Ten Take Home Lessons from the First 10 Years of the CTN and 10 Recommendations for the Future

REFERENCES

• Institute of Medicine. Bridging the Gap between Practice and Research: Forging Partnerships with Community-Based Drug and Alcohol Treatment. Washington, DC: National Academy Press, 1998.
   Google Scholar
• Tai B, Straus MM, Liu D, Sparenborg S, Jackson R, McCarty D. The first decade of the National Drug Abuse Treatment Clinical Trials Network: Bridging the gap between research and practice to improve drug abuse treatment. J Subst Abuse Treat 2010; 38(Suppl. 1):S4–S13.
   PubMed Web of Science ®Google Scholar
• Hanson GR, Leshner AI, Tai B. Putting drug abuse research to work in real-life settings. J Subst Abuse Treat 2002; 23:69–70.
   PubMed Web of Science ®Google Scholar
• Nunes EV, Ball SA, Booth R, Brigham G, Calsyn DA, Carroll KM, Feaster DJ, Hien D, Hubbard RL, Ling W, Petry NM, Rotrosen J, Selzer J, Stitzer M, Tross S, Wakim P, Winhusen T, Woody G. Multisite effectiveness trials of treatments for substance abuse and co-occurring problems: Have we chosen the best designs? J Subst Abuse Treat 2010; 38(Suppl. 1):S97–S112, PMCID: PMC2909698.
   PubMed Web of Science ®Google Scholar
• Chambless DL, Hollon SD. Defining empirically supported therapies. J Consult Clin Psychol 1998; 66(1):7–18.
   PubMed Web of Science ®Google Scholar
• Chambless DL, Ollendick TH. Empirically supported psychological interventions: Controversies and evidence. Annu Rev Psychol 2001; 52:685–716.
   PubMed Web of Science ®Google Scholar
• Onken LS, Blaine JD, Battjes R. Behavioral therapy research: A conceptualization of a process. In Innovative Approaches for Difficult to Treat Populations. Hennegler SW, Amentos, R, eds. Washington, DC: American Psychiatric Press, 1997; 477–485.
   Google Scholar
• Rounsaville BJ, Carroll KM, Onken LS. A stage model of behavioral therapies research: Getting started and moving on from Stage I. Clin Psychol: Sci Pract 2001; 8:133–142.
   Web of Science ®Google Scholar
• Fixsen DL, Naoom SF, Blase KA, Friedman RM, Wallace F, Implementation Research: A Synthesis of the Literature, University of South Florida, Louis de la Parte Florida Mental Health Institute, the National Implementation Research Network (FMHI Publication #231), Tampa: FL, 2005.
   Google Scholar
• Carroll KM, Rounsaville BJ. Bridging the gap between research and practice in substance abuse treatment: A hybrid model linking efficacy and effectiveness research. Psychiatr Serv 2003; 54:333–339.
   PubMed Web of Science ®Google Scholar
• Baer JS, Ball SA, Campbell BK, Miele GM, Schoener EP, Tracy K. Training and fidelity monitoring of behavioral interventions in multi-site addictions research. Drug Alcohol Depend 2007; 87:107–118.
   PubMed Web of Science ®Google Scholar
• Carroll KM, Rounsaville BJ. A vision of the next generation of behavioral therapies research in the addictions. Addiction 2007; 102(6):850–862, discussion 863–869. PMCID: PMC2148498.
   PubMed Web of Science ®Google Scholar
• Hien DA, Jiang H, Campbell AN, Hu MC, Miele GM, Cohen LR, Brigham GS, Capstick C, Kulaga A, Robinson J, Suarez-Morales L, Nunes EV. Do treatment improvements in PTSD severity affect substance use outcomes? A secondary analysis from a randomized clinical trial in NIDA’s Clinical Trials Network. Am J Psychiatry 2010; 167(1):95–101.
   PubMed Web of Science ®Google Scholar
• Roll JM, Petry NM, Stitzer ML, Brecht ML, Peirce JM, McCann MJ, Blaine J, MacDonald M, Dimaria J, Lucero L, Kellogg S. Contingency management for the treatment of methamphetamine use disorders. Am J Psychiatry 2006; 163(11):1993–1999.
   PubMed Web of Science ®Google Scholar
• Burlew AK, Feaster D, Brecht ML, Hubbard R. Measurement and data analysis in research addressing health disparities in substance abuse. J Subst Abuse Treat 2009; 36(1):25–43.
   PubMed Web of Science ®Google Scholar
• Wells EA, Saxon AJ, Calsyn DA, Jackson TR, Donovan DM. Study results from the Clinical Trials Network’s first 10 years: Where do they lead? J Subst Abuse Treat 2010; 38 (Suppl. 1):S14–S30.
