A Systematic Review on Anti-diabetic and Cardioprotective Potential of Gallic Acid: A Widespread Dietary Phytoconstituent

References

• Einarson, T. R.; Acs, A.; Ludwig, C.; Panton, U. H. Prevalence of Cardiovascular Disease in Type 2 Diabetes: A Systematic Literature Review of Scientific Evidence from across the World in 2007-2017. Cardiovasc. Diabetol. 2018, 17(1), 83. DOI: https://doi.org/10.1186/s12933-018-0728-6.
   PubMed Web of Science ®Google Scholar
• Global Health Estimates. Disease Burden by Cause, Age, Sex, by Country and by Region, 2000-2016; World Health Organization: Geneva, 2016.
   Google Scholar
• Danaei, G.; Finucane, M. M.; Lu, Y.; Singh, G. M.; Cowan, M. J.; Paciorek, C. J.; Lin, J. K.; Farzadfar, F.; Khang, Y. H.; Stevens, G. A. National, Regional, and Global Trends in Fasting Plasma Glucose and Diabetes Prevalence since 1980: Systematic Analysis of Health Examination Surveys and Epidemiological Studies with 370 Country-Years and 2· 7 Million Participants. Lancet. 2011, 378(9785), 31–40. DOI: https://doi.org/10.1016/S0140-6736(11)60679-X.
   PubMed Web of Science ®Google Scholar
• Leon, B. M.; Maddox, T. M. Diabetes and Cardiovascular Disease: Epidemiology, Biological Mechanisms, Treatment Recommendations and Future Research. World J. Diabetes. 2015, 6(13), 1246–1258. DOI: https://doi.org/10.4239/wjd.v6.i13.1246.
   PubMed Web of Science ®Google Scholar
• Wahren, J.; Felig, P.; Cerasi, E.; Luft, R. Splanchnic and Peripheral Glucose and Amino Acid Metabolism in Diabetes Mellitus. J. Clin. Invest. 1972, 51(7), 1870–1878. DOI: https://doi.org/10.1172/JCI106989.
   PubMed Web of Science ®Google Scholar
• Moree, S. S.; Kavishankar, G.; Rajesha, J. Antidiabetic Effect of Secoisolariciresinol Diglucoside in Streptozotocin-Induced Diabetic Rats. Phytomedicine. 2013, 20(3–4), 237–245. DOI: https://doi.org/10.1016/j.phymed.2012.11.011.
   PubMed Web of Science ®Google Scholar
• Battiprolu, P. K.; Gillette, T. G.; Wang, Z. V.; Lavandero, S.; Hill, J. A. Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets. Drug Discov.Today. 2010, 7(2), 135–143. DOI: https://doi.org/10.1016/j.ddmec.2010.08.001.
   Google Scholar
• Singh, V. P.; Bali, A.; Singh, A.; Jaggi, A. S. Advanced Glycation End Products and Diabetic Complications. Korean J. Physiol. Pharmacol. 2014, 18(1), 1–14. DOI: https://doi.org/10.4196/kjpp.2014.18.1.1.
   PubMed Web of Science ®Google Scholar
• Iacobellis, G.; Ribaudo, M. C.; Zappaterreno, A.; Iannucci, C. V.; Leonetti, F. Relation between Epicardial Adipose Tissue and Left Ventricular Mass. Am. J. Cardiol. 2004, 94(8), 1084–1087. DOI: https://doi.org/10.1016/j.amjcard.2004.06.075.
   PubMed Web of Science ®Google Scholar
• Ahmed, N. Advanced Glycation Endproducts—Role in Pathology of Diabetic Complications. Diabetes Res. Clin. Pr. 2005, 67(1), 3–21. DOI: https://doi.org/10.1016/j.diabres.2004.09.004.
   PubMed Web of Science ®Google Scholar
• Graham, I.; Atar, D.; Borch-Johnsen, K.; Boysen, G.; Burell, G.; Cifkova, R.; Dallongeville, J.; De Backer, G.; Ebrahim, S.; Gjelsvik, B. European Guidelines on Cardiovascular Disease Prevention in Clinical Practice: Executive Summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by Representatives of Nine Societies and by Invited Experts). Eur. Heart J. 2007, 28(19), 2375–2414. DOI: https://doi.org/10.1093/eurheartj/ehm316.
   PubMed Web of Science ®Google Scholar
• Hemingway, R. W.; Laks, P. E. Plant Polyphenols: Synthesis, Properties, Significance; Springer Science & Business Media, 2012, Plenum Press, New York.
   Google Scholar
• Pandurangan, A. K.; Mohebali, N.; Norhaizan, M. E.; Looi, C. Y. Gallic Acid Attenuates Dextran Sulfate Sodium-Induced Experimental Colitis in Balb/C Mice. Drug Des. Dev. Ther. 2015, 9, 3923. DOI: https://doi.org/10.2147/DDDT.S86345.
   PubMed Web of Science ®Google Scholar
• Koyama, K.; Goto-Yamamoto, N.; Hashizume, K. Influence of Maceration Temperature in Red Wine Vinification on Extraction of Phenolics from Berry Skins and Seeds of Grape (Vitis Vinifera). Biosci. Biotech. Bioch. 2007, 71(4), 958–965. DOI: https://doi.org/10.1271/bbb.60628.
   PubMed Web of Science ®Google Scholar
• Hodgson, J. M.; Morton, L. W.; Puddey, I. B.; Beilin, L. J.; Croft, K. D. Gallic Acid Metabolites are Markers of Black Tea Intake in Humans. J. Agr. Food Chem. 2000, 48(6), 2276–2280. DOI: https://doi.org/10.1021/jf000089s.
