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Cell Growth and Development

Involvement of Alpha-PAK-Interacting Exchange Factor in the PAK1–c-Jun NH2-Terminal Kinase 1 Activation and Apoptosis Induced by Benzo[a]pyrene

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Pages 6796-6807 | Received 14 Jun 2001, Accepted 17 Jul 2001, Published online: 27 Mar 2023

REFERENCES

  • Archuleta, M. M., G. L. Schieven, J. A. Ledbetter, G. G. Deanin, and S. W. Burchiel. 1993. 7,12-Dimethylbenz[a] anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium. Proc. Natl. Acad. Sci. USA 90:6105–6109.
  • Bagrodia, S., D. Bailey, Z. Lenard, M. Hart, J. L. Guan, R. T. Premont, S. J. Taylor, and R. A. Cerione. 1999. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J. Biol. Chem. 274:22393–22400.
  • Bagrodia, S., B. Derijard, R. J. Davis, and R. A. Cerione. 1995. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen activated protein kinase activation. J. Biol. Chem. 270:27995–27998.
  • Bagrodia, S., S. J. Taylor, K. A. Jordon, L. Van Aelst, and R. A. Cerione. 1998. A novel regulator of p21-activated kinases. J. Biol. Chem. 273:23633–23636.
  • Bossy-Wetzel, E., L. Bakiri, and M. Yaniv. 1997. Induction of apoptosis by the transcription factor c-Jun. EMBO J. 16:1695–1709.
  • Bral, C. M., and K. S. Ramos. 1997. Identification of benzo[a]pyrene-inducible cis-acting elements within c-Ha-ras transcriptional regulatory sequences. Mol. Pharmacol. 52:974–982.
  • Brown, J. L., L. Stowers, M. Baer, J. Trejo, S. Coughlin, and J. Chant. 1996. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol. 6:598–605.
  • Burchiel, S. W., D. A. Davis, S. D. Ray, and S. L. Barton. 1993. DMBA induces programmed cell death (apoptosis) in the A20.1 murine B cell lymphoma. Fundam, Appl. Toxicol. 21:120–124.
  • Chen, Y. R., X. Wang, D. Templeton, R. J. Davis, and T. H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929–31936.
  • Chen, Z., H. Seimiya, M. Naito, T. Mashima, A. Kizaki, S. Dan, M. Imaizumi, H. Ichijo, K. Miyazono, and T. Tsuruo. 1999. ASK1 mediates apoptotic cell death induced by genotoxic stress. Oncogene 18:173–180.
  • Chin, B. Y., M. E. Choi, M. D. Burdick, R. M. Strieter, T. H. Risby, and A. M. Choi. 1998. Induction of apoptosis by particulate matter: role of TNF-alpha and MAPK. Am. J. Physiol. 275:L942–L949.
  • Conney, A. H.. 1982. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res. 42:4875–4917.
  • Daniels, R. H., F. T. Zenke, and G. M. Bokoch. 1999. alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J. Biol. Chem. 274:6047–6050.
  • Derijard, B., J. Raingeaud, T. Barrett, I. H. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682–685.
  • Eldridge, S. R., M. N. Gould, and B. E. Butterworth. 1992. Genotoxicity of environmental agents in human mammary epithelial cells. Cancer Res 52:5617–5621.
  • Ethier, S. P., and R. L. Ullrich. 1982. Induction of mammary tumors in virgin female BALB/c mice by single low doses of 7,12-dimethylbenz[a]anthracene. JNCI 69:1199–1203.
  • Hawkins, P. T., A. Eguinoa, R. G. Qiu, D. Stokoe, F. T. Cooke, R. Walters, S. Wennstrom, L. Claesson-Welsh, T. Evans, M. Symons, and L. Stephens. 1995. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5:393–403.
  • Heidelberger, C.. 1975. Chemical carcinogenesis. Annu. Rev. Biochem. 44:79–121.
  • Hing, H., J. Xiao, N. Harden, L. Lim, and S. L. Zipursky. 1999. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97:853–863.
  • Huberman, E., L. Sachs, S. K. Yang, and V. Gelboin. 1976. Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells. Proc. Natl. Acad. Sci. USA 73:607–611.
  • Ichijo, H., E. Nishida, K. Irie, P. ten Dijke, M. Saitoh, T. Moriguchi, M. Takagi, K. Matsumoto, K. Miyazono, and Y. Gotoh. 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275:90–94.
  • Johnson, N. L., A. M. Gardner, K. M. Diener, C. A. Lange-Carter, J. Gleavy, M. B. Jarpe, A. Minden, M. Karin, L. I. Zon, and G. L. Johnson. 1996. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J. Biol. Chem. 271:3229–3237.
  • Karin, M.. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483–16486.
  • Kawazoe, N., M. Watabe, Y. Masuda, S. Nakajo, and K. Nakaya. 1999. Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. Oncogene 18:2413–2421.
  • Kong, Y. Y., K. D. Fischer, M. F. Bachmann, S. Mariathasan, I. Kozieradzki, M. P. Nghiem, D. Bouchard, A. Bernstein, P. S. Ohashi, and J. M. Penninger. 1998. Vav regulates peptide-specific apoptosis in thymocytes. J. Exp. Med. 188:2099–2111.
  • Krieger, J. A., J. L. Born, and S. W. Burchiel. 1994. Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 127:268–274.
  • Lei, W., R. Yu, S. Mandlekar, and A. N. Kong. 1998. Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene. Cancer Res. 58:2102–2106.
  • Lenczowski, J. M., L. Dominguez, A. M. Eder, L. B. King, C. M. Zacharchuk, and J. D. Ashwell. 1997. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol. Cell. Biol. 17:170–181.
  • Manser, E., T. H. Loo, C. G. Koh, Z. S. Zhao, X. Q. Chen, L. Tan, I. Tan, T. Leung, and L. Lim. 1998. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1:183–192.
