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Research Article

Targeted treatment for osteoarthritis: drugs and delivery system

, , , , , , & show all
Pages 1861-1876 | Received 16 Jul 2021, Accepted 16 Aug 2021, Published online: 13 Sep 2021

References

  • Abd-Allah H, Kamel AO, Sammour OA. (2016). Injectable long acting chitosan/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam: optimization and in vivo evaluation. Carbohydr Polym 149:263–73.
  • Aciksoz S, Akyuz A, Tunay S. (2017). The effect of self-administered superficial local hot and cold application methods on pain, functional status and quality of life in primary knee osteoarthritis patients. J Clin Nurs 26:5179–90.
  • Ackermann J, Merkely G, Shah N, Gomoll AH. (2019). Decreased graft thickness is associated with subchondral cyst formation after osteochondral allograft transplantation in the knee. Am J Sports Med 47:2123–9.
  • Ajuied A, Wong F, Smith C, et al. (2014). Anterior cruciate ligament injury and radiologic progression of knee osteoarthritis: a systematic review and meta-analysis. Am J Sports Med 42:2242–52.
  • Alessio N, Stellavato A, Aprile D, et al. (2021). Timely supplementation of hydrogels containing sulfated or unsulfated chondroitin and hyaluronic acid affects mesenchymal stromal cells commitment toward chondrogenic differentiation. Front Cell Dev Biol 9:641529.
  • Arunkumar P, Indulekha S, Vijayalakshmi S, Srivastava R. (2016a). Synthesis, characterizations, in vitro and in vivo evaluation of etoricoxib-loaded poly (caprolactone) microparticles – a potential intra-articular drug delivery system for the treatment of osteoarthritis. J Biomater Sci Polym Ed 27:303–16.
  • Arunkumar P, Indulekha S, Vijayalakshmi S, Srivastava R. (2016b). Poly (caprolactone) microparticles and chitosan thermogels based injectable formulation of etoricoxib for the potential treatment of osteoarthritis. Mater Sci Eng C Mater Biol Appl 61:534–44.
  • Aziz DE, Abdelbary AA, Elassasy AI. (2018). Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation. Drug Deliv 25:815–26.
  • Bacon K, LaValley MP, Jafarzadeh SR, Felson D. (2020). Does cartilage loss cause pain in osteoarthritis and if so, how much? Ann Rheum Dis 79:1105–10.
  • Bajpayee AG, De la Vega RE, Scheu M, et al. (2017). Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis. Eur Cell Mater 34:341–64.
  • Bajpayee AG, Quadir MA, Hammond PT, Grodzinsky AJ. (2016). Charge based intra-cartilage delivery of single dose dexamethasone using avidin nano-carriers suppresses cytokine-induced catabolism long term. Osteoarthr Cartil 24:71–81.
  • Bannuru RR, Osani MC, Vaysbrot EE, et al. (2019). OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr Cartil 27:1578–89.
  • Bartels EM, Bliddal H, Schøndorff PK, et al. (2010). Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials. Osteoarthr Cartil 18:289–96.
  • Becker SJ, Bot AG, Curley SE, et al. (2013). A prospective randomized comparison of neoprene vs. thermoplast hand-based thumb spica splinting for trapeziometacarpal arthrosis. Osteoarthr Cartil 21:668–75.
  • Berenbaum F, Wallace IJ, Lieberman DE, Felson DT. (2018). Modern-day environmental factors in the pathogenesis of osteoarthritis. Nat Rev Rheumatol 14:674–81.
  • Berry H, Bird HA, Black C, et al. (1992). A double blind, multicentre, placebo controlled trial of lornoxicam in patients with osteoarthritis of the hip and knee. Ann Rheum Dis 51:238–42.
  • Bexkens R, van Bergen CJA, van den Bekerom MPJ, et al. (2018). Decreased defect size and partial restoration of subchondral bone on computed tomography after arthroscopic debridement and microfracture for osteochondritis dissecans of the capitellum. Am J Sports Med 46:2954–9.