   PubMed Web of Science ®Google Scholar
• Pathak, S.; Niranjan, K.; Padh, H.; Rajani, M. TLC Densitometric Method for the Quantification of Eugenol and Gallic Acid in Clove. Chromatographia. 2004, 60(3–4), 241–244. DOI: https://doi.org/10.1365/s10337-004-0373-y.
   Web of Science ®Google Scholar
• Gálvez, M. C.; Barroso, C. G.; Pérez-Bustamante, J. A. Analysis of Polyphenolic Compounds of Different Vinegar Samples. Z. Lebensmittel-Untersuchung Forsch. 1994, 199(1), 29–31. DOI: https://doi.org/10.1007/BF01192948.
   Google Scholar
• Madlener, S.; Illmer, C.; Horvath, Z.; Saiko, P.; Losert, A.; Herbacek, I.; Grusch, M.; Elford, H. L.; Krupitza, G.; Bernhaus, A. Gallic Acid Inhibits Ribonucleotide Reductase and Cyclooxygenases in Human Hl-60 Promyelocytic Leukemia Cells. Cancer Lett. 2007, 245(1–2), 156–162. DOI: https://doi.org/10.1016/j.canlet.2006.01.001.
   PubMed Web of Science ®Google Scholar
• Pal, S. M.; Avneet, G.; Siddhraj, S. S. Gallic Acid: Pharamcological Promising Lead Molecule: A Review. Int. J. Pharmacog. Phytochem. Res. 2018, 10(4), 132–138.
   Google Scholar
• Roberts, A. T.; Martin, C. K.; Liu, Z.; Amen, R. J.; Woltering, E. A.; Rood, J. C.; Caruso, M. K.; Yu, Y.; Xie, H.; Greenway, F. L. The Safety and Efficacy of a Dietary Herbal Supplement and Gallic Acid for Weight Loss. J. Med. Food. 2007, 10(1), 184–188. DOI: https://doi.org/10.1089/jmf.2006.272.
   PubMed Web of Science ®Google Scholar
• Mämmelä, P.; Savolainen, H.; Lindroos, L.; Kangas, J.; Vartiainen, T. Analysis of Oak Tannins by Liquid Chromatography-Electrospray Ionisation Mass Spectrometry. J. Chromatogr. A. 2000, 891(1), 75–83. DOI: https://doi.org/10.1016/S0021-9673(00)00624-5.
   PubMed Web of Science ®Google Scholar
• Alemika, T. E.; Onawunmi, G. O.; Olugbade, T. Antibacterial Phenolics from Boswellia Dalzielii. Nigerian J. Nat. Prod. Med. 2006, 10(1), 108–110.
   Google Scholar
• Chanwitheesuk, A.; Teerawutgulrag, A.; Kilburn, J. D.; Rakariyatham, N. Antimicrobial Gallic Acid from Caesalpinia Mimosoides Lamk. Food Chem. 2007, 100(3), 1044–1048. DOI: https://doi.org/10.1016/j.foodchem.2005.11.008.
   Web of Science ®Google Scholar
• Borde, V.; Pangrikar, P.; Tekale, S. Gallic Acid in Ayurvedic Herbs and Formulations. Rec. Res. Sci.Tech. 2011, 3(7), 51-54.
   Google Scholar
• Samad, N.; Javed, A. Therapeutic Effects of Gallic Acid: Current Scenario. J. Phytochem. Biochem. 2018, 2, 113.
   Google Scholar
• Latha, R. C. R.; Daisy, P. Insulin-secretagogue, Antihyperlipidemic and Other Protective Effects of Gallic Acid Isolated from Terminalia Bellerica Roxb. In Streptozotocin-induced Diabetic Rats. Chem-Biol. Interact. 2011, 189(1–2), 112–118. DOI: https://doi.org/10.1016/j.cbi.2010.11.005.
   PubMed Web of Science ®Google Scholar
• Al-Salih, R. M. Clinical Experimental Evidence: Synergistic Effect of Gallic Acid and Tannic Acid as Antidiabetic and Antioxidant Agents. Thi-Qar Med. J. 2010, 4(4), 109–119.
   Google Scholar
• Priscilla, D. H.; Prince, P. S. M. Cardioprotective Effect of Gallic Acid on Cardiac Troponin-T, Cardiac Marker Enzymes, Lipid Peroxidation Products and Antioxidants in Experimentally Induced Myocardial Infarction in Wistar Rats. Chem-Biol. Interact. 2009, 179(2–3), 118–124. DOI: https://doi.org/10.1016/j.cbi.2008.12.012.
   PubMed Web of Science ®Google Scholar
• Prince, P. S. M.; Priscilla, H.; Devika, P. T. Gallic Acid Prevents Lysosomal Damage in Isoproterenol Induced Cardiotoxicity in Wistar Rats. Eur. J. Pharmacol. 2009, 615(1–3), 139–143. DOI: https://doi.org/10.1016/j.ejphar.2009.05.003.
   PubMed Web of Science ®Google Scholar
• Sevgi, K.; Tepe, B.; Sarikurkcu, C. Antioxidant and DNA Damage Protection Potentials of Selected Phenolic Acids. Food Chem. Toxicol. 2015, 77, 12–21. DOI: https://doi.org/10.1016/j.fct.2014.12.006.
   PubMed Web of Science ®Google Scholar
• Chamorro, S.; Viveros, A.; Alvarez, I.; Vega, E.; Brenes, A. Changes in Polyphenol and Polysaccharide Content of Grape Seed Extract and Grape Pomace after Enzymatic Treatment. Food Chem. 2012, 133(2), 308–314. DOI: https://doi.org/10.1016/j.foodchem.2012.01.031.
