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Review

Application of dental nanomaterials: potential toxicity to the central nervous system

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Pages 3547-3565 | Published online: 14 May 2015

References

  • BleekerEAde JongWHGeertsmaREConsiderations on the EU definition of a nanomaterial: science to support policy makingRegul Toxicol Pharm2013651119125
  • Juanola-FeliuEThe nanotechnology revolution in Barcelona: innovation and creativity by universitiesManage Int200913111123
  • KasraeiSSamiLHendiSAlikhaniMYRezaei-SoufiLKhamverdiZAntibacterial properties of composite resins incorporating silver and zinc oxide nanoparticles on Streptococcus mutans and LactobacillusRestor Dent Endod201439210911424790923
  • NiuLNFangMJiaoKTetrapod-like zinc oxide whisker enhancement of resin compositeJ Dent Res201089774675020439932
  • MemarzadehKShariliASHuangJRawlinsonSCAllakerRPNanoparticulate zinc oxide as a coating material for orthopedic and dental implantsJ Biomed Mater Res A2015103398198924862288
  • JavidiMZareiMNaghaviNMortazaviMNejatAHZinc oxide nanoparticles as sealer in endodontics and its sealing abilityContemp Clin Dent201451202424808690
  • FrohlichERobleggEModels for oral uptake of nanoparticles in consumer productsToxicology20122911–3101722120540
  • KeelanJANanotoxicology: nanoparticles versus the placentaNat Nanotechnol20116526326421546898
  • ShimizuMTainakaHObaTMizuoKUmezawaMTakedaKMaternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mousePart Fibre Toxicol200962019640265
  • LuSDuffinRPolandCEfficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammationEnviron Health Perspect2009117224124719270794
  • LeeCMJeongHJYunKNOptical imaging to trace near infrared fluorescent zinc oxide nanoparticles following oral exposureInt J Nanomedicine201273203320922811605
  • WangYChenZBaTSusceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticlesSmall201399–101742175222945798
  • SternSTMcNeilSENanotechnology safety concerns revisitedToxicol Sci2008101142117602205
  • MedinaCSantos-MartinezMJRadomskiACorriganOIRadomskiMWNanoparticles: pharmacological and toxicological significanceBr J Pharmacol2007150555255817245366
  • Adamcakova-DoddAStebounovaLVKimJSToxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation modelsPart Fibre Toxicol2014111524684892
  • MaLLiuJLiNOxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavityBiomaterials20103119910519783296
  • NelAXiaTMadlerLLiNToxic potential of materials at the nanolevelScience2006311576162262716456071
  • BalosSPilicBPetronijevicBMarkovicDMirkovicSSarcevIImproving mechanical properties of flowable dental composite resin by adding silica nanoparticlesVojnosanit Pregl201370547748323789287
  • WangRBaoSLiuFWear behavior of light-cured resin composites with bimodal silica nanostructures as fillersMat Sci Eng C Mater201333847594766
  • XuHHWeirMDSunLStrong nanocomposites with Ca, PO(4), and F release for caries inhibitionJ Dent Res2010891192819948941
  • XiaYZhangFXieHGuNNanoparticle-reinforced resin-based dental compositesJ Dent200836645045518407396
  • WangWSunXHuangLStructure-property relationships in hybrid dental nanocomposite resins containing monofunctional and multifunctional polyhedral oligomeric silsesquioxanesInt J Nanomedicine2014984185224550674
  • MeloMAChengLZhangKWeirMDRodriguesLKXuHHNovel dental adhesives containing nanoparticles of silver and amorphous calcium phosphateJ Biomed Mater Res B Appl Biomater2013292199210
  • WagnerABelliRStotzelCHilpertAMullerFALohbauerUBiomimetically- and hydrothermally-grown HAp nanoparticles as reinforcing fillers for dental adhesivesJ Adhes Dent201315541342223560259
  • HabekostLVCamachoGBLimaGSOgliariFACubasGBMoraesRRNanoparticle loading level and properties of experimental hybrid resin luting agentsJ Prosthodont201221754054522672507