  • Bhatti FUR, Hasty KA, Cho H. (2019). Anti-inflammatory role of TPCA-1 encapsulated nanosomes in porcine chondrocytes against TNF-α stimulation. Inflammopharmacology 27:1011–9.
  • Bijlsma JW, Berenbaum F, Lafeber FP. (2011). Osteoarthritis: an update with relevance for clinical practice. Lancet 377:2115–26.
  • Bishnoi M, Jain A, Hurkat P, Jain SK. (2014). Aceclofenac-loaded chondroitin sulfate conjugated SLNs for effective management of osteoarthritis. J Drug Target 22:805–12.
  • Blagojevic M, Jinks C, Jeffery A, Jordan KP. (2010). Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthr Cartil 18:24–33.
  • Bodkin SG, Werner BC, Slater LV, Hart JM. (2020). Post-traumatic osteoarthritis diagnosed within 5 years following ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 28:790–6.
  • Bruyère O, Cooper C, Pelletier JP, et al. (2014). An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum 44:253–63.
  • Carlier Y, Desmoineaux P, Lenoir H, Vidil A. (2019). Prospective comparative analysis of arthroscopic debridement for primary and post-traumatic elbow osteoarthritis. Orthop Traumatol Surg Res 105:S217–s220.
  • Carlier Y, Lenoir H, Rouleau DM, et al. (2019). Arthroscopic debridement for osteoarthritis of the elbow: results and analysis of predictive factors. Orthop Traumatol Sur Res 105:S221–S7.
  • Chan FK, Lanas A, Scheiman J, et al. (2010). Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 376:173–9.
  • Chan FKL, Ching JYL, Tse YK, et al. (2017). Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet 389:2375–82.
  • Chen CY, Li C, Ke CJ, et al. (2021). Kartogenin enhances chondrogenic differentiation of MSCs in 3D tri-copolymer scaffolds and the self-designed bioreactor system. Biomolecules 11.
  • Chen H, Qin Z, Zhao J, et al. (2019). Cartilage-targeting and dual MMP-13/pH responsive theranostic nanoprobes for osteoarthritis imaging and precision therapy. Biomaterials 225:119520.
  • Chen X, Liu Y, Wen Y, et al. (2019). A photothermal-triggered nitric oxide nanogenerator combined with siRNA for precise therapy of osteoarthritis by suppressing macrophage inflammation. Nanoscale 11:6693–709.
  • Cheng YH, Chavez E, Tsai KL, et al. (2017). Effects of thermosensitive chitosan-gelatin based hydrogel containing glutathione on Cisd2-deficient chondrocytes under oxidative stress. Carbohydr Polym 173:17–27.
  • Crawford ZT, Schumaier AP, Glogovac G, Grawe BM. (2019). Return to sport and sports-specific outcomes after osteochondral allograft transplantation in the knee: a systematic review of studies with at least 2 years’ mean follow-up. Arthroscopy 35:1880–9.
  • Davies NM, McLachlan AJ, Day RO, Williams KM. (2000). Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet 38:225–42.
  • de Oliveira Melo M, Pompeo KD, Baroni BM, Vaz MA. (2016). Effects of neuromuscular electrical stimulation and low-level laser therapy on neuromuscular parameters and health status in elderly women with knee osteoarthritis: a randomized trial. J Rehabil Med 48:293–9.
  • Dwivedi P, Nayak V, Kowshik M. (2015). Role of gold nanoparticles as drug delivery vehicles for chondroitin sulfate in the treatment of osteoarthritis. Biotechnol Prog 31:1416–22.
  • Ekman E, Mäkelä K, Kohonen I, et al. (2018). Favourable long-term functional and radiographical outcome after osteoautograft transplantation surgery of the knee: a minimum 10-year follow-up. Knee Surg Sports Traumatol Arthrosc 26:3560–5.