   PubMed Web of Science ®Google Scholar
• Dianat, M.; Sadeghi, N.; Badavi, M.; Panahi, M.; Moghadam, M. T. Protective Effects of Co-Administration of Gallic Acid and Cyclosporine on Rat Myocardial Morphology against Ischemia/Reperfusion. Jundishapur J. Nat. Pharma. Prod. 2014, 9(4), e17186 (1-6).
   Google Scholar
• Rehman, M. U.; Tahir, M.; Ali, F.; Qamar, W.; Lateef, A.; Khan, R.; Quaiyoom, A.; Sultana, S. Cyclophosphamide-Induced Nephrotoxicity, Genotoxicity, and Damage in Kidney Genomic Dna of Swiss Albino Mice: The Protective Effect of Ellagic Acid. Mol. Cell. Biochem. 2012, 365(1–2), 119–127.
   PubMed Web of Science ®Google Scholar
• Singh, J. P.; Singh, A. P.; Bhatti, R. Explicit Role of Peroxisome Proliferator–Activated Receptor Gamma in Gallic Acid–Mediated Protection against Ischemia-Reperfusion–Induced Acute Kidney Injury in Rats. J. Surg. Res. 2014, 187(2), 631–639. DOI: https://doi.org/10.1016/j.jss.2013.11.1088.
   PubMed Web of Science ®Google Scholar
• Palipoch, S. A Review of Oxidative Stress in Acute Kidney Injury: Protective Role of Medicinal Plants-Derived Antioxidants. African J. Trad. Complement. Alter. Med. 2013, 10(4), 88–93.
   PubMedGoogle Scholar
• Kim, D. O.; Lee, K. W.; Lee, H. J.; Lee, C. Y. Vitamin C Equivalent Antioxidant Capacity (VCEAC) of Phenolic Phytochemicals. J. Agri. Food Chem. 2002, 50(13), 3713–3717. DOI: https://doi.org/10.1021/jf020071c.
   PubMed Web of Science ®Google Scholar
• Kahkeshani, N.; Farzaei, F.; Fotouhi, M.; Alavi, S. S.; Bahramsoltani, R.; Naseri, R.; Momtaz, S.; Abbasabadi, Z.; Rahimi, R.; Farzaei, M. H.; et al. Pharmacological Effects of Gallic Acid in Health and Disease: A Mechanistic review. Iranian J.Basic Med. Sci. 2019, 22(3), 225–237.
   PubMed Web of Science ®Google Scholar
• Volpe, C. M. O.; Villar-Delfino, P. H.; Dos Anjos, P. M. F.; Nogueira-Machado, J. A. Cellular Death, Reactive Oxygen Species (Ros) and Diabetic Complications. Cell Death Dis. 2018, 9(2), 119. DOI: https://doi.org/10.1038/s41419-017-0135-z.
   PubMed Web of Science ®Google Scholar
• Farkhondeh, T.; Samarghandian, S.; Borji, A. An Overview on Cardioprotective and Anti-Diabetic Effects of Thymoquinone. Asian Pac. J. Trop. Med. 2017, 10(9), 849–854. DOI: https://doi.org/10.1016/j.apjtm.2017.08.020.
   PubMed Web of Science ®Google Scholar
• Badhani, B.; Sharma, N.; Kakkar, R. Gallic Acid: A Versatile Antioxidant with Promising Therapeutic and Industrial Applications. RSC Adv. 2015, 5(35), 27540–27557. DOI: https://doi.org/10.1039/C5RA01911G.
   Web of Science ®Google Scholar
• Punithavathi, V. R.; Prince, P. S. M.; Kumar, R.; Selvakumari, J. Antihyperglycaemic, Antilipid Peroxidative and Antioxidant Effects of Gallic Acid on Streptozotocin Induced Diabetic Wistar Rats. Eur.J. Pharmacol. 2011, 650(1), 465–471. DOI: https://doi.org/10.1016/j.ejphar.2010.08.059.
   PubMed Web of Science ®Google Scholar
• Kade, I. J.; Ogunbolude, Y.; Kamdem, J. P.; Rocha, J. B. T. Influence of Gallic Acid on Oxidative Stress-Linked Streptozotocin-Induced Pancreatic Dysfunction in Diabetic Rats. J Basic Clin. Physiol. Pharmacol. 2014, 25(1), 35–45. DOI: https://doi.org/10.1515/jbcpp-2012-0062.
   PubMedGoogle Scholar
• Ramkumar, K.; Vijayakumar, R.; Vanitha, P.; Suganya, N.; Manjula, C.; Rajaguru, P.; Sivasubramanian, S.; Gunasekaran, P. Protective Effect of Gallic Acid on Alloxan-Induced Oxidative Stress and Osmotic Fragility in Rats. Human Exp.Toxicol. 2014, 33(6), 638–649. DOI: https://doi.org/10.1177/0960327113504792.
   PubMed Web of Science ®Google Scholar
• Bak, E. J.; Kim, J.; Jang, S.; Woo, G. H.; Yoon, H. G.; Yoo, Y. J.; Cha, J. H. Gallic Acid Improves Glucose Tolerance and Triglyceride Concentration in Diet-Induced Obesity Mice. Scand. J Clin. Lab. Invest. 2013, 73(8), 607–614. DOI: https://doi.org/10.3109/00365513.2013.831470.
