Combined impact of HLA-allele matching and the CD34-positive cell dose on optimal unit selection for single-unit cord blood transplantation in adults

References

• Barker JN, Davies SM, DeFor T, et al. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood. 2001;97(10):2957–2961.
   PubMed Web of Science ®Google Scholar
• Annual Report of Nationwide Survey 2019. The Japanese Data Center for Hematopoietic Cell Transplantation/The Japan Society for Hematopoietic Cell Transplantation. In http://www.jdchct.or.jp/data/report/2019/.
   Google Scholar
• Brunstein CG, Petersdorf EW, DeFor TE, et al. Impact of allele-level HLA mismatch on outcomes in recipients of double umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2016;22(3):487–492.
   PubMed Web of Science ®Google Scholar
• Wagner JE, Jr., Eapen M, Carter S, Blood and Marrow Transplant Clinical Trials Network, et al. One-unit versus two-unit cord-blood transplantation for hematologic cancers. N Engl J Med. 2014;371(18):1685–1694.
   PubMed Web of Science ®Google Scholar
• Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 2005;105(3):1343–1347.
   PubMed Web of Science ®Google Scholar
• Brunstein CG, Cutler CS, DeFor TE, et al. Matching at human leukocyte antigen-C improved the outcomes after double umbilical cord blood transplantation for recipients of two to four of six human leukocyte antigen-matched grafts. Biol Blood Marrow Transplant. 2017;23(1):126–133.
   PubMed Web of Science ®Google Scholar
• Hurley CK, Wagner JE, Setterholm MI, et al. Advances in HLA: practical implications for selecting adult donors and cord blood units. Biol Blood Marrow Transplant. 2006;12(1 Suppl 1):28–33.
   PubMed Web of Science ®Google Scholar
• Dehn J, Spellman S, Hurley CK, et al. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR. Blood. 2019;134(12):924–934.
   PubMedGoogle Scholar
• Politikos I, Davis E, Nhaissi M, et al. Guidelines for Cord Blood Unit Selection. Biol Blood Marrow Transplant. 2020;26(12):2190–2196.
   PubMed Web of Science ®Google Scholar
• Barker JN, Scaradavou A, Stevens CE. Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood. 2010;115(9):1843–1849.
   PubMed Web of Science ®Google Scholar
• Rocha V, Gluckman E, European Eurocord-Netcord registry and European Blood and Marrow Transplant group. Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft- and transplantation-related factors. Br J Haematol. 2009;147(2):262–274.
   PubMed Web of Science ®Google Scholar
• Atsuta Y, Kanda J, Takanashi M, on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation, et al. Different effects of HLA disparity on transplant outcomes after single-unit cord blood transplantation between pediatric and adult patients with leukemia. Haematologica. 2013;98(5):814–822.
   PubMed Web of Science ®Google Scholar
• Kanda J, Hayashi H, Ruggeri A, et al. Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study. Leukemia. 2020;34(1):128–137.
   PubMed Web of Science ®Google Scholar
• Yokoyama H, Morishima Y, Fuji S, et al. Impact of HLA allele mismatch at HLA-A, -B, -C, and -DRB1 in single cord blood transplantation. Biol Blood Marrow Transplant. 2020;26(3):519–528.
   PubMed Web of Science ®Google Scholar
• Hough R, Danby R, Russell N, et al. Recommendations for a standard UK approach to incorporating umbilical cord blood into clinical transplantation practice: an update on cord blood unit selection, donor selection algorithms and conditioning protocols. Br J Haematol. 2016;172(3):360–370.
   PubMed Web of Science ®Google Scholar
• Shiina T, Suzuki S, Ozaki Y, et al. Super high resolution for single molecule-sequence-based typing of classical HLA loci at the 8-digit level using next generation sequencers. Tissue Antigens. 2012;80(4):305–316.
   PubMedGoogle Scholar
• Hosomichi K, Shiina T, Tajima A, et al. The impact of next-generation sequencing technologies on HLA research. J Hum Genet. 2015;60(11):665–673.
   PubMed Web of Science ®Google Scholar
• Yabe T, Azuma F, Kashiwase K, on behalf of Japanese Cord Blood Transplantation Histocompatibility Research Group, et al. HLA-DPB1 mismatch induces a graft-versus-leukemia effect without severe acute GVHD after single-unit umbilical cord blood transplantation. Leukemia. 2018;32(1):168–175.
   PubMed Web of Science ®Google Scholar
• Bacigalupo A, Ballen K, Rizzo D, et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant. 2009;15(12):1628–1633.
   PubMed Web of Science ®Google Scholar
• Zino E, Frumento G, Marktel S, et al. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. Blood. 2004;103(4):1417–1424.