  • El-Gogary RI, Khattab MA, Abd-Allah H. (2020). Intra-articular multifunctional celecoxib loaded hyaluronan nanocapsules for the suppression of inflammation in an osteoarthritic rat model. Int J Pharm 583:119378.
  • El-Say KM, Abd-Allah FI, Lila AE, et al. (2016). Diacerein niosomal gel for topical delivery: development, in vitro and in vivo assessment. J Liposome Res 26:57–68.
  • Eltobshi AA, Mohamed EA, Abdelghani GM, Nouh AT. (2018). Self-nanoemulsifying drug-delivery systems for potentiated anti-inflammatory activity of diacerein. IJN 13:6585–602.
  • Fattahpour S, Shamanian M, Tavakoli N, et al. (2020). An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles. Int J Biol Macromol 151:220–9.
  • Frank RM, Cotter EJ, Lee S, et al. (2018). Do outcomes of osteochondral allograft transplantation differ based on age and sex? A comparative matched group analysis. Am J Sports Med 46:181–91.
  • Frank RM, Lee S, Levy D, et al. (2017). Osteochondral allograft transplantation of the knee: analysis of failures at 5 years. Am J Sports Med 45:864–74.
  • Fu K, Robbins SR, McDougall JJ. (2018). Osteoarthritis: the genesis of pain. Rheumatology 57:iv43–50.
  • Furia JP. (2010). Arthroscopic debridement and synovectomy for treating basal joint arthritis. Arthroscopy 26:34–40.
  • Geiger BC, Wang S, Padera RF, Jr, et al. (2018). Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis. Sci Transl Med 10:eaat8800.
  • Glyn-Jones S, Palmer AJ, Agricola R, et al. (2015). Osteoarthritis. Lancet 386:376–87.
  • Gomes Carreira AC, Jones A, Natour J. (2010). Assessment of the effectiveness of a functional splint for osteoarthritis of the trapeziometacarpal joint on the dominant hand: a randomized controlled study. J Rehabil Med 42:469–74.
  • Gómez-Gaete C, Retamal M, Chávez C, et al. (2017). Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis. Eur J Pharm Sci 96:390–7.
  • Ha W, Wang ZH, Zhao XB, Shi YP. (2021). Reinforced supramolecular hydrogels from attapulgite and cyclodextrin pseudopolyrotaxane for sustained intra-articular drug delivery. Macromol Biosci 21:e2000299.
  • Hall PE, Derry S, Moore RA, McQuay HJ. (2009). Single dose oral lornoxicam for acute postoperative pain in adults. Cochrane Database Syst Rev 2009:CD007441.
  • Hamza YE-S, Aburahma MH. (2009). Design and in vitro evaluation of novel sustained-release double-layer tablets of lornoxicam: utility of cyclodextrin and xanthan gum combination. AAPS PharmSciTech 10:1357–67.
  • Hattori K, Heissig B, Tashiro K, et al. (2001). Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 97:3354–60.
  • Henrotin Y, Mathy M, Sanchez C, Lambert C. (2010). Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis 2:335–48.
  • Hernandez PA, Wells J, Usheva E, et al. (2020). Early-onset osteoarthritis originates at the chondrocyte level in hip dysplasia. Sci Rep 10:627.
  • He T, Zhang C, Vedadghavami A, et al. (2020). Multi-arm avidin nano-construct for intra-cartilage delivery of small molecule drugs. J Controlled Release 318:109–23.
  • He Y, Wu Z, Xu L, et al. (2020). The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis. Cell Mol Life Sci 77:3729–43.
  • Hochberg MC, Martel-Pelletier J, Monfort J, et al. (2016). Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Ann Rheum Dis 75:37–44.
  • Hochberg MC, Altman RD, April KT, et al. (2012). American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res 64:465–74.
  • Hsu BB, Park MH, Hagerman SR, Hammond PT. (2014). Multimonth controlled small molecule release from biodegradable thin films. Proc Natl Acad Sci U S A 111:12175–80.