   PubMed Web of Science ®Google Scholar
• Gandhi, G. R.; Jothi, G.; Antony, P. J.; Balakrishna, K.; Paulraj, M. G.; Ignacimuthu, S.; Stalin, A.; Al-Dhabi, N. A. Gallic Acid Attenuates High-Fat Diet Fed-Streptozotocin-Induced Insulin Resistance via Partial Agonism of PPARγ in Experimental Type 2 Diabetic Rats and Enhances Glucose Uptake through Translocation and Activation of Glut4 in PI3k/P-Akt Signaling Pathway. Eur. J. Pharmacol. 2014, 745, 201–216. DOI: https://doi.org/10.1016/j.ejphar.2014.10.044.
   PubMed Web of Science ®Google Scholar
• Abdel-Moneim, A.; El-Twab, S. M. A.; Yousef, A. I.; Reheim, E. S. A.; Ashour, M. B. Modulation of Hyperglycemia and Dyslipidemia in Experimental Type 2 Diabetes by Gallic Acid and p-Coumaric Acid: The Role of Adipocytokines and PPARγ. Biomed. Pharmacother. 2018, 105, 1091–1097. DOI: https://doi.org/10.1016/j.biopha.2018.06.096.
   PubMed Web of Science ®Google Scholar
• Doan, K. V.; Ko, C. M.; Kinyua, A. W.; Yang, D. J.; Choi, Y. H.; Oh, I. Y.; Nguyen, N. M.; Ko, A.; Choi, J. Y.; Jeong, Y. Gallic Acid Regulates Body Weight and Glucose Homeostasis through AMPK Activation. Endocrinol. 2015, 156(1), 157–168. DOI: https://doi.org/10.1210/en.2014-1354.
   PubMed Web of Science ®Google Scholar
• Vishnu Prasad, C.; Anjana, T.; Banerji, A.; Gopalakrishnapillai, A. Gallic Acid Induces Glut4 Translocation and Glucose Uptake Activity in 3T3‐L1 Cells. FEBS Lett. 2010, 584(3), 531–536. DOI: https://doi.org/10.1016/j.febslet.2009.11.092.
   PubMed Web of Science ®Google Scholar
• Adefegha, S. A.; Oboh, G.; Ejakpovi, I. I.; Oyeleye, S. I. Antioxidant and Antidiabetic Effects of Gallic and Protocatechuic Acids: A Structure–Function Perspective. Compar. Clin. Pathol. 2015, 24(6), 1579–1585. DOI: https://doi.org/10.1007/s00580-015-2119-7.
   Google Scholar
• Sameermahmood, Z.; Raji, L.; Saravanan, T.; Vaidya, A.; Mohan, V.; Balasubramanyam, M. Gallic Acid Protects RINm5F β‐Cells from Glucolipotoxicity by Its Aantiapoptotic and Insulin‐secretagogue Actions. Phytother. Res. 2010, 24(S1), S83–S94. DOI: https://doi.org/10.1002/ptr.2926.
   PubMed Web of Science ®Google Scholar
• Jayamani, J.; Shanmugam, G. Gallic Acid, One of the Components in Many Plant Tissues, Is a Potential Inhibitor for Insulin Amyloid Fibril Formation. Eur. J. Med. Chem. 2014, 85, 352–358. DOI: https://doi.org/10.1016/j.ejmech.2014.07.111.
   PubMed Web of Science ®Google Scholar
• Umadevi, S.; Gopi, V.; Simna, S.; Parthasarathy, A.; Yousuf, S.; Elangovan, V. Studies on the Cardio Protective Role of Gallic Acid against Age-Induced Cell Proliferation and Oxidative Stress in H9C2 (2-1) Cells. Cardiovas. Toxicol. 2012, 12(4), 304–311. DOI: https://doi.org/10.1007/s12012-012-9170-2.
   PubMed Web of Science ®Google Scholar
• Umadevi, S.; Gopi, V.; Vellaichamy, E. Inhibitory Effect of Gallic Acid on Advanced Glycation End Products Induced Up-Regulation of Inflammatory Cytokines and Matrix Proteins in H9C2 (2-1) Cells. Cardiovas. Toxicol. 2013, 13(4), 396–405. DOI: https://doi.org/10.1007/s12012-013-9222-2.
   PubMed Web of Science ®Google Scholar
• Jin, L.; Lin, M. Q.; Piao, Z. H.; Cho, J. Y.; Kim, G. R.; Choi, S. Y.; Ryu, Y.; Sun, S.; Kee, H. J.; Jeong, M. H. Gallic Acid Attenuates Hypertension, Cardiac Remodeling, and Fibrosis in Mice with NGg-Nitro-L-Arginine Methyl Ester-Induced Hypertension via Regulation of Histone Deacetylase 1 or Histone Deacetylase 2. J. Hypertens. 2017, 35(7), 1502–1512. DOI: https://doi.org/10.1097/HJH.0000000000001327.
   PubMed Web of Science ®Google Scholar
• Ryu, Y.; Jin, L.; Kee, H. J.; Piao, Z. H.; Cho, J. Y.; Kim, G. R.; Choi, S. Y.; Lin, M. Q.; Jeong, M. H. Gallic Acid Prevents Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis through Regulation of JNK2 Signaling and Smad3 Binding Activity. Sci. Rep. 2016, 6, 34790. DOI: https://doi.org/10.1038/srep34790.
   PubMed Web of Science ®Google Scholar
• Jin, L.; Piao, Z. H.; Sun, S.; Liu, B.; Kim, G. R.; Seok, Y. M.; Lin, M. Q.; Ryu, Y.; Choi, S. Y.; Kee, H. J. Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats. Sci. Rep. 2017, 7(1), 15607. DOI: https://doi.org/10.1038/s41598-017-15925-1.