  • JallotENedelecJMGrimaultASSTEM and EDXS characterisation of physico-chemical reactions at the periphery of sol-gel derived Zn-substituted hydroxyapatites during interactions with biological fluidsColloid Surf B2005423–4205210
  • KrisanapiboonABuranapanitkitBOungbhoKBiocompatability of hydroxyapatite composite as a local drug delivery systemJ Orthop Surg (Hong Kong)200614331531817200535
  • QiXLiHQiaoBDevelopment and characterization of an injectable cement of nano calcium-deficient hydroxyapatite/multi(amino acid) copolymer/calcium sulfate hemihydrate for bone repairInt J Nanomedicine201384441445224293996
  • HuberFXBelyaevOHillmeierJFirst histological observations on the incorporation of a novel nanocrystalline hydroxyapatite paste OSTIM in human cancellous boneBMC Musculoskelet Disord200675016762071
  • YangCLeeJSJungUWSeoYKParkJKChoiSHPeriodontal regeneration with nano-hyroxyapatite-coated silk scaffolds in dogsJ Periodontal Implant Sci201343631532224455445
  • AnSHMatsumotoTMiyajimaHNakahiraAKimKHImazatoSPorous zirconia/hydroxyapatite scaffolds for bone reconstructionDent Mater201228121221123123018082
  • De AzaAHChevalierJFantozziGSchehlMTorrecillasRCrack growth resistance of alumina, zirconia and zirconia toughened alumina ceramics for joint prosthesesBiomaterials200223393794511774853
  • UnoMKurachiMWakamatsuNDoiYEffects of adding silver nanoparticles on the toughening of dental porcelainJ Prosthet Dent2013109424124723566605
  • HanYKiat-amnuaySPowersJMZhaoYEffect of nano-oxide concentration on the mechanical properties of a maxillofacial silicone elastomerJ Prosthet Dent2008100646547319033031
  • Acosta-TorresLSMendietaINunez-AnitaRECajero-JuarezMCastanoVMCytocompatible antifungal acrylic resin containing silver nanoparticles for denturesInt J Nanomedicine201274777478622969297
  • KarlssonMPalsgardEWilshawPRDi SilvioLInitial in vitro interaction of osteoblasts with nano-porous aluminaBiomaterials200324183039304612895576
  • PardunKTreccaniLVolkmannECharacterization of wet powder-sprayed zirconia/calcium phosphate coating for dental implantsClin Implant Dent Relat Res201517118619823574454
  • UezonoMTakakudaKKikuchiMSuzukiSMoriyamaKHydroxy-apatite/collagen nanocomposite-coated titanium rod for achieving rapid osseointegration onto bone surfaceJ Biomed Mater Res B Appl Biomater201310161031103823554303
  • MendoncaGMendoncaDBAragaoFJCooperLFAdvancing dental implant surface technology – from micron- to nanotopographyBiomaterials200829283822383518617258
  • LeboldTJungCMichaelisJBrauchleCNanostructured silica materials as drug-delivery systems for doxorubicin: single molecule and cellular studiesNano Lett2009982877288319572735
  • MuLFengSSA novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGSJ Control Release2003861334812490371
  • MelanconMPLuWZhongMTargeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancerBiomaterials201132307600760821745689
  • ErdoganSLiposomal nanocarriers for tumor imagingJ Biomed Nanotechnol20095214115020055092
  • WeirAWesterhoffPFabriciusLHristovskiKvon GoetzNTitanium dioxide nanoparticles in food and personal care productsEnviron Sci Technol20124642242225022260395
  • GeraetsLOomenAGSchroeterJDColemanVACasseeFRTissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: results from a 28-day exposure studyToxicol Sci2012127246347322430073
  • ChenYLiuLModern methods for delivery of drugs across the blood–brain barrierAdv Drug Deliv Rev201264764066522154620
  • PatelTZhouJPiepmeierJMSaltzmanWMPolymeric nanoparticles for drug delivery to the central nervous systemAdv Drug Deliv Rev201264770170522210134
  • BeduneauASaulnierPBenoitJPActive targeting of brain tumors using nanocarriersBiomaterials200728334947496717716726
  • SpectorRNature and consequences of mammalian brain and CSF efflux transporters: four decades of progressJ Neurochem20101121132319860860
