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Critical Reviews in Food Science and Nutrition Volume 60, 2020 - Issue 13
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Reviews

Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake

Taylor C. WallaceDepartment of Nutrition and Food Studies, George Mason University, Fairfax, Virginia, USA; ;Think Healthy Group, Inc., Washington, DC, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-9403-2745
ORCID Icon,
Regan L. BaileyDepartment of Nutrition Science, Purdue University, West Lafayette, Indiana, USA;
,
Jeffrey B. BlumbergFriedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA;
,
Britt Burton-FreemanCenter for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Bedford Park, Illinois, USA;
,
C-y. Oliver ChenFriedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA; ;Biofortis Research, Merieux NutriSciences, Addison, Illinois, USA;
,
Kristi M. Crowe-WhiteDepartment of Human Nutrition, University of Alabama, Tuscaloosa, Alabama, USA; ORCID Iconhttp://orcid.org/0000-0003-2497-4582
ORCID Icon,
Adam DrewnowskiDepartment of Epidemiology, University of Washington, Seattle, Washington, USA;
,
Shirin HooshmandSchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, California, USA;
,
Elizabeth JohnsonFriedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA;
,
Richard LewisBone and Body Composition Laboratory, College of Family and Consumer Sciences, University of Georgia, Athens, Georgia, USA;
,
Robert MurrayCollege of Education and Human Ecology, The Ohio State University, Columbus, Ohio, USA;
,
Sue A. ShapsesDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, USA;
&
Ding Ding WangD&V Systematic Evidence Review, Bronx, New York, USA
 show all
Pages 2174-2211 | Published online: 03 Jul 2019

References

  • Abar, L., A. R. Vieira, D. Aune, C. Stevens, S. Vingeliene, D. A. Navarro Rosenblatt, D. Chan, D. C. Greenwood, and T. Norat. 2016. Blood concentrations of carotenoids and retinol and lung cancer risk: An update of the WCRF-AICR systematic review of published prospective studies. Cancer Medicine 5 (8):2069–83. doi: 10.1002/cam4.676.
  • Abushita, A. A., H. G. Daood, and P. A. Biacs. 2000. Change in carotenoids and antioxidant vitamins in tomato as a function of varietal and technological factors. Journal of Agricultural and Food Chemistry 48 (6):2075–81.
  • Adebawo, O., B. Salau, E. Ezima, O. Oyefuga, E. Ajani, G. Idowu, A. Famodu, and O. Osilesi. 2006. Fruits and vegetables moderate lipid cardiovascular risk factor in hypertensive patients. Lipids in Health and Disease 5 (1):14. doi: 10.1186/1476-511X-5-14.
  • Age-Related Eye Disease Study Research Group. 2000. Risk factors associated with age-related macular degeneration. A case-control study in the Age-Related Eye Disease Study: Age-Related Eye Disease Study Report Number 3. Ophthalmology 107 (12):2224–32.
  • Akbaraly, T. N., E. J. Brunner, J. E. Ferrie, M. G. Marmot, M. Kivimaki, and A. Singh-Manoux. 2009. Dietary pattern and depressive symptoms in middle age. British Journal of Psychiatry 195 (5):408–13. doi: 10.1192/bjp.bp.108.058925.
  • Al-Solaiman, Y., A. Jesri, W. K. Mountford, D. T. Lackland, Y. Zhao, and B. M. Egan. 2010. DASH lowers blood pressure in obese hypertensives beyond potassium, magnesium and fibre. Journal of Human Hypertension 24 (4):237–46. doi: 10.1038/jhh.2009.58.
  • Al-Zalabani, A. H., K. F. J. Stewart, A. Wesselius, A. M. W. J. Schols, and M. P. Zeegers. 2016. Modifiable risk factors for the prevention of bladder cancer: A systematic review of meta-analyses. European Journal of Epidemiology 31 (9):811–51. doi: 10.1007/s10654-016-0138-6.
  • Allen, S., J. R. Britton, and J. A. Leonardi-Bee. 2009. Association between antioxidant vitamins and asthma outcome measures: Systematic review and meta-analysis. Thorax 64 (7):610–9. doi: 10.1136/thx.2008.101469.
  • Angeloni, C., J. P. E. Spencer, E. Leoncini, P. L. Biagi, and S. Hrelia. 2007. Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress. Biochimie 89 (1):73–82. doi: 10.1016/j.biochi.2006.09.006.
  • Anstee, Q. M., G. Targher, and C. P. Day. 2013. Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nature Reviews Gastroenterology & Hepatology 10 (6):330–44. doi: 10.1038/nrgastro.2013.41.
  • Appel, L. J., T. J. Moore, E. Obarzanek, W. M. Vollmer, L. P. Svetkey, F. M. Sacks, G. A. Bray, T. M. Vogt, J. A. Cutler, M. M. Windhauser, et al. 1997. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. New England Journal of Medicine 336 (16):1117–24. doi: 10.1056/NEJM199704173361601.
  • Arjmandi, B. H., S. A. Johnson, S. Pourafshar, N. Navaei, K. S. George, S. Hooshmand, S. C. Chai, and N. S. Akhavan. 2017. Bone-protective effects of dried plum in postmenopausal women: Efficacy and possible mechanisms. Nutrients 9 (5):496. doi: 10.3390/nu9050496.
  • Aromataris, E., R. Fernandez, C. M. Godfrey, C. Holly, H. Khalil, and P. Tungpunkom. 2015. Summarizing systematic reviews: Methodological development, conduct and reporting of an umbrella review approach. International Journal of Evidence-Based Healthcare 13 (3):132–40. doi: 10.1097/xeb.0000000000000055.
  • Aronow, P. M., D. Karlan, and L. E. Pinson. 2018. The effect of images of Michelle Obama’s face on trick-or-treaters’ dietary choices: A randomized control trial. PLoS One 13 (1):e0189693. doi: 10.1371/journal.pone.0189693.
  • Aune, D., D. S. M. Chan, A. R. Vieira, D. A. N. Rosenblatt, R. Vieira, D. C. Greenwood, and T. Norat. 2012. Fruits, vegetables and breast cancer risk: A systematic review and meta-analysis of prospective studies. Breast Cancer Research and Treatment 134 (2):479–93. doi: 10.1007/s10549-012-2118-1.
  • Aune, D., E. Giovannucci, P. Boffetta, L. T. Fadnes, N. Keum, T. Norat, D. C. Greenwood, E. Riboli, L. J. Vatten, and S. Tonstad. 2017. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality—A systematic review and dose-response meta-analysis of prospective studies. International Journal of Epidemiology 46 (3):1029–56. doi: 10.1093/ije/dyw319.
  • Aune, D., N. Keum, E. Giovannucci, L. T. Fadnes, P. Boffetta, D. C. Greenwood, S. Tonstad, L. J. Vatten, E. Riboli, and T. Norat. 2016. Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: Systematic review and dose-response meta-analysis of prospective studies. BMJ 353:i2716. doi: 10.1136/bmj.i2716..
  • Aune, D., R. Lau, D. S. M. Chan, R. Vieira, D. C. Greenwood, E. Kampman, and T. Norat. 2011. Nonlinear reduction in risk for colorectal cancer by fruit and vegetable intake based on meta-analysis of prospective studies. Gastroenterology 141 (1):106–18. doi: 10.1053/j.gastro.2011.04.013.
  • Bahadori, S., J. Salamzadeh, M. Kamalinejad, M. R. Shams Ardekani, M. Keshavarz, and A. Ahmadzadeh. 2016. Study of the effect of an oral formulation of fig and olive on rheumatoid arthritis (RA) remission indicators: A randomized clinical trial. Iranian Journal of Pharmaceutical Research 15 (3):537–45.
  • Bailey, R. L., E. A. Parker, D. G. Rhodes, J. D. Goldman, J. C. Clemens, A. J. Moshfegh, S. V. Thuppal, and C. M. Weaver. 2016. Estimating sodium and potassium intakes and their ratio in the American Diet: Data from the 2011–2012 NHANES. The Journal of Nutrition 146 (4):745–50. doi: 10.3945/jn.115.221184.
  • Baldrick, F. R., J. S. Elborn, J. V. Woodside, K. Treacy, J. M. Bradley, C. C. Patterson, B. C. Schock, M. Ennis, I. S. Young, and M. C. McKinley. 2012. Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: A randomised controlled trial. European Respiratory Journal 39 (6):1377–84. doi: 10.1183/09031936.00086011.
  • Bandera, E. V., L. H. Kushi, D. F. Moore, D. M. Gifkins, and M. L. McCullough. 2007. Fruits and vegetables and endometrial cancer risk: A systematic literature review and meta-analysis. Nutrition and Cancer 58 (1):6–21. doi: 10.1080/01635580701307929.
  • Barbaresko, J., M. Koch, M. B. Schulze, and U. Nöthlings. 2013. Dietary pattern analysis and biomarkers of low-grade inflammation: A systematic literature review. Nutrition Reviews 71 (8):511–27. doi: 10.1111/nure.12035.
  • Barberger-Gateau, P., C. Raffaitin, L. Letenneur, C. Berr, C. Tzourio, J. F. Dartigues, and A. Alperovitch. 2007. Dietary patterns and risk of dementia: The three-city cohort study. Neurology 69 (20):1921–30. doi: 10.1212/01.wnl.0000278116.37320.52.
  • Barcelo, S., J. M. Gardiner, A. Gescher, and J. K. Chipman. 1996. CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis 17 (2):277–82. doi: 10.1093/carcin/17.2.277.
  • Basu, A., M. Rhone, and T. J. Lyons. 2010. Berries: Emerging impact on cardiovascular health. Nutrition Reviews 68 (3):168–77. doi: 10.1111/j.1753-4887.2010.00273.x.
  • Basu, A., J. Schell, and R. H. Scofield. 2018. Dietary fruits and arthritis. Food & Function 9 (1):70–7. doi: 10.1039/C7FO01435J.
  • Bauer, U. E., P. A. Briss, R. A. Goodman, and B. A. Bowman. 2014. Prevention of chronic disease in the 21st century: Elimination of the leading preventable causes of premature death and disability in the USA. Lancet 384 (9937):45–52. doi: 10.1016/S0140-6736(14)60648-6.
  • Bazzano, L. A., T. Y. Li, K. J. Joshipura, and F. B. Hu. 2008. Intake of fruit, vegetables, and fruit juices and risk of diabetes in women. Diabetes Care 31 (7):1311–7. doi: 10.2337/dc08-0080.
  • Bechthold, A., H. Boeing, C. Schwedhelm, G. Hoffmann, S. Knüppel, K. Iqbal, S. De Henauw, N. Michels, B. Devleesschauwer, S. Schlesinger, and L. Schwingshackl. 2019. Food groups and risk of coronary heart disease, stroke and heart failure: A systematic review and dose-response meta-analysis of prospective studies. Critical Reviews in Food Science and Nutrition 59 (7):1071–90. doi: 10.1080/10408398.2017.1392288.
  • Ben, Q., J. Zhong, J. Liu, L. Wang, Y. Sun, L. Yv, and Y. Yuan. 2015. Association between consumption of fruits and vegetables and risk of colorectal adenoma: A PRISMA-compliant meta-analysis of observational studies. Medicine 94 (42):e1599. doi: 10.1097/MD.0000000000001599.
  • Benetou, V., P. Orfanos, D. Feskanich, K. Michaëlsson, U. Pettersson‐Kymmer, S. Eriksson, F. Grodstein, A. Wolk, A. Bellavia, L. A. Ahmed, et al. 2016. Fruit and vegetable intake and hip fracture incidence in older men and women: The CHANCES Project: Fruit and vegetable intake and hip fracture incidence. Journal of Bone and Mineral Research 31 (9):1743–52. doi: 10.1002/jbmr.2850.
  • Bhatnagar, S., and S. Taneja. 2001. Zinc and cognitive development. British Journal of Nutrition 85 (S2):S139–S145. doi: 10.1079/BJN2000306.
  • Biesalski, H. K., M. Berneburg, T. Grune, M. Kerscher, J. Krutmann, W. Raab, J. Reimann, T. Reuther, L. Robert, and T. Schwarz. 2003. Oxidative and premature skin ageing. Experimental Dermatology 12 (s3):3–15. doi: 10.1111/j.0906-6705.2003.00148.x.
  • Birch, L. L., and A. K. Ventura. 2009. Preventing childhood obesity: What works? International Journal of Obesity 33 (S1):S74–S81. doi: 10.1038/ijo.2009.22.
  • Black, B. S., P. V. Rabins, and P. S. German. 1999. Predictors of nursing home placement among elderly public housing residents. Gerontologist 39 (5):559–68. doi: 10.1093/geront/39.5.559.
  • Blanch, N., P. M. Clifton, and J. B. Keogh. 2015. A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake. Nutrition, Metabolism & Cardiovascular Diseases 25 (3):253–66. doi: 10.1016/j.numecd.2014.10.001.
  • Blumberg, J., R. P. Heaney, M. Huncharek, T. Scholl, M. Stampfer, R. Vieth, C. M. Weaver, and S. H. Zeisel. 2010. Evidence-based criteria in the nutritional context. Nutrition Reviews 68 (8):478–84. doi: 10.1111/j.1753-4887.2010.00307.x.
  • Bonaccio, M., G. Pounis, C. Cerletti, M. B. Donati, L. Iacoviello, G. de Gaetano, and MOLI-SANI Study Investigators. 2017. Mediterranean diet, dietary polyphenols and low grade inflammation: Results from the MOLI-SANI study: Mediterranean diet, polyphenols and low grade inflammation. British Journal of Clinical Pharmacology 83 (1):107–13. doi: 10.1111/bcp.12924.
  • Bonequi, P., F. Meneses-Gonzalez, P. Correa, C. S. Rabkin, and M. C. Camargo. 2013. Risk factors for gastric cancer in Latin America: A meta-analysis. Cancer Causes & Control 24 (2):217–31. doi: 10.1007/s10552-012-0110-z.
  • Boone, C. W., G. J. Kelloff, and W. F. Maolone. 1990. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review. Cancer Research 50:2–9.
  • Bowler, R. P. 2004. Oxidative stress in the pathogenesis of asthma. Current Allergy and Asthma Reports 4 (2):116–22. doi: 10.1007/s11882-004-0056-7.
  • Brookie, K. L., G. I. Best, and T. S. Conner. 2018. Intake of raw fruits and vegetables is associated with better mental health than intake of processed fruits and vegetables. Frontiers in Psychology 9:487 doi: 10.3389/fpsyg.2018.00487.
  • Brown, L., E. B. Rimm, J. M. Seddon, E. L. Giovannucci, L. Chasan-Taber, D. Spiegelman, W. C. Willett, and S. E. Hankinson. 1999. A prospective study of carotenoid intake and risk of cataract extraction in US men. The American Journal of Clinical Nutrition 70 (4):517–24. doi: 10.1093/ajcn/70.4.517.
  • Byberg, L., A. Bellavia, N. Orsini, A. Wolk, and K. Michaelsson. 2015. Fruit and vegetable intake and risk of hip fracture: A cohort study of Swedish men and women. Journal of Bone and Mineral Research 30 (6):976–84. doi: 10.1002/jbmr.2384.
  • Byrd-Bredbenner, C., M. G. Ferruzzi, V. L. Fulgoni, R. Murray, E. Pivonka, and T. C. Wallace. 2017. Satisfying America’s fruit gap: Summary of an expert roundtable on the role of 100% fruit juice: Filling America’s fruit intake gap with 100% fruit juice. Journal of Food Science 82 (7):1523–34. doi: 10.1111/1750-3841.13754.
