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Original Research

Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo

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Pages 4645-4665 | Published online: 17 Jun 2020

References

  • Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the united states. Cancer Res. 2014;74:2913–2921. doi:10.1158/0008-5472.CAN-14-015524840647
  • SEER Cancer Stat Facts: Pancreatic Cancer. Bethesda: National Cancer Institute; 4 2019 Available from: https://seer.cancer.gov/statfacts/html/pancreas.html. Accessed 520, 2020.
  • Kamisawa T, Isawa T, Koike M, et al. Hematogenous metastases of pancreatic ductal carcinoma. Pancreas. 1995;11:345–349. doi:10.1097/00006676-199511000-000058532650
  • Labori KJ, Katz MH, Tzeng CW, et al. Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma—a population-based cohort study. Acta Oncol. 2016;55:265–277. doi:10.3109/0284186X.2015.106844526213211
  • Neoptolemos JP, Palmer DH, Ghaneh P, et al. European Study Group for Pancreatic Cancer. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, Phase 3 trial. Lancet. 2017;389:1011–1024.28129987
  • Golcher H, Brunner TB, Witzigmann H, et al. Neoadjuvant chemoradiation therapy with gemcitabine/cisplatin and surgery versus immediate surgery in resectable pancreatic cancer: results of the first prospective randomized Phase II trial. Strahlenther Onkol. 2015;191:7–16. doi:10.1007/s00066-014-0737-725252602
  • Regine WF, Winter KA, Abrams RA, et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial. JAMA. 2008;299:1019–1026. doi:10.1001/jama.299.9.101918319412
  • Sandler AB, Nemunaitis J, Denham C, et al. Phase III trial of gemcitabine plus cisplatin vs. cisplatin alone in patients with locally advanced or metastatic non-small cell lung cancer. J Clin Oncol. 2000;18:122–130.10623702
  • von der Maase H, Hansen SW, Roberts JT, et al. Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol. 2000;18:3068–3070. doi:10.1200/JCO.2000.18.17.306811001674
  • Albain KS, Nag SM, Calderillo-Ruiz G, et al. Global phase III study of gemcitabine plus paclitaxel (GT) vs. paclitaxel (T) as frontline therapy for metastatic breast cancer (MBC): first report of overall survival. J Clin Oncol. 2004;22(suppl 14):510. doi:10.1200/jco.2004.22.14_suppl.510
  • Burris HA, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403–2413. doi:10.1200/JCO.1997.15.6.24039196156
  • Kim MP, Gallick GE. Gemcitabine resistance in pancreatic cancer: picking the key players. Clin Cancer Res. 2008;14:1284–1285. doi:10.1158/1078-0432.CCR-07-224718316544
  • de Sousa Cavalcante L, Monteiro G. Gemcitabine: metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer. Eur J Pharmacol. 2014;741:8–16. doi:10.1016/j.ejphar.2014.07.04125084222
  • Amrutkar M, Gladhaug IP. Pancreatic cancer chemoresistance to gemcitabine. Cancers. 2017;9:E157. doi:10.3390/cancers911015729144412
  • Jakobisiak M, Golab J. Potential antitumor effects of statins (Review). Int J Oncol. 2003;23:1055–1069.12963986
  • Altwairgi AK. Statins are potential anticancerous agents (Review). Oncol Rep. 2015;33:1019–1039. doi:10.3892/or.2015.374125607255
  • Kubatka P, Bojková B, Kassayová M, et al. Combination of pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model. Acta Histochem. 2014;116:1454–1461. doi:10.1016/j.acthis.2014.09.01025450902
  • You HY, Zhang WJ, Xie XM, et al. Pitavastatin suppressed liver cancer cells in vitro and in vivo. Onco Targets Ther. 2016;9:5383–5388. doi:10.2147/OTT.S10690627621652
  • de Wolf E, Abdullah MI, Jones SM, et al. Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer. Sci Rep. 2017;7:5410. doi:10.1038/s41598-017-05595-428710496
  • Abdullah MI, Abed MN, Richardson A. Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Sci Rep. 2017;7(1):8090.28808351
  • Al-Qatati A, Aliwaini S. Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells. Oncol Lett. 2017;14:7993–7999. doi:10.3892/ol.2017.718929344241
  • Paškevičiūtė M, Petrikaitė V. Differences of statin activity in 2D and 3D pancreatic cancer cell cultures. Drug Des Devel Ther. 2017;11:3273–3280. doi:10.2147/DDDT.S149411
  • Ouyang G, Liu Z, Huang S, et al. Gemcitabine plus cisplatin versus gemcitabine alone in the treatment of pancreatic cancer: a meta-analysis. World J Surg Oncol. 2016;14:59. doi:10.1186/s12957-016-0813-926927942
  • Neoptolemos JP, Palmer DH, Ghaneh P, et al. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2017;389(10073):1011–1024.28129987
  • Yunis AA, Arimura GK, Russin DJ. Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase. Int J Cancer. 1977;19:128–135. doi:10.1002/ijc.2910190118832918