  • KaoYYChengTJYangDMWangCTChiungYMLiuPSDemonstration of an olfactory bulb-brain translocation pathway for ZnO nanoparticles in rodent cells in vitro and in vivoJ Mol Neurosci201248246447122528453
  • HwangSRKimKNano-enabled delivery systems across the blood–brain barrierArch Pharm Res2014371243024170511
  • CaragliaMDe RosaGSalzanoGNanotech revolution for the anti-cancer drug delivery through blood–brain-barrierCurr Cancer Drug Tar2012123186196
  • BarbuEMolnarETsibouklisJGoreckiDCThe potential for nanoparticle-based drug delivery to the brain: overcoming the blood–brain barrierExpert Opin Drug Deliv20096655356519435406
  • JainKKNanobiotechnology-based strategies for crossing the blood–brain barrierNanomedicine (Lond)2012781225123322931448
  • WatsonREDesessoJMHurttMECapponGDPostnatal growth and morphological development of the brain: a species comparisonBirth Defects Res B Dev Reprod Toxicol200677547148417066419
  • YamashitaKYoshiokaYHigashisakaKSilica and titanium dioxide nanoparticles cause pregnancy complications in miceNat Nanotechnol20116532132821460826
  • OkadaYTachibanaKYanagitaSTakedaKPrenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspringJ Toxicol Sci201338336337023665935
  • YuLEYungLYLOngCNTranslocation and effects of gold nanoparticles after inhalation exposure in ratsNanotoxicology200713235242
  • Biddlestone-ThorpeLMarchiNGuoKNanomaterial-mediated CNS delivery of diagnostic and therapeutic agentsAdv Drug Deliv Rev201264760561322178615
  • WangBFengWYZhuMTNeurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in miceJ Nanopart Res20091114153
  • ShahLYadavSAmijiMNanotechnology for CNS delivery of bio-therapeutic agentsDrug Deliv Transl Res20133433635123894728
  • De LorenzoAJThe olfactory neuron and the blood–brain barrierLondonCIBA Foundation Symposium Series J&A Churchill1970
  • ThorneRGPronkGJPadmanabhanVFreyWH2ndDelivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administrationNeuroscience2004127248149615262337
  • DhuriaSVHansonLRFreyWH2ndIntranasal delivery to the central nervous system: mechanisms and experimental considerationsJ Pharm Sci20109941654167319877171
  • OberdorsterGOberdorsterEOberdorsterJNanotoxicology: an emerging discipline evolving from studies of ultrafine particlesEnviron Health Perspect2005113782383916002369
  • VilellaATosiGGrabruckerAMInsight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distributionJ Control Release201417419520124316476
  • AmaraSBen-SlamaIMradIAcute exposure to zinc oxide nanoparticles does not affect the cognitive capacity and neurotransmitters levels in adult ratsNanotoxicology20148suppl 120821524524369
  • ZhangLBaiRLiBRutile TiO2 particles exert size and surface coating dependent retention and lesions on the murine brainToxicol Lett20112071738121855616
  • KumarVKumariAGuleriaPYadavSKEvaluating the toxicity of selected types of nanochemicalsRev Environ Contam T201221539121
  • LiYLiJYinJSystematic influence induced by 3 nm titanium dioxide following intratracheal instillation of miceJ Nanosci Nanotechno2010101285448549
  • ZeYHuRWangXNeurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticlesJ Biomed Mater Res A2014102247047823533084
  • KwonJTSeoGBJoAluminum nanoparticles induce ERK and p38MAPK activation in rat brainToxicol Res201329318118524386518
  • MaranoFHussainSRodrigues-LimaFBaeza-SquibanABolandSNanoparticles: molecular targets and cell signallingArch Toxicol201185773374120502881
  • ShrivastavaRRazaSYadavAKushwahaPFloraSJSEffects of sub-acute exposure to TiO2, ZnO and Al2O3 nanoparticles on oxidative stress and histological changes in mouse liver and brainDrug Chem Toxicol201437333634724344737
  • HuRZhengLZhangTMolecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticlesJ Hazard Mater20111911–3324021570177