   PubMed Web of Science ®Google Scholar
• Bhutia, Y.; Ghosh, A.; Sherpa, M. L.; Pal, R.; Mohanta, P. K. Serum Malondialdehyde Level: Surrogate Stress Marker in the Sikkimese Diabetics. J. Nat. Sci. Biol. Med. 2011, 2(1), 107–112. DOI: https://doi.org/10.4103/0976-9668.82309.
   PubMedGoogle Scholar
• Moller, D. E. The Mechanisms of Action of PPARs. Annu. Rev. Med. 2002, 53(1), 409–435. DOI: https://doi.org/10.1146/annurev.med.53.082901.104018.
   PubMed Web of Science ®Google Scholar
• Thangavel, N.; Al Bratty, M.; Akhtar Javed, S.; Ahsan, W.; Alhazmi, H. A. Targeting Peroxisome Proliferator-Activated Receptors Using Thiazolidinediones: Strategy for Design of Novel Antidiabetic Drugs. Int. J. Med. Chem. 2017, 2017, 20.
   Web of Science ®Google Scholar
• Lin, J.; Wu, H.; Tarr, P. T.; Zhang, C. Y.; Wu, Z.; Boss, O.; Michael, L. F.; Puigserver, P.; Isotani, E.; Olson, E. N.; et al. Transcriptional Co-Activator Pgc-1α Drives the Formation of Slow-Twitch Muscle Fibres. Nature. 2002, 418(6899), 797–801. DOI: https://doi.org/10.1038/nature00904.
   PubMed Web of Science ®Google Scholar
• Vats, D.; Mukundan, L.; Odegaard, J. I.; Zhang, L.; Smith, K. L.; Morel, C. R.; Greaves, D. R.; Murray, P. J.; Chawla, A. Oxidative Metabolism and Pgc-1beta Attenuate Macrophage-Mediated Inflammation. Cell Metab. 2006, 4(1), 13–24. DOI: https://doi.org/10.1016/j.cmet.2006.05.011.
   PubMed Web of Science ®Google Scholar
• Claret, M.; Smith, M. A.; Batterham, R. L.; Selman, C.; Choudhury, A. I.; Fryer, L. G. D.; Clements, M.; Al-Qassab, H.; Heffron, H.; Xu, A. W.; et al. AMPK Is Essential for Energy Homeostasis Regulation and Glucose Sensing by POMC and AgRP Neurons. J. Clin. Invest. 2007, 117(8), 2325–2336. DOI: https://doi.org/10.1172/JCI31516.
   PubMed Web of Science ®Google Scholar
• Moreno-Santos, I.; Pérez-Belmonte, L. M.; Macías-González, M.; Mataró, M. J.; Castellano, D.; López-Garrido, D.; Porras-Martín, C.; Sánchez-Fernández, P. L.; Gómez-Doblas, J. J.; Cardona, F.; et al. Type 2 Diabetes Is Associated with Decreased Pgc1α Expression in Epicardial Adipose Tissue of Patients with Coronary Artery Disease. J. Transl. Med. 2016, 14(1), 243. DOI: https://doi.org/10.1186/s12967-016-0999-1.
   PubMed Web of Science ®Google Scholar
• Sun, G.; Tarasov, A. I.; McGinty, J.; McDonald, A.; da Silva Xavier, G.; Gorman, T.; Marley, A.; French, P. M.; Parker, H.; Gribble, F.; et al. Ablation of AMP-Activated Protein Kinase α1 and α2 from Mouse Pancreatic Beta Cells and Rip2.Cre Neurons Suppresses Insulin Release. Vivo. Diabetol. 2010, 53(5), 924–936. DOI: https://doi.org/10.1007/s00125-010-1692-1.
   PubMed Web of Science ®Google Scholar
• Kurth-Kraczek, E. J.; Hirshman, M. F.; Goodyear, L. J.; Winder, W. W. 5ʹ AMP-Activated Protein Kinase Activation Causes Glut4 Translocation in Skeletal Muscle. Diabetes. 1999, 48(8), 1667–1671. DOI: https://doi.org/10.2337/diabetes.48.8.1667.
   PubMed Web of Science ®Google Scholar
• Jeon, S. M. Regulation and Function of AMPK in Physiology and Diseases. Exp. Mol. Med. 2016, 48(7), 245. DOI: https://doi.org/10.1038/emm.2016.81.
   PubMed Web of Science ®Google Scholar
• Lee, W. J.; Kim, M.; Park, H. S.; Kim, H. S.; Jeon, M. J.; Oh, K. S.; Koh, E. H.; Won, J. C.; Kim, M. S.; Oh, G. T.; et al. AMPK Activation Increases Fatty Acid Oxidation in Skeletal Muscle by Activating PPARalpha and PGC-1. Biochem. Biophys. Res. Commun. 2006, 340(1), 291–295. DOI: https://doi.org/10.1016/j.bbrc.2005.12.011.
   PubMed Web of Science ®Google Scholar
• Ojuka, E. O.; Nolte, L. A.; Holloszy, J. O. Increased Expression of Glut-4 and Hexokinase in Rat Epitrochlearis Muscles Exposed to AICAR in Vitro. J. Appl. Physiol. 2000, 88(3), 1072–1075. DOI: https://doi.org/10.1152/jappl.2000.88.3.1072.
   PubMed Web of Science ®Google Scholar
• Arsenijevic, D.; Onuma, H.; Pecqueur, C.; Raimbault, S.; Manning, B. S.; Miroux, B.; Couplan, E.; Alves-Guerra, M. C.; Goubern, M.; Surwit, R.; et al. Disruption of the Uncoupling Protein-2 Gene in Mice Reveals a Role in Immunity and Reactive Oxygen Species Production. Nat. Genet. 2000, 26(4), 435–439. DOI: https://doi.org/10.1038/82565.