  • Hu Q, Ding B, Yan X, et al. (2017). Polyethylene glycol modified PAMAM dendrimer delivery of kartogenin to induce chondrogenic differentiation of mesenchymal stem cells. Nanomedicine 13:2189–98.
  • Hügle T, Geurts J. (2017). What drives osteoarthritis? Synovial versus subchondral bone pathology. Rheumatology 56:1461–71.
  • Jain A, Singh R, Singh S, Singh S. (2015). Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats. J Biomed Res 29:405–13.
  • Jain A, Singh SK, Singh Y, Singh S. (2013). Development of lipid nanoparticles of diacerein, an antiosteoarthritic drug for enhancement in bioavailability and reduction in its side effects. J Biomed Nanotechnol 9:891–900.
  • Janssen M, Timur UT, Woike N, et al. (2016). Celecoxib-loaded PEA microspheres as an auto regulatory drug-delivery system after intra-articular injection. J Control Release 244:30–40.
  • Jiang T, Petersen RR, Call G, et al. (2011). Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis. J Biomed Mater Res B Appl Biomater 97:355–63.
  • Jones A, Silva PG, Silva AC, et al. (2012). Impact of cane use on pain, function, general health and energy expenditure during gait in patients with knee osteoarthritis: a randomised controlled trial. Ann Rheum Dis 71:172–9.
  • Jung JH, Kim SE, Kim HJ, et al. (2020). A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. Int J Pharm 581:119249.
  • Kamel R, Salama AH, Mahmoud AA. (2016). Development and optimization of self-assembling nanosystem for intra-articular delivery of indomethacin. Int J Pharm 515:657–68.
  • Kang ML, Kim JE, Im GI. (2016). Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis. Acta Biomater 39:65–78.
  • Kawanami T, LaBonte LR, Amin J, et al. (2020). A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers. Int J Pharm 585:119519.
  • Kidd B, Frenzel W. (1996). A multicenter, randomized, double blind study comparing lornoxicam with diclofenac in osteoarthritis. J Rheumatol 23:1605–11.
  • Kim C, Nevitt M, Guermazi A, et al. (2018). Brief report: leg length inequality and hip osteoarthritis in the multicenter osteoarthritis study and the osteoarthritis initiative. Arthritis Rheumatol 70:1572–6.
  • Kirkley A, Birmingham TB, Litchfield RB, et al. (2008). A randomized trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 359:1097–107.
  • Kolasinski SL, Neogi T, Hochberg MC, et al. (2020). 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol 72:220–33.
  • Kulkarni K, Karssiens T, Kumar V, Pandit H. (2016). Obesity and osteoarthritis. Maturitas 89:22–8.
  • Lan Q, Lu R, Chen H, et al. (2020). MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis. J Nanobiotechnology 18:117.
  • Langella LG, Casalechi HL, Tomazoni SS, et al. (2018). Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty – a randomized, triple-blind, placebo-controlled clinical trial. Lasers Med Sci 33:1933–40.
  • Lee YK, Kim SW, Park JY, et al. (2017). Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential. Int J Nanomedicine 12:5761–79.
  • Li L, Yang X, Yang L, et al. (2019). Biomechanical analysis of the effect of medial meniscus degenerative and traumatic lesions on the knee joint. Am J Transl Res 11:542–56.
  • Li Z, Zhao S, Wang H, et al. (2019). Functional groups influence and mechanism research of UiO-66-type metal-organic frameworks for ketoprofen delivery. Colloids Surf B Biointerfaces 178:1–7.
  • Lin LL, Li YT, Tu JF, et al. (2018). Effectiveness and feasibility of acupuncture for knee osteoarthritis: a pilot randomized controlled trial. Clin Rehabil 32:1666–75.
  • Lin LL, Tu JF, Wang LQ, et al. (2020). Acupuncture of different treatment frequencies in knee osteoarthritis: a pilot randomised controlled trial. Pain 161:2532–8.