   PubMed Web of Science ®Google Scholar
• Tanaka J, Morishima Y, Takahashi Y, et al. Effects of KIR ligand incompatibility on clinical outcomes of umbilical cord blood transplantation without ATG for acute leukemia in complete remission. Blood Cancer J. 2013;3:e164.
   PubMed Web of Science ®Google Scholar
• Ruggeri A. Optimizing cord blood selection. Hematology Am Soc Hematol Educ Program. 2019;2019(1):522–531.
   PubMedGoogle Scholar
• Cox D. Regression models and life tables. J R Stat Soc B. 1972;34:187–200.
   Google Scholar
• Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94(446):496–509.
   Web of Science ®Google Scholar
• Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 2013;48(3):452–458.
   PubMed Web of Science ®Google Scholar
• Sanz J, Jaramillo FJ, Planelles D, et al. Impact on outcomes of human leukocyte antigen matching by allele-level typing in adults with acute myeloid leukemia undergoing umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2014;20(1):106–110.
   PubMed Web of Science ®Google Scholar
• Eapen M, Klein JP, Ruggeri A, Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marrow Transplantation, et al. Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. Blood. 2014;123(1):133–140.
   PubMed Web of Science ®Google Scholar
• Kogler G, Enczmann J, Rocha V, et al. High-resolution HLA typing by sequencing for HLA-A, -B, -C, -DR, -DQ in 122 unrelated cord blood/patient pair transplants hardly improves long-term clinical outcome. Bone Marrow Transplant. 2005;36(12):1033–1041.
   PubMed Web of Science ®Google Scholar
• Konuma T, Kato S, Oiwa-Monna M, et al. Cryopreserved CD34+ cell dose, but not total nucleated cell dose, influences hematopoietic recovery and extensive chronic graft-versus-host disease after single-unit cord blood transplantation in adult patients. Biol Blood Marrow Transplant. 2017;23(7):1142–1150.
   PubMed Web of Science ®Google Scholar
• Nakasone H, Tabuchi K, Uchida N, et al. Which is more important for the selection of cord blood units for haematopoietic cell transplantation: the number of CD34-positive cells or total nucleated cells? Br J Haematol. 2019;185(1):166–169.
   PubMed Web of Science ®Google Scholar
• Wagner JE, Barker JN, DeFor TE, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100(5):1611–1618.
   PubMed Web of Science ®Google Scholar
• Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001;344(24):1815–1822.
   PubMed Web of Science ®Google Scholar
• Page KM, Zhang L, Mendizabal A, et al. Total colony-forming units are a strong, independent predictor of neutrophil and platelet engraftment after unrelated umbilical cord blood transplantation: a single-center analysis of 435 cord blood transplants. Biol Blood Marrow Transplant. 2011;17(9):1362–1374.
   PubMed Web of Science ®Google Scholar
• Van Haute I, Lootens N, De SS, et al. Viable CD34+ stem cell content of a cord blood graft: which measurement performed before transplantation is most representative? Transfusion. 2004;44(4):547–554.
   PubMed Web of Science ®Google Scholar
• Barnett D, Granger V, Kraan J, for and on behalf of the CD34 Task Force of the European Working Group of Clinical Cell Analysis (EWGCCA), et al. Reduction of intra- and interlaboratory variation in CD34+ stem cell enumeration using stable test material, standard protocols and targeted training. DK34 Task Force of the European Working Group of Clinical Cell Analysis (EWGCCA). Br J Haematol. 2000;108(4):784–792.
   PubMed Web of Science ®Google Scholar
• Brocklebank AM, Sparrow RL. Enumeration of CD34+ cells in cord blood: a variation on a single-platform flow cytometric method based on the ISHAGE gating strategy. Cytometry. 2001;46(4):254–261.
   PubMedGoogle Scholar
• Spellman S, Hurley CK, Brady C, National Marrow Donor Program Cord Blood Advisory Group, et al. Guidelines for the development and validation of new potency assays for the evaluation of umbilical cord blood. Cytotherapy. 2011;13(7):848–855.
   PubMed Web of Science ®Google Scholar
• Kai S, Wake A, Okada M, et al. Double-unit cord blood transplantation after myeloablative conditioning for patients with hematologic malignancies: a multicenter phase II study in Japan. Biol Blood Marrow Transplant. 2013;19(5):812–819.
   PubMed Web of Science ®Google Scholar
• Morishima Y, Morishita Y, Tanimoto M, et al. Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity. The Nagoya Bone Marrow Transplantation Group. Blood. 1989;74(6):2252–2256.
   PubMed Web of Science ®Google Scholar
• Mytilineos D, Tsamadou C, Neuchel C, et al. The human leukocyte antigen-DPB1 degree of compatibility is determined by its expression level and mismatch permissiveness: a German multicenter analysis. Front Immunol. 2020;11:614976.
   PubMed Web of Science ®Google Scholar