a). Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells. J. Nutr. Sci. Vitaminol (Tokyo). 60(2):122–128.
  • Mitruţ, P., Burada, F., Enescu, A., Scorei, R., Badea, D., Genunche-Dumitrescu, A., Rogoz, I. and Manea M. (2009). The genotoxicity study of resveratrol in primary gastric adenocarcinoma cell cultures. Rom. J. Morphol. Embryol. 50(3):429–433.
  • Mohapatra, P., Satapathy, S. R., Siddharth, S., Das, D., Nayak, A. and Kundu, C. N. (2015). Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling. Int. J. Biochem. Cell. Biol. 66:75–84.
  • Mohapatra, P., Satapathy, S. R., Das, D., Siddharth, S., Choudhuri, T. and Kundu, C. N. (2014). Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathway. Toxicol. Appl. Pharmacol. 275(3):221–231.
  • Nie, P., Hu, W., Zhang, T., Yang, Y., Hou, B., and Zou, Z. (2015). Synergistic induction of erlotinib-mediated apoptosis by resveratrol in human non-small-cell lung cancer cells by down-regulating survivin and up-regulating PUMA. Cell. Physiol. Biochem. 35(6):2255–2271.
  • Ojesina, A. I., Lichtenstein, L., Freeman, S. S., Pedamallu, C. S., Imaz-Rosshandler, I. et al. (2014). Landscape of genomic alterations in cervical carcinomas. Nature 506(7488):371–375.
  • O'Reilly, K. M., Mclaughlin, A. M., Beckett, W. S. and Sime, P. J. (2007). Asbestos-related lung disease. Am. Fam. Physician. 75(5):683–688.
  • Osman, A. M., Al-Malki, H. S., Al-Harthi, S. E., El-Hanafy, A. A., Elashmaoui, H. M. and Elshal, M. F. (2015). Modulatory role of resveratrol on cytotoxic activity of cisplatin, sensitization and modification of cisplatin resistance in colorectal cancer cells. Mol. Med. Rep. 12(1):1368–1374.
  • Ou, X., Chen, Y., Cheng, X., Zhang, X., and He, Q. (2014). Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells. Oncol. Rep. 32(6):2803–2809.
  • Peng, D. Y., Song, H. and Liu, L. B. (2015). Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells. J. Huazhong Univ. Sci. Technolog. Med. Sci. 35(4):485–489.
  • Raghubeer, S., Nagiah, S., Phulukdaree, A. and Chuturgoon, A. (2015). The phytoalexin resveratrol ameliorates ochratoxin A toxicity in human embryonic kidney (HEK293) Cells. J. Cell Biochem. 116(12):2947–2955.
  • Rahman, I., Biswas, S. K. and Kirkham, P. A. (2006). Regulation of inflammation and redox signaling by dietary polyphenols. Biochem. Pharmacol. 72:1439–1452.
  • Reagan-Shaw, S., Afaq, F., Aziz, M. H. and Ahmad, N. (2004). Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin. Oncogene 23(30):5151–5160.
  • Rezk, Y. A., Balulad, S. S., Keller, R. S. and Bennett, J. A. (2006). Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin: study in human gynecologic cancer cell lines and in rodent heart. Am. J. Obstet. Gynecol. 194(5):e23–6.
  • Riles, W. L., Erickson, J., Nayyar, S., Atten, M. J., Attar, B. M. and Holian, O. (2006). Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells. World J. Gastroenterol. 12(35):5628–5634.
  • Robbins, R. J. and Schlumberger, M. J. (2005). The evolving role of 131I for the treatment of differentiated thyroid carcinoma. J. Nucl. Med. 46:28S–37S.
  • Roy, P., Madan, E., Kalra, N., Nigam, N., George, J., Ray, R. S., Hans, R. K., Prasad, S. and Shukla, Y. (2009). Resveratrol enhances ultraviolet B-induced cell death through nuclear factor-kappaB pathway in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun. 384(2):215–220.
  • Roy, P., Kalra, N., Prasad, S., George, J. and Shukla, Y. (2009a). Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways. Pharm. Res. 26(1):211–217.