  • Chou T-C, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enz Regul. 1984;22:27–55. doi:10.1016/0065-2571(84)90007-4
  • Le N, Vinci A, Schober M, et al. Real-world clinical practice of intensified chemotherapies for metastatic pancreatic cancer: results from a pan-european questionnaire study. Digestion. 2016;94:222–229. doi:10.1159/00045325728030863
  • Zhong S, Qie S, Yang L, et al. S-1 monotherapy versus S-1 combination therapy in gemcitabine-refractory advanced pancreatic cancer: a meta-analysis (PRISMA) of randomized control trials. Medicine (Baltimore). 2017;96:e7611. doi:10.1097/MD.000000000000761128746215
  • Neoptolemos JP, Palmer DH, Ghaneh P, et al. European Study Group for Pancreatic Cancer. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2017;389(10073):1011–1024.28129987
  • Huang P, Chubb S, Hertel LW, et al. Action of 2ʹ,2ʹ- difluorodeoxycytidine on DNA synthesis. Cancer Res. 1991;51:6110–6117.1718594
  • Ferreira CG, Span SW, Peters GJ, et al. Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res. 2000;60:7133–7141.11156422
  • Chandler NM, Canete JJ, Callery MP. Caspase-3 drives apoptosis in pancreatic cancer cells after treatment with gemcitabine. J Gastrointest Surg. 2004;8:1072–1078. doi:10.1016/j.gassur.2004.09.05415585396
  • Fujino M, Miura S, Matsuo Y, et al. Pitavastatin-induced downregulation of CCR2 and CCR5 in monocytes is associated with the arrest of cell-cycle in S phase. Atherosclerosis. 2006;187:301–308. doi:10.1016/j.atherosclerosis.2005.10.00816289073
  • Jiang P, Mukthavaram R, Chao Y, et al. In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. Br J Cancer. 2014;111:1562–1571. doi:10.1038/bjc.2014.43125093497
  • Gbelcová H, Rimpelová S, Knejzlík Z, et al. Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells. Lipids Health Dis. 2017;16:250. doi:10.1186/s12944-017-0641-029262834
  • Bocci G, Fioravanti A, Orlandi P, et al. Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. Br J Cancer. 2005;93:319–330. doi:10.1038/sj.bjc.660272016052215
  • Tsuboi Y, Kurimoto M, Nagai S, et al. Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines. J Neurosurg. 2009;110:594–604. doi:10.3171/2008.8.JNS1764819046042
  • Blanquicett C, Saif MW, Buchsbaum DJ, et al. Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects. Clin Cancer Res. 2005;11:8773–8781. doi:10.1158/1078-0432.CCR-05-062716361565
  • Byeon HJ, Choi SH, Choi JS, et al. Apoptotic activity and antitumor efficacy of PEGylated TNF-related apoptosis-inducing ligand (TRAIL) in a Mia Paca-2 cell-xenografted mouse model. Biomed Pharmacother. 2014;68:65–69. doi:10.1016/j.biopha.2013.10.01024268811
  • Smith PF, Grossman SJ, Gerson RJ, et al. Studies on the mechanism of simvastatin- induced thyroid hypertrophy and follicular cell adenoma in the rat. Toxicol Pathol. 1991;19:197–205. doi:10.1177/0192623391019003011780636
  • Robison RL, Suter W, Cox RH. Carcinogenicity and mutagenicity studies with fluvastatin, a new, entirely synthetic HMG CoA reductase inhibitor. Fundam Appl Toxicol. 1994;23:9–20. doi:10.1006/faat.1994.10737958569
  • Lamprecht J, Wojcik C, Jakobisiak M, et al. Lovastatin induces mitotic abnormalities in various cell lines. Cell Biol Int. 1999;23(1):51–60. doi:10.1006/cbir.1998.032210527548
  • Warburg O. On respiratory impairment in cancer cells. Science. 1956;124(3215):269–270.13351639
  • Sastre-Serra J, Valle A, Company MM, et al. Estrogen down- regulates uncoupling proteins and increases oxidative stress in breast cancer. Free Radic Biol Med. 2010;48:506–512. doi:10.1016/j.freeradbiomed.2009.11.02519969066
  • Solaini G, Sgarbi G, Baracca A. Oxidative phosphorylation in cancer cells. Biochim Biophys Acta. 2011;1807:534–542. doi:10.1016/j.bbabio.2010.09.00320849810
  • Houston MA, Augenlicht LH, Heerdt BG. Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression. PLoS One. 2011;6:e25207. doi:10.1371/journal.pone.002520721966455
  • Zhu YY, Huang HY, Wu YL. Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells. Mol Med Rep. 2015;12:5012–5018. doi:10.3892/mmr.2015.403326151733
  • Dey R, Moraes CT. Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. J Biol Chem. 2000;275:7087–7094. doi:10.1074/jbc.275.10.708710702275
  • Vander Heiden MG, Chandel NS, Williamson EK, et al. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell. 1997;91:627–637. doi:10.1016/S0092-8674(00)80450-X9393856
  • Yue W, Lee JK, Abe K, et al. Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient TR− rats. Drug Metab Dispos. 2011;39:441–447. doi:10.1124/dmd.110.03518821106720