  • Win-ShweTTFujimakiHNanoparticles and neurotoxicityInt J Mol Sci20111296267628022016657
  • ChoiJZhengQDKatzHEGuilarteTRSilica-based nanoparticle uptake and cellular response by primary microgliaEnviron Health Perspect2010118558959520439179
  • TobeEHMitochondrial dysfunction, oxidative stress, and major depressive disorderNeuropsych Dis Treat20139567573
  • ZhangYYuCGHuangGYWangCLWenLPNano rare-earth oxides induced size-dependent vacuolization: an independent pathway from autophagyInt J Nanomedicine2010560160920856835
  • ChenLMiaoYChenLThe role of low levels of fullerene C60 nanocrystals on enhanced learning and memory of rats through persistent CaMKII activationBiomaterials201435349269927925129570
  • HanDDTianYTZhangTRenGGYangZNano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar ratsInt J Nanomedicine201161453146121796247
  • LiTShiTTLiXBZengSLYinLHPuYPEffects of Nano-MnO2 on dopaminergic neurons and the spatial learning capability of ratsInt J Env Res Pub He201411879187930
  • KimEMPalmerPHowardVEffect of Intracerebroventricular injection of TiO2 nanoparticles on complex behaviour in the ratJ Nanosci Nanotechno2013131283258330
  • CuiYChenXZhouZPrenatal exposure to nanoparticulate titanium dioxide enhances depressive-like behaviors in adult ratsChemosphere2014969910423972732
  • SorceSKrauseKHNOX enzymes in the central nervous system: from signaling to diseaseAntioxid Redox Sign2009111024812504
  • MassaadCAKlannEReactive oxygen species in the regulation of synaptic plasticity and memoryAntioxid Redox Sign2011141020132054
  • SchappiMGJaquetVBelliDCKrauseKHHyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidaseSemin Immunopathol200830325527118509648
  • ThomasMPChartrandKReynoldsAVitvitskyVBanerjeeRGendelmanHEIon channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson’s diseaseJ Neurochem2007100250351917241161
  • HuRGongXDuanYNeurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticlesBiomaterials201031318043805020692697
  • KrolSChallenges in drug delivery to the brain: nature is against usJ Control Release2012164214515522609350
  • ArmulikAGenovéGMäeMPericytes regulate the blood–brain barrierNature20104687323557U23120944627
  • WohlfartSGelperinaSKreuterJTransport of drugs across the blood–brain barrier by nanoparticlesJ Control Release2012161226427321872624
  • PowersCMBaleASKraftADDevelopmental neurotoxicity of engineered nanomaterials: identifying research needs to support human health risk assessmentToxicol Sci2013134222524223708405
  • YeDRaghnaillMNBraminiMNanoparticle accumulation and transcytosis in brain endothelial cell layersNanoscale2013522111531116524077327
  • WeissCKKohnleMVLandfesterKThe first step into the brain: uptake of NIO-PBCA nanoparticles by endothelial cells in vitro and in vivo, and direct evidence for their blood–brain barrier permeationChem Med Chem2008391395140318613205
  • Halamoda KenzaouiBChapuis BernasconiCGuney-AyraSJuillerat-JeanneretLInduction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cellsBiochem J2012441381382122026563
  • HanadaSFujiokaKInoueYKanayaFManomeYYamamotoKCell-based in vitro blood–brain barrier model can rapidly evaluate nanoparticles’ brain permeability in association with particle size and surface modificationInt J Mol Sci20141521812182524469316
  • BrunECarriereMMabondzoAIn vitro evidence of dysregulation of blood–brain barrier function after acute and repeated/long-term exposure to TiO2 nanoparticlesBiomaterials201233388689622027597
  • OgunsholaOOIn vitro modeling of the blood–brain barrier: simplicity versus complexityCurr Pharm Design2011172627552761
  • Pilakka-KanthikeelSAtluriVSRSagarVSaxenaSKNairMTargeted brain derived neurotropic factors (BDNF) delivery across the blood–brain barrier for neuro-protection using magnetic nano carriers: an in-vitro studyPLoS One201384e6224123653680