  • Liu P, Gu L, Ren L, et al. (2019). Intra-articular injection of etoricoxib-loaded PLGA-PEG-PLGA triblock copolymeric nanoparticles attenuates osteoarthritis progression. Am J Transl Res 11:6775–89.
  • Liu X, Corciulo C, Arabagian S, et al. (2019). Adenosine-Functionalized Biodegradable PLA-b-PEG nanoparticles ameliorate osteoarthritis in rats. Sci Rep 9:7430.
  • Liu Y, Ding W, Wang HL, et al. (2019). Gut microbiota and obesity-associated osteoarthritis. Osteoarthr Cartil 27:1257–65.
  • Lo Presti M, Costa GG, Grassi A, et al. (2020). Graft-preserving arthroscopic debridement with hardware removal is effective for septic arthritis after anterior cruciate ligament reconstruction: a clinical, arthrometric, and magnetic resonance imaging evaluation. Am J Sports Med 48:1907–15.
  • Loffredo FS, Pancoast JR, Cai L, et al. (2014). Targeted delivery to cartilage is critical for in vivo efficacy of insulin-like growth factor 1 in a rat model of osteoarthritis. Arthr Rheumatol 66:1247–55.
  • Lohberger B, Kaltenegger H, Weigl L, et al. (2019). Mechanical exposure and diacerein treatment modulates integrin-FAK-MAPKs mechanotransduction in human osteoarthritis chondrocytes. Cell Signal 56:23–30.
  • Lolli A, Sivasubramaniyan K, Vainieri ML, et al. (2019). Hydrogel-based delivery of antimiR-221 enhances cartilage regeneration by endogenous cells. J Control Release 309:220–30.
  • Luan X, Tian X, Zhang H, et al. (2019). Exercise as a prescription for patients with various diseases. J Sport Health Sci 8:422–41.
  • Lynch TS, O’Connor M, Minkara AA, et al. (2019). Biomarkers for femoroacetabular impingement and hip osteoarthritis: a systematic review and meta-analysis. Am J Sports Med 47:2242–50.
  • MacLean SB, Oni T, Crawford LA, Deshmukh SC. (2013). Medium-term results of arthroscopic debridement and capsulectomy for the treatment of elbow osteoarthritis. J Shoulder Elbow Surg 22:653–7.
  • Magri G, Selmin F, Cilurzo F, Fotaki N. (2019). Biorelevant release testing of biodegradable microspheres intended for intra-articular administration. Eur J Pharm Biopharm 139:115–22.
  • Martel-Pelletier J, Barr AJ, Cicuttini FM, et al. (2016). Osteoarthritis. Nat Rev Dis Primers 2:16072.
  • Maudens P, Seemayer CA, Thauvin C, et al. (2018). Nanocrystal-polymer particles: extended delivery carriers for osteoarthritis treatment. Small 14.
  • McAlindon TE, Bannuru RR, Sullivan MC, et al. (2014). OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil 22:363–88.
  • Misra D, Fielding RA, Felson DT, et al. (2019). Risk of knee osteoarthritis with obesity, sarcopenic obesity, and sarcopenia. Arthritis Rheumatol 71:232–7.
  • Mistry H, Metcalfe A, Smith N, et al. (2019). The cost-effectiveness of osteochondral allograft transplantation in the knee. Knee Surg Sports Traumatol Arthrosc 27:1739–53.
  • Moe RH, Fernandes L, Osterås N. (2012). Daily use of a cane for two months reduced pain and improved function in patients with knee osteoarthritis. J Physiother 58:128.
  • Moseley JB, O’Malley K, Petersen NJ, et al. (2002). A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 347:81–8.
  • Muthuri SG, McWilliams DF, Doherty M, Zhang W. (2011). History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies. Osteoarthr Cartil 19:1286–93.
  • Nicoliche T, Maldonado DC, Faber J, Silva M. (2020). Evaluation of the articular cartilage in the knees of rats with induced arthritis treated with curcumin. PLOS One 15:e0230228.