  • Martin, S. J., and D. R. Green. 1995. Protease activation during apoptosis: death by a thousand cuts?. Cell 82:349–352.
  • Miller, J. A.. 1970. Carcinogenesis by chemicals: an overview. Clowes Memorial Lecture. Cancer Res. 30:559–571.
  • Mounho, B. J., and S. W. Burchiel. 1998. Alterations in human B cell calcium homeostasis by polycyclic aromatic hydrocarbons: possible associations with cytochrome P450 metabolism and increased protein tyrosine phosphorylation. Toxicol. Appl. Pharmacol. 149:80–89.
  • Nebert, D. W., and F. J. Gonzalez. 1987. P450 genes: structure, evolution, and regulation. Annu. Rev. Biochem. 56:945–993.
  • Nicholson, D. W., A. Ali, N. A. Thornberry, J. P. Vaillancourt, C. K. Ding, M. Gallant, Y. Gareau, P. R. Griffin, M. Labelle, Y. A. Lazebnik, N. A. Munday, S. M. Raju, M. E. Smulson, T. T. Yamin, V. L. Yu, and D. K. Miller. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37–43.
  • Nishina, H., K. D. Fischer, L. Radvanyi, A. Shahinian, R. Hakem, E. A. Rubie, A. Bernstein, T. W. Mak, J. R. Woodgett, and J. M. Penninger. 1997. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385:350–353.
  • Obermeier, A., S. Ahmed, E. Manser, S. C. Yen, C. Hall, and L. Lim. 1998. PAK promotes morphological changes by acting upstream of Rac. EMBO J. 17:4328–4339.
  • Oh, W. K., J. C. Yoo, D. Jo, Y. H. Song, M. G. Kim, and D. Park. 1997. Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem. Biophys. Res. Commun. 235:794–798.
  • Pitot, H. C., and Y. P. Dragan. 1996. Chemical carcinogenesis. Casarett and Doull's toxicology.. C. D. Klassen. 201–267. McGraw-Hill Book Co., New York, N.Y
  • Rorke, E. A., N. Sizemore, H. Mukhtar, L. H. Couch, and P. C. Howard. 1998. Polycyclic aromatic hydrocarbons enhance terminal cell death of human ectocervical cells. Int. J. Oncol. 13:557–563.
  • Rowlands, J. C., and J. A. Gustafsson. 1997. Aryl hydrocarbon receptor-mediated signal transduction. Crit. Rev. Toxicol. 27:109–134.
  • Sadhu, D. N., M. Merchant, S. H. Safe, and K. S. Ramos. 1993. Modulation of protooncogene expression in rat aortic smooth muscle cells by benzo[a]pyrene. Arch. Biochem. Biophys. 300:124–131.
  • Salas, V. M., and S. W. Burchiel. 1998. Apoptosis in Daudi human B cells in response to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol. Toxicol. Appl. Pharmacol. 151:367–376.
  • Schurmann, A., A. F. Mooney, L. C. Sanders, M. A. Sells, H. G. Wang, J. C. Reed, and G. M. Bokoch. 2000. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol. Cell. Biol. 20:453–461.
  • Shimizu, S., Y. Eguchi, H. Kosaka, W. Kamiike, H. Matsuda, and Y. Tsujimoto. 1995. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374:811–813.
  • Tanaka, M., R. Gupta, and B. J. Mayer. 1995. Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol. Cell. Biol. 15:6829–6837.
  • Tanaka, M., W. Lu, R. Gupta, and B. J. Mayer. 1997. Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development. Proc. Natl. Acad. Sci. USA 94:4493–4498.
  • Tang, Y., J. Yu, and J. Field. 1999. Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts. Mol. Cell. Biol. 19:1881–1891.
  • Tannheimer, S. L., S. P. Ethier, K. K. Caldwell, and S. W. Burchiel. 1998. Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line. Carcinogenesis 19:1291–1297.
  • Taylor, S. J., and D. Shalloway. 1996. Cell cycle-dependent activation of Ras. Curr. Biol. 6:1621–1627.
  • Tewari, M., L. T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D. R. Beidler, G. G. Poirier, G. S. Salvesen, and V. M. Dixit. 1995. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801–809.
  • Thomas, A., T. Giesler, and E. White. 2000. p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene 19:5259–5269.
  • Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, A. Haimovitz-Friedman, Z. Fuks, and R. N. Kolesnick. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75–79.
  • Vojtek, A. B., and J. A. Cooper. 1995. Rho family members: activators of MAP kinase cascades. Cell 82:527–529.
  • Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326–1331.
  • Yang, D. D., C. Y. Kuan, A. J. Whitmarsh, M. Rincon, T. S. Zheng, R. J. Davis, P. Rakic, and R. A. Flavell. 1997. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389:865–870.
  • Yeh, W. C., A. Shahinian, D. Speiser, J. Kraunus, F. Billia, A. Wakeham, J. L. de la Pompa, D. Ferrick, B. Hum, N. Iscove, P. Ohashi, M. Rothe, D. V. Goeddel, and T. W. Mak. 1997. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7:715–725.
  • Yoshii, S., M. Tanaka, Y. Otsuki, D. Y. Wang, R. J. Guo, Y. Zhu, R. Takeda, H. Hanai, E. Kaneko, and H. Sugimura. 1999. alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. Oncogene 18:5680–5690.
  • Zhang, S., J. Han, M. A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch, and G. M. Bokoch. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem. 270:23934–23936.
  • Zhao, Z. S., E. Manser, T. H. Loo, and L. Lim. 2000. Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol. Cell. Biol. 20:6354–6363.

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