Natural product-based nanomedicine: recent advances and issues

References

• StrohlWRThe role of natural products in a modern drug discovery programDrug Discov Today200052394110652450
   PubMed Web of Science ®Google Scholar
• ManlySPPadmanabhaRLoweSENatural products or not? How to screen for natural products in the emerging HTS paradigmMethods Mol Biol200219015316812029820
   PubMedGoogle Scholar
• LuDWilliamsPGWangGMetabolic engineering for the development and manufacturing of pharmaceuticalsTaoJLinGLieseABiocatalysis for the Pharmaceutical Industry Discovery, Development, and ManufacturingSingaporeJohn Wiley & Sons Asia2009247271
   Google Scholar
• KhushnudTMousaSAPotential role of naturally derived polyphenols and their nanotechnology delivery in cancerMol Biotechnol2013551788623371307
   PubMed Web of Science ®Google Scholar
• BonifacioBVSilvaPBRamosMANegriKMBauabTMChorilliMNanotechnology-based drug delivery systems and herbal medicines: a reviewInt J Nanomedicine2014911524363556
   PubMed Web of Science ®Google Scholar
• SharmaRAEudenSAPlattonSLPhase I clinical trial of oral curcumin: biomarkers of systemic activity and complianceClin Cancer Res200410206847685415501961
   PubMed Web of Science ®Google Scholar
• AnandPKunnumakkaraABNewmanRAAggarwalBBBioavailability of curcumin: problems and promisesMol Pharm20074680781817999464
   PubMed Web of Science ®Google Scholar
• ManachCWilliamsonGMorandCScalbertARemesyCBioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studiesAm J Clin Nutr2005811 suppl230S242S15640486
   PubMed Web of Science ®Google Scholar
• ThilakarathnaSHRupasingheHPFlavonoid bioavailability and attempts for bioavailability enhancementNutrients2013593367338723989753
   PubMed Web of Science ®Google Scholar
• AuffanMRoseJBotteroJYLowryGVJolivetJPWiesnerMRTowards a definition of inorganic nanoparticles from an environmental, health and safety perspectiveNat Nanotechnol200941063464119809453
   PubMed Web of Science ®Google Scholar
• McNeilSENanoparticle therapeutics: a personal perspectiveWiley Interdiscip Rev Nanomed Nanobiotechnol20091326427120049796
   PubMed Web of Science ®Google Scholar
• DubeANicolazzoJALarsonIChitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (−)-epigallocatechin gallateEur J Pharm Sci201041221922520600878
   PubMed Web of Science ®Google Scholar
• TanQLiuWGuoCZhaiGPreparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical deliveryInt J Nanomedicine201161621163021904452
   PubMed Web of Science ®Google Scholar
• SannaVRoggioAMSilianiSDevelopment of novel cationic chitosan- and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrolInt J Nanomedicine201275501551623093904
   PubMed Web of Science ®Google Scholar
• BarhateGGautamMGairolaSJadhavSPokharkarVEnhanced mucosal immune responses against tetanus toxoid using novel delivery system comprised of chitosan-functionalized gold nanoparticles and botanical adjuvant: characterization, immunogenicity, and stability assessmentJ Pharm Sci2014103113448345625219511
   PubMed Web of Science ®Google Scholar
• CasettariLIllumLChitosan in nasal delivery systems for therapeutic drugsJ Control Release201419018920024818769
   PubMed Web of Science ®Google Scholar
• LiangJLiFFangYCytotoxicity and apoptotic effects of tea polyphenolloaded chitosan nanoparticles on human hepatoma HepG2 cellsMater Sci Eng C Mater Biol Appl20143671324433880
   PubMed Web of Science ®Google Scholar
• SamarasingheRMKanwarRKKumarKKanwarJRAntiarthritic and chondroprotective activity of Lakshadi Guggul in novel alginate-enclosed chitosan calcium phosphate nanocarriersNanomedicine (Lond)20149681983724401101
   PubMed Web of Science ®Google Scholar
• LeonarduzziGTestaGSotteroBGambaPPoliGDesign and development of nanovehicle-based delivery systems for preventive or therapeutic supplementation with flavonoidsCurr Med Chem2010171749519941477
   PubMed Web of Science ®Google Scholar