  • Sareen, D., van Ginkel, P. R., Takach, J. C., Mohiuddin, A., Darjatmoko, S. R., Albert, D. M. and Polans, A. S. (2006). Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells. Invest. Ophthalmol. Vis. Sci. 47(9):3708–3716.
  • Saud, S. M., Li, W., Morris, N. L., Matter, M. S., Colburn, N. H., Kim, Y. S. and Young, M. R. (2014). Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. Carcinogenesis 35(12):2778–2786.
  • Schiller, J. T. and Davies, P. (2004). Delivering on the promise: HPV vaccines and cervical cancer. Nat. Rev. Microbiol. 2(4):343–347.
  • Schroeter, A. and Marko, D. (2014). Resveratrol modulates the topoisomerase inhibitory potential of doxorubicin in human colon carcinoma cells. Molecules 19(12):20054–20072.
  • Seino, M., Okada, M., Shibuya, K., Seino, S., Suzuki, S., Takeda, H., Ohta, T., Kurachi, H. and Kitanaka, C. (2015). Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells. Anticancer Res. 35(1):85–96.
  • Selvaraj, S., Sun, Y., Sukumaran, P. and Singh, B. B. (2016). Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway. Mol. Carcinog. 55(5):818–831.
  • Seyed, M. A., Jantan, I., Bukhari, S. N. A. and Vijayaraghavan, K. (2016). A comprehensive review on the chemotherapeutic potential of piceatannol for cancer treatment, with mechanistic insights. J. Agric. Food Chem. 64:725–737.
  • Sexton, E., Van Themsche, C., LeBlanc, K., Parent, S., Lemoine, P. and Asselin, E. (2006). Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol. Cancer. 5:45.
  • Shan, Z., Yang, G., Xiang, W., Pei-jun, W. and Bin, Z. (2014). Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro. J. Cancer Res. Clin. Oncol. 140(3):371–374.
  • Shi, Q., Geldenhuys, W., Sutariya, V., Bishayee, A., Patel, I. and Bhatia, D. (2015). CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells. Genes Cancer. 6:220–230.
  • Shi, T., Liou, L. S., Sadhukhan, P., Duan, Z. H., Novick, A. C., Hissong, J. G., Almasan, A. and DiDonato, J. A. (2004). Effects of resveratrol on gene expression in renal cell carcinoma. Cancer Biol. Ther. 3(9):882–888.
  • Shih, A., Davis, F. B., Lin, H. Y. and Davis, P. J. (2002). Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism. J. Clin. Endocrinol. Metab. 87(3):1223–1232.
  • Shin, K. O., Park, N. Y., Seo, C. H., Hong, S. P., Oh, K. W., Hong, J. T., Han, S. K. and Lee, Y. M. (2012). Inhibition of sphingolipid metabolism enhances resveratrol chemotherapy in human gastric cancer cells. Biomol. Ther. (Seoul). 20(5):470–476.
  • Shrotriya, S., Agarwal, R. and Sclafani, R. A. (2015). A perspective on chemoprevention by resveratrol in head and neck squamous cell carcinoma. Adv. Exp. Med. Biol. 815:333–348.
  • Shrotriya, S., Tyagi, A., Deep, G., Orlicky, D. J., Wisell, J., Wang, X. J., Sclafani, R. A., Agarwal, R. and Agarwal, C. (2015). Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Mol. Carcinog. 54(4):291–300.
  • Singh, B., Shoulson, R., Chatterjee, A., Ronghe A, Bhat, N. K., Dim, D. C. and Bhat, H. K. (2014). Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways. Carcinogenesis 35(8):1872–1880.
  • Stocco, B., Toledo, K., Salvador, M., Paulo, M., Koyama, N. and Torqueti Toloi, M. R. (2012). Dose-dependent effect of resveratrol on bladder cancer cells: chemoprevention and oxidative stress. Maturitas 72(1):72–78.