  • Calder, P. C., N. Ahluwalia, R. Albers, N. Bosco, R. Bourdet-Sicard, D. Haller, S. T. Holgate, L. S. Jönsson, M. E. Latulippe, A. Marcos, et al. 2013. A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies. British Journal of Nutrition 109 (S1):S1–S34. doi: 10.1017/s0007114512005119.
  • Calder, P. C., N. Ahluwalia, F. Brouns, T. Buetler, K. Clement, K. Cunningham, K. Esposito, L. S. Jönsson, H. Kolb, M. Lansink, et al. 2011. Dietary factors and low-grade inflammation in relation to overweight and obesity. British Journal of Nutrition 106 (S3):S5–S78. doi: 10.1017/s0007114511005460.
  • Calder, P. C., A. Boobis, D. Braun, C. L. Champ, L. Dye, S. Einöther, A. Greyling, C. Matthys, P. Putz, S. Wopereis, et al. 2017a. Improving selection of markers in nutrition research: Evaluation of the criteria proposed by the ILSI Europe Marker Validation Initiative. Nutrition Research Reviews 30 (1):73–81. doi: 10.1017/S0954422416000263.
  • Calder, P. C., N. Bosco, R. Bourdet-Sicard, L. Capuron, N. Delzenne, J. Doré, C. Franceschi, M. J. Lehtinen, T. Recker, S. Salvioli, et al. 2017b. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Research Reviews 40:95–119. doi: 10.1016/j.arr.2017.09.001.
  • Campbell, R., D. Gross, G. A. Grandits, and J. D. Potter. 1994. Plasma carotenoids as biomarkers of vegetable and fruit intake. Cancer Epidemiology 3:493–500.
  • Canfora, E. E., J. W. Jocken, and E. E. Blaak. 2015. Short-chain fatty acids in control of body weight and insulin sensitivity. Nature Reviews Endocrinology 11 (10):577–91. doi: 10.1038/nrendo.2015.128.
  • Cao, L., L. Tan, H.-F. Wang, T. Jiang, X.-C. Zhu, H. Lu, M.-S. Tan, and J.-T. Yu. 2016. Dietary patterns and risk of dementia: A systematic review and meta-analysis of cohort studies. Molecular Neurobiology 53 (9):6144–54. doi: 10.1007/s12035-015-9516-4.
  • Carter, P., L. J. Gray, J. Troughton, K. Khunti, and M. J. Davies. 2010. Fruit and vegetable intake and incidence of type 2 diabetes mellitus: Systematic review and meta-analysis. BMJ 341 (4):c4229. doi: 10.1136/bmj.c4229.
  • Casas, R., R. Estruch, and E. Sacanella. 2018. Influence of bioactive nutrients on the atherosclerotic process: A review. Nutrients 10 (11):1630. doi: 10.3390/nu10111630.
  • Center, J. R., T. V. Nguyen, D. Schneider, P. N. Sambrook, and J. A. Eisman. 1999. Mortality after all major types of osteoporotic fracture in men and women: An observational study. Lancet 353 (9156):878–82. doi: 10.1016/S0140-6736(98)09075-8.
  • Cerhan, J. R., K. G. Saag, L. A. Merlino, T. R. Mikuls, and L. A. Criswell. 2003. Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. American Journal of Epidemiology 157 (4):345–54. doi: 10.1093/aje/kwf205.
  • Cevenini, E., D. Monti, and C. Franceschi. 2013. Inflamm-ageing. Current Opinion in Clinical Nutrition and Metabolic Care 16 (1):14–20.
  • Chadban, S. J., E. M. Briganti, P. G. Kerr, D. W. Dunstan, T. A. Welborn, P. Z. Zimmet, and R. C. Atkins. 2003. Prevalence of kidney damage in Australian adults: The AusDiab kidney study. Journal of the American Society of Nephrology: JASN 14 (7 Suppl 2):S131–S138.
  • Chai, N. C., D. S. Bond, A. Moghekar, A. I. Scher, and B. L. Peterlin. 2014. Obesity and headache: Part II – Potential mechanism and treatment considerations. Headache 54 (3):459–71. doi: 10.1111/head.12297.
  • Charytoniuk, T., K. Drygalski, K. Konstantynowicz-Nowicka, K. Berk, and A. Chabowski. 2017. Alternative treatment methods attenuate the development of NAFLD: A review of resveratrol molecular mechanisms and clinical trials. Nutrition 34:108–17. doi: 10.1016/j.nut.2016.09.001.
  • Chen, G.-C., D.-B. Lv, Z. Pang, and Q.-F. Liu. 2013a. Fruits and vegetables consumption and risk of non-Hodgkin’s lymphoma: A meta-analysis of observational studies. International Journal of Cancer 133 (1):190–200. doi: 10.1002/ijc.27992.
  • Chen, J., Y. Song, and L. Zhang. 2013b. Lycopene/tomato consumption and the risk of prostate cancer: A systematic review and meta-analysis of prospective studies. Journal of Nutritional Science and Vitaminology 59 (3):213–23. doi: 10.3177/jnsv.59.213.
  • Chinese Nutrition Society. 2018. The Chinese Dietary Guidelines. Accessed July 31, 2018. http://dg.en.cnsoc.org/index.html.
  • Christen, W. G., S. Liu, D. A. Schaumberg, and J. E. Buring. 2005. Fruit and vegetable intake and the risk of cataract in women. The American Journal of Clinical Nutrition 81 (6):1417–22. doi: 10.1093/ajcn/81.6.1417.
  • Chun, O. K., S.-J. Chung, K. J. Claycombe, and W. O. Song. 2008. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. The Journal of Nutrition 138 (4):753–60. doi: 10.1093/jn/138.4.753.
  • Clemens, R., A. Drewnowski, M. G. Ferruzzi, C. D. Toner, and D. Welland. 2015. Squeezing fact from fiction about 100% fruit juice. Advances in Nutrition 6 (2):236S–43S. doi: 10.3945/an.114.007328.
  • Coleman, A. L., K. L. Stone, G. Kodjebacheva, F. Yu, K. L. Pedula, K. E. Ensrud, J. A. Cauley, M. C. Hochberg, F. Topouzis, F. Badala, et al. 2008. Glaucoma risk and the consumption of fruits and vegetables among older women in the Study of Osteoporotic Fractures. American Journal of Ophthalmology 145 (6):1081–9. doi: 10.1016/j.ajo.2008.01.022.
  • Colijn, J. M., G. H. S. Buitendijk, E. Prokofyeva, D. Alves, M. L. Cachulo, A. P. Khawaja, A. Cougnard-Gregoire, B. M. J. Merle, C. Korb, M. G. Erke, et al. 2017. Prevalence of age-related macular degeneration in Europe: The past and the future. Ophthalmology 124 (12):1753–63. doi: 10.1016/j.ophtha.2017.05.035.
  • Cook, L. T., G. A. O'Reilly, M. I. Goran, M. J. Weigensberg, D. Spruijt-Metz, and J. N. Davis. 2014. Vegetable consumption is linked to decreased visceral and liver fat and improved insulin resistance in overweight Latino youth. Journal of the Academy of Nutrition and Dietetics 114 (11):1776–83. doi: 10.1016/j.jand.2014.01.017.
  • Cooke, L. J., L. C. Chambers, E. V. Añez, H. A. Croker, D. Boniface, M. R. Yeomans, and J. Wardle. 2011. Eating for pleasure or profit: The effect of incentives on children's enjoyment of vegetables. Psychological Science 22 (2):190–6. doi: 10.1177/0956797610394662.
  • Cooper, A. J., S. J. Sharp, M. A. H. Lentjes, R. N. Luben, K.-T. Khaw, N. J. Wareham, and N. G. Forouhi. 2012. A prospective study of the association between quantity and variety of fruit and vegetable intake and incident type 2 diabetes. Diabetes Care 35 (6):1293–300. doi: 10.2337/dc11-2388.
  • Cotillard, A., S. P. Kennedy, L. C. Kong, E. Prifti, N. Pons, E. Le Chatelier, M. Almeida, B. Quinquis, F. Levenez, N. Galleron, et al. 2013. Dietary intervention impact on gut microbial gene richness. Nature 500 (7464):585–8. doi: 10.1038/nature12480.
  • Cox, M. A., J. Jackson, M. Stanton, A. Rojas-Triana, L. Bober, M. Laverty, X. Yang, F. Zhu, J. Liu, S. Wang, et al. 2009. Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines. World Journal of Gastroenterology 15 (44):5549–57. doi: 10.3748/wjg.15.5549.
  • Cremer, J., I. Segota, C.-Y. Yang, M. Arnoldini, J. T. Sauls, Z. Zhang, E. Gutierrez, A. Groisman, and T. Hwa. 2016. Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel. Proceedings of the National Academy of Sciences of the United States of America 113 (41):11414–9. doi: 10.1073/pnas.1601306113.
  • Cross, A. J., J. W. Lampe, C. L. Rock, and C. J. Boushey. 2017. Biomarkers and their use in nutrition intervention. In Nutrition in the prevention and treatment of disease, edited by A. M. Coulston, C. J. Boushey, M. G. Ferruzzi, and L. M. Delahanty, 217–34. London, UK: Elsevier.
  • Crowe-White, K., C. E. O'Neil, J. S. Parrott, S. Benson-Davies, E. Droke, M. Gutschall, K. S. Stote, T. Wolfram, and P. Ziegler. 2016. Impact of 100% fruit juice consumption on diet and weight status of children: An evidence-based review. Critical Reviews in Food Science and Nutrition 56 (5):871–84. doi: 10.1080/10408398.2015.1061475.
  • Crowe-White, K., J. S. Parrott, K. S. Stote, M. Gutschall, S. Benson-Davies, E. Droke, C. E. O'Neil, T. Wolfram, and P. Ziegler. 2017. Metabolic impact of 100% fruit juice consumption on antioxidant/oxidant status and lipid profiles of adults: An evidence-based review. Critical Reviews in Food Science and Nutrition 57 (1):152–62. doi: 10.1080/10408398.2015.1102861.
  • Crowe, K. M., and E. Murray. 2013. Deconstructing a fruit serving: Comparing the antioxidant density of select whole fruit and 100% fruit juices. Journal of the Academy of Nutrition and Dietetics 113 (10):1354–8. doi: 10.1016/j.jand.2013.04.024.
  • da Silva Pereira, A. C., A. P. Dionísio, N. J. Wurlitzer, R. E. Alves, E. S. de Brito, A. M. D. O. e Silva, I. M. Brasil, and J. Mancini Filho. 2014. Effect of antioxidant potential of tropical fruit juices on antioxidant enzyme profiles and lipid peroxidation in rats. Food Chemistry 157:179–85. doi: 10.1016/j.foodchem.2014.01.090.
  • Dauchet, L., P. Amouyel, and J. Dallongeville. 2005. Fruit and vegetable consumption and risk of stroke: A meta-analysis of cohort studies. Neurology 65 (8):1193–7. doi: 10.1212/01.wnl.0000180600.09719.53.
  • Dauchet, L., P. Amouyel, S. Hercberg, and J. Dallongeville. 2006. Fruit and vegetable consumption and risk of coronary heart disease: A meta-analysis of cohort studies. The Journal of Nutrition 136 (10):2588–93. doi: 10.1093/jn/136.10.2588.
  • Daviglus, M. L., C. C. Bell, W. Berrettini, P. E. Bowen, E. S. Connolly, N. J. Cox, J. M. Dunbar-Jacob., et al. 2010. NIH state-of-the-science conference statement: Preventing Alzheimer’s disease and cognitive decline. NIH Consensus and State-of-the-Science Statements 27 (4):1–30.
  • de Koning-Backus, A. P. M., G. H. S. Buitendijk, J. C. Kiefte-de Jong, J. M. Colijn, A. Hofman, J. R. Vingerling, E. B. Haverkort, O. H. Franco, and C. C. W. Klaver. 2019. Intake of vegetables, fruit, and fish is beneficial for age-related macular degeneration. American Journal of Ophthalmology 198:70–9. doi: 10.1016/j.ajo.2018.09.036.
  • de Lorgeril, M., S. Renaud, N. Mamelle, P. Salen, J. L. Martin, I. Monjaud, J. Guidollet, P. Touboul, and J. Delaye. 1994. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343 (8911):1454–9. doi: 10.1016/S0140-6736(94)92580-1.
  • De Rosa, V., M. Galgani, M. Santopaolo, A. Colamatteo, R. Laccetti, and G. Matarese. 2015. Nutritional control of immunity: Balancing the metabolic requirements with an appropriate immune function. Seminars in Immunology 27 (5):300–9. doi: 10.1016/j.smim.2015.10.001.
  • DeChristopher, L. R., and K. L. Tucker. 2018. Excess free fructose, high-fructose corn syrup and adult asthma: The Framingham offspring cohort. British Journal of Nutrition 119 (10):1157–67. doi: 10.1017/S0007114518000417.
  • DeChristopher, L. R., J. Uribarri, and K. L. Tucker. 2016. Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2–9 years. Public Health Nutrition 19 (1):123–30. doi: 10.1017/S1368980015000865.
  • Deckersbach, T., S. K. Das, L. E. Urban, T. Salinardi, P. Batra, A. M. Rodman, A. R. Arulpragasam, D. D. Dougherty, and S. B. Roberts. 2014. Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention. Nutrition & Diabetes 4 (9):e129. doi: 10.1038/nutd.2014.26.
  • Deehan, E. C., R. M. Duar, A. M. Armet, M. E. Perez-Muñoz, M. Jin, and J. Walter. 2017. Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health. Microbiology Spectrum 5 (5):BAD-0019-2017. doi: 10.1128/microbiolspec.BAD-0019-2017..
  • Delzenne, N. M., P. D. Cani, A. Everard, A. M. Neyrinck, and L. B. Bindels. 2015. Gut microorganisms as promising targets for the management of type 2 diabetes. Diabetologia 58 (10):2206–17. doi: 10.1007/s00125-015-3712-7.
  • Dessypris, N., M. A. Karalexi, E. Ntouvelis, A.-A. Diamantaras, V. Papadakis, M. Baka, E. Hatzipantelis, M. Kourti, M. Moschovi, S. Polychronopoulou, et al. 2017. Association of maternal and index child’s diet with subsequent leukemia risk: A systematic review and meta-analysis. Cancer Epidemiology 47:64–75. doi: 10.1016/j.canep.2017.01.003.
  • DGAC. 2015. Scientific report of the 2015 Dietary Guidelines Advisory Committee: Advisory report to the Secretary of Health and Human Services and the secretary of agriculture. Washington, DC: U.S. Department of Agriculture Agricultural Research Service.
  • DGAC and OverDrive Inc. 2016. Dietary Guidelines for Americans 2015–2020. Accessed August 17, 2018. http://kyunbound.lib.overdrive.com/ContentDetails.htm?ID=D2E702A6-B2A3-48B1-93ED-B9E085738FC6.
  • Di Landro, A., S. Cazzaniga, F. Cusano, A. Bonci, C. Carla, M. L. Musumeci, A. Patrizi, V. Bettoli, E. Pezzarossa, M. Caproni, et al. 2016. Adult female acne and associated risk factors: Results of a multicenter case-control study in Italy. Journal of the American Academy of Dermatology 75 (6):1134–41.e1. doi: 10.1016/j.jaad.2016.06.060.