• MuqbilIMasoodASarkarFHMohammadRMAzmiASProgress in nanotechnology based approaches to enhance the potential of chemopreventive agentsCancers (Basel)20113142844524212623
   PubMedGoogle Scholar
• FahrAvan HoogevestPMaySBergstrandNLeighMLTransfer of lipophilic drugs between liposomal membranes and biological interfaces: consequences for drug deliveryEur J Pharm Sci2005263–425126516112849
   PubMed Web of Science ®Google Scholar
• YallapuMMJaggiMChauhanSCCurcumin nanoformulations: a future nanomedicine for cancerDrug Discov Today2012171–2718021959306
   PubMed Web of Science ®Google Scholar
• ÜnerMYenerGImportance of solid lipid nanoparticles (SLN) in various administration routes and future perspectivesInt J Nanomedicine20072328930018019829
   PubMed Web of Science ®Google Scholar
• YallapuMMJaggiMChauhanSCCurcumin nanomedicine: a road to cancer therapeuticsCurr Pharm Des201319111994201023116309
   PubMed Web of Science ®Google Scholar
• NaksuriyaOOkonogiSSchiffelersRMHenninkWECurcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatmentBiomaterials201435103365338324439402
   PubMed Web of Science ®Google Scholar
• LiuYFengNNanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM)Adv Colloid Interface Sci2015221607625999266
   PubMed Web of Science ®Google Scholar
• LuoYCobbREZhaoHRecent advances in natural product discoveryCurr Opin Biotechnol20143023023725260043
   PubMed Web of Science ®Google Scholar
• GrynkiewiczGŚlifirskiPCurcumin and curcuminoids in quest for medicinal statusActa Biochim Pol201259220121222590694
   PubMed Web of Science ®Google Scholar
• RothwellJADayAJMorganMRExperimental determination of octanol-water partition coefficients of quercetin and related flavonoidsJ Agric Food Chem200553114355436015913295
   PubMed Web of Science ®Google Scholar
• LiJLiuPLiuJPBioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug-phospholipids complex techniqueEur J Pharm Biopharm2013831768623085582
   PubMed Web of Science ®Google Scholar
• LeeWHLooCYYoungPMTrainiDMasonRSRohanizadehRRecent advances in curcumin nanoformulation for cancer therapyExpert Opin Drug Deliv20141181183120124857605
   PubMed Web of Science ®Google Scholar
• WangNFengYElaborating the role of natural products-induced autophagy in cancer treatment: achievements and artifacts in the state of the artBiomed Res Int2015201593420725821829
   PubMed Web of Science ®Google Scholar
• AokiHTakadaYKondoSSawayaRAggarwalBBKondoYEvidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathwaysMol Pharmacol2007721293917395690
   PubMed Web of Science ®Google Scholar
• ZhuangWLongLZhengBCurcumin promotes differentiation of glioma-initiating cells by inducing autophagyCancer Sci2012103468469022192169
   PubMed Web of Science ®Google Scholar
• XiaoKJiangJGuanCCurcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cellsJ Pharmacol Sci2013123210210924048094
   PubMed Web of Science ®Google Scholar
• MorgenszternDMcLeodHLPI3K/Akt/mTOR pathway as a target for cancer therapyAnticancer Drugs200516879780316096426
   PubMed Web of Science ®Google Scholar
• SaikiSSasazawaYImamichiYCaffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibitionAutophagy20117217618721081844
   PubMed Web of Science ®Google Scholar
• KhanKHYapTAYanLCunninghamDTargeting the PI3K-AKT-mTOR signaling network in cancerChin J Cancer201332525326523642907
   PubMed Web of Science ®Google Scholar
• WangMYuTZhuCResveratrol triggers protective autophagy through the ceramide/Akt/mTOR pathway in melanoma B16 cellsNutr Cancer201466343544024579778
   PubMed Web of Science ®Google Scholar
• WangGWangJJToTSZhaoHFJungWRole of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomesInt J Nanomedicine2015105005502326345416
   PubMed Web of Science ®Google Scholar
• Di PietroADayanGConseilGP-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationshipsBraz J Med Biol Res199932892593910454753
   PubMed Web of Science ®Google Scholar