   PubMed Web of Science ®Google Scholar
• Mailloux, R. J.; Harper, M. E. Uncoupling Proteins and the Control of Mitochondrial Reactive Oxygen Species Production. Free Rad. Biol. Med. 2011, 51(6), 1106–1115. DOI: https://doi.org/10.1016/j.freeradbiomed.2011.06.022.
   PubMed Web of Science ®Google Scholar
• Brand, M. D.; Esteves, T. C. Physiological Functions of the Mitochondrial Uncoupling Proteins UCP2 and UCP3. Cell Metab. 2005, 2(2), 85–93. DOI: https://doi.org/10.1016/j.cmet.2005.06.002.
   PubMed Web of Science ®Google Scholar
• Calegari, V. C.; Zoppi, C. C.; Rezende, L. F.; Silveira, L. R.; Carneiro, E. M.; Boschero, A. C. Endurance Training Activates AMP-Activated Protein Kinase, Increases Expression of Uncoupling Protein 2 and Reduces Insulin Secretion from Rat Pancreatic Islets. J. Endocrinol. 2011, 208(3), 257–264. DOI: https://doi.org/10.1530/JOE-10-0450.
   PubMed Web of Science ®Google Scholar
• Wang, S.; Song, P.; Zou, M. H. AMP-Activated Protein Kinase, Stress Responses and Cardiovascular Diseases. Clin. Sci. 2012, 122(12), 555–573. DOI: https://doi.org/10.1042/CS20110625.
   PubMed Web of Science ®Google Scholar
• Moris, D.; Spartalis, M.; Spartalis, E.; Karachaliou, G. S.; Karaolanis, G. I.; Tsourouflis, G.; Tsilimigras, D. I.; Tzatzaki, E.; Theocharis, S. The Role of Reactive Oxygen Species in the Pathophysiology of Cardiovascular Diseases and the Clinical Significance of Myocardial Redox. Ann. Transl. Med. 2017, 5(16), 326. DOI: https://doi.org/10.21037/atm.2017.06.27.
   PubMed Web of Science ®Google Scholar
• Kalofoutis, C.; Piperi, C.; Kalofoutis, A.; Harris, F.; Phoenix, D.; Singh, J. Type II Diabetes Mellitus and Cardiovascular Risk Factors: Current Therapeutic Approaches. Exp. Clin. Cardiol. 2007, 12(1), 17–28.
   PubMedGoogle Scholar
• Ansley, D. M.; Wang, B. Oxidative Stress and Myocardial Injury in the Diabetic Heart. J. Pathol. 2013, 229(2), 232–241. DOI: https://doi.org/10.1002/path.4113.
   PubMed Web of Science ®Google Scholar
• Boyer, N. M.; Laskey, W. K.; Cox, M.; Hernandez, A. F.; Peterson, E. D.; Bhatt, D. L.; Cannon, C. P.; Fonarow, G. C. Trends in Clinical, Demographic, and Biochemical Characteristics of Patients with Acute Myocardial Infarction from 2003 to 2008: A Report from the American Heart Association Get with the Guidelines Coronary Artery Disease Program. J. Am. Heart Assoc. 2012, 1(4), e001206.
   PubMed Web of Science ®Google Scholar
• Panth, N.; Paudel, K. R.; Parajuli, K. Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease. Adv. Med. 2016, 9152732.
   PubMedGoogle Scholar
• Ali, F.; Naqvi, S. A. S.; Bismillah, M.; Wajid, N. Comparative Analysis of Biochemical Parameters in Diabetic and Non-Diabetic Acute Myocardial Infarction Patients. Indian Heart J. 2016, 68(3), 325–331. DOI: https://doi.org/10.1016/j.ihj.2015.09.026.
   PubMedGoogle Scholar
• de Souza Bastos, A.; Graves, D. T.; de Melo Loureiro, A. P.; Júnior, C. R.; Corbi, S. C. T.; Frizzera, F.; Scarel-Caminaga, R. M.; Câmara, N. O.; Andriankaja, O. M.; Hiyane, M. I.; et al. Diabetes and Increased Lipid Peroxidation are Associated with Systemic Inflammation Even in Well-Controlled Patients. J. Diabetes Complications. 2016, 30(8), 1593–1599. DOI: https://doi.org/10.1016/j.jdiacomp.2016.07.011.
   PubMed Web of Science ®Google Scholar
• Aryaeian, N.; Sedehi, S. K.; Arablou, T. Polyphenols and Their Effects on Diabetes Management: A Review. Med. J. Islam Repub. Iran. 2017, 31, 134. DOI: https://doi.org/10.14196/mjiri.31.134.
   PubMedGoogle Scholar
• Tangney, C. C.; Rasmussen, H. E. Polyphenols, Inflammation, and Cardiovascular Disease. Curr. Atheroscler. Rep. 2013, 15(5), 324. DOI: https://doi.org/10.1007/s11883-013-0324-x.
   PubMed Web of Science ®Google Scholar
• Patel, S. S.; Goyal, R. K. Cardioprotective Effects of Gallic Acid in Diabetes-Induced Myocardial Dysfunction in Rats. Pharmacog. Res. 2011, 3(4), 239. DOI: https://doi.org/10.4103/0974-8490.89743.
   PubMedGoogle Scholar
• Kulkarni, J.; Swamy, A. V. Cardioprotective Effect of Gallic Acid against Doxorubicin-Induced Myocardial Toxicity in Albino Rats. Indian J. Health Sci. Biomed. Res. 2015, 8(1), 28. DOI: https://doi.org/10.4103/2349-5006.158219.