   PubMed Web of Science ®Google Scholar
• Mohr DC, Spring B, Freedland KE, Beckner V, Arean P, Hollon SD, Ockene J, Kaplan R. The selection and design of control conditions for randomized controlled trials of psychological interventions. Psychother Psychosom 2009; 78(5The Clinical Trials Network: A Decade of Progress (Guest Editor: Edward Nunes)):275–284.
   PubMed Web of Science ®Google Scholar
• Kazdin AE. Comparative outcome studies of psychotherapy: Methodological issues and strategies. J Consult Clin Psychol 1986; 54:95–105.
   PubMed Web of Science ®Google Scholar
• Dutra L, Stathopoulou G, Basden SL, Leyro TM, Powers MB, Otto MW. A meta-analytic review of psychosocial interventions for substance use disorders. Am J Psychiatry 2008; 165(2):179–187.
   PubMed Web of Science ®Google Scholar
• Prendergast M, Podus D, Finney JW, Greenwell L, Roll JM. Contingency management for treatment of substance use disorders: A meta-analysis. Addiction 2006; 101:1546–1560.
   PubMed Web of Science ®Google Scholar
• Peirce JM, Petry NM, Stitzer ML, Blaine JD, Kellog S, Satterfield F, Schwartz M, Krasnansky J, Pencer E, Silva-Vazquez L, Kirby KC, Royer-Malvestuto C, Roll JM, Cohen A, Copersino ML, Kolodner K, Li R, and for the Clinical Trials Network. Effects of lower-cost incentives on stimulant abstinence in methadone maintenance treatment: A National Drug Abuse Treatment Clinical Trials Network Study. Arch Gen Psychiatry 2006; 63:201–208.
   PubMed Web of Science ®Google Scholar
• Petry NM, Peirce JM, Stitzer ML, Blaine JD, Roll JM, Cohen A, Obert J, Killeen T, Saladin ME, Cowell M, Kirby KC, Sterling R, Royer-Malvestuto C, Hamilton J, Booth RE, Macdonald M, Liebert M, Rader L, Burns R, DiMaria J, Copersino ML, Stabile PO, Kolodner K, Li R, and for the Clinical Trials Network. Effect of prize-based incentives on outcomes in stimulant abusers in outpatient psychosocial treatment programs: A National Drug Abuse Clinical Trials Network Study. Arch Gen Psychiatry 2006; 62:1148–1156.
   Web of Science ®Google Scholar
• Olmstead TA, Sindelar JL, Petry NM. Cost-effectiveness of prize-based incentives for stimulant abusers in outpatient psychosocial treatment programs. Drug Alcohol Depend 2007; 87:175–182.
   PubMed Web of Science ®Google Scholar
• Olmstead TA, Sindelar JL, Petry NM. Clinic variation in the cost-effectiveness of contingency management. Am J Addict 2007; 16(6):457–460.
   PubMed Web of Science ®Google Scholar
• Sindelar JL, Olmstead TA, Peirce J. Cost-effectiveness of prize-based contingency management in methadone maintenance programs. Addiction 2007; 102:1463–1471.
   PubMed Web of Science ®Google Scholar
• Kirby KC, Benishek LA, Dugosh KL, Kerwin ME. Substance abuse treatment providers’ beliefs and objections regarding contingency management: Implications for dissemination. Drug Alcohol Depend 2006; 85(1):19–27.
   PubMed Web of Science ®Google Scholar
• Simpson DD, Joe GW, Brown BS. Treatment retention and follow-up outcomes in the Drug Abuse Treatment Outcome Study (DATOS). Psychol Addict Behav 1997; 11:294–307.
   Web of Science ®Google Scholar
• Amaro H, Arevalo S, Gonzalez G, Szapocznik J, Iguchi MY. Needs and scientific opportunities for research on substance abuse treatments among Hispanic adults. Drug Alcohol Depend 2006; 84S:S64–S75.
   Web of Science ®Google Scholar
• Carroll KM, Martino S, Suarez-Morales L, Ball SA, Miller WR, Rosa C, Anez LM, Paris MP, Nich C, Frankforter TL, Matthews J, Szapocznik J. A multisite randomized effectiveness study of motivational enhancement therapy for Spanish-speaking substance abusers. J Consult Clin Psychol 2009; 77:993–999, PMCID: PMC 2792592.
   PubMed Web of Science ®Google Scholar
• Ducharme LJ, Knudsen HK, Roman PM, Johnson JA. Innovation adoption in substance abuse treatment: Exposure, trialability, and the Clinical Trials Network. J Subst Abuse Treat 2007; 32(4):321–329.