• BorskaSChmielewskaMWysockaTDrag-ZalesinskaMZabelMDziegielPIn vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDRFood Chem Toxicol20125093375338322750388
   PubMed Web of Science ®Google Scholar
• NguyenHZhangSMorrisMEEffect of flavonoids on MRP1-mediated transport in Panc-1 cellsJ Pharm Sci200392225025712532374
   PubMed Web of Science ®Google Scholar
• ChangHChenBInhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa LinnaeusInt J Nanomedicine2015105059508026345201
   PubMed Web of Science ®Google Scholar
• KirstHADeveloping new antibacterials through natural product researchExpert Opin Drug Discov20138547949323480029
   PubMed Web of Science ®Google Scholar
• OuattaraBSimardREHolleyRAPietteGJBéginAAntibacterial activity of selected fatty acids and essential oils against six meat spoilage organismsInt J Food Microbiol1997372–31551629310850
   PubMed Web of Science ®Google Scholar
• SharmaGRaturiKDangSGuptaSGabraniRCombinatorial antimicrobial effect of curcumin with selected phytochemicals on Staphylococcus epidermidisJ Asian Nat Prod Res201416553554124773066
   PubMed Web of Science ®Google Scholar
• LvFLiangHYuanQLiCIn vitro antimicrobial effects and mechanism of action of selected plant essential oil combinations against four food-related microorganismsFood Res Intern20114430573064
   Web of Science ®Google Scholar
• GillAOHolleyRAMechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakeiAppl Environ Microbiol200470105750575515466510
   PubMed Web of Science ®Google Scholar
• NairHBSungBYadavVRKannappanRChaturvediMMAggarwalBBDelivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancerBiochem Pharmacol201080121833184320654584
   PubMed Web of Science ®Google Scholar
• PrasadSPhromnoiKYadavVRChaturvediMMAggarwalBBTargeting inflammatory pathways by flavonoids for prevention and treatment of cancerPlanta Med201076111044106320635307
   PubMed Web of Science ®Google Scholar
• BalaIBhardwajVHariharanSKharadeSVRoyNRavi KumarMNSustained release nanoparticulate formulation containing antioxidantellagic acid as potential prophylaxis system for oral administrationJ Drug Target2006141273416603449
   PubMed Web of Science ®Google Scholar
• TakahashiMUechiSTakaraKAsikinYWadaKEvaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcuminJ Agric Food Chem200957199141914619757811
   PubMed Web of Science ®Google Scholar
• FeliceFZambitoYBelardinelliEDelivery of natural polyphenols by polymeric nanoparticles improves the resistance of endothelial progenitor cells to oxidative stressEur J Pharm Sci2013503–439339923988846
   PubMed Web of Science ®Google Scholar
• RameshkumarASivasudhaTJeyadeviRIn vitro antioxidant and antimicrobial activities of Merremia emarginata using thio glycolic acid-capped cadmium telluride quantum dotsColloids Surf B Biointerfaces2013101748222796774
   PubMed Web of Science ®Google Scholar
• ZuYWuWZhaoXEnhancement of solubility, antioxidant ability and bioavailability of taxifolin nanoparticles by liquid antisolvent precipitation techniqueInt J Pharm20144711–236637624882039
   PubMedGoogle Scholar
• JørgensenLVMadsenHLThomsenMKDragstedLOSkibstedLHRegeneration of phenolic antioxidants from phenoxyl radicals: an ESR and electrochemical study of antioxidant hierarchyFree Radic Res199930320722010711791
   PubMed Web of Science ®Google Scholar
• WeberWMHunsakerLAAbcouwerSFDeckLMVander JagtDLAntioxidant activities of curcumin and related enonesBioorg Med Chem200513113811382015863007
   PubMed Web of Science ®Google Scholar
• ZhaoGRZhangHMYeTXCharacterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid BFood Chem Toxicol2008461738117719161
   PubMed Web of Science ®Google Scholar
• XueMZhangLYangMBerberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db miceInt J Nanomedicine2015105049505726346310
   PubMed Web of Science ®Google Scholar
• AbdelwahabSISheikhBYTahaMMThymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administrationInt J Nanomedicine201382163217223818776