  • Dinu, M., G. Pagliai, A. Casini, and F. Sofi. 2018. Food groups and risk of age-related macular degeneration: A systematic review with meta-analysis. European Journal of Nutrition. doi: 10.1007/s00394-018-1771-5.
  • Dragsted, L. O., Q. Gao, G. Praticò, C. Manach, D. S. Wishart, A. Scalbert, and E. J. M. Feskens. 2017. Dietary and health biomarkers-time for an update. Genes & Nutrition 12 (1):24. doi: 10.1186/s12263-017-0578-y.
  • Drewnowski, A., J. Buszkiewicz, and A. Aggarwal. 2019. Soda, salad, and socioeconomic status: Findings from the Seattle Obesity Study (SOS). SSM - Population Health 7:100339. doi: 10.1016/j.ssmph.2018.100339.
  • Drewnowski, A., and C. D. Rehm. 2013. Vegetable cost metrics show that potatoes and beans provide most nutrients per penny. PLoS One 8 (5):e63277. doi: 10.1371/journal.pone.0063277.
  • Ellwood, K., D. A. Balentine, J. T. Dwyer, J. W. Erdman, P. C. Gaine, and C. L. Kwik-Uribe. 2014. Considerations on an approach for establishing a framework for bioactive food components. Advances in Nutrition 5 (6):693–701. doi: 10.3945/an.114.006312.
  • Ersoy, L., T. Ristau, Y. T. Lechanteur, M. Hahn, C. B. Hoyng, B. Kirchhof, A. I. den Hollander, and S. Fauser. 2014. Nutritional risk factors for age-related macular degeneration. BioMed Research International 2014:1. doi: 10.1155/2014/413150.
  • EUFIC. 2006. The determinants of food choice. Accessed March 17, 2019. https://www.eufic.org/en/healthy-living/article/the-determinants-of-food-choice.
  • European Association for the Study of the Liver, European Association for the Study of Diabetes, and European Association for the Study of Obesity (EASL-EASD-EASO). 2016. EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. Journal of Hepatology 64 (6):1388–402. doi: 10.1016/j.jhep.2015.11.004..
  • Evans, E. W., R. B. Lipton, B. L. Peterlin, H. A. Raynor, J. G. Thomas, K. C. O'Leary, J. Pavlovic, R. R. Wing, and D. S. Bond. 2015. Dietary intake patterns and diet quality in a nationally representative sample of women with and without severe headache or migraine. Headache 55 (4):550–61. doi: 10.1111/head.12527.
  • Fang, X., J. Wei, X. He, P. An, H. Wang, L. Jiang, D. Shao, H. Liang, Y. Li, F. Wang, et al. 2015. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. European Journal of Cancer 51 (18):2820–32. doi: 10.1016/j.ejca.2015.09.010.
  • FAO. 2018. Food-based dietary guidelines. Accessed May 4, 2018. http://www.fao.org/nutrition/education/food-dietary-guidelines/home/en/.
  • Ferlay, J., I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray. 2015. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer 136 (5):E359–E386. doi: 10.1002/ijc.29210.
  • Fitó, M., O. Melander, J. Martínez, E. Toledo, C. Carpéné, and D. Corella. 2016. Advances in integrating traditional and omic biomarkers when analyzing the effects of the Mediterranean diet intervention in cardiovascular prevention. International Journal of Molecular Sciences 17 (9):1469. doi: 10.3390/ijms17091469.
  • Ford, E. S., and A. H. Mokdad. 2001. Fruit and vegetable consumption and diabetes mellitus incidence among U.S. adults. Preventive Medicine 32 (1):33–9. doi: 10.1006/pmed.2000.0772.
  • Franceschi, C., M. Capri, D. Monti, S. Giunta, F. Olivieri, F. Sevini, M. P. Panourgia, L. Invidia, L. Celani, M. Scurti, et al. 2007. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mechanisms of Ageing and Development 128 (1):92–105. doi: 10.1016/j.mad.2006.11.016.
  • Freedman, M. R., and V. L. Fulgoni. 2016. Canned vegetable and fruit consumption is associated with changes in nutrient intake and higher diet quality in children and adults: National Health and Nutrition Examination Survey 2001–2010. Journal of the Academy of Nutrition and Dietetics 116 (6):940–8. doi: 10.1016/j.jand.2015.10.013.
  • Freedman, M. R., and D. R. Keast. 2012. Potatoes, including French fries, contribute key nutrients to diets of US adults: NHANES 2003–2006. Journal of Nutritional Therapeutics 1 (1):1–11.
  • Fujioka, N., B. W. Ransom, S. G. Carmella, P. Upadhyaya, B. R. Lindgren, A. Roper-Batker, D. K. Hatsukami, V. A. Fritz, C. Rohwer, and S. S. Hecht. 2016. Harnessing the power of cruciferous vegetables: Developing a biomarker for Brassica vegetable consumption using urinary 3,3'-diindolylmethane. Cancer Prevention Research 9 (10):788–93. doi: 10.1158/1940-6207.CAPR-16-0136.
  • Gan, Y., X. Tong, L. Li, S. Cao, X. Yin, C. Gao, C. Herath, W. Li, Z. Jin, Y. Chen, et al. 2015. Consumption of fruit and vegetable and risk of coronary heart disease: A meta-analysis of prospective cohort studies. International Journal of Cardiology 183:129–37. doi: 10.1016/j.ijcard.2015.01.077.
  • Gandini, S., H. Merzenich, C. Robertson, and P. Boyle. 2000. Meta-analysis of studies on breast cancer risk and diet: The role of fruit and vegetable consumption and the intake of associated micronutrients. European Journal of Cancer 36 (5):636–46. doi: 10.1016/S0959-8049(00)00022-8.
  • GBD 2013 Mortality and Causes of Death Collaborators. 2015. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 385 (9963):117–71. doi: 10.1016/S0140-6736(14)61682-2..
  • Geyer, M., and C. Schönfeld. 2018. Novel insights into the pathogenesis of osteoarthritis. Current Rheumatology Reviews 14 (2):98–107. doi: 10.2174/1573397113666170807122312.
  • Ghavipour, M., G. Sotoudeh, E. Tavakoli, K. Mowla, J. Hasanzadeh, and Z. Mazloom. 2017. Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in rheumatoid arthritis patients. European Journal of Clinical Nutrition 71 (1):92–6. doi: 10.1038/ejcn.2016.151.
  • Giaconi, J. A., F. Yu, K. L. Stone, K. L. Pedula, K. E. Ensrud, J. A. Cauley, M. C. Hochberg, and A. L. Coleman. 2012. The association of consumption of fruits/vegetables with decreased risk of glaucoma among older African-American women in the Study of Osteoporotic Fractures. American Journal of Ophthalmology 154 (4):635–44. doi: 10.1016/j.ajo.2012.03.048.
  • Gillette Guyonnet, S., G. Abellan Van Kan, S. Andrieu, P. Barberger Gateau, C. Berr, M. Bonnefoy, J. F. Dartigues, L. de Groot, M. Ferry, P. Galan, et al. 2007. IANA task force on nutrition and cognitive decline with aging. The Journal of Nutrition, Health and Aging 11 (2):132–52.
  • Goldberg, J., G. Flowerdew, E. Smith, J. A. Brody, and M. O. Tso. 1988. Factors associated with age-related macular degeneration. An analysis of data from the first National Health and Nutrition Examination Survey. American Journal of Epidemiology 128 (4):700–10. doi: 10.1093/oxfordjournals.aje.a115023.
  • Gomes, J. M. G., J. d A. Costa, and R. d C. G. Alfenas. 2017. Metabolic endotoxemia and diabetes mellitus: A systematic review. Metabolism 68:133–44. doi: 10.1016/j.metabol.2016.12.009.
  • Gong, G., Y. Qin, W. Huang, S. Zhou, X. Yang, and D. Li. 2010. Rutin inhibits hydrogen peroxide-induced apoptosis through regulating reactive oxygen species mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells. European Journal of Pharmacology 628 (1-3):27–35. doi: 10.1016/j.ejphar.2009.11.028.
  • Gonzalez-Gallego, J., M. V. Garcia-Mediavilla, S. Sanchez-Campos, and M. J. Tunon. 2010. Fruit polyphenols, immunity and inflammation. British Journal of Nutrition 104 (Suppl 3):S15–S27. doi: 10.1017/s0007114510003910..
  • Gonzalez-Vallinas, M., M. Gonzalez-Castejon, A. Rodriguez-Casado, and A. Ramirez de Molina. 2013. Dietary phytochemicals in cancer prevention and therapy: A complementary approach with promising perspectives. Nutrition Reviews 71:585–99. doi: 10.111.nure.12051.
  • Goraya, N., J. Simoni, C.-H. Jo, and D. E. Wesson. 2013. A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate. Clinical Journal of the American Society of Nephrology 8 (3):371–81. doi: 10.2215/CJN.02430312.
  • Goraya, N., J. Simoni, C.-H. Jo, and D. E. Wesson. 2014. Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate. Kidney International 86 (5):1031–8. doi: 10.1038/ki.2014.83.
  • Goraya, N., J. Simoni, C. Jo, and D. E. Wesson. 2012. Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. Kidney International 81 (1):86–93. doi: 10.1038/ki.2011.313.
  • Greene, L. S. 1999. Asthma, oxidant stress, and diet. Nutrition 15 (11-12):899–907. doi: 10.1016/S0899-9007(99)00209-9.
  • Guariguata, L., D. R. Whiting, I. Hambleton, J. Beagley, U. Linnenkamp, and J. E. Shaw. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice 103 (2):137–49. doi: 10.1016/j.diabres.2013.11.002.
  • Gunn, C., J. Weber, A.-T. McGill, and M. Kruger. 2015. Increased intake of selected vegetables, herbs and fruit may reduce bone turnover in post-menopausal women. Nutrients 7 (4):2499–517. doi: 10.3390/nu7042499.
  • Hales, C. M., C. D. Fryar, M. D. Carroll, D. S. Freedman, and C. L. Ogden. 2018. Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007–2008 to 2015–2016. JAMA 319 (16):1723–5. doi: 10.1001/jama.2018.3060.
  • Hamer, M., and Y. Chida. 2007. Intake of fruit, vegetables, and antioxidants and risk of type 2 diabetes: Systematic review and meta-analysis. Journal of Hypertension 25 (12):2361–9. doi: 10.1097/HJH.0b013e3282efc214.
  • Hamidi, M., B. A. Boucher, A. M. Cheung, J. Beyene, and P. S. Shah. 2011. Fruit and vegetable intake and bone health in women aged 45 years and over: A systematic review. Osteoporosis International 22 (6):1681–93. doi: 10.1007/s00198-010-1510-0.
  • Han, H. S., C. B. Chang, D.-C. Lee, and J.-Y. Lee. 2017. Relationship between total fruit and vegetable intake and self-reported knee pain in older adults. The Journal of Nutrition, Health & Aging 21 (7):750–8. doi: 10.1007/s12603-016-0842-7.
  • Han, J. M., A. N. Jo, S. M. Lee, H. S. Bae, D. W. Jun, Y. K. Cho, K. T. Suk, J. H. Yoon, S. B. Ahn, Y. J. Cho, et al. 2014. Associations between intakes of individual nutrients or whole food groups and non-alcoholic fatty liver disease among Korean adults. Journal of Gastroenterology and Hepatology 29 (6):1265–72.
  • Harasym, J., and R. Oledzki. 2014. Effect of fruit and vegetable antioxidants on total antioxidant capacity of blood plasma. Nutrition 30 (5):511–7. doi: 10.1016/j.nut.2013.08.019.
  • Hardcastle, A. C., L. Aucott, W. D. Fraser, D. M. Reid, and H. M. Macdonald. 2011a. Dietary patterns, bone resorption and bone mineral density in early post-menopausal Scottish women. European Journal of Clinical Nutrition 65 (3):378–85. doi: 10.1038/ejcn.2010.264.
  • Hardcastle, A. C., L. Aucott, D. M. Reid, and H. M. Macdonald. 2011b. Associations between dietary flavonoid intakes and bone health in a Scottish population. Journal of Bone and Mineral Research 26 (5):941–7. doi: 10.1002/jbmr.285.
  • Harding, A.-H., N. J. Wareham, S. A. Bingham, K. Khaw, R. Luben, A. Welch, and N. G. Forouhi. 2008. Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: The European prospective investigation of cancer—Norfolk prospective study. Archives of Internal Medicine 168 (14):1493–9. doi: 10.1001/archinte.168.14.1493.
  • Hawkes, C., T. G. Smith, J. Jewell, J. Wardle, R. A. Hammond, S. Friel, A. M. Thow, and J. Kain. 2015. Smart food policies for obesity prevention. Lancet 385 (9985):2410–21. doi: 10.1016/S0140-6736(14)61745-1.
  • He, F. J., C. A. Nowson, M. Lucas, and G. A. MacGregor. 2007. Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: Meta-analysis of cohort studies. Journal of Human Hypertension 21 (9):717–28. doi: 10.1038/sj.jhh.1002212.
  • He, F. J., C. A. Nowson, and G. A. MacGregor. 2006. Fruit and vegetable consumption and stroke: Meta-analysis of cohort studies. Lancet 367 (9507):320–6. doi: 10.1016/S0140-6736(06)68069-0.
  • He, J., Y. Gu, and S. Zhang. 2017. Consumption of vegetables and fruits and breast cancer survival: A systematic review and meta-analysis. Scientific Reports 7 (1):599. doi: 10.1038/s41598-017-00635-5..
  • Health Canada. 2014. Canada’s Food Guides: Education and awareness. Accessed May 4, 2018. https://www.canada.ca/en/health-canada/services/canada-food-guides.html.
  • Heyman, M. B., and S. A. Abrams. 2017. Fruit juice in infants, children, and adolescents: Current recommendations. Pediatrics 139 (6):e20170967. doi: 10.1542/peds.2017-0967.
  • Hodge, A. M., D. R. English, K. O'Dea, and G. G. Giles. 2004. Glycemic index and dietary fiber and the risk of type 2 diabetes. Diabetes Care 27 (11):2701–6.
  • Hogg, J. C., F. Chu, S. Utokaparch, R. Woods, W. M. Elliott, L. Buzatu, R. M. Cherniack, R. M. Rogers, F. C. Sciurba, H. O. Coxson, et al. 2004. The nature of small-airway obstruction in chronic obstructive pulmonary disease. New England Journal of Medicine 350 (26):2645–53. doi: 10.1056/NEJMoa032158.
  • Holscher, H. D. 2017. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes 8 (2):172–84. doi: 10.1080/19490976.2017.1290756.
  • Holt, E. M., L. M. Steffen, A. Moran, S. Basu, J. Steinberger, J. A. Ross, C.-P. Hong, and A. R. Sinaiko. 2009. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. Journal of the American Dietetic Association 109 (3):414–21. doi: 10.1016/j.jada.2008.11.036.
  • Hooshmand, S., S. C. Chai, R. L. Saadat, M. E. Payton, K. Brummel-Smith, and B. H. Arjmandi. 2011. Comparative effects of dried plum and dried apple on bone in postmenopausal women. British Journal of Nutrition 106 (6):923–30. doi: 10.1017/S000711451100119X.
  • Hooshmand, S., M. Kern, D. Metti, P. Shamloufard, S. C. Chai, S. A. Johnson, M. E. Payton, and B. H. Arjmandi. 2016. The effect of two doses of dried plum on bone density and bone biomarkers in osteopenic postmenopausal women: A randomized, controlled trial. Osteoporosis International 27 (7):2271–9. doi: 10.1007/s00198-016-3524-8.