  • Nishida K, Matsumoto T, Takayama K, et al. (2017). Remaining mild varus limb alignment leads to better clinical outcome in total knee arthroplasty for varus osteoarthritis. Knee Surg Sports Traumatol Arthrosc 25:3488–94.
  • Nissen SE, Yeomans ND, Solomon DH, et al. (2016). Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med 375:2519–29.
  • Okumu A, DiMaso M, Löbenberg R. (2009). Computer simulations using GastroPlus to justify a biowaiver for etoricoxib solid oral drug products. Eur J Pharm Biopharm 72:91–8.
  • Ouyang Z, Tan T, Liu C, et al. (2019). Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd2(CO3)3@PDA nanoparticles via TLR-2/NF-κB/Akt signaling. Biomaterials 205:50–63.
  • Pascual-Garrido C, Daley E, Verma NN, Cole BJ. (2017). A comparison of the outcomes for cartilage defects of the knee treated with biologic resurfacing versus focal metallic implants. Arthroscopy 33:364–73.
  • Pavelka K, Bruyère O, Cooper C, et al. (2016). Diacerein: benefits, risks and place in the management of osteoarthritis. an opinion-based report from the ESCEO. Drugs Aging 33:75–85.
  • Perni S, Prokopovich P. (2020). Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage. J Mater Chem B 8:5096–108.
  • Petit A, Sandker M, Müller B, et al. (2014). Release behavior and intra-articular biocompatibility of celecoxib-loaded acetyl-capped PCLA-PEG-PCLA thermogels. Biomaterials 35:7919–28.
  • Poulsen E, Goncalves GH, Bricca A, et al. (2019). Knee osteoarthritis risk is increased 4-6 fold after knee injury – a systematic review and meta-analysis. Br J Sports Med 53:1454–63.
  • Prieto-Alhambra D, Judge A, Javaid MK, et al. (2014). Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis 73:1659–64.
  • Puljak L, Marin A, Vrdoljak D, et al. (2017). Celecoxib for osteoarthritis. Cochrane Database Syst Rev 5:CD009865.
  • Rannou F, Dimet J, Boutron I, et al. (2009). Splint for base-of-thumb osteoarthritis: a randomized trial. Ann Intern Med 150:661–9.
  • Ratanavaraporn J, Soontornvipart K, Shuangshoti S, et al. (2017). Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model. Inflammopharmacology 25:211–21.
  • Reed GW, Abdallah MS, Shao M, et al. (2018). Effect of aspirin coadministration on the safety of celecoxib, naproxen, or ibuprofen. J Am Coll Cardiol 71:1741–51.
  • Rehman M, Madni A, Ihsan A, et al. (2015). Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior. Int J Nanomed 10:2805–14.
  • Reyes C, Leyland KM, Peat G, et al. (2016). Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study. Arthritis Rheumatol 68:1869–75.
  • Roseti L, Desando G, Cavallo C, et al. (2019). Articular cartilage regeneration in osteoarthritis. Cells 8:1305.
  • Rothenberg JB, Jayaram P, Naqvi U, et al. (2017). The role of low-intensity pulsed ultrasound on cartilage healing in knee osteoarthritis: a review. PM R 9:1268–77.
  • Rothrauff BB, Jorge A, de Sa D, et al. (2020). Anatomic ACL reconstruction reduces risk of post-traumatic osteoarthritis: a systematic review with minimum 10-year follow-up. Knee Surg Sports Traumatol Arthrosc 28:1072–84.
  • Rutjes AW, Jüni P, da Costa BR, et al. (2012). Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med 157:180–91.
  • Sacchetti C, Liu-Bryan R, Magrini A, et al. (2014). Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes. ACS Nano 8:12280–91.
  • Salama AH, Abdelkhalek AA, Elkasabgy NA. (2020). Etoricoxib-loaded bio-adhesive hybridized polylactic acid-based nanoparticles as an intra-articular injection for the treatment of osteoarthritis. Int J Pharm 578:119081.
  • Salgado C, Guénée L, Černý R, et al. (2020). Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation. Int J Pharm 589:119783.