   PubMed Web of Science ®Google Scholar
• McCarty D, Fuller B, Kaskutas LA, Wendt WW, Nunes EV, Miller M, Forman R, Magruder KM, Arfken C, Copersino M, Floyd A, Sindelar J, Edmundson E. Treatment programs in the National Drug Abuse Treatment Clinical Trials Network. Drug Alcohol Depend 2008; 92(1–3):200–207.
   PubMed Web of Science ®Google Scholar
• Ling W, Amass L, Shoptaw S, Annon JJ, Hillhouse M, Babcock D, Brigham G, Harrer J, Reid MC, Muir J, Buchan B, Orr D, Woody GE, Krejci J, Ziedonis D, for the Buprenorphine/Naloxone Collaborative Study Group. A multicenter randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: Findings from the National Institute on Drug Abuse Clinical Trials Network. Addiction 2005; 100:1090–1100.
   PubMed Web of Science ®Google Scholar
• Woody GE, Poole SA, Subramaniam G, Dugosh K, Bogenschutz M, Abbott P, Patkar A, Publicker M, McCain K, Potter JS, Forman R, Vetter V, McNicholas L, Blaine J, Lynch KG, Fudala P. Extended vs short-term buprenorphine-naloxone for treatment of opioid-addicted youth: A randomized trial. J Am Med Assoc 2008; 300(17):2003–2011.
   PubMed Web of Science ®Google Scholar
• Ball SA, Martino S, Nich C, Frankforter TL, Van Horn D, Crits-Christoph P, Woody GE, Obert JL, Farentinos C, Carroll KM. Site matters: Multisite randomized trial of motivational enhancement therapy in community drug abuse clinics. J Consult Clin Psychol 2007; 75(4):556–567, PMCID: PMC2148493.
   PubMed Web of Science ®Google Scholar
• Carroll KM, Ball SA, Nich C, Martino S, Frankforter T, Crits-Christoph P, Farentinos C, Mikulich-Gilbertson S, Morgenstern J, Obert JL, Polcin D, Snead N, Woody GE, and for the Clinical Trials Network. Motivational interviewing to improve treatment engagement and outcome in individuals seeking treatment for substance abuse: A multisite effectiveness study. Drug Alcohol Depend 2006; 81:301–312, PMCID: PMC2386852.
   PubMed Web of Science ®Google Scholar
• Petry NM, Roll JM, Rounsaville BJ, Ball SA, Stitzer M, Peirce JM, Blaine J, Kirby KC, McCarty D, Carroll KM. Serious adverse events in randomized psychosocial treatment studies: Safety or arbitrary edicts? J Consult Clin Psychol 2008; 76(6):1076–1082, PMCID: PMC2756150.
   PubMed Web of Science ®Google Scholar
• Petry NM, Kolodner KB, Li R, Peirce JM, Roll JM, Stitzer ML, Hamilton JA. Prize-based contingency management does not increase gambling. Drug Alcohol Depend 2006; 83(3):269–273.
   PubMed Web of Science ®Google Scholar
• Barlow DH. Negative effects from psychological treatments: A perspective. Am Psychologist 2010; 65(1):13–20.
   PubMed Web of Science ®Google Scholar
• Santa Ana E, Martino S, Ball SA, Nich C, Carroll KM. What is usual about “treatment as usual”: Audiotaped ratings of standard treatment in the Clinical Trials Network. J Subst Abuse Treat 2008; 35:369–379, PMCID: PMC2712113.
   PubMed Web of Science ®Google Scholar
• Bamatter W, Carroll KM, Anez LM, Paris Jr M, Ball SA, Nich C, Frankforter TL, Suarez-Morales L, Szapocznik J, Martino S. Informal discussions in substance abuse treatment sessions with Spanish-speaking clients. J Subst Abuse Treat 2010; 39(4):353–363.
   PubMed Web of Science ®Google Scholar
• Martino S, Ball SA, Nich C, Frankforter TL, Carroll KM. Informal discussions in substance abuse treatment sessions. J Subst Abuse Treat 2009; 36(4):366–375, PMCID: PMC2705985.
   PubMed Web of Science ®Google Scholar
• Martino S, Ball S, Nich C, Frankforter TL, Carroll KM. Correspondence of motivational enhancement treatment integrity ratings among therapists, supervisors, and observers. Psychother Res 2009; 19(2):181–193, PMCID: PMC2782382.
   PubMed Web of Science ®Google Scholar
• Martino S, Brigham G, Higgins C, Gallon S, Freese TE, Albright LM, Hulsey EG, Storti SA, Perl H, Nugent CD, Pintello D, Condon TP. Partnerships and pathways of dissemination: The NIDA-SAMHSA blending initiative in the Clinical Trials Network. J Subst Abuse Treat 2010; 38(Suppl. 1):S31–S43.