  • Hornick, B. A., and L. Weiss. 2011. Comparative nutrient analysis of commonly consumed vegetables: Support for recommending a nutrition education approach emphasizing specific vegetables to improve nutrient intakes. Nutrition Today 46 (3):130. doi: 10.1097/NT.0b013e31821a82f3.
  • Hosseini, B., B. S. Berthon, A. Saedisomeolia, M. R. Starkey, A. Collison, P. A. B. Wark, and L. G. Wood. 2018. Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: A systematic literature review and meta-analysis. The American Journal of Clinical Nutrition 108 (1):136–55. doi: 10.1093/ajcn/nqy082.
  • Hosseini, B., B. S. Berthon, P. Wark, and L. G. Wood. 2017. Effects of fruit and vegetable consumption on risk of asthma, wheezing and immune responses: A systematic review and meta-analysis. Nutrients 9 (4):341. doi: 10.3390/nu9040341.
  • Howlett, J. F., V. A. Betteridge, M. Champ, S. A. S. Craig, A. Meheust, and J. M. Jones. 2010. The definition of dietary fiber—Discussions at the Ninth Vahouny Fiber Symposium: Building scientific agreement. Food & Nutrition Research 54. doi: 10.3402/fnr.v54i0.5750.
  • Hoy, M. K., and J. D. Goldman. 2014. Dietary fiber intake of the U.S. population: What we eat in America, NHANES 2009–2010. U. S. Department of Agriculture 12:6.
  • Hu, D., L. Cheng, and W. Jiang. 2018. Fruit and vegetable consumption and the risk of postmenopausal osteoporosis: A meta-analysis of observational studies. Food & Function 9 (5):2607–16. doi: 10.1039/c8fo00205c.
  • Hu, D., J. Huang, Y. Wang, D. Zhang, and Y. Qu. 2014. Fruits and vegetables consumption and risk of stroke: A meta-analysis of prospective cohort studies. Stroke 45 (6):1613–9. doi: 10.1161/STROKEAHA.114.004836.
  • Hu, X. H., L. E. Markson, R. B. Lipton, W. F. Stewart, and M. L. Berger. 1999. Burden of migraine in the United States: Disability and economic costs. Archives of Internal Medicine 159 (8):813–8.
  • Hwang, J., J. Wang, P. Morazzoni, H. N. Hodis, and A. Sevanian. 2003. The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: An antioxidant mechanism for cell-mediated LDL modification. Free Radical Biology and Medicine 34 (10):1271–82. doi: 10.1016/S0891-5849(03)00104-7.
  • Hyson, D. A. 2015. A review and critical analysis of the scientific literature related to 100% fruit juice and human health. Advances in Nutrition 6 (1):37–51. doi: 10.3945/an.114.005728.
  • IARC. 2014. World cancer report 2014. Lyon, France: International Agency for Research on Cancer.
  • IARC Working Group on the Evaluation of Cancer-Preventive Strategies. 2016. Breast cancer screening. Accessed November 14, 2018. http://public.eblib.com/choice/publicfullrecord.aspx?p=4770630.
  • IOM. 1998. Dietary reference intakes: Proposed definition and plan for review of dietary antioxidants and related compounds. Washington, DC: National Academies Press.
  • IOM. 2001. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academies Press.
  • IOM. 2005a. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, DC: National Academies Press.
  • IOM. 2005b. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). Washington, DC: National Academies Press.
  • Jacka, F. N., J. A. Pasco, A. Mykletun, L. J. Williams, A. M. Hodge, S. L. O'Reilly, G. C. Nicholson, M. A. Kotowicz, and M. Berk. 2010. Association of Western and traditional diets with depression and anxiety in women. American Journal of Psychiatry 167 (3):305–11. doi: 10.1176/appi.ajp.2009.09060881.
  • Jenkins, D. J. A., F. B. Hu, L. C. Tapsell, A. R. Josse, and C. W. C. Kendall. 2008. Possible benefit of nuts in type 2 diabetes. The Journal of Nutrition 138 (9):1752S–6S. doi: 10.1093/jn/138.9.1752S.
  • Jha, V., G. Garcia-Garcia, K. Iseki, Z. Li, S. Naicker, B. Plattner, R. Saran, A. Y.-M. Wang, and C.-W. Yang. 2013. Chronic kidney disease: Global dimension and perspectives. Lancet 382 (9888):260–72. doi: 10.1016/S0140-6736(13)60687-X.
  • Jiang, X., J. Huang, D. Song, R. Deng, J. Wei, and Z. Zhang. 2017. Increased consumption of fruit and vegetables is related to a reduced risk of cognitive impairment and dementia: Meta-analysis. Frontiers in Aging Neuroscience 9:18. doi: 10.3389/fnagi.2017.00018..
  • Jin, J., Z. Ouyang, and Z. Wang. 2014. Association of fruit and vegetables with the risk of nasopharyngeal cancer: Evidence from a meta-analysis. Scientific Reports 4:5229. doi: 10.1038/srep05229.
  • John, J. H., S. Ziebland, P. Yudkin, L. S. Roe, H. A. Neil, and Oxford Fruit and Vegetable Study Group. 2002. Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: A randomised controlled trial. Lancet 359 (9322):1969–74. doi: 10.1016/S0140-6736(02)98858-6.
  • Johnson, C. M., C. Wei, J. E. Ensor, D. J. Smolenski, C. I. Amos, B. Levin, and D. A. Berry. 2013. Meta-analyses of colorectal cancer risk factors. Cancer Causes & Control 24 (6):1207–22. doi: 10.1007/s10552-013-0201-5.
  • Johnson, E. J. 2014. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutrition Reviews 72 (9):605–12. doi: 10.1111/nure.12133.
  • Johnston, K. L., M. N. Clifford, and L. M. Morgan. 2002. Possible role for apple juice phenolic compounds in the acute modification of glucose tolerance and gastrointestinal hormone secretion in humans. Journal of the Science of Food and Agriculture 82 (15):1800–5. doi: 10.1002/jsfa.1264.
  • Jones, J. M. 2014. CODEX-aligned dietary fiber definitions help to bridge the ‘fiber gap’. Nutrition Journal 13:34 doi: 10.1186/1475-2891-13-34.
  • Joseph, S. V., I. Edirisinghe, and B. M. Burton-Freeman. 2016. Fruit polyphenols: A review of anti-inflammatory effects in humans. Critical Reviews in Food Science and Nutrition 56 (3):419–44. doi: 10.1080/10408398.2013.767221.
  • Jung, S., D. Spiegelman, L. Baglietto, L. Bernstein, D. A. Boggs, P. A. van den Brandt, J. E. Buring, J. R. Cerhan, M. M. Gaudet, G. G. Giles, et al. 2013. Fruit and vegetable intake and risk of breast cancer by hormone receptor status. JNCI: Journal of the National Cancer Institute 105 (3):219–36. doi: 10.1093/jnci/djs635.
  • Kaiser, K. A., A. W. Brown, M. M. Bohan Brown, J. M. Shikany, R. D. Mattes, and D. B. Allison. 2014. Increased fruit and vegetable intake has no discernible effect on weight loss: A systematic review and meta-analysis. The American Journal of Clinical Nutrition 100 (2):567–76. doi: 10.3945/ajcn.114.090548.
  • Kalkwarf, H. J., V. Gilsanz, J. M. Lappe, S. Oberfield, J. A. Shepherd, T. N. Hangartner, X. Huang, M. M. Frederick, K. K. Winer, and B. S. Zemel. 2010. Tracking of bone mass and density during childhood and adolescence. The Journal of Clinical Endocrinology and Metabolism 95 (4):1690–8. doi: 10.1210/jc.2009-2319.
  • Kaluza, J., S. C. Larsson, N. Orsini, A. Linden, and A. Wolk. 2017. Fruit and vegetable consumption and risk of COPD: A prospective cohort study of men. Thorax 72 (6):500–9. doi: 10.1136/thoraxjnl-2015-207851.
  • Kang, J. H., A. Ascherio, and F. Grodstein. 2005. Fruit and vegetable consumption and cognitive decline in aging women. Annals of Neurology 57 (5):713–20. doi: 10.1002/ana.20476.
  • Kang, J. H., W. C. Willett, B. A. Rosner, E. Buys, J. L. Wiggs, and L. R. Pasquale. 2016. Association of dietary nitrate intake with primary open-angle glaucoma: A prospective analysis from the Nurses’ Health Study and Health Professionals Follow-up Study. JAMA Ophthalmology 134 (3):294. doi: 10.1001/jamaophthalmol.2015.5601.
  • Karlsen, A., L. Retterstøl, P. Laake, I. Paur, S. K. Bøhn, L. Sandvik, and R. Blomhoff. 2007. Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. The Journal of Nutrition 137 (8):1951–4. doi: 10.1093/jn/137.8.1951.
  • Kelly, J. T., S. C. Palmer, S. N. Wai, M. Ruospo, J.-J. Carrero, K. L. Campbell, and G. F. M. Strippoli. 2017. Healthy dietary patterns and risk of mortality and ESRD in CKD: A meta-analysis of cohort studies. Clinical Journal of the American Society of Nephrology 12 (2):272–9. doi: 10.2215/CJN.06190616.
  • Keranis, E., D. Makris, P. Rodopoulou, H. Martinou, G. Papamakarios, Z. Daniil, E. Zintzaras, and K. I. Gourgoulianis. 2010. Impact of dietary shift to higher-antioxidant foods in COPD: A randomised trial. European Respiratory Journal 36 (4):774–80. doi: 10.1183/09031936.00113809.
  • Kim, E.-K., H. Kim, H. Kim, and N. Chang. 2017. Relation of dietary fruit and vegetable intake and smoking to age-related macular degeneration in elderly men in Korea. Advances in Nutrition 8 (1):3. doi: 10.1093/advances/8.1.3..
  • Kim, E.-K., H. Kim, O. Kwon, and N. Chang. 2018. Associations between fruits, vegetables, vitamin A, β-carotene and flavonol dietary intake, and age-related macular degeneration in elderly women in Korea: The Fifth Korea National Health and Nutrition Examination Survey. European Journal of Clinical Nutrition 72 (1):161–7. doi: 10.1038/ejcn.2017.152.
  • Kim, V., and G. J. Criner. 2013. Chronic bronchitis and chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 187 (3):228–37. doi: 10.1164/rccm.201210-1843CI.
  • Kim, Y., and Y. Je. 2017. Flavonoid intake and mortality from cardiovascular disease and all causes: A meta-analysis of prospective cohort studies. Clinical Nutrition ESPEN 20:68–77. doi: 10.1016/j.clnesp.2017.03.004.
  • Klurfeld, D. M., C. D. Davis, R. W. Karp, E. Allen-Vercoe, E. B. Chang, B. Chassaing, G. C. Fahey, B. R. Hamaker, H. D. Holscher, J. W. Lampe, et al. 2018. Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome. American Journal of Physiology-Endocrinology and Metabolism 315 (6):E1087–E1097. doi: 10.1152/ajpendo.00058.2018.
  • Knekt, P., J. Kumpulainen, R. Järvinen, H. Rissanen, M. Heliövaara, A. Reunanen, T. Hakulinen, and A. Aromaa. 2002. Flavonoid intake and risk of chronic diseases. The American Journal of Clinical Nutrition 76 (3):560–8. doi: 10.1093/ajcn/76.3.560.
  • Kong, F., Y. Hua, B. Zeng, R. Ning, Y. Li, and J. Zhao. 2016. Gut microbiota signatures of longevity. Current Biology 26 (18):R832–R833. doi: 10.1016/j.cub.2016.08.015.
  • Kong, L. C., B. A. Holmes, A. Cotillard, F. Habi-Rachedi, R. Brazeilles, S. Gougis, N. Gausserès, P. D. Cani, S. Fellahi, J.-P. Bastard, et al. 2014. Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. PLoS One 9 (10):e109434. doi: 10.1371/journal.pone.0109434.
  • Kootte, R. S., A. Vrieze, F. Holleman, G. M. Dallinga-Thie, E. G. Zoetendal, W. M. de Vos, A. K. Groen, J. B. L. Hoekstra, E. S. Stroes, and M. Nieuwdorp. 2012. The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes, Obesity and Metabolism 14 (2):112–20. doi: 10.1111/j.1463-1326.2011.01483.x.
  • Koushik, A., D. Spiegelman, D. Albanes, K. E. Anderson, L. Bernstein, P. A. van den Brandt, L. Bergkvist, D. R. English, J. L. Freudenheim, C. S. Fuchs, et al. 2012. Intake of fruits and vegetables and risk of pancreatic cancer in a pooled analysis of 14 cohort studies. American Journal of Epidemiology 176 (5):373–86. doi: 10.1093/aje/kws027.
  • Kresty, L. A., S. R. Mallery, and G. D. Stoner. 2016. Black raspberries in cancer clinical trials: Past, present and future. Journal of Berry Research 6 (2):251–61. doi: 10.3233/JBR-160125.
  • Krinsky, N. I., J. T. Landrum, and R. A. Bone. 2003. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annual Review of Nutrition 23 (1):171–201. doi: 10.1146/annurev.nutr.23.011702.073307.
  • Kunisawa, J., and H. Kiyono. 2013. Vitamin-mediated regulation of intestinal immunity. Frontiers in Immunology 4:189. doi: 10.3389/fimmu.2013.00189..
  • Kuo, C.-F., S.-F. Luo, L.-C. See, I.-J. Chou, H.-C. Chang, and K.-H. Yu. 2013. Rheumatoid arthritis prevalence, incidence, and mortality rates: A nationwide population study in Taiwan. Rheumatology International 33 (2):355–60. doi: 10.1007/s00296-012-2411-7.
  • Kurotani, K., A. Nanri, A. Goto, T. Mizoue, M. Noda, M. Kato, M. Inoue, S. Tsugane, and Japan Public Health Center-Based Prospective Study Group. 2013. Vegetable and fruit intake and risk of type 2 diabetes: Japan Public Health Center-Based Prospective Study. British Journal of Nutrition 109 (4):709–17. doi: 10.1017/S0007114512001705.
  • Kushi, L. H., C. Doyle, M. McCullough, C. L. Rock, W. Demark-Wahnefried, E. V. Bandera, S. Gapstur, A. V. Patel, K. Andrews, and T. Gansler. 2012. American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA: A Cancer Journal for Clinicians 62 (1):30–67. doi: 10.3322/caac.20140.
  • La, V. D., A. B. Howell, and D. Grenier. 2009. Cranberry proanthocyanidins inhibit MMP production and activity. Journal of Dental Research 88 (7):627–32. doi: 10.1177/0022034509339487.
  • Lai, J. S., S. Hiles, A. Bisquera, A. J. Hure, M. McEvoy, and J. Attia. 2014. A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults. The American Journal of Clinical Nutrition 99 (1):181–97. doi: 10.3945/ajcn.113.069880.
  • Langsetmo, L., D. A. Hanley, J. C. Prior, S. I. Barr, T. Anastassiades, T. Towheed, D. Goltzman, S. Morin, S. Poliquin, N. Kreiger, et al. 2011. Dietary patterns and incident low-trauma fractures in postmenopausal women and men aged ≥50 y: A population-based cohort study. The American Journal of Clinical Nutrition 93 (1):192–9. doi: 10.3945/ajcn.110.002956.
  • Law, M. R., and J. K. Morris. 1998. By how much does fruit and vegetable consumption reduce the risk of ischaemic heart disease? European Journal of Clinical Nutrition 52 (8):549–56. doi: 10.1038/sj.ejcn.1600603.