   Google Scholar
• El-Hussainy, E. H. M.; Hussein, A. M.; Abdel-Aziz, A.; El-Mehasseb, I. Effects of Aluminum Oxide (Al2o3) Nanoparticles on Ecg, Myocardial Inflammatory Cytokines, Redox State, and Connexin 43 and Lipid Profile in Rats: Possible Cardioprotective Effect of Gallic Acid. Can. J. Physiol. Pharmacol. 2016, 94(8), 868–878. DOI: https://doi.org/10.1139/cjpp-2015-0446.
   PubMed Web of Science ®Google Scholar
• Padma, V. V.; Poornima, P.; Prakash, C.; Bhavani, R. Oral Treatment with Gallic Acid and Quercetin Alleviates Lindane-Induced Cardiotoxicity in Rats. Can. J. Physiol. Pharmacol. 2012, 91(2), 134–140. DOI: https://doi.org/10.1139/cjpp-2012-0279.
   Web of Science ®Google Scholar
• Badavi, M.; Sadeghi, N.; Dianat, M.; Samarbafzadeh, A. Effects of Gallic Acid and Cyclosporine A on Antioxidant Capacity and Cardiac Markers of Rat Isolated Heart after Ischemia/Reperfusion. Iranian Red Cres. Med. J. 2014, 16(6), e16424 (1-7).
   Web of Science ®Google Scholar
• Ramezani-Aliakbari, F.; Badavi, M.; Dianat, M.; Mard, S. A.; Ahangarpour, A. Effects of Gallic Acid on Hemodynamic Parameters and Infarct Size after Ischemia-Reperfusion in Isolated Rat Hearts with Alloxan-Induced Diabetes. Biomed. Pharmacother. 2017, 96, 612–618. DOI: https://doi.org/10.1016/j.biopha.2017.10.014.
   PubMed Web of Science ®Google Scholar
• Umadevi, S.; Gopi, V.; Parthasarathy, A.; Elangovan, V. Ameliorative Potential of Gallic Acid on the Activation of ROS and Down-Regulation of Antioxidant Enzymes in Cardiac Tissue of Rats Infused with Advanced Glycation End Products. J. Appl. Pharm. Sci. 2011, 1(7), 189.
   Google Scholar
• Akinrinde, A. S.; Omobowale, O.; Oyagbemi, A.; Asenuga, E.; Ajibade, T. Protective Effects of Kolaviron and Gallic Acid against Cobalt-Chloride-Induced Cardiorenal Dysfunction via Suppression of Oxidative Stress and Activation of the Erk Signaling Pathway. Can. J. Physiol. Pharmacol. 2016, 94(12), 1276–1284. DOI: https://doi.org/10.1139/cjpp-2016-0197.
   PubMed Web of Science ®Google Scholar
• Ajibade, T. O.; Oyagbemi, A. A.; Omobowale, T. O.; Asenuga, E. R.; Afolabi, J. M.; Adedapo, A. A. Mitigation of Diazinon-Induced Cardiovascular and Renal Dysfunction by Gallic Acid. Interdiscip. Toxicol. 2016, 9(2), 66–77. DOI: https://doi.org/10.1515/intox-2016-0008.
   PubMedGoogle Scholar
• Habtemariam, S.; Sureda, A.; Hajizadeh Moghaddam, A.; Fazel Nabavi, S.; Mohammad Nabavi, S.; Abolhasani, F. Protective Role of Gallic Acid Isolated from Peltiphyllum Peltatum against Sodium Fluoride-Induced Oxidative Stress in Rat’s Heart. Lett. Drug Des. Discov. 2013, 10(3), 277–282.
   Web of Science ®Google Scholar
• Bakheet, M. S.; Soltan, S.; Gadalla, A.; Haredy, H. H.; Shakoor, M. A. Antioxidants (Vitamin E and Gallic Acid) as Valuable Protective Factors against Myocardial Infarction. Basic Res. J. Med. Clin. Sci. 2014, 3, 109–122.
   Google Scholar
• Ogunsanwo, O. R.; Oyagbemi, A. A.; Omobowale, T. O.; Asenuga, E. R.; Saba, A. B. Biochemical and Electrocardiographic Studies Nn the Beneficial Effects of Gallic Acid in Cyclophosphamide-Induced Cardiorenal Dysfunction. J. Complement Integr. Med. 2017, 14(3). DOI: https://doi.org/10.1515/jcim-2016-0161.
   Google Scholar
• Omóbòwálé, T. O.; Oyagbemi, A. A.; Folasire, A. M.; Ajibade, T. O.; Asenuga, E. R.; Adejumobi, O. A.; Ola-Davies, O. E.; Oyetola, O.; James, G.; Adedapo, A. A. Ameliorative Effect of Gallic Acid on Doxorubicin-Induced Cardiac Dysfunction in Rats. J. Basic Clin. Physiol. Pharmacol. 2018, 29(1), 19–27. DOI: https://doi.org/10.1515/jbcpp-2016-0194.
   PubMedGoogle Scholar
• Meerson, F. Z.; Kagan, V. E.; Kozlov Yu, P.; Belkina, L. M.; Arkhipenko Yu, V. The Role of Lipid Peroxidation in Pathogenesis of Ischemic Damage and the Antioxidant Protection of the Heart. Basic Res. Cardiol. 1982, 77(5), 465–485. DOI: https://doi.org/10.1007/BF01907940.