   PubMed Web of Science ®Google Scholar
• Sindelar JL, Ebel B, Petry NM. What do we get for our money: Cost-effectiveness of adding contingency management. Addiction 2007; 102:309–316.
   PubMed Web of Science ®Google Scholar
• Hughes JR, Benowitz N, Hatsukami D, Mermelstein RJ, Shiffman S. Clarification of SRNT Workgroup guidelines for measures in clinical trials of smoking cessation therapies. Nicotine Tob Res 2004; 6(5The Clinical Trials Network: A Decade of Progress (Guest Editor: Edward Nunes)):863–864.
   PubMed Web of Science ®Google Scholar
• Anton RE, Randall CL. Measurement and choice of drinking outcome variables in the COMBINE Study. J Stud Alcohol Suppl 2005; 15:104–109, discussion 92–93.
   Google Scholar
• Kadden RM, Litt MD. Searching for treatment outcome measures for use across trials. J Stud Alcohol 2004; 65(1):145–152.
   PubMed Web of Science ®Google Scholar
• Jacobson NS, Roberts LJ, Berns SB, McGlinchey JB. Methods for defining and determining the clinical significance of treatment effects: Description, application and alternatives. J Consult Clin Psychol 1999; 67:300–307.
   PubMed Web of Science ®Google Scholar
• Kendall PC, Marrs-Garcia A, Nath SR, Sheldrick RC. Normative comparisons for the evaluation of clinical significance. J Consult Clin Psychol 1999; 67:285–299.
   PubMed Web of Science ®Google Scholar
• Atkins DC, Bedics JD, McGlinchey JB, Beauchaine TP. Assessing clinical significance: Does it matter which method we use? J Consult Clin Psychol 2005; 73(5The Clinical Trials Network: A Decade of Progress (Guest Editor: Edward Nunes)):982–989.
   PubMed Web of Science ®Google Scholar
• Cisler RA, Kowalchulk RK, Saunders SM, Zweben A, Trinh HQ. Applying clinical significance methodology to alcoholism treatment trials: Determining recovery outcome status with individual- and population-based measures. Alcohol Clin Exp Res 2005; 29:1991–2000.
   Google Scholar
• Anton RF, O’Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift RM, Weiss RD, Williams LD, Zweben A, for the COMBINE Study Research Group. Combined pharmacotherapies and behavioral interventions for alcohol dependence: The COMBINE Study. J Am Med Assoc 2006; 2006:2003–2017.
   Google Scholar
• Miller WR, Manuel JK. How large must a treatment effect be before it matters to practitioners? An estimation method and demonstration. Drug Alcohol Rev 2008; 27(5The Clinical Trials Network: A Decade of Progress (Guest Editor: Edward Nunes)):524–528.
   PubMed Web of Science ®Google Scholar
• Luce BR, Kramer JM, Goodman SN, Connor JT, Tunis S, Whicher D, Schwartz JS. Rethinking randomized clinical trials for comparative effectiveness research: The need for transformational change. Ann Intern Med 2009; 151(3):206–209.
   PubMed Web of Science ®Google Scholar
• Lauer MS, Collins FS. Using science to improve the nation’s health system: NIH’s commitment to comparative effectiveness research. J Am Med Assoc 2010; 303(21):2182–2183.
   Web of Science ®Google Scholar
• Hien DA, Wells EA, Jiang H, Suarez-Morales L, Campbell AN, Cohen LR, Miele GM, Killeen T, Brigham GS, Zhang Y, Hansen C, Hodgkins C, Hatch-Maillette M, Brown C, Kulaga A, Kristman-Valente A, Chu M, Sage R, Robinson JA, Liu D, Nunes EV. Multisite randomized trial of behavioral interventions for women with co-occurring PTSD and substance use disorders. J Consult Clin Psychol 2009; 77(4):607–619.
   PubMed Web of Science ®Google Scholar
• Winhusen TM, Somoza EC, Brigham GS, Liu DS, Green CA, Covey LS, Croghan IT, Adler LA, Weiss RD, Leimberger JD, Lewis DF, Dorer EM. Impact of attention-deficit/hyperactivity disorder (ADHD) treatment on smoking cessation intervention in ADHD smokers: A randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 2010; 71:1680.
   Google Scholar
• Kraemer HC, Wilson GT, Fairburn CG, Agras WS. Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry 2002; 59:877–883.
   PubMed Web of Science ®Google Scholar
• Nock MK. Conceptual and design essentials for evaluating mechanisms of change. Alcohol Clin Exp Res 