  • Le Port, A., A. Gueguen, E. Kesse-Guyot, M. Melchior, C. Lemogne, H. Nabi, M. Goldberg, M. Zins, and S. Czernichow. 2012. Association between dietary patterns and depressive symptoms over time: A 10-year follow-up study of the GAZEL cohort. PLoS One 7 (12):e51593. doi: 10.1371/journal.pone.0051593.
  • Ledoux, T. A., M. D. Hingle, and T. Baranowski. 2011. Relationship of fruit and vegetable intake with adiposity: A systematic review. Obesity Reviews 12 (5):e143–e150. doi: 10.1111/j.1467-789X.2010.00786.x.
  • Lefer, A. M. 1990. Prostacyclin, high density lipoproteins, and myocardial ischemia. Circulation 81 (6):2013–5. doi: 10.1161/01.CIR.81.6.2013.
  • Lewis, S. J., and K. W. Heaton. 1997. Stool form scale as a useful guide to intestinal transit time. Scandinavian Journal of Gastroenterology 32 (9):920–4. doi: 10.3109/00365529709011203.
  • Li, B., G. Jiang, G. Zhang, Q. Xue, H. Zhang, C. Wang, and T. Zhao. 2014a. Intake of vegetables and fruit and risk of esophageal adenocarcinoma: A meta-analysis of observational studies. European Journal of Nutrition 53 (7):1511–21. doi: 10.1007/s00394-014-0656-5.
  • Li, B., F. Li, L. Wang, and D. Zhang. 2016. Fruit and vegetables consumption and risk of hypertension: A meta-analysis. The Journal of Clinical Hypertension 18 (5):468–76. doi: 10.1111/jch.12777.
  • Li, D., L. Yang, S. Deng, W. Ling, Z. Liu, L. Yang, Y. Chen, and Z. Du. 2017. Effects of anthocyanins on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. Advances in Nutrition: An International Review Journal 8 (5):684–93. doi: 10.3945/an.116.014852.
  • Li, F., X. Liu, W. Wang, and D. Zhang. 2015. Consumption of vegetables and fruit and the risk of inflammatory bowel disease: A meta-analysis. European Journal of Gastroenterology & Hepatology 27 (6):623–30. doi: 10.1097/MEG.0000000000000330.
  • Li, M., Y. Fan, X. Zhang, W. Hou, and Z. Tang. 2014b. Fruit and vegetable intake and risk of type 2 diabetes mellitus: Meta-analysis of prospective cohort studies. BMJ Open 4 (11):e005497. doi: 10.1136/bmjopen-2014-005497.
  • Li, Y. 2014. Association between fruit and vegetable intake and risk for glioma: A meta-analysis. Nutrition 30 (11-12):1272–8. doi: 10.1016/j.nut.2014.03.027.
  • Lin, Y.-C., T.-C. Wu, P.-Y. Chen, L.-Y, Hsieh, and S.-L. Yeh. 2010. Comparison of plasma and intake levels of antioxidant nutrients in patients with chronic obstructive pulmonary disease and healthy people in Taiwan: A case-control study. Asia Pacific Journal of Clinical Nutrition 19 (3):393–401. doi: 10.6133/apjcn.2010.19.3.14..
  • Liu, H., X.-C. Wang, G.-H. Hu, Z.-F. Guo, P. Lai, L. Xu, T.-B. Huang, and Y.-F. Xu. 2015. Fruit and vegetable consumption and risk of bladder cancer: An updated meta-analysis of observational studies. European Journal of Cancer Prevention 24 (6):508–16. doi: 10.1097/CEJ.0000000000000119.
  • Liu, J., J. Wang, Y. Leng, and C. Lv. 2013. Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: A meta-analysis of observational studies. International Journal of Cancer 133 (2):473–85. doi: 10.1002/ijc.28024.
  • Liu, R. H. 2004. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. The Journal of Nutrition 134 (12):3479S–85S. doi: 10.1093/jn/134.12.3479S.
  • Liu, R. H. 2013. Dietary bioactive compounds and their health implications: Dietary bioactive compounds and health. Journal of Food Science 78 (s1):A18–A25. doi: 10.1111/1750-3841.12101.
  • Liu, S., M. Serdula, S.-J. Janket, N. R. Cook, H. D. Sesso, W. C. Willett, J. E. Manson, and J. E. Buring. 2004. A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women. Diabetes Care 27 (12):2993–6.
  • Liu, X., Y. Yan, F. Li, and D. Zhang. 2016. Fruit and vegetable consumption and the risk of depression: A meta-analysis. Nutrition 32 (3):296–302. doi: 10.1016/j.nut.2015.09.009.
  • Liu, Z., and A. Lin. 2014. Dietary factors and thyroid cancer risk: A meta-analysis of observational studies. Nutrition and Cancer 66 (7):1165–78. doi: 10.1080/01635581.2014.951734.
  • Loef, M., and H. Walach. 2012. Fruit, vegetables and prevention of cognitive decline or dementia: A systematic review of cohort studies. The Journal of Nutrition, Health & Aging 16 (7):626–30.
  • Loke, W. M., J. M. Proudfoot, S. Stewart, A. J. McKinley, P. W. Needs, P. A. Kroon, J. M. Hodgson, and K. D. Croft. 2008. Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity. Biochemical Pharmacology 75 (5):1045–53. doi: 10.1016/j.bcp.2007.11.002.
  • Loomba, R., and A. J. Sanyal. 2013. The global NAFLD epidemic. Nature Reviews Gastroenterology & Hepatology 10 (11):686–90. doi: 10.1038/nrgastro.2013.171.
  • Lunet, N., C. Valbuena, A. L. Vieira, C. Lopes, C. Lopes, L. David, F. Carneiro, and H. Barros. 2007. Fruit and vegetable consumption and gastric cancer by location and histological type: Case-control and meta-analysis. European Journal of Cancer Prevention 16 (4):312–27. doi: 10.1097/01.cej.0000236255.95769.22.
  • Luo, S. Y., Y. Li, H. Luo, X. H. Yin, D. R. Lin, K. Zhao, G. L. Huang, and J. K. Song. 2016. Increased intake of vegetables, but not fruits, may be associated with reduced risk of hip fracture: A meta-analysis. Scientific Reports 6:19783. doi: 10.1038/srep19783.
  • Lupton, J. R., S. A. Atkinson, N. Chang, C. G. Fraga, J. Levy, M. Messina, D. P. Richardson, B. van Ommen, Y. Yang, J. C. Griffiths, et al. 2014. Exploring the benefits and challenges of establishing a DRI-like process for bioactives. European Journal of Nutrition 53 (Suppl 1):1–9. doi: 10.1007/s00394-014-0666-3.
  • Macdonald, H. M., A. J. Black, L. Aucott, G. Duthie, S. Duthie, R. Sandison, A. C. Hardcastle, S. A. Lanham New, W. D. Fraser, and D. M. Reid. 2008. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: A randomized controlled trial. The American Journal of Clinical Nutrition 88 (2):465–74. doi: 10.1093/ajcn/88.2.465.
  • Macdonald, H. M., A. C. Hardcastle, G. G. Duthie, S. J. Duthie, L. Aucott, R. Sandison, M. J. Shearer, and D. M. Reid. 2009. Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers. British Journal of Nutrition 102 (10):1477–86. doi: 10.1017/S0007114509990377.
  • Macready, A. L., T. W. George, M. F. Chong, D. S. Alimbetov, Y. Jin, A. Vidal, J. P. E. Spencer, O. B. Kennedy, K. M. Tuohy, A.-M. Minihane, et al. 2014. Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease—FLAVURS: A randomized controlled trial. The American Journal of Clinical Nutrition 99 (3):479–89. doi: 10.3945/ajcn.113.074237.
  • Makki, K., E. C. Deehan, J. Walter, and F. Bäckhed. 2018. The impact of dietary fiber on gut microbiota in host health and disease. Cell Host Microbe 23 (6):705–15. doi: 10.1016/j.chom.2018.05.012.
  • Mares, J. 2016. Lutein and zeaxanthin isomers in eye health and disease. Annual Review of Nutrition 36 (1):571–602. doi: 10.1146/annurev-nutr-071715-051110.
  • Marques-Vidal, P., P. Ravasco, and M. Ermelinda Camilo. 2006. Foodstuffs and colorectal cancer risk: A review. Clinical Nutrition 25 (1):14–36. doi: 10.1016/j.clnu.2005.09.008.
  • Maslowski, K. M., and C. R. Mackay. 2011. Diet, gut microbiota and immune responses. Nature Immunology 12 (1):5–9. doi: 10.1038/ni0111-5.
  • Maslowski, K. M., A. T. Vieira, A. Ng, J. Kranich, F. Sierro, D. Yu, H. C. Schilter., et al. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461 (7268):1282–6. doi: 10.1038/nature08530.
  • Mateen, S., S. Moin, A. Q. Khan, A. Zafar, and N. Fatima. 2016. Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS One 11 (4):e0152925. doi: 10.1371/journal.pone.0152925.
  • Matthews, F. E., A. Arthur, L. E. Barnes, J. Bond, C. Jagger, L. Robinson, C. Brayne, and Medical Research Council Cognitive Function and Ageing Collaboration. 2013. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the Cognitive Function and Ageing Study I and II. Lancet 382 (9902):1405–12. doi: 10.1016/S0140-6736(13)61570-6.
  • Mayhew, A. J., R. J. de Souza, D. Meyre, S. S. Anand, and A. Mente. 2016. A systematic review and meta-analysis of nut consumption and incident risk of CVD and all-cause mortality. British Journal of Nutrition 115 (2):212–25. doi: 10.1017/S0007114515004316.
  • Mayne, S. T. 2003. Antioxidant nutrients and chronic disease: Use of biomarkers of exposure and oxidative stress status in epidemiologic research. The Journal of Nutrition 133 (3):933S–40S. doi: 10.1093/jn/133.3.933S.
  • Mayne, S. T., B. Cartmel, S. Scarmo, L. Jahns, I. V. Ermakov, and W. Gellermann. 2013. Resonance Raman spectroscopic evaluation of skin carotenoids as a biomarker of carotenoid status for human studies. Archives of Biochemistry and Biophysics 539 (2):163–70. doi: 10.1016/j.abb.2013.06.007.
  • McCall, D. O., C. P. McGartland, M. C. McKinley, C. C. Patterson, P. Sharpe, D. R. McCance, I. S. Young, and J. V. Woodside. 2009. Dietary intake of fruits and vegetables improves microvascular function in hypertensive subjects in a dose-dependent manner. Circulation 119 (16):2153–60. doi: 10.1161/CIRCULATIONAHA.108.831297.
  • McDannell, R., and A. E. M. McLean. 1988. Chemical and biological properties of indole glucosinolates (glucobrassicins): A review. Food and Chemical Toxicology 26:59–70. doi: 10.1016/0278-6915(88)90042-7.
  • McDonough, J. E., R. Yuan, M. Suzuki, N. Seyednejad, W. M. Elliott, P. G. Sanchez, A. C. Wright, W. B. Gefter, L. Litzky, H. O. Coxson, et al. 2011. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. New England Journal of Medicine 365 (17):1567–75. doi: 10.1056/NEJMoa1106955.
  • McMartin, S. E., F. N. Jacka, and I. Colman. 2013. The association between fruit and vegetable consumption and mental health disorders: Evidence from five waves of a national survey of Canadians. Preventive Medicine 56 (3–4):225–30. doi: 10.1016/j.ypmed.2012.12.016.
  • McTiernan, A., J. Wactawski-Wende, L. Wu, R. J. Rodabough, N. B. Watts, F. Tylavsky, R. Freeman, S. Hendrix, and R. Jackson. 2009. Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: The Women’s Health Initiative Dietary Modification Trial. The American Journal of Clinical Nutrition 89 (6):1864–76. doi: 10.3945/ajcn.2008.26956.
  • Meng, H., W. Hu, Z. Chen, and Y. Shen. 2014. Fruit and vegetable intake and prostate cancer risk: A meta-analysis. Asia-Pacific Journal of Clinical Oncology 10 (2):133–40. doi: 10.1111/ajco.12067.
  • Mente, A., L. de Koning, H. S. Shannon, and S. S. Anand. 2009. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Archives of Internal Medicine 169 (7):659–69. doi: 10.1001/archinternmed.2009.38.
  • Merikangas, K. R., J.-P. He, M. Burstein, S. A. Swanson, S. Avenevoli, L. Cui, C. Benjet, K. Georgiades, and J. Swendsen. 2010. Lifetime prevalence of mental disorders in U.S. adolescents: Results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry 49 (10):980–9. doi: 10.1016/j.jaac.2010.05.017.
  • Mewborn, C. M., C. A. Lindbergh, T. L. Robinson, M. A. Gogniat, D. P. Terry, K. R. Jean, B. R. Hammond, L. M. Renzi-Hammond, and L. S. Miller. 2018a. Lutein and zeaxanthin are positively associated with visual-spatial functioning in older adults: An fMRI study. Nutrients 10 (4):458. doi: 10.3390/nu10040458.
  • Mewborn, C. M., D. P. Terry, L. M. Renzi-Hammond, B. R. Hammond, and L. S. Miller. 2018b. Relation of retinal and serum lutein and zeaxanthin to white matter integrity in older adults: A diffusion tensor imaging study. Archives of Clinical Neuropsychology 33 (7):861–74. doi: 10.1093/acn/acx109.
  • Meyer, K. A., L. H. Kushi, D. R. Jacobs, J. Slavin, T. A. Sellers, and A. R. Folsom. 2000. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. The American Journal of Clinical Nutrition 71 (4):921–30. doi: 10.1093/ajcn/71.4.921.
  • Michels, K. B., A. P. Mohllajee, E. Roset-Bahmanyar, G. P. Beehler, and K. B. Moysich. 2007. Diet and breast cancer: A review of the prospective observational studies. Cancer 109 (S12):2712–49. doi: 10.1002/cncr.22654.
  • Minihane, A. M., S. Vinoy, W. R. Russell, A. Baka, H. M. Roche, K. M. Tuohy, J. L. Teeling, E. E. Blaak, M. Fenech, D. Vauzour, et al. 2015. Low-grade inflammation, diet composition and health: Current research evidence and its translation. British Journal of Nutrition 114 (7):999–1012. doi: 10.1017/S0007114515002093.
  • Misso, N. L. A., J. Brooks-Wildhaber, S. Ray, H. Vally, and P. J. Thompson. 2005. Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma. European Respiratory Journal 26 (2):257–64. doi: 10.1183/09031936.05.00006705.
  • Miyake, Y., S. Sasaki, K. Tanaka, and Y. Hirota. 2010. Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. Allergy 65 (6):758–65. doi: 10.1111/j.1398-9995.2009.02267.x.
  • Moeller, S. M., A. Taylor, K. L. Tucker, M. L. McCullough, L. T. Chylack, S. E. Hankinson, W. C. Willett, and P. F. Jacques. 2004. Overall adherence to the Dietary Guidelines for Americans is associated with reduced prevalence of early age-related nuclear lens opacities in women. The Journal of Nutrition 134 (7):1812–9. doi: 10.1093/jn/134.7.1812.
  • Moeller, S. M., R. Voland, L. Tinker, B. A. Blodi, M. L. Klein, K. M. Gehrs, E. J. Johnson, et al. 2008. Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the carotenoids in the Age-Related Eye Disease Study, an ancillary study of the Women’s Health Initiative. Archives of Ophthalmology 126 (3):354–64. doi: 10.1001/archopht.126.3.354.