  • Sharma L. (2021). Osteoarthritis of the knee. N Engl J Med 384:51–9.
  • Shep D, Khanwelkar C, Gade P, Karad S. (2019). Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials 20:214.
  • Shi GX, Tu JF, Wang TQ, et al. (2020). Effect of electro-acupuncture (EA) and manual acupuncture (MA) on markers of inflammation in knee osteoarthritis. JPR 13:2171–9.
  • Silverstein FE, Faich G, Goldstein JL, et al. (2000). Gastrointestinal toxicity with celecoxib vs. nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib long-term arthritis safety study. JAMA 284:1247–55.
  • Silverwood V, Blagojevic-Bucknall M, Jinks C, et al. (2015). Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthr Cartil 23:507–15.
  • Skelley NW, Namdari S, Chamberlain AM, et al. (2015). Arthroscopic debridement and capsular release for the treatment of shoulder osteoarthritis. Arthroscopy 31:494–500.
  • Solomon DH, Husni ME, Libby PA, et al. (2017). The risk of major NSAID toxicity with celecoxib, ibuprofen, or naproxen: a secondary analysis of the PRECISION trial. Am J Med 130:1415–22.e4.
  • Solomon DH, Husni ME, Wolski KE, et al. (2018). Differences in safety of nonsteroidal antiinflammatory drugs in patients with osteoarthritis and patients with rheumatoid arthritis: a randomized clinical trial. Arthritis Rheumatol 70:537–46.
  • Springer B, Bechler U, Waldstein W, et al. (2020). The influence of femoral and tibial bony anatomy on valgus OA of the knee. Knee Surg Sports Traumatol Arthrosc 28:2998–3006.
  • Stefani RM, Lee AJ, Tan AR, et al. (2020). Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair. Acta Biomater 102:326–40.
  • Stone KR, Pelsis JR, Na K, et al. (2017). Articular cartilage paste graft for severe osteochondral lesions of the knee: a 10- to 23-year follow-up study. Knee Surg Sports Traumatol Arthrosc 25:3824–33.
  • Suchaoin W, Bonengel S, Griessinger JA, et al. (2016). Novel bioadhesive polymers as intra-articular agents: chondroitin sulfate-cysteine conjugates. Eur J Pharm Biopharm 101:25–32.
  • Sulistio A, Reyes-Ortega F, D’Souza AM, et al. (2017). Precise control of drug loading and release of an NSAID-polymer conjugate for long term osteoarthritis intra-articular drug delivery. J Mater Chem B 5:6221–6.
  • Tellegen AR, Rudnik-Jansen I, Pouran B, et al. (2018). Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis. Drug Deliv 25:1438–47.
  • Thompson CL, Patel R, Kelly TA, et al. (2015). Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. Arthritis Res Ther 17:373.
  • Tu JF, Yang JW, Shi GX, et al. (2021). Efficacy of intensive acupuncture versus sham acupuncture in knee osteoarthritis: a randomized controlled trial. Arthritis Rheumatol 73:448–58.
  • van Midwoud PM, Sandker M, Hennink WE, et al. (2018). In vivo pharmacokinetics of celecoxib loaded endcapped PCLA-PEG-PCLA thermogels in rats after subcutaneous administration. Eur J Pharm Biopharm 131:170–7.
  • Villamagna IJ, Gordon TN, Hurtig MB, et al. (2019). Poly(ester amide) particles for controlled delivery of celecoxib. J Biomed Mater Res A 107:1235–43.
  • Wallace IJ, Worthington S, Felson DT, et al. (2017). Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci U S A 114:9332–6.
  • Wang C, Yan L, Yan B, et al. (2019). Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis. J Ethnopharmacol 231:545–54.
  • Wang LJ, Zeng N, Yan ZP, et al. (2020). Post-traumatic osteoarthritis following ACL injury. Arthritis Res Ther 22:57.
  • Wang S, Wei X, Sun X, et al. (2018). A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system. Int J Nanomedicine 13:617–31.