   PubMed Web of Science ®Google Scholar
• PengLHXuSYShanYHSequential release of salidroside and paeonol from a nanospherehydrogel system inhibits ultraviolet B-induced melanogenesis in guinea pig skinInt J Nanomedicine201491897190824790432
   PubMed Web of Science ®Google Scholar
• CeliaCTrapassoELocatelliMAnticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cellsColloids Surf B Biointerfaces201311254855324099646
   PubMed Web of Science ®Google Scholar
• PundSBoradeGRasveGImprovement of anti-inflammatory and anti-angiogenic activity of berberine by novel rapid dissolving nanoemulsifying techniquePhytomedicine201421330731424176841
   PubMed Web of Science ®Google Scholar
• DingSMZhangZHSongJChengXDJiangJJiaXBEnhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersionInt J Nanomedicine201492327233324872695
   PubMed Web of Science ®Google Scholar
• KakkarVSinghSSinglaDKaurIPExploring solid lipid nanoparticles to enhance the oral bioavailability of curcuminMol Nutr Food Res201155349550320938993
   PubMed Web of Science ®Google Scholar
• XieXTaoQZouYPLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanismsJ Agric Food Chem201159179280928921797282
   PubMed Web of Science ®Google Scholar
• ShobaGJoyDJosephTMajeedMRajendranRSrinivasPSInfluence of piperine on the pharmacokinetics of curcumin in animals and human volunteersPlanta Med19986443533569619120
   PubMed Web of Science ®Google Scholar
• LambertJDHongJKimDHMishinVMYangCSPiperine enhances the bioavailability of the tea polyphenol (−)-epigallocatechin-3-gallate in miceJ Nutr200413481948195215284381
   PubMed Web of Science ®Google Scholar
• SurhYJAnti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short reviewFood Chem Toxicol20024081091109712067569
   PubMed Web of Science ®Google Scholar
• OnoKHasegawaKNaikiHYamadaMCurcumin has potent anti-amyloidogenic effects for Alzheimer’s beta-amyloid fibrils in vitroJ Neurosci Res200475674275014994335
   PubMed Web of Science ®Google Scholar
• MaheshwariRKSinghAKGaddipatiJSrimalRCMultiple biological activities of curcumin: a short reviewLife Sci200678182081208716413584
   PubMed Web of Science ®Google Scholar
• ShenHHuXSzymusiakMWangZJLiuYOrally administered nanocurcumin to attenuate morphine tolerance: comparison between negatively charged PLGA and partially and fully PEGylated nanoparticlesMol Pharm201310124546455124195658
   PubMedGoogle Scholar
• GuptaSCPatchvaSAggarwalBBTherapeutic roles of curcumin: lessons learned from clinical trialsAAPS J201315119521823143785
   PubMed Web of Science ®Google Scholar
• WahlstromBBlennowGA study on the fate of curcumin in the ratActa Pharmacol Toxicol (Copenhagen)19784328692
   PubMedGoogle Scholar
• NarayananNKNargiDRandolphCNarayananBALiposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout miceInt J Cancer200912511819326431
   PubMed Web of Science ®Google Scholar
• LiRQiaoXLiQMetabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometryJ Chromatogr B Analyt Technol Biomed Life Sci20118792627512758
   PubMed Web of Science ®Google Scholar
• BishtSMizumaMFeldmannGSystemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancerMol Cancer Ther2010982255226420647339
   PubMed Web of Science ®Google Scholar
• ChunYSBishtSChennaVIntraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: implications for breast cancer chemoprevention in at-risk populationsCarcinogenesis201233112242224922831956
   PubMed Web of Science ®Google Scholar
• BhawanaBasniwalRKButtarHSJainVKJainNCurcumin nanoparticles: preparation, characterization, and antimicrobial studyJ Agric Food Chem20115952056206121322563
   PubMed Web of Science ®Google Scholar
• RajasekaranMAnnarajJA lucid build-up of nanostructured curcumin, quercetin and their interaction with DNAJ Nanosci Nanotechnol20141474874487924757956
   PubMed Web of Science ®Google Scholar
• SinghAAhmadIAkhterSNanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studiesColloids Surf B Biointerfaces201310282283223104039
   PubMed Web of Science ®Google Scholar
• BhattaRSChandasanaHChhonkerYSMucoadhesive nanoparticles for prolonged ocular delivery of natamycin: in vitro and pharmacokinetics studiesInt J Pharm20124321–210511222569234
   PubMedGoogle Scholar
• LiYSunSChangQA strategy for the improvement of the bioavailability and antiosteoporosis activity of BCS IV flavonoid glycosides through the formulation of their lipophilic aglycone into nanocrystalsMol Pharm20131072534254223659498
   PubMedGoogle Scholar
• TranTHGuoYSongDBrunoRSLuXQuercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailabilityJ Pharm Sci2014103384085224464737
   PubMed Web of Science ®Google Scholar
• SiddiquiIAAdhamiVMAhmadNMukhtarHNanochemoprevention: sustained release of bioactive food components for cancer preventionNutr Cancer201062788389020924964
   PubMed Web of Science ®Google Scholar
• SinghMBhatnagarPSrivastavaAKKumarPShuklaYGuptaKCEnhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticlesJ Biomed Nanotechnol20117120221485870
   PubMed Web of Science ®Google Scholar
• GohulkumarMGurushankarKRajendra PrasadNKrishnakumarNEnhanced cytotoxicity and apoptosis-induced anticancer effect of silibinin-loaded nanoparticles in oral carcinoma (KB) cellsMater Sci Eng C Mater Biol Appl20144127428224907761
   PubMed Web of Science ®Google Scholar
• MajumdarDJungKHZhangHLuteolin nanoparticle in chemo-prevention: in vitro and in vivo anticancer activityCancer Prev Res2014716573
   Web of Science ®Google Scholar
• BhardwajRKGlaeserHBecquemontLKlotzUGuptaSKFrommMFPiperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4J Pharmacol Exp Ther2002302264565012130727
   PubMed Web of Science ®Google Scholar
• Al-ShawiMKOmoteHThe remarkable transport mechanism of P-glycoprotein: a multidrug transporterJ Bioenerg Biomembr200537648949616691488
   PubMed Web of Science ®Google Scholar
• GuptaVAsehARiosCNAggarwalBBMathurABFabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapyInt J Nanomedicine2009411512219516890
   PubMed Web of Science ®Google Scholar
• TestaGGambaPBadilliULoading into nanoparticles improves quercetin’s efficacy in preventing neuroinflammation induced by oxysterolsPLoS One201495e9679524802026
   PubMed Web of Science ®Google Scholar
• HuangSChangSJYangMChenJJChangWHNanoscale hepatoprotective herbal decoction attenuates hepatic stellate cell activity and chloroform-induced liver damage in miceInt J Nanomedicine201161365137121760731
   PubMed Web of Science ®Google Scholar
• LinCHAl-SuwayehSAHungCFChenCCFangJYCamptothecin-loaded liposomes with alpha-melanocyte-stimulating hormone enhance cytotoxicity toward and cellular uptake by melanomas: an application of nanomedicine on natural productJ Tradit Complement Med20133210210924716164
   PubMedGoogle Scholar
• SheltonMCPosey-DowtyJDLingerfeltLKirkSKKleinSEdgarKJEnhanced dissolution of poorly soluble drugs from solid dispersions in carboxymethylcellulose acetate butyrate matricesEdgarKJHeinzeTBuchananCMPolysaccharide Materials: Performance by DesignWashington, DCACS200993113
   Google Scholar
• LiBHarichKWegielLTaylorLSEdgarKJStability and solubility enhancement of ellagic acid in cellulose ester solid dispersionsCarbohydr Polym20139221443145023399175
   PubMed Web of Science ®Google Scholar
• LiBKoneckeSHarichKWegielLTaylorLSEdgarKJSolid dispersion of quercetin in cellulose derivative matrices influences both solubility and stabilityCarbohydr Polym20139222033204023399255
   PubMed Web of Science ®Google Scholar
• LiBKoneckeSWegielLATaylorLSEdgarKJBoth solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matricesCarbohydr Polymers201398111081116
   PubMed Web of Science ®Google Scholar
• AbdulkarimMFAbdullahGZChitneniMTopical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocreamInt J Nanomedicine2010591592421116332