  • Montonen, J., R. Järvinen, M. Heliövaara, A. Reunanen, A. Aromaa, and P. Knekt. 2005. Food consumption and the incidence of type II diabetes mellitus. European Journal of Clinical Nutrition 59 (3):441–8. doi: 10.1038/sj.ejcn.1602094.
  • Morris, M. C., D. A. Evans, C. C. Tangney, J. L. Bienias, and R. S. Wilson. 2006. Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 67 (8):1370–6. doi: 10.1212/01.wnl.0000240224.38978.d8.
  • Mottaghi, T., F. Amirabdollahian, and F. Haghighatdoost. 2018. Fruit and vegetable intake and cognitive impairment: A systematic review and meta-analysis of observational studies. European Journal of Clinical Nutrition 72 (10):1336–44. doi: 10.1038/s41430-017-0005-x.
  • Movassagh, E. Z., and H. Vatanparast. 2017. Current evidence on the association of dietary patterns and bone health: A scoping review. Advances in Nutrition: An International Review Journal 8 (1):1.2–16. doi: 10.3945/an.116.013326.
  • Mukai, Y., and S. Sato. 2009. Polyphenol-containing azuki bean (vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutrition, Metabolism & Cardiovascular Diseases 19 (7):491–7. doi: 10.1016/j.numecd.2008.09.007.
  • Muraki, I., F. Imamura, J. E. Manson, F. B. Hu, W. C. Willett, R. M. van Dam, and Q. Sun. 2013. Fruit consumption and risk of type 2 diabetes: Results from three prospective longitudinal cohort studies. BMJ 347 (1):f5001. doi: 10.1136/bmj.f5001.
  • Murphy, L. B., M. G. Cisternas, K. J. Greenlund, W. Giles, C. Hannan, and C. G. Helmick. 2017. Defining arthritis for public health surveillance: Methods and estimates in four US population health surveys. Arthritis Care & Research 69 (3):356–67. doi: 10.1002/acr.22943.
  • Murphy, M. M., N. Stettler, K. M. Smith, and R. Reiss. 2014. Associations of consumption of fruits and vegetables during pregnancy with infant birth weight or small for gestational age births: A systematic review of the literature. International Journal of Women's Health 6:899–912. doi: 10.2147/IJWH.S67130.
  • Murray, C. J. L. 2013. The state of US health, 1990–2010: Burden of diseases, injuries, and risk factors. JAMA 310 (6):591–606. doi: 10.1001/jama.2013.13805.
  • Mursu, J., J. K. Virtanen, T.-P. Tuomainen, T. Nurmi, and S. Voutilainen. 2014. Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study. The American Journal of Clinical Nutrition 99 (2):328–33. doi: 10.3945/ajcn.113.069641.
  • Musso, G. 2003. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 37 (4):909–16. doi: 10.1053/jhep.2003.50132.
  • Myasoedova, E., C. S. Crowson, H. M. Kremers, T. M. Therneau, and S. E. Gabriel. 2010. Is the incidence of rheumatoid arthritis rising? Results from Olmsted County, Minnesota, 1955–2007. Arthritis & Rheumatology 62 (6):1576–82. doi: 10.1002/art.27425.
  • Myint, P. K., A. A. Welch, S. A. Bingham, P. G. Surtees, N. W. J. Wainwright, R. N. Luben, N. J. Wareham, R. D. Smith, I. M. Harvey, N. E. Day, et al. 2007. Fruit and vegetable consumption and self-reported functional health in men and women in the European prospective investigation into cancer–norfolk (EPIC–norfolk): A population-based cross-sectional study. Public Health Nutrition 10 (1):34–41. doi: 10.1017/S1368980007222608.
  • Mytton, O. T., K. Nnoaham, H. Eyles, P. Scarborough, and C. Ni Mhurchu. 2014. Systematic review and meta-analysis of the effect of increased vegetable and fruit consumption on body weight and energy intake. BMC Public Health 14:886. doi: 10.1186/1471-2458-14-886..
  • Nanri, A., D. Yoshida, T. Yamaji, T. Mizoue, R. Takayanagi, and S. Kono. 2008. Dietary patterns and C-reactive protein in Japanese men and women. The American Journal of Clinical Nutrition 87 (5):1488–96. doi: 10.1093/ajcn/87.5.1488.
  • Nantz, M. P., C. A. Rowe, C. Nieves, and S. S. Percival. 2006. Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate. The Journal of Nutrition 136 (10):2606–10. doi: 10.1093/jn/136.10.2606.
  • Netting, M. J., P. F. Middleton, and M. Makrides. 2014. Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches. Nutrition 30 (11-12):1225–41. doi: 10.1016/j.nut.2014.02.015.
  • Neville, C. E., I. S. Young, S. E. C. M. Gilchrist, M. C. McKinley, A. Gibson, J. D. Edgar, and J. V. Woodside. 2014. Effect of increased fruit and vegetable consumption on bone turnover in older adults: A randomised controlled trial. Osteoporosis International 25 (1):223–33. doi: 10.1007/s00198-013-2402-x.
  • NIH Consensus Development Panel on Osteoporosis Prevention. 2001. Osteoporosis prevention, diagnosis, and therapy. JAMA 285 (6):785–95. doi: 10.1001/jama.285.6.785..
  • NIH Office of Dietary Supplements. 2018. Bioactive food components initiatives. Accessed July 20, 2018. https://ods.od.nih.gov/Research/Bioactive_Food_Components_Initiatives.aspx.
  • Nishida, C., R. Uauy, S. Kumanyika, and P. Shetty. 2004. The Joint WHO/FAO Expert Consultation on diet, nutrition and the prevention of chronic diseases: Process, product and policy implications. Public Health Nutrition 7 (1a):245–50. doi: 10.1079/PHN2003592.
  • Nooyens, A. C. J., H. B. Bueno-de-Mesquita, M. P. J. van Boxtel, B. M. van Gelder, H. Verhagen, and W. M. M. Verschuren. 2011. Fruit and vegetable intake and cognitive decline in middle-aged men and women: The Doetinchem Cohort Study. British Journal of Nutrition 106 (5):752–61. doi: 10.1017/S0007114511001024.
  • Nurk, E., H. Refsum, C. A. Drevon, G. S. Tell, H. A. Nygaard, K. Engedal, and A. D. Smith. 2010. Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study. British Journal of Nutrition 104 (8):1190–201. doi: 10.1017/S0007114510001807.
  • Nurmatov, U., G. Devereux, and A. Sheikh. 2011. Nutrients and foods for the primary prevention of asthma and allergy: Systematic review and meta-analysis. The Journal of Allergy and Clinical Immunology 127 (3):724–33.e1–e30. doi: 10.1016/j.jaci.2010.11.001.
  • Ogden, C. L., M. D. Carroll, H. G. Lawman, C. D. Fryar, D. Kruszon-Moran, B. K. Kit, and K. M. Flegal. 2016. Trends in obesity prevalence among children and adolescents in the United States, 1988–1994 through 2013–2014. JAMA 315 (21):2292–9. doi: 10.1001/jama.2016.6361.
  • Okoko, B. J., P. G. Burney, R. B. Newson, J. F. Potts, and S. O. Shaheen. 2007. Childhood asthma and fruit consumption. European Respiratory Journal 29 (6):1161–8. doi: 10.1183/09031936.00097806.
  • Palmer, D. 2013. The effect of age on thymic function. Frontiers in Immunology 4:316. doi: 10.3389/fimmu.2013.00316.
  • Palmer, S. C., J. K. Maggo, K. L. Campbell, J. C. Craig, D. W. Johnson, B. Sutanto, M. Ruospo, A. Tong, and G. F. Strippoli. 2017. Dietary interventions for adults with chronic kidney disease. Cochrane Database of Systematic Reviews 2017 (4):CD011998. doi: 10.1002/14651858.CD011998.pub2..
  • Paluszkiewicz, P., K. Smolińska, I. Dębińska, and W. A. Turski. 2012. Main dietary compounds and pancreatic cancer risk. The quantitative analysis of case-control and cohort studies. Cancer Epidemiology 36 (1):60–7. doi: 10.1016/j.canep.2011.05.004.
  • Pappas, A., A. Liakou, and C. C. Zouboulis. 2016. Nutrition and skin. Reviews in Endocrine and Metabolic Disorders 17 (3):443–8. doi: 10.1007/s11154-016-9374-z.
  • Park, S., M.-Y. Kim, D. H. Lee, S. H. Lee, E. J. Baik, C.-H. Moon, S. W. Park, E. Y. Ko, S.-R. Oh, and Y.-S. Jung. 2009. Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect. European Journal of Nutrition 48 (4):235–42. doi: 10.1007/s00394-009-0007-0.
  • Pascolini, D., and S. P. Mariotti. 2012. Global estimates of visual impairment: 2010. British Journal of Ophthalmology 96 (5):614–8. doi: 10.1136/bjophthalmol-2011-300539.
  • Patel, B. D. 2006. Dietary antioxidants and asthma in adults. Thorax 61 (5):388–93. doi: 10.1136/thx.2004.024935.
  • Pattison, D. J., D. P. Symmons, M. Lunt, A. Welch, S. A. Bingham, N. E. Day, and A. J. Silman. 2005. Dietary β-cryptoxanthin and inflammatory polyarthritis: Results from a population-based prospective study. The American Journal of Clinical Nutrition 82 (2):451–5. doi: 10.1093/ajcn/82.2.451.
  • Pattison, D. J., D. P. M. Symmons, M. Lunt, A. Welch, R. Luben, S. A. Bingham, K.-T. Khaw, N. E. Day, and A. J. Silman. 2004. Dietary risk factors for the development of inflammatory polyarthritis: Evidence for a role of high level of red meat consumption. Arthritis & Rheumatism 50 (12):3804–12. doi: 10.1002/art.20731.
  • Pavia, M., C. Pileggi, C. G. A. Nobile, and I. F. Angelillo. 2006. Association between fruit and vegetable consumption and oral cancer: A meta-analysis of observational studies. The American Journal of Clinical Nutrition 83 (5):1126–34. doi: 10.1093/ajcn/83.5.1126.
  • Peluso, I., C. Miglio, G. Morabito, F. Ioannone, and M. Serafini. 2015. Flavonoids and immune function in human: A systematic review. Critical Reviews in Food Science and Nutrition 55 (3):383–95. doi: 10.1080/10408398.2012.656770.
  • Pera, A., C. Campos, N. López, F. Hassouneh, C. Alonso, R. Tarazona, and R. Solana. 2015. Immunosenescence: Implications for response to infection and vaccination in older people. Maturitas 82 (1):50–5. doi: 10.1016/j.maturitas.2015.05.004.
  • Pereira, S. S., and J. I. Alvarez-Leite. 2014. Low-grade inflammation, obesity, and diabetes. Current Obesity Reports 3 (4):422–31. doi: 10.1007/s13679-014-0124-9.
  • Pinent, M., M. Blay, M. C. Bladé, M. J. Salvadó, L. Arola, and A. Ardévol. 2004. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology 145 (11):4985–90. doi: 10.1210/en.2004-0764.
  • Poutanen, K. S., P. Dussort, A. Erkner, S. Fiszman, K. Karnik, M. Kristensen, and C. F. Marsaux. 2017. A review of the characteristics of dietary fibers relevant to appetite and energy intake outcomes in human intervention trials. The American Journal of Clinical Nutrition 106 (3):747–54. doi: 10.3945/ajcn.117.157172.
  • Prince, M. J., F. Wu, Y. Guo, L. M. Gutierrez Robledo, M. O'Donnell, R. Sullivan, and S. Yusuf. 2015. The burden of disease in older people and implications for health policy and practice. Lancet 385 (9967):549–62. doi: 10.1016/S0140-6736(14)61347-7.
  • Produce for Better Health Foundation. 2015. State of the Plate: 2015 Study on America’s Consumption of Fruit & Vegetables. Accessed March 17, 2019. http://www.pbhfoundation.org/pdfs/about/res/pbh_res/State_of_the_Plate_2015_WEB_Bookmarked.pdf.
  • Psaltopoulou, T., T. N. Sergentanis, D. B. Panagiotakos, I. N. Sergentanis, R. Kosti, and N. Scarmeas. 2013. Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis. Annals of Neurology 74 (4):580–91. doi: 10.1002/ana.23944.
  • Qiu, R., W.-T. Cao, H.-Y. Tian, J. He, G.-D. Chen, and Y.-M. Chen. 2017. Greater intake of fruit and vegetables is associated with greater bone mineral density and lower osteoporosis risk in middle-aged and elderly adults. PLoS One 12 (1):e0168906. doi: 10.1371/journal.pone.0168906.
  • Raghavan, R., C. Dreibelbis, B. Kingshipp, Y. P. Wong, B. Abrams, A. D. Gernand, K. M. Rasmussen, A. M. Siega-Riz, J. Stang, K. O. Casavale, et al. 2019a. Dietary patterns before and during pregnancy and birth outcomes: A systematic review. The American Journal of Clinical Nutrition 109 (Supplement_1):729S–56S. doi: 10.1093/ajcn/nqy353.
  • Raghavan, R., C. Dreibelbis, B. Kingshipp, Y. P. Wong, B. Abrams, A. D. Gernand, K. M. Rasmussen, A. M. Siega-Riz, J. Stang, K. O. Casavale, et al. 2019b. Dietary patterns before and during pregnancy and maternal outcomes: A systematic review. The American Journal of Clinical Nutrition 109 (Supplement_1):705S–28S.
  • Raj Krishnamurthy, V. M., G. Wei, B. C. Baird, M. Murtaugh, M. B. Chonchol, K. L. Raphael, T. Greene, and S. Beddhu. 2012. High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. Kidney International 81 (3):300–6. doi: 10.1038/ki.2011.355.
  • Ranard, K. M., S. Jeon, E. S. Mohn, J. C. Griffiths, E. J. Johnson, and J. W. Erdman. 2017. Dietary guidance for lutein: Consideration for intake recommendations is scientifically supported. European Journal of Nutrition 56 (S3):37–42. doi: 10.1007/s00394-017-1580-2.
  • Renzi-Hammond, L. M., E. R. Bovier, L. M. Fletcher, L. S. Miller, C. M. Mewborn, C. A. Lindbergh, J. H. Baxter, and B. R. Hammond. 2017. Effects of a lutein and zeaxanthin intervention on cognitive function: A randomized, double-masked, placebo-controlled trial of younger healthy adults. Nutrients 9 (11):1246. doi: 10.3390/nu9111246.
  • Rickman, J. C., D. M. Barrett, and C. M. Bruhn. 2007a. Nutritional comparison of fresh, frozen and canned fruits and vegetables. Part 1. Vitamins C and B and phenolic compounds. Journal of the Science of Food and Agriculture 87 (6):930–44. doi: 10.1002/jsfa.2825.
  • Rickman, J. C., C. M. Bruhn, and D. M. Barrett. 2007b. Nutritional comparison of fresh, frozen, and canned fruits and vegetables II. Vitamin A and carotenoids, vitamin E, minerals and fiber. Journal of the Science of Food and Agriculture 87 (7):1185–96. doi: 10.1002/jsfa.2824.
  • Riley, L., H. Gouda, M. Cowan, and World Health Organization. 2017. Noncommunicable diseases progress monitor, 2017.
  • Rist, P. M., J. E. Buring, and T. Kurth. 2015. Dietary patterns according to headache and migraine status: A cross-sectional study. Cephalalgia 35 (9):767–75. doi: 10.1177/0333102414560634.