  • Wang T, He C. (2018). Pro-inflammatory cytokines: the link between obesity and osteoarthritis. Cytokine Growth Factor Rev 44:38–50.
  • Wang TQ, Li YT, Wang LQ, et al. (2020). Electroacupuncture versus manual acupuncture for knee osteoarthritis: a randomized controlled pilot trial. Acupunct Med 38:291–300.
  • Wu Y, Wang Z, Lin Z, et al. (2020). Salvianolic acid a has anti-osteoarthritis effect in vitro and in vivo. Front Pharmacol 11:682.
  • Wyles CC, Heidenreich MJ, Jeng J, et al. (2017). The John Charnley award: redefining the natural history of osteoarthritis in patients with hip dysplasia and impingement. Clin Orthop Related Res 475:336–50.
  • Xu J, She G, Gui T, et al. (2020). Knee muscle atrophy is a risk factor for development of knee osteoarthritis in a rat model. J Orthop Translat 22:67–72.
  • Xu X, Liang Y, Li X, et al. (2021). Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration. Biomaterials 269:120539.
  • Xu X, Lv H, Li X, et al. (2017). Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro. Biochem Cell Biol 95:644–51.
  • Yan H, Duan X, Pan H, et al. (2019). Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery. Sci Rep 9:442.
  • Yeomans ND, Graham DY, Husni ME, et al. (2018). Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial. Aliment Pharmacol Ther 47:1453–63.
  • Yu Y, Brouillette MJ, Seol D, et al. (2015). Use of recombinant human stromal cell-derived factor 1α-loaded fibrin/hyaluronic acid hydrogel networks to achieve functional repair of full-thickness bovine articular cartilage via homing of chondrogenic progenitor cells. Arthritis Rheumatol 67:1274–85.
  • Zavgorodnya O, Carmona-Moran CA, Kozlovskaya V, et al. (2017). Temperature-responsive nanogel multilayers of poly(N-vinylcaprolactam) for topical drug delivery. J Colloid Interface Sci 506:589–602.
  • Zeggini E, Panoutsopoulou K, Southam L, et al. (2012). Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380:815–23.
  • Zhang K, Yang J, Sun Y, et al. (2020). Thermo-sensitive dual-functional nanospheres with enhanced lubrication and drug delivery for the treatment of osteoarthritis. Chemistry 26:10564–74.
  • Zhang R, Zhang Q, Zou Z, et al. (2021). Curcumin supplementation enhances bone marrow mesenchymal stem cells to promote the anabolism of articular chondrocytes and cartilage repair. Cell Transplant 30:963689721993776.
  • Zhang R, Fang H, Chen Y, et al. (2012). Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray. PLOS One 7:e32356.
  • Zhang Z, Huang G. (2012). Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis. Drug Deliv 19:255–63.
  • Zhang Z, Leong DJ, Xu L, et al. (2016). Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther 18:128.
  • Zhao C, Liu Q, Wang K. (2017). Artesunate attenuates ACLT-induced osteoarthritis by suppressing osteoclastogenesis and aberrant angiogenesis. Biomed Pharmacother 96:410–6.
  • Zhao Y, Teng B, Sun X, et al. (2020). Synergistic effects of kartogenin and transforming growth factor-β3 on chondrogenesis of human umbilical cord mesenchymal stem cells in vitro. Orthop Surg 12:938–45.
  • Zhong C, Feng J, Lin X, Bao Q. (2017). Continuous release of bone morphogenetic protein-2 through nano-graphene oxide-based delivery influences the activation of the NF-κB signal transduction pathway. IJN Volume 12:1215–26.
  • Zhou M, Lozano N, Wychowaniec JK, et al. (2019). Graphene oxide: a growth factor delivery carrier to enhance chondrogenic differentiation of human mesenchymal stem cells in 3D hydrogels. Acta Biomater 96:271–80.
  • Zhou Y, Ming J, Deng M, et al. (2020). Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med 98:1479–91.