   PubMed Web of Science ®Google Scholar
• AscensoAPinhoSEleutérioCLycopene from tomatoes: vesicular nanocarrier formulations for dermal deliveryJ Agric Food Chem201361307284729323826819
   PubMed Web of Science ®Google Scholar
• BennetDKangSCGangJKimSPhotoprotective effects of apple peel nanoparticlesInt J Nanomedicine201499310824379668
   PubMed Web of Science ®Google Scholar
• PanyamJLabhasetwarVBiodegradable nanoparticles for drug and gene delivery to cells and tissueAdv Drug Deliv Rev200355332934712628320
   PubMed Web of Science ®Google Scholar
• SouKGoinsBTakeokaSTsuchidaEPhillipsWTSelective uptake of surface-modified phospholipid vesicles by bone marrow macrophages in vivoBiomaterials200728162655266617316790
   PubMed Web of Science ®Google Scholar
• SouKInenagaSTakeokaSTsuchidaELoading of curcumin into macrophages using lipid-based nanoparticlesInt J Pharm20083521–228729318063327
   PubMed Web of Science ®Google Scholar
• YallapuMMOthmanSFCurtisETCurcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applicationsInt J Nanomedicine201271761177922619526
   PubMed Web of Science ®Google Scholar
• LiLXiangDShigdarSEpithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cellsInt J Nanomedicine201491083109624591829
   PubMed Web of Science ®Google Scholar
• GargASinghSTargeting of eugenol-loaded solid lipid nanoparticles to the epidermal layer of human skinNanomedicine (Lond)2014981223123823987096
   PubMed Web of Science ®Google Scholar
• HuangWWangXShiCFine-tuning vitamin E-containing telodendrimers for efficient delivery of gambogic acid in colon cancer treatmentMol Pharm20151241216122925692376
   PubMedGoogle Scholar
• BarretoACSantiagoVRFreireRMMagnetic nanosystem for cancer therapy using oncocalyxone a, an antitomour secondary metabolite isolated from a Brazilian plantInt J Mol Sci2013149182691828324013376
   PubMed Web of Science ®Google Scholar
• El-GogaryRIRubioNWangJTPolyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivoACS Nano2014821384140124397686
   PubMed Web of Science ®Google Scholar
• LoureiroJAGomesBCoelhoMAdo Carmo PereiraMRochaSTargeting nanoparticles across the blood-brain barrier with monoclonal antibodiesNanomedicine (Lond)20149570972224827845
   PubMed Web of Science ®Google Scholar
• SheikDABrooksLFrantzenKDewhurstSYangJInhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticlesACS Nano2015921829183625619867
   PubMed Web of Science ®Google Scholar
• DreadenECAustinLAMackeyMAEl-SayedMASize matters: gold nanoparticles in targeted cancer drug deliveryTher Deliv20123445747822834077
   PubMedGoogle Scholar
• PanyamJZhouWZPrabhaSSahooSKLabhasetwarVRapid endolysosomal escape of poly (D,L-lactide-co-glycolide) nanoparticles: implications for drug and gene deliveryFASEB J200216101217122612153989
   PubMed Web of Science ®Google Scholar
• MegillALeeTDiBattistaAMA tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesisJ Neurosci201333229306931823719799
   PubMed Web of Science ®Google Scholar
• FangLGouSLiuXCaoFChengLDesign, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivativesBioorg Med Chem Lett2014241404324342238
   PubMed Web of Science ®Google Scholar
• MurphyMPSmithRADrug delivery to mitochondria: the key to mitochondrial medicineAdv Drug Deliv Rev200041223525010699318
   PubMed Web of Science ®Google Scholar
• BouarabLMaheraniBKheirolomoomAInfluence of lecithin-lipid composition on physico-chemical properties of nanoliposomes loaded with a hydrophobic moleculeColloids Surf B Biointerfaces201411519720424355384
   PubMed Web of Science ®Google Scholar
• CaiHWenXWenLEnhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administrationInt J Nanomedicine201495591560125489245
   PubMed Web of Science ®Google Scholar
• BishtSFeldmannGSoniSPolymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): a novel strategy for human cancer therapyJ Nanobiotechnology20075317439648
   PubMedGoogle Scholar