  • Rosenlund, H., I. Kull, G. Pershagen, A. Wolk, M. Wickman, and A. Bergstrom. 2011. Fruit and vegetable consumption in relation to allergy: Disease-related modification of consumption? The Journal of Allergy and Clinical Immunology 127 (5):1219–25. doi: 10.1016/j.jaci.2010.11.019.
  • Roth, G. A., L. Dwyer-Lindgren, A. Bertozzi-Villa, R. W. Stubbs, C. Morozoff, M. Naghavi, A. H. Mokdad, and C. J. L. Murray. 2017. Trends and patterns of geographic variation in cardiovascular mortality among US counties, 1980–2014. JAMA 317 (19):1976–92. doi: 10.1001/jama.2017.4150.
  • Rybicka, M., I. Baranowska-Bosiacka, B. Żyluk, P. Nowacki, and D. Chlubek. 2012. The role of magnesium in migraine pathogenesis. Potential use of magnesium compounds in prevention and treatment of migraine headaches. Journal of Elementology 17 (2):345–56. doi: 10.5601/jelem.2012.17.2.15..
  • Sabia, S., H. Nabi, M. Kivimaki, M. J. Shipley, M. G. Marmot, and A. Singh-Manoux. 2009. Health behaviors from early to late midlife as predictors of cognitive function: The Whitehall II Study. American Journal of Epidemiology 170 (4):428–37. doi: 10.1093/aje/kwp161.
  • Saghafian, F., H. Malmir, P. Saneei, A. Milajerdi, B. Larijani, and A. Esmaillzadeh. 2018. Fruit and vegetable consumption and risk of depression: Accumulative evidence from an updated systematic review and meta-analysis of epidemiological studies. British Journal of Nutrition 119 (10):1087–101. doi: 10.1017/S0007114518000697.
  • Salas-Salvadó, J., A. Garcia-Arellano, R. Estruch, F. Marquez-Sandoval, D. Corella, M. Fiol, E. Gómez-Gracia, E. Viñoles, F. Arós, and C. Herrera. 2008. Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease. European Journal of Clinical Nutrition 62 (5):651–9. doi: 10.1038/sj.ejcn.1602762.
  • Salomone, F., J. Godos, and S. Zelber-Sagi. 2016. Natural antioxidants for non-alcoholic fatty liver disease: Molecular targets and clinical perspectives. Liver International 36 (1):5–20. doi: 10.1111/liv.12975.
  • Sánchez-Villegas, A., M. Delgado-Rodríguez, A. Alonso, J. Schlatter, F. Lahortiga, L. Serra Majem, and M. A. Martínez-González. 2009. Association of the Mediterranean dietary pattern with the incidence of depression: The Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Archives of General Psychiatry 66 (10):1090–8. doi: 10.1001/archgenpsychiatry.2009.129.
  • Sánchez-Villegas, A., E. Toledo, J. de Irala, M. Ruiz-Canela, J. Pla-Vidal, and M. A. Martínez-González. 2012. Fast-food and commercial baked goods consumption and the risk of depression. Public Health Nutrition 15 (3):424–32. doi: 10.1017/S1368980011001856.
  • Sánchez-Villegas, A., L. Verberne, J. De Irala, M. Ruíz-Canela, E. Toledo, L. Serra-Majem, and M. A. Martínez-González. 2011. Dietary fat intake and the risk of depression: The SUN project. PLoS One 6 (1):e16268. doi: 10.1371/journal.pone.0016268.
  • Sanders, M. G. H., L. M. Pardo, R. S. Ginger, J. C. Kiefte-de Jong, and T. Nijsten. 2019. Association between diet and seborrheic dermatitis: A cross-sectional study. Journal of Investigative Dermatology 139 (1):108–14. doi: 10.1016/j.jid.2018.07.027.
  • Santoro, A., R. Ostan, M. Candela, E. Biagi, P. Brigidi, M. Capri, and C. Franceschi. 2018. Gut microbiota changes in the extreme decades of human life: A focus on centenarians. Cellular and Molecular Life Sciences 75 (1):129–48. doi: 10.1007/s00018-017-2674-y.
  • Sargeant, L. A., A. Jaeckel, and N. J. Wareham. 2000. Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC norfolk. European Respiratory Journal 16 (3):397–403. doi: 10.1034/j.1399-3003.2000.016003397.x.
  • Sarkar, D., A. Sharma, and G. Talukder. 1994. Chlorophyll and chlorophyllin as modifiers of genotoxic effects. Mutation Research 318 (3):239–47.
  • Schlesinger, S., M. Neuenschwander, C. Schwedhelm, G. Hoffmann, A. Bechthold, H. Boeing, and L. Schwingshackl. 2019. Food groups and risk of overweight, obesity, and weight gain: A systematic review and dose-response meta-analysis of prospective studies. Advances in Nutrition 10 (2):205–18. doi: 10.1093/advances/nmy092.
  • Schell, J., R. Scofield, J. Barrett, B. Kurien, N. Betts, T. Lyons, Y. Zhao, and A. Basu. 2017. Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis. Nutrients 9 (9):949. doi: 10.3390/nu9090949.
  • Schoenaker, D. A. J. M., S. S. Soedamah-Muthu, and G. D. Mishra. 2014. The association between dietary factors and gestational hypertension and pre-eclampsia: A systematic review and meta-analysis of observational studies. BMC Medicine 12:157. doi: 10.1186/s12916-014-0157-7..
  • Schwarzenberg, S. J., and M. K. Georgieff, and Committee on Nutrition. 2018. Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health. Pediatrics 141 (2):e20173716. doi: 10.1542/peds.2017-3716.
  • Schwingshackl, L., and G. Hoffmann. 2015. Diet quality as assessed by the Healthy Eating Index, the Alternate Healthy Eating Index, the Dietary Approaches to Stop Hypertension score, and health outcomes: A systematic review and meta-analysis of cohort studies. Journal of the Academy of Nutrition and Dietetics 115 (5):780–800.e5. doi: 10.1016/j.jand.2014.12.009.
  • Schwingshackl, L., G. Hoffmann, A.-M. Lampousi, S. Knuppel, K. Iqbal, C. Schwedhelm, A. Bechthold, S. Schlesinger, and H. Boeing. 2017a. Food groups and risk of type 2 diabetes mellitus: A systematic review and meta-analysis of prospective studies. European Journal of Epidemiology 32 (5):363–75. doi: 10.1007/s10654-017-0246-y.
  • Schwingshackl, L., C. Schwedhelm, G. Hoffmann, S. Knuppel, K. Iqbal, V. Andriolo, A. Bechthold, S. Schlesinger, and H. Boeing. 2017b. Food groups and risk of hypertension: A systematic review and dose-response meta-analysis of prospective studies. Advances in Nutrition: An International Review Journal 8 (6):793–803. doi: 10.3945/an.117.017178.
  • Schwingshackl, L., C. Schwedhelm, G. Hoffmann, S. Knüppel, A. Laure Preterre, K. Iqbal, A. Bechthold, S. De Henauw, N. Michels, B. Devleesschauwer, et al. 2018. Food groups and risk of colorectal cancer. International Journal of Cancer 142 (9):1748–58. doi: 10.1002/ijc.31198.
  • Schwingshackl, L., C. Schwedhelm, G. Hoffmann, A.-M. Lampousi, S. Knüppel, K. Iqbal, A. Bechthold, S. Schlesinger, and H. Boeing. 2017c. Food groups and risk of all-cause mortality: A systematic review and meta-analysis of prospective studies. The American Journal of Clinical Nutrition 105 (6):1462–73. doi: 10.3945/ajcn.117.153148.
  • Seddon, J. M., U. A. Ajani, R. D. Sperduto, R. Hiller, N. Blair, T. C. Burton, M. D. Farber., et al. 1994. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA: The Journal of the American Medical Association 272 (18):1413–20. doi: 10.1001/jama.1994.03520180037032.
  • Seeman, E., G. Bianchi, S. Khosla, J. A. Kanis, and E. Orwoll. 2006. Bone fragility in men – Where are we? Osteoporosis International 17 (11):1577–83. doi: 10.1007/s00198-006-0160-8.
  • Sergentanis, T. N., T. Psaltopoulou, I. Ntanasis-Stathopoulos, A. Liaskas, I.-G. Tzanninis, and M.-A. Dimopoulos. 2018. Consumption of fruits, vegetables, and risk of hematological malignancies: A systematic review and meta-analysis of prospective studies. Leukemia & Lymphoma 59 (2):434–47. doi: 10.1080/10428194.2017.1339873.
  • Seyedrezazadeh, E., M. P. Moghaddam, K. Ansarin, M. R. Vafa, S. Sharma, and F. Kolahdooz. 2014. Fruit and vegetable intake and risk of wheezing and asthma: A systematic review and meta-analysis. Nutrition Reviews 72 (7):411–28. doi: 10.1111/nure.12121.
  • Sherzai, A., L. T. Heim, C. Boothby, and A. D. Sherzai. 2012. Stroke, food groups, and dietary patterns: A systematic review. Nutrition Reviews 70 (8):423–35. doi: 10.1111/j.1753-4887.2012.00490.x.
  • Shi, L., Z. W. Liu, Y. Li, C. Gong, H. Zhang, L. J. Song, C. Y. Huang, and M. Li. 2012. The prevalence of nonalcoholic fatty liver disease and its association with lifestyle/dietary habits among university faculty and staff in Chengdu. Biomedical and Environmental Sciences 25 (4):383–91. doi: 10.3967/0895-3988.2012.04.002..
  • Shin, J. Y., J. Y. Kim, H. T. Kang, K. H. Han, and J. Y. Shim. 2015. Effect of fruits and vegetables on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. International Journal of Food Sciences and Nutrition 66 (4):416–25. doi: 10.3109/09637486.2015.1025716.
  • Siegel, R. L., K. D. Miller, and A. Jemal. 2016. Cancer statistics, 2016. CA: A Cancer Journal for Clinicians 66 (1):7–30. doi: 10.3322/caac.21332.
  • Singh, N. P., G. K. Ingle, V. K. Saini, A. Jami, P. Beniwal, M. Lal, and G. S. Meena. 2009. Prevalence of low glomerular filtration rate, proteinuria and associated risk factors in North India using Cockcroft-Gault and modification of diet in renal disease equation: An observational, cross-sectional study. BMC Nephrology 10:4. doi: 10.1186/1471-2369-10-4..
  • Skoczek-Rubinska, A., J. Bajerska, and K. Menclewicz. 2018. Effects of fruit and vegetables intake in periodontal diseases: A systematic review. Dental and Medical Problems 55 (4):431–9. doi: 10.17219/dmp/99072.
  • Slavin, J. L., and B. Lloyd. 2012. Health benefits of fruits and vegetables. Advances in Nutrition 3 (4):506–16. doi: 10.3945/an.112.002154.
  • Song, W., C. M. Derito, M. K. Liu, X. He, M. Dong, and R. H. Liu. 2010. Cellular antioxidant activity of common vegetables. Journal of Agricultural and Food Chemistry 58 (11):6621–9. doi: 10.1021/jf9035832.
  • Spagnuolo, C., S. Moccia, and G. L. Russo. 2018. Anti-inflammatory effects of flavonoids in neurodegenerative disorders. European Journal of Medicinal Chemistry 153:105–15. doi: 10.1016/j.ejmech.2017.09.001.
  • Stahl, W., and H. Sies. 2012. β-carotene and other carotenoids in protection from sunlight. The American Journal of Clinical Nutrition 96 (5):1179S–84S. doi: 10.3945/ajcn.112.034819.
  • Stewart, W. F., J. Roy, and R. B. Lipton. 2013. Migraine prevalence, socioeconomic status, and social causation. Neurology 81 (11):948–55. doi: 10.1212/WNL.0b013e3182a43b32.
  • Stice, E., and K. Burger. 2019. Neural vulnerability factors for obesity. Clinical Psychology Review 68:38–53. doi: 10.1016/j.cpr.2018.12.002.
  • Storey, M., and P. Anderson. 2018. Total fruit and vegetable consumption increases among consumers of frozen fruit and vegetables. Nutrition 46:115–21. doi: 10.1016/j.nut.2017.08.013.
  • Storey, M. L., and P. A. Anderson. 2016. Vegetable consumption and selected nutrient intakes of women of childbearing age. Journal of Nutrition Education and Behavior 48 (10):691–6.e1. doi: 10.1016/j.jneb.2016.07.014.
  • Sun-Edelstein, C., and A. Mauskop. 2009. Role of magnesium in the pathogenesis and treatment of migraine. Expert Review of Neurotherapeutics 9 (3):369–79. doi: 10.1586/14737175.9.3.369.
  • Thom, D. H., M. N. Haan, and S. K. Van Den Eeden. 1997. Medically recognized urinary incontinence and risks of hospitalization, nursing home admission and mortality. Age and Ageing 26 (5):367–74. doi: 10.1093/ageing/26.5.367.
  • Tian, Y., L. Su, J. Wang, X. Duan, and X. Jiang. 2018. Fruit and vegetable consumption and risk of the metabolic syndrome: A meta-analysis. Public Health Nutrition 21 (4):756–65. doi: 10.1017/S136898001700310X.
  • Tursi, A. 2017. Dietary pattern and colonic diverticulosis. Current Opinion in Clinical Nutrition & Metabolic Care 20 (5):409–13. doi: 10.1097/MCO.0000000000000403.
  • U.K. Government. 2018. The Eatwell Guide. Accessed May 4, 2018. https://www.gov.uk/government/publications/the-eatwell-guide.
  • U.S. Federal Interagency Forum on Aging-Related Statistics. 2010. Older Americans 2010: Key indicators of well-being. Washington, DC: U.S. Government Printing Office.
  • Ueda, H., C. Yamazaki, and M. Yamazaki. 2004. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. Bioscience, Biotechnology, and Biochemistry 68 (1):119–25. doi: 10.1271/bbb.68.119.
  • USDA. 2015. What we eat in America, NHANES 2009–10: Table 1a. Mean daily food patterns cup equivalents consumed per individual, by gender and age, in the United States, 2009–2010. https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/fped/table_1_fped_gen_0910.pdf.
  • USDA. 2018a. 2015–2020 Dietary Guidelines for Americans. Accessed May 4, 2018. https://health.gov/dietaryguidelines/2015/.
  • USDA. 2018b. Salad consumption in the U.S.: What we eat in America, NHANES 2011–2014. Accessed July 20, 2018. https://www.ars.usda.gov/research/publications/publication/?seqNo115=350651.
  • van Egmond-Fröhlich, A. W. A., D. Weghuber, and M. de Zwaan. 2012. Association of symptoms of attention-deficit/hyperactivity disorder with physical activity, media time, and food intake in children and adolescents. PLoS One 7 (11):e49781. doi: 10.1371/journal.pone.0049781.
  • Vieira, A. R., L. Abar, D. S. M. Chan, S. Vingeliene, E. Polemiti, C. Stevens, D. Greenwood, and T. Norat. 2017. Foods and beverages and colorectal cancer risk: A systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project. Annals of Oncology 28 (8):1788–802. doi: 10.1093/annonc/mdx171.
  • Vieira, A. R., L. Abar, S. Vingeliene, D. S. M. Chan, D. Aune, D. Navarro-Rosenblatt, C. Stevens, D. Greenwood, and T. Norat. 2016. Fruits, vegetables and lung cancer risk: A systematic review and meta-analysis. Annals of Oncology 27 (1):81–96. doi: 10.1093/annonc/mdv381.