  • GromnicovaRDaviesHASreekanthreddyPGlucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitroPLoS One2013812e8104324339894
  • SumiNNishiokuTTakataFLipopolysaccharide-activated microglia induce dysfunction of the blood–brain barrier in rat Microvascular endothelial cells co-cultured with microgliaCell Mol Neurobiol201030224725319728078
  • WongHLWuXYBendayanRNanotechnological advances for the delivery of CNS therapeuticsAdv Drug Deliv Rev201264768670022100125
  • AshaRaniPVHandeMPValiyaveettilSAnti-proliferative activity of silver nanoparticlesBMC Cell Biol2009106519761582
  • WileyDTWebsterPGaleADavisMETranscytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptorP Natl Acad Sci U S A20131102186628667
  • RaghnaillMNBraminiMYeDParacrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticlesAnalyst2014139592393024195103
  • WangJDengXZhangFChenDDingWZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytesNanoscale Res Lett20149111724624962
  • PickardMRJenkinsSIKollerCJFurnessDNChariDMMagnetic nanoparticle labeling of astrocytes derived for neural transplantationTissue Eng Part C Methods2011171899920666601
  • LaiJCLaiMBJandhyamSExposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblastsInt J Nanomedicine20083453354519337421
  • XueYWuJSunJFour types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitroToxicol Lett20122142919822939914
  • Huerta-GarcíaEPérez-AriztiJAMárquez-RamírezSGTitanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cellsFree Radic Biol Med201473849424824983
  • WangYWangBZhuMTMicroglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposureToxicol Lett20112051263721596115
  • WuJSunJAXueYInvolvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cellsToxicol Lett2010199326927620863874
  • LiuSCXuLJZhangTRenGGYangZOxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cellsToxicology20102671–317217719922763
  • ValdiglesiasVCostaCKiliçGNeuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticlesEnviron Int2013559210023535050
  • ValdiglesiasVCostaCSharmaVComparative study on effects of two different types of titanium dioxide nanoparticles on human neuronal cellsFood Chem Toxicol20135735236123597443
  • XieHRHuLSLiGYSH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson’s diseaseChin Med J (Engl)201012381086109220497720
  • ChiangHMXiaQZouXNanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cellsJ Nanosci Nanotechnol20121232126213522755030
  • ZieminskaEStafiejAStruzynskaLThe role of the glutamatergic NMDA receptor in nanosilver-evoked neurotoxicity in primary cultures of cerebellar granule cellsToxicology2014315384824291493
  • ZhaoJXuLZhangTRenGYangZInfluences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neuronsNeurotoxicology200930222023019146874
  • LiuZRenGZhangTYangZAction potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticlesToxicology2009264317918419683029
  • GrabruckerAMGarnerCCBoeckersTMDevelopment of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidencesPLoS One201163e1785121448455
  • XuLJZhaoJXZhangTRenGGYangZIn vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currentsEnviron Toxicol200924321121718623077
  • YangZLiuZWAllakerRPA review of nanoparticle functionality and toxicity on the central nervous systemJ R Soc Interface20107suppl 4S411S42220519209
  • WangYCuiJSunXZhangYTunneling-nanotube development in astrocytes depends on p53 activationCell Death Differ201118473274221113142
  • TosiGVilellaAChhabraRInsight on the fate of CNS-targeted nanoparticles. Part II: intercellular neuronal cell-to-cell transportJ Control Release20141779610724417968
  • ParkEJYiJKimYChoiKParkKSilver nanoparticles induce cytotoxicity by a Trojan-horse type mechanismToxicol In Vitro201024387287819969064
  • Monteiro-RiviereNAInmanAOZhangLWLimitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell lineToxicol Appl Pharmacol2009234222223518983864