• GugulothuDKulkarniAPatravaleVDandekarPpH-sensitive nanoparticles of curcumin-celecoxib combination: evaluating drug synergy in ulcerative colitis modelJ Pharm Sci2014103268769624375287
   PubMed Web of Science ®Google Scholar
• LiFLiXLiBPreparation of magnetic polylactic acid microspheres and investigation of its releasing property for loading curcuminJ Magn Magn Mater20113232227702775
   Web of Science ®Google Scholar
• TiyaboonchaiWTungpraditWPlianbangchangPFormulation and characterization of curcuminoids loaded solid lipid nanoparticlesInt J Pharm20073371–229930617287099
   PubMed Web of Science ®Google Scholar
• RochaSGeneralovRPereira MdoCPeresIJuzenasPCoelhoMAEpigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemopreventionNanomedicine (Lond)201161798721182420
   PubMed Web of Science ®Google Scholar
• GomesCMoreiraRGCastell-PerezEPoly (DL-lactide-co-glycolide) (PLGA) nanoparticles with entrapped trans-cinnamaldehyde and eugenol for antimicrobial delivery applicationsJ Food Sci2011762N16N2421535781
   PubMed Web of Science ®Google Scholar
• BhushanSKakkarVPalHCEnhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from Boswellia serrataMol Pharm201310122523523237302
   PubMed Web of Science ®Google Scholar
• KumariAYadavSKPakadeYBSinghBYadavSCDevelopment of biodegradable nanoparticles for delivery of quercetinColloids Surf B Biointerfaces201080218419220598513
   PubMed Web of Science ®Google Scholar
• DateAANagarsenkerMSPatereSLecithin-based novel cationic nanocarriers (Leciplex) II: improving therapeutic efficacy of quercetin on oral administrationMol Pharm20118371672621480639
   PubMed Web of Science ®Google Scholar
• HeQZhangJChenFGuoLZhuZShiJAn anti-ROS/hepatic fibrosis drug delivery system based on salvianolic acid B loaded mesoporous silica nanoparticlesBiomaterials201031307785779620674009
   PubMed Web of Science ®Google Scholar
• CirpanliYBilensoyEDoganALCalisSDevelopment of polymeric and cyclodextrin nanoparticles for camptothecin deliveryJ Control Release20101481e21e2321529600
   PubMed Web of Science ®Google Scholar
• SilvaLMHillLEFigueiredoEGomesCLDelivery of phytochemicals of tropical fruit by-products using poly (DL-lactide-co-glycolide) (PLGA) nanoparticles: synthesis, characterization, and antimicrobial activityFood Chem201416536237025038688
   PubMed Web of Science ®Google Scholar
• FominaNMcFearinCSermsakdiMEdiginOAlmutairiAUV and near-IR triggered release from polymeric nanoparticlesJ Am Chem Soc2010132289540954220568765
   PubMed Web of Science ®Google Scholar
• DiJPriceJGuXJiangXJingYGuZUltrasound-triggered regulation of blood glucose levels using injectable nano-networkAdv Healthc Mater20143681181624255016
   PubMed Web of Science ®Google Scholar
• JainKKNanobiotechnology-based strategies for crossing the blood-brain barrierNanomedicine (Lond)2012781225123322931448
   PubMed Web of Science ®Google Scholar
• MullerRHGohlaSKeckCMState of the art of nanocrystals – special features, production, nanotoxicology aspects and intracellular deliveryEur J Pharm Biopharm20117811921266197
   PubMed Web of Science ®Google Scholar
• Bernkop-SchnürchANanocarrier systems for oral drug delivery: do we really need them?Eur J Pharm Sci201349227227723537503
   PubMed Web of Science ®Google Scholar
• KrolSChallenges in drug delivery to the brain: nature is against usJ Control Release2012164214515522609350
   PubMed Web of Science ®Google Scholar
• De JongWHBormPJDrug delivery and nanoparticles: applications and hazardsInt J Nanomedicine20083213314918686775
   PubMed Web of Science ®Google Scholar
• KamalyNXiaoZValenciaPMRadovic-MorenoAFFarokhzadOCTargeted polymeric therapeutic nanoparticles: design, development and clinical translationChem Soc Rev20124172971301022388185
   PubMed Web of Science ®Google Scholar
• PillaiGNanomedicines for cancer therapy: an update of FDA approved and those under various stages of developmentSOJ Pharm Pharm Sci20141213
   Google Scholar