  • Vieira, A. R., S. Vingeliene, D. S. M. Chan, D. Aune, L. Abar, D. Navarro Rosenblatt, D. C. Greenwood, and T. Norat. 2015. Fruits, vegetables, and bladder cancer risk: A systematic review and meta-analysis. Cancer Medicine 4 (1):136–46. doi: 10.1002/cam4.327.
  • Villegas, R., X. O. Shu, Y.-T. Gao, G. Yang, T. Elasy, H. Li, and W. Zheng. 2008. Vegetable but not fruit consumption reduces the risk of type 2 diabetes in Chinese women. The Journal of Nutrition 138 (3):574–80. doi: 10.1093/jn/138.3.574.
  • Vingeliene, S., D. S. M. Chan, A. R. Vieira, E. Polemiti, C. Stevens, L. Abar, D. Navarro Rosenblatt, D. C. Greenwood, and T. Norat. 2017. An update of the WCRF/AICR systematic literature review and meta-analysis on dietary and anthropometric factors and esophageal cancer risk. Annals of Oncology 28 (10):2409–19. doi: 10.1093/annonc/mdx338.
  • Wakai, K., K. Matsuo, C. Nagata, T. Mizoue, K. Tanaka, I. Tsuji, S. Sasazuki, T. Shimazu, N. Sawada, M. Inoue, et al. 2011. Lung cancer risk and consumption of vegetables and fruit: An evaluation based on a systematic review of epidemiological evidence from Japan. Japanese Journal of Clinical Oncology 41 (5):693–708. doi: 10.1093/jjco/hyr027.
  • Wallace, I. J., S. Worthington, D. T. Felson, R. D. Jurmain, K. T. Wren, H. Maijanen, R. J. Woods, and D. E. Lieberman. 2017. Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proceedings of the National Academy of Sciences of the United States of America 114 (35):9332–6. doi: 10.1073/pnas.1703856114.
  • Wallace, I. R., C. T. McEvoy, S. J. Hunter, L. L. Hamill, C. N. Ennis, P. M. Bell, C. C. Patterson, J. V. Woodside, I. S. Young, and M. C. McKinley. 2013. Dose-response effect of fruit and vegetables on insulin resistance in people at high risk of cardiovascular disease: A randomized controlled trial. Diabetes Care 36 (12):3888–96. doi: 10.2337/dc13-0718.
  • Wallace, T. 2017. Dried plums, prunes and bone health: A comprehensive review. Nutrients 9 (4):401. doi: 10.3390/nu9040401.
  • Wallace, T., M. Slavin, and C. Frankenfeld. 2016. Systematic review of anthocyanins and markers of cardiovascular disease. Nutrients 8 (1):32. doi: 10.3390/nu8010032.
  • Wallace, T. C. 2011. Anthocyanins in cardiovascular disease. Advances in Nutrition 2 (1):1–7. doi: 10.3945/an.110.000042.
  • Wallace, T. C., J. B. Blumberg, E. J. Johnson, and A. Shao. 2015. Dietary bioactives: Establishing a scientific framework for recommended intakes. Advances in Nutrition 6 (1):1–4. doi: 10.3945/an.114.007294.
  • Wallace, T. C., S. Bultman, C. D’Adamo, C. R. Daniel, J. Debelius, E. Ho, H. Eliassen, D. Lemanne, P. Mukherjee, T. N. Seyfried, et al. 2019. Personalized nutrition in disrupting cancer — Proceedings from the 2017 American College of Nutrition Annual Meeting. Journal of the American College of Nutrition 38 (1):1–14. doi: 10.1080/07315724.2018.1500499.
  • Wallace, T. C., F. Guarner, K. Madsen, M. D. Cabana, G. Gibson, E. Hentges, and M. E. Sanders. 2011. Human gut microbiota and its relationship to health and disease. Nutrition Reviews 69 (7):392–403. doi: 10.1111/j.1753-4887.2011.00402.x.
  • Wang, H., M. Naghavi, C. Allen, R. M. Barber, Z. A. Bhutta, A. Carter, D. C. Casey, F. J. Charlson, A. Z. Chen, M. M. Coates, et al. 2016a. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet 388 (10053):1459–544. doi: 10.1016/S0140-6736(16)31012-1.
  • Wang, M., S. Qin, T. Zhang, X. Song, and S. Zhang. 2015a. The effect of fruit and vegetable intake on the development of lung cancer: A meta-analysis of 32 publications and 20,414 cases. European Journal of Clinical Nutrition 69 (11):1184–92. doi: 10.1038/ejcn.2015.64.
  • Wang, P.-Y., J.-C. Fang, Z.-H. Gao, C. Zhang, and S.-Y. Xie. 2016b. Higher intake of fruits, vegetables or their fiber reduces the risk of type 2 diabetes: A meta-analysis. Journal of Diabetes Investigation 7 (1):56–69. doi: 10.1111/jdi.12376.
  • Wang, Q., Y. Chen, X. Wang, G. Gong, G. Li, and C. Li. 2014a. Consumption of fruit, but not vegetables, may reduce risk of gastric cancer: Results from a meta-analysis of cohort studies. European Journal of Cancer 50 (8):1498–509. doi: 10.1016/j.ejca.2014.02.009.
  • Wang, X., Y. Ouyang, J. Liu, M. Zhu, G. Zhao, W. Bao, and F. B. Hu. 2014b. Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: Systematic review and dose-response meta-analysis of prospective cohort studies. BMJ 349 (3):g4490. doi: 10.1136/bmj.g4490.
  • Wang, X., Y. Y. Ouyang, J. Liu, and G. Zhao. 2014c. Flavonoid intake and risk of CVD: A systematic review and meta-analysis of prospective cohort studies. British Journal of Nutrition 111 (1):1–11. doi: 10.1017/S000711451300278X.
  • Wang, Y., F. Li, Z. Wang, T. Qiu, Y. Shen, and M. Wang. 2015b. Fruit and vegetable consumption and risk of lung cancer: A dose-response meta-analysis of prospective cohort studies. Lung Cancer 88 (2):124–30. doi: 10.1016/j.lungcan.2015.02.015.
  • Warrilow, A., D. Mellor, A. McKune, and K. Pumpa. 2019. Dietary fat, fibre, satiation, and satiety—a systematic review of acute studies. European Journal of Clinical Nutrition 73:333–44. doi: 10.1038/s41430-018-0295-7..
  • Watson, R. R., and V. R. Preedy. 2013. Bioactive food as dietary interventions for cardiovascular disease. In Bioactive foods in chronic disease states, edited by R. Watson and V. Preedy, 719. Boston, MA: Elsevier.
  • Wattenberg, L. W. 1975. Effects of dietary constituents on the metabolism of chemical carcinogens. Cancer Research 35 (11 Pt. 2):3326–31.
  • WCRF and AICR. 2018. Diet, nutrition, physical activity and cancer: A global perspective: A summary of the Third Expert Report. https://www.wcrf.org/dietandcancer/summary-third-expert-report.
  • Weaver, C. M., D. D. Alexander, C. J. Boushey, B. Dawson-Hughes, J. M. Lappe, M. S. LeBoff, S. Liu, A. C. Looker, T. C. Wallace, and D. D. Wang. 2016a. Calcium plus vitamin D supplementation and risk of fractures: An updated meta-analysis from the National Osteoporosis Foundation. Osteoporosis International 27 (1):367–76. doi: 10.1007/s00198-015-3386-5.
  • Weaver, C. M., C. M. Gordon, K. F. Janz, H. J. Kalkwarf, J. M. Lappe, R. Lewis, M. O’Karma, T. C. Wallace, and B. S. Zemel. 2016b. The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: A systematic review and implementation recommendations. Osteoporosis International 27 (4):1281–386. doi: 10.1007/s00198-015-3440-3.
  • Weaver, C. M., B. R. Martin, G. S. Jackson, G. P. McCabe, M. Peacock, and M. Wastney. 2017. Calcium-41: A technology for monitoring changes in bone mineral. Osteoporosis International 28 (4):1215–23. doi: 10.1007/s00198-016-3849-3.
  • Wedick, N. M., A. Pan, A. Cassidy, E. B. Rimm, L. Sampson, B. Rosner, W. Willett, F. B. Hu, Q. Sun, and R. M. van Dam. 2012. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. The American Journal of Clinical Nutrition 95 (4):925–33. doi: 10.3945/ajcn.111.028894.
  • WHO. 2002. The World Health Report 2002: Reducing risks, promoting healthy life. Geneva, Switzerland: World Health Organization.
  • Wirth, W., D. J. Hunter, M. C. Nevitt, L. Sharma, C. K. Kwoh, C. Ladel, and F. Eckstein. 2017. Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 25 (12):2063–71. doi: 10.1016/j.joca.2017.08.005.
  • Wong, W. L., X. Su, X. Li, C. M. G. Cheung, R. Klein, C.-Y. Cheng, and T. Y. Wong. 2014. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis. The Lancet Global Health 2 (2):e106–16. doi: 10.1016/S2214-109X(13)70145-1.
  • Woo, H. D., S. Park, K. Oh, H. J. Kim, H. R. Shin, H. K. Moon, and J. Kim. 2014. Diet and cancer risk in the Korean population: A meta-analysis. Asian Pacific Journal of Cancer Prevention: APJCP 15 (19):8509–19.
  • Wood, L. G., and P. G. Gibson. 2009. Dietary factors lead to innate immune activation in asthma. Pharmacology & Therapeutics 123 (1):37–53. doi: 10.1016/j.pharmthera.2009.03.015.
  • Wren, T. A. L., H. J. Kalkwarf, B. S. Zemel, J. M. Lappe, S. Oberfield, J. A. Shepherd, K. A. Winer, and V. Gilsanz. 2014. Longitudinal tracking of dual-energy X-ray absorptiometry bone measures over 6 years in children and adolescents: Persistence of low bone mass to maturity. The Journal of Pediatrics 164 (6):1280–5. doi: 10.1016/j.jpeds.2013.12.040.
  • Wright, N. C., A. C. Looker, K. G. Saag, J. R. Curtis, E. S. Delzell, S. Randall, and B. Dawson-Hughes. 2014. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. Journal of Bone and Mineral Research 29 (11):2520–6. doi: 10.1002/jbmr.2269.
  • Wu, L., D. Sun, and Y. He. 2016. Fruit and vegetables consumption and incident hypertension: Dose-response meta-analysis of prospective cohort studies. Journal of Human Hypertension 30 (10):573–80. doi: 10.1038/jhh.2016.44.
  • Wu, L., D. Sun, and Y. Tan. 2017. Intake of fruit and vegetables and the incident risk of cognitive disorders: A systematic review and meta-analysis of cohort studies. The Journal of Nutrition, Health & Aging 21 (10):1284–90. doi: 10.1007/s12603-017-0875-6.
  • Wu, Y.-C., D. Zheng, J.-J. Sun, Z.-K. Zou, and Z.-L. Ma. 2015a. Meta-analysis of studies on breast cancer risk and diet in Chinese women. International Journal of Clinical and Experimental Medicine 8 (1):73–85.
  • Wu, Y., D. Zhang, X. Jiang, and W. Jiang. 2015b. Fruit and vegetable consumption and risk of type 2 diabetes mellitus: A dose-response meta-analysis of prospective cohort studies. Nutrition, Metabolism & Cardiovascular Diseases 25 (2):140–7. doi: 10.1016/j.numecd.2014.10.004.
  • Xi, B., S. Li, Z. Liu, H. Tian, X. Yin, P. Huai, W. Tang, D. Zhou, and L. M. Steffen. 2014. Intake of fruit juice and incidence of type 2 diabetes: A systematic review and meta-analysis. PLoS One 9 (3):e93471. doi: 10.1371/journal.pone.0093471.
  • Xu, C., X.-T. Zeng, T.-Z. Liu, C. Zhang, Z.-H. Yang, S. Li, and X.-Y. Chen. 2015. Fruits and vegetables intake and risk of bladder cancer: A PRISMA-compliant systematic review and dose-response meta-analysis of prospective cohort studies. Medicine 94 (17):e759. doi: 10.1097/MD.0000000000000759.
  • Yahia, E. M., M. E. Maldonado Celis, and M. Svendsen. 2017. The contribution of fruit and vegetable consumption to human health. In Fruit and vegetable phytochemicals, edited by Elhadi M. Yahia, 1–52. Chichester, UK: John Wiley & Sons, Ltd.
  • Yang, Y., F. Wu, T. Winzenberg, and G. Jones. 2018. Tracking of areal bone mineral density from age eight to young adulthood and factors associated with deviation from tracking: A 17-year prospective cohort study. Journal of Bone and Mineral Research 33 (5):832–9. doi: 10.1002/jbmr.3361.
  • Yang, Y., D. Zhang, N. Feng, G. Chen, J. Liu, G. Chen, and Y. Zhu. 2014. Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: A meta-analysis. Gastroenterology 147 (5):1031–42. doi: 10.1053/j.gastro.2014.08.005.
  • Yao, B., Y. Yan, X. Ye, H. Fang, H. Xu, Y. Liu, S. Li, and Y. Zhao. 2014. Intake of fruit and vegetables and risk of bladder cancer: A dose-response meta-analysis of observational studies. Cancer Causes & Control 25 (12):1645–58. doi: 10.1007/s10552-014-0469-0.
  • Zhan, J., Y.-J. Liu, L.-B. Cai, F.-R. Xu, T. Xie, and Q.-Q. He. 2017. Fruit and vegetable consumption and risk of cardiovascular disease: A meta-analysis of prospective cohort studies. Critical Reviews in Food Science and Nutrition 57 (8):1650–63. doi: 10.1080/10408398.2015.1008980.
  • Zhang, L., F. Wang, L. Wang, W. Wang, B. Liu, J. Liu, M. Chen, Q. He, Y. Liao, X. Yu, et al. 2012. Prevalence of chronic kidney disease in China: A cross-sectional survey. Lancet 379 (9818):815–22. doi: 10.1016/S0140-6736(12)60033-6.
  • Zhang, S., Z. Jia, Z. Yan, and J. Yang. 2017. Consumption of fruits and vegetables and risk of renal cell carcinoma: A meta-analysis of observational studies. Oncotarget 8 (17):27892–903. doi: 10.18632/oncotarget.15841..
  • Zhang, Y., and D.-Z. Zhang. 2018. Associations of vegetable and fruit consumption with metabolic syndrome. A meta-analysis of observational studies. Public Health Nutrition 21 (9):1693–703. doi: 10.1017/S1368980018000381.
  • Zhang, L. X., R. V. Cooney, and J. S. Bertram. 1992. Carotenoids up-regulate connexin-43 gene expression independent of their proviamin A or antioxidant properties. Cancer Research 52 (20):5707–12.
  • Zhang, Y., and P. Talalay. 1994. Anticarcinogenic activities of organic isothiocyanate: Chemistry and mechanisms. Cancer Research 54:1976S–81S.
  • Zhao, L.-G., J.-W. Sun, Y. Yang, X. Ma, Y.-Y. Wang, and Y.-B. Xiang. 2016. Fish consumption and all-cause mortality: A meta-analysis of cohort studies. European Journal of Clinical Nutrition 70 (2):155–61. doi: 10.1038/ejcn.2015.72.
  • Zhu, F., B. Du, and B. Xu. 2018. Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: A review. Critical Reviews in Food Science and Nutrition 58 (8):1260–70. doi: 10.1080/10408398.2016.1251390.

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