  • GriffithsSMSinghNJenkinsGJDextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyesAnal Chem201183103778378521469681
  • KettigerHSchipanskiAWickPHuwylerJEngineered nanomaterial uptake and tissue distribution: from cell to organismInt J Nanomedicine201383255326924023514
  • RaspopovRVGmoshinskiiIVPopovKIKrasnoiarovaOVKhotimchenkoSAMethods of nanoparticles control in food and biological objects. Report 1. Use of microscopic and chromatography investigation methodsVopr Pitan2012812411 Russian22774471
  • AroraSRajwadeJMPaknikarKMNanotoxicology and in vitro studies: the need of the hourToxicol Appl Pharmacol2012258215116522178382
  • CliftMJGehrPRothen-RutishauserBNanotoxicology: a perspective and discussion of whether or not in vitro testing is a valid alternativeArch Toxicol201185772373120499226
  • DhawanASharmaVToxicity assessment of nanomaterials: methods and challengesAnal Bioanal Chem2010398258960520652549
  • KrollADierkerCRommelCCytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assaysPart Fibre Toxicol20118921345205
  • HanleyCThurberAHannaCPunnooseAZhangJHWingettDGThe Influences of cell type and ZnO nanoparticle Size on immune cell cytotoxicity and cytokine inductionNanoscale Res Lett20094121409142020652105
  • DonaldsonKBormPJCastranovaVGulumianMThe limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticlesPart Fibre Toxicol200961319397808
  • KimJSPetersTMO’ShaughnessyPTAdamcakova-DoddAThornePSValidation of an in vitro exposure system for toxicity assessment of air-delivered nanomaterialsToxicol In Vitro201327116417322981796
  • CostantinoLBoraschiDIs there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?Drug Discov Today2012177–836737822094246
  • LaurentSBurteaCThirifaysCHafeliUOMahmoudiMCrucial ignored parameters on nanotoxicology: the importance of toxicity assay modifications and “cell vision”PLoS One201271306314
  • LesniakACampbellAMonopoliMPLynchISalvatiADawsonKASerum heat inactivation affects protein corona composition and nanoparticle uptakeBiomaterials201031369511951821059466
  • MahmoudiMMonopoliMPRezaeiMThe protein corona mediates the impact of nanomaterials and slows amyloid beta fibrillationChembiochem201314556857223420562
  • MirshafieeVMahmoudiMLouKYChengJJKraftMLProtein corona significantly reduces active targeting yieldChem Commun2013492525572559
  • SalvatiAPitekASMonopoliMPTransferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surfaceNat Nanotechnol20138213714323334168
  • TakharPMahantSIn vitro methods for nanotoxicity assessment: advantages and applicationsArch Appl Sci Res201132389403
  • BlockMLElderAAutenRLThe outdoor air pollution and brain health workshopNeurotoxicology201233597298422981845
  • RodierPMEnvironmental causes of central nervous system maldevelopmentPediatrics200411341076108315060202
  • SparkmanNLJohnsonRWNeuroinflammation associated with aging sensitizes the brain to the effects of infection or stressNeuroimmunomodulat2008154–6323330
  • von BernhardiRTichauerJEEugeninJAging-dependent changes of microglial cells and their relevance for neurodegenerative disordersJ Neurochem201011251099111420002526
  • CarveyPMPunatiANewmanMBProgressive dopamine neuron loss in Parkinson’s disease: the multiple hit hypothesisCell Transplant200615323925016719059
  • QinLYWuXFBlockMLSystemic LPS causes chronic neuroinflammation and progressive neurodegenerationGlia200755545346217203472
  • GiordanoGTaitLFurlongCEColeTBKavanaghTJCostaLGGender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expressionFree Radical Bio Med2013589810823376469
  • CostaLGde LaatRDaoKPellacaniCColeTBFurlongCEParaoxonase-2 (PON2) in brain and its potential role in neuroprotectionNeurotoxicology2014433924012887
  • SegalMBThe choroid plexuses and the barriers between the blood and the cerebrospinal fluidCell Mol Neurobiol200020218319610696509