  • Tang, Q., Li, G., Wei, X., Zhang, J., Chiu, J. F., Hasenmayer, D., Zhang, D. and Zhang, H. (2013). Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. Cancer Lett. 336(2):325–337.
  • Thun, M. J., Hannan, L. M., Adams-Campbell, L. L. et al. (2008). Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Medicine. 5(9):e185.
  • Tomoaia, G., Horovitz, O., Mocanu, A., Nita, A., Avram, A., Racz CP2, Soritau, O., Cenariu, M. and Tomoaia-Cotisel, M. (2015). Effects of doxorubicin mediated by gold nanoparticles and resveratrol in two human cervical tumor cell lines. Colloids Surf. B Biointerfaces. 135:726–734.
  • Truong, M., Cook, M. R., Pinchot, S. N., Kunnimalaiyaan, M. and Chen, H. (2011). Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann. Surg. Oncol. 18(5):1506–1511.
  • Tsao, A. S. (2007). Lung Carcinoma: Tumors of the Lungs. Merck Manual Professional Edition, Online edition. Retrieved 15 August 2007.
  • Tsan, M.-F., White, J. E., Maheshwari, J. G. and Chikkappa, G. (2002). Anti-leukemia effect of resveratrol. Leuk. Lymphoma. 43(5):983–987.
  • Varoni, E. M., Lo Faro, A. F., Sharifi-Rad, J. and Iriti, M. (2016). Anticancer molecular mechanisms of resveratrol. Front. Nutr. 3:8. doi: 10.3389/fnut.2016.00008.
  • Venturelli, S., Berger, A., Böcker, A., Busch, C. et al. (2013). Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells. PLoS One. 8(8):e73097.
  • Wang, L., Li, H. and Zhang, D. (2016). Anti-tumor composition of resveratrol and its preparation method. Yibei (Tianjin) Biotechnology Co., Ltd., Peop. Rep. China. From Faming Zhuanli Shenqing, CN 105596889 A 20160525.
  • Wang, S., Chen, R., Morott, J., Repka, M. A., Wang, Y. and Chen, M. (2015). mPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Expert Opin. Drug Deliv. 12(3):361–373.
  • Wang, Z., Li, W., Meng, X. and Jia, B. (2012). Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1. Clin. Exp. Pharmacol. Physiol. 39(3):227–232.
  • Wang, Z., Zhang, L., Ni, Z., Sun, J., Gao, H., Cheng, Z., Xu, J. and Yin, P. (2015). Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-κB signaling and suppressing cAMP-responsive element transcriptional activity. Tumour Biol. 36(12):9499–9510.
  • Wang, Z., Li, W., Meng, X. and Jia, B. (2012). Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1. Clin. Exp. Pharmacol. Physiol. 39(3):227–232.
  • WHO. World Cancer Report 2014. Chapter 1.1. ISBN 9283204298.
  • WHO. World Cancer Report 2014. Chapter 5.1. ISBN 9283204298.
  • Wong, J. C. and Fiscus, R. R. (2015). Resveratrol at anti-angiogenesis/anticancer concentrations suppresses protein kinase G signaling and decreases IAPs expression in HUVECs. Anticancer Res. 35(1):273–281.
  • Woodall, C. E., Li, Y., Liu, Q-H., Wo, J. and Martin, R. C. (2009). Chemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation. Anticancer Drugs. 20(6):437–443.
  • Wu, M-L., Li, H., Yu, L-J., Chen, X-Y., Kong, Q-Y., Song, X., Shu, X-H. and Liu, J. (2014). Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PLoS One. 9(2):e89806.
  • Wu, X. P., Xiong, M., Xu, C. S., Duan, L. N., Dong, Y. Q., Luo, Y., Niu, T. H. and Lu, C. R. (2015). Resveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation. Acta Pharmacol. Sin. 36(3):353–361.
  • Yang, H., Zheng, Y., Li, T. W., Peng, H., Fernandez-Ramos, D., Martínez-Chantar, M. L., Rojas, A. L., Mato, J. M. and Lu, S. C. (2013). Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. J. Biol. Chem. 288(32):23161–23170.
