Subcellular G-protein coupled receptor signaling hints at greater therapeutic selectivity

Bibliography

• Re RN. The cellular biology of angiotensin: paracrine, autocrine and intracrine actions in cardiovascular tissues. J Mol Cell Cardiol 1989;21(Suppl 5):63-9
   Google Scholar
• Ferrandon S, Feinstein TN, Castro M, et al. Sustained cyclic AMP production by parathyroid hormone receptor endocytosis. Nat Chem Biol 2009;5(10):734-42
   PubMed Web of Science ®Google Scholar
• Benard G, Massa F, Puente N, et al. Mitochondrial CB(1) receptors regulate neuronal energy metabolism. Nat Neurosci 2012;15(4):558-64
   PubMed Web of Science ®Google Scholar
• Joyal JS, Nim S, Zhu T, et al. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med 2014;20(10):1165-73
   PubMed Web of Science ®Google Scholar
• Kang J, Shi Y, Xiang B, et al. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 2005;123(5):833-47
   Google Scholar
• Mathew D, Ataman B, Chen J, et al. Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 2005;310(5752):1344-7
   Google Scholar
• Mosca TJ, Schwarz TL. The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat Neurosci 2010;13(8):935-43
   Google Scholar
• Vilardaga JP, Jean-Alphonse FG, Gardella TJ. Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol 2014;10(9):700-6
   PubMed Web of Science ®Google Scholar
• Tafesse FG, Guimaraes CP, Maruyama T, et al. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. J Biol Chem 2014;289(35):24005-18
   PubMed Web of Science ®Google Scholar
• Young A, Powelson EB, Whitney IE, et al. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci 2008;49(7):3245-52
   PubMed Web of Science ®Google Scholar
• Omary MB, Kagnoff MF. Identification of nuclear receptors for VIP on a human colonic adenocarcinoma cell line. Science 1987;238(4833):1578-81
   PubMedGoogle Scholar
• Di Benedetto A, Sun L, Zambonin CG, et al. Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor. Proc Natl Acad Sci USA 2014;111(46):16502-7
   Google Scholar
• Vaniotis G, Glazkova I, Merlen C, et al. Regulation of cardiac nitric oxide signaling by nuclear beta-adrenergic and endothelin receptors. J Mol Cell Cardiol 2013;62:58-68
   Google Scholar
• Lee DK, Lanca AJ, Cheng R, et al. Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem 2004;279(9):7901-8
   PubMedGoogle Scholar
• Wright CD, Chen Q, Baye NL, et al. Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ Res 2008;103(9):992-1000
   Google Scholar
• Gobeil F, Fortier A, Zhu T, et al. G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm. Can J Physiol Pharmacol 2006;84(3-4):287-97
   PubMedGoogle Scholar
• Maraldi NM, Mazzotti G, Capitani S, et al. Morphological evidence of function-related localization of phospholipids in the cell nucleus. Adv Enzyme Regul 1992;32:73-90
   PubMedGoogle Scholar
• Zimber A, Nguyen QD, Gespach C. Nuclear bodies and compartments: functional roles and cellular signalling in health and disease. Cell Signal 2004;16(10):1085-104
   Google Scholar
• Fricker M, Hollinshead M, White N, et al. Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol 1997;136(3):531-44
   Google Scholar
• Song S, Rosen KM, Corfas G. Biological function of nuclear receptor tyrosine kinase action. Cold Spring Harb Perspect Biol 2013;5(7). pii: a009001
   Google Scholar
• Mizuno-Yamasaki E, Rivera-Molina F, Novick P. GTPase networks in membrane traffic. Annu Rev Biochem 2012;81:637-59
   PubMed Web of Science ®Google Scholar
• Cullen PJ, Korswagen HC. Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol 2012;14(1):29-37
   Google Scholar
• Willard FS, Crouch MF. Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins. Immunol Cell Biol 2000;78(4):387-94
   PubMedGoogle Scholar
• Scott MG, Le Rouzic E, Perianin A, et al. Differential nucleocytoplasmic shuttling of beta-arrestins. Characterization of a leucine-rich nuclear export signal in beta-arrestin2. J Biol Chem 2002;277(40):37693-701
   PubMedGoogle Scholar
• Zhang Y, Matkovich SJ, Duan X, et al. Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure. Circ Heart Fail 2011;4(5):659-68
   Google Scholar
• Hepler JR. R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain. Sci STKE 2005;2005:294-pe38
   Google Scholar
• Li B, Jie W, Huang L, et al. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nat Neurosci 2014;17(8):1055-63
   PubMedGoogle Scholar
• Bading H. Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci 2013;14(9):593-608
   Google Scholar
• Tadevosyan A, Letourneau M, Folch B, et al. Photo-releasable ligands to study intracrine angiotensin II signalling. J Physiol 2015;593(3):521-39
   Google Scholar
• Marrache AM, Gobeil FJr, Bernier SG, et al. Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. J Immunol 2002;169(11):6474-81
   PubMedGoogle Scholar
• Cohen O, Granek R. Nucleus-targeted drug delivery: theoretical optimization of nanoparticles decoration for enhanced intracellular active transport. Nano Lett 2014;14(5):2515-21
   Google Scholar
• Wang F, Wang Y, Zhang X, et al. Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery. J Control Release 2014;174:126-36
   PubMed Web of Science ®Google Scholar
• Rin Jean S, Tulumello DV, Wisnovsky SP, et al. Molecular vehicles for mitochondrial chemical biology and drug delivery. ACS Chem Biol 2014;9(2):323-33
   PubMed Web of Science ®Google Scholar