   PubMed Web of Science ®Google Scholar
• Fukuda, K.; Davies Sean, S.; Nakajima, T.; Ong, B. H.; Kupershmidt, S.; Fessel, J.; Amarnath, V.; Anderson Mark, E.; Boyden Penelope, A.; Viswanathan Prakash, C.; et al. Oxidative Mediated Lipid Peroxidation Recapitulates Proarrhythmic Effects on Cardiac Sodium Channels. Circ. Res. 2005, 97(12), 1262–1269. DOI: https://doi.org/10.1161/01.RES.0000195844.31466.e9.
   PubMed Web of Science ®Google Scholar
• Gawel, S.; Wardas, M.; Niedworok, E.; Wardas, P. Malondialdehyde (MDA) as a Lipid Peroxidation Marker. Wiadomosci Lekarskie. 2004, 57(9–10), 453–455.
   PubMedGoogle Scholar
• Pradhan, A. D.; Manson, J. E.; Rifai, N.; Buring, J. E.; Ridker, P. M. C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus. JAMA. 2001, 286(3), 327–334. DOI: https://doi.org/10.1001/jama.286.3.327.
   PubMed Web of Science ®Google Scholar
• Mythili, S.; Malathi, N. Diagnostic Markers of Acute Myocardial Infarction. Biomed. Rep. 2015, 3(6), 743–748. DOI: https://doi.org/10.3892/br.2015.500.
   PubMed Web of Science ®Google Scholar
• Ighodaro, O. M.; Akinloye, O. A. First Line Defence Antioxidants-Superoxide Dismutase (Sod), Catalase (Cat) and Glutathione Peroxidase (Gpx): Their Fundamental Role in the Entire Antioxidant Defence Grid. Alexandria J. Med. 2018, 54(4), 287–293. DOI: https://doi.org/10.1016/j.ajme.2017.09.001.
   Web of Science ®Google Scholar
• Wildenthal, K.; Decker, R. S. The Role of Lysosomes in the Heart. Adv. Myocardiol. 1980, 2, 349–358.
   PubMedGoogle Scholar
• Roell, W.; Klein, A. M.; Breitbach, M.; Becker, T. S.; Parikh, A.; Lee, J.; Zimmermann, K.; Reining, S.; Gabris, B.; Ottersbach, A.; et al. Overexpression of Cx43 in Cells of the Myocardial Scar: Correction of Post-Infarct Arrhythmias through Heterotypic Cell-Cell Coupling. Sci. Rep. 2018, 8(1), 7145. DOI: https://doi.org/10.1038/s41598-018-25147-8.
   PubMed Web of Science ®Google Scholar
• Clausen, M. V.; Hilbers, F.; Poulsen, H. The Structure and Function of the Na,K-Atpase Isoforms in Health and Disease. Front. Physiol. 2017, 8(371). DOI: https://doi.org/10.3389/fphys.2017.00371.
   Google Scholar
• Schwinger, R. H. G.; Bundgaard, H.; Müller-Ehmsen, J.; Kjeldsen, K. The Na, K-Atpase in the Failing Human Heart. Cardiovas. Res. 2003, 57(4), 913–920. DOI: https://doi.org/10.1016/S0008-6363(02)00767-8.
   PubMed Web of Science ®Google Scholar
• Johnson, G. L.; Lapadat, R. Mitogen-Activated Protein Kinase Pathways Mediated by Erk, Jnk, and P38 Protein Kinases. Science. 2002, 298(5600), 1911–1912. DOI: https://doi.org/10.1126/science.1072682.
   PubMed Web of Science ®Google Scholar
• Vlahopoulos, S.; Zoumpourlis, V. C. JNK: A Key Modulator of Intracellular Signaling. Biochem. 2004, 69(8), 844–854.
   PubMed Web of Science ®Google Scholar
• Yoon, Y. W.; Kang, T. S.; Lee, B. K.; Chang, W.; Hwang, K. C.; Rhee, J. H.; Min, P. K.; Hong, B. K.; Rim, S. J.; Kwon, H. M. Pathobiological Role of Advanced Glycation Endproducts via Mitogen-Activated Protein Kinase Dependent Pathway in the Diabetic Vasculopathy. Exp.Mol. Med. 2008, 40, 398. DOI: https://doi.org/10.3858/emm.2008.40.4.398.
   PubMed Web of Science ®Google Scholar
• Fishman, S. L.; Sonmez, H.; Basman, C.; Singh, V.; Poretsky, L. The Role of Advanced Glycation End-Products in the Development of Coronary Artery Disease in Patients with and without Diabetes Mellitus: A Review. Mol. Med. 2018, 24(1), 59. DOI: https://doi.org/10.1186/s10020-018-0060-3.
   PubMed Web of Science ®Google Scholar
• Hu, P.; Lai, D.; Lu, P.; Gao, J.; He, H. ERK and Akt Signaling Pathways are Involved in Advanced Glycation End Product-Induced Autophagy in Rat Vascular Smooth Muscle Cells. Int. J. Mol. Med. 2012, 29(4), 613–618. DOI: https://doi.org/10.3892/ijmm.2012.891.
   PubMed Web of Science ®Google Scholar
• Prasad, A.; Bekker, P.; Tsimikas, S. Advanced Glycation End Products and Diabetic Cardiovascular Disease. Cardiol. Rev. 2012, 20(4), 177–183. DOI: https://doi.org/10.1097/CRD.0b013e318244e57c.
   PubMed Web of Science ®Google Scholar
• Eddy, A. A.; Neilson, E. G. Chronic Kidney Disease Progression. J. Am. Soc. Nephrol. 2006, 17(11), 2964–2966. DOI: https://doi.org/10.1681/ASN.2006070704.
   PubMed Web of Science ®Google Scholar