  • Yang, J., Liu, J., Lyu, X. and Fei, S. (2015). Resveratrol inhibits cell proliferation and up-regulates MICA/B expression in human colon cancer stem cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 31(7):889–893.
  • Yang, Q., Xu, E., Dai, J., Liu, B., Han, Z., Wu, J., Zhang, S., Peng, B., Zhang, Y. and Jiang, Y. (2015a). A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol. Appl. Pharmacol. 285(2):79–88.
  • Yang, R., Zhang, H. and Zhu, L. (2011). Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal cancer cells. Mol. Med. Rep. 4(5):981–983.
  • Yang, Y., Cui, J., Xue, F., Overstreet, A. M., Zhan, Y., Shan, D., Li, H., Li, H., Wang, Y., Zhang, M., Yu, C. and Xu, Z. D. (2016). Resveratrol represses pokemon expression in human glioma cells. Mol. Neurobiol. 53(2):1266–1278.
  • Yu, X. M., Jaskula-Sztul, R., Ahmed, K. and Harrison, A. D. (2013). Kunnimalaiyaan M, Chen H. Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth. Mol. Cancer Ther. 12(7):1276–1287.
  • Yu, X.-D., Yang, J.-l., Zhang, W.-L. and Liu, D.-X. (2016). Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest. Tumor Biology. 37(3):2871–2877.
  • Yu, H. B., Zhang, H. F., Zhang, X., Li, D. Y., Xue, H. Z., Pan, C. E. and Zhao, S. H. (2010). Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-kappa B-mediated mechanism. Hepatogastroenterology 57:1241–1246.
  • Zhang, L., Li, J., Duan, J. and Yuan, X. (2016). Medicine for treating thyroid cancer. Faming Zhuanli Shenqing. 2016, CN 105748504 A 20160713.Zhang, P., Li, H., Yang, B., Yang, F.,
  • Zhang L. L., Kong, Q. Y., Chen, X. Y., Wu, M. L. and Liu, J. (2014). Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes Cancer. 5(5, 6):154–164.
  • Zhang, X. L., Yu, H., Xiong, Y. Y., Ma, S. T., Zhao, L. and She, S. F. (2013). Resveratrol down-regulates Myosin light chain kinase, induces apoptosis and inhibits diethylnitrosamine-induced liver tumorigenesis in rats. Int. J. Mol. Sci. 14(1):1940–1951.
  • Zheng, G. H. and Li, H. Q. (2008). Effects of garlic oil combined with resveratrol on inducting of apoptosis and expression of Fas, bcl-2 and bax in human gastric cancer cell line. Zhonghua Yu Fang Yi Xue Za Zhi. 42(1):39–42.
  • Zhong, L.-X., Li, H., Wu, M.-L., Liu, X.-Y., Zhong, M.-J., Chen, X.-Y., Liu, J. and Zhang, Y. (2015). Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells. J. Ovarian Res. 8:25.
  • Zhou, C., Ding, J. and Wu, Y. (2014). Resveratrol induces apoptosis of bladder cancer cells via miR-21 regulation of the Akt/Bcl-2 signaling pathway. Mol. Med. Rep. 9(4):1467–1473.
  • Zhou, H. B., Yan, Y., Sun, Y. N. and Zhu, J. R. (2003). Resveratrol induces apoptosis in human esophageal carcinoma cells. World J. Gastroenterol. 9(3):408–411.
  • Zlotogorski, A., Dayan, A., Dayan, D., Chaushu, G., Salo, T. and Vered, M. Nutraceuticals as new treatment approaches for oral cancer: II. Green tea extracts and resveratrol. Oral Oncol. 49(6):502–506.
  • Zulueta, A., Caretti, A., Signorelli, P. and Ghidoni, R. (2015). Resveratrol: A potential challenger against gastric cancer. World J. Gastroenterol. 21(37):10636–10643.
  • Zunino, S. J. and Storms, D. H. (2015). Physiological levels of resveratrol metabolites are ineffective as anti-leukemia agents against Jurkat leukemia cells. Nutr. Cancer. 67(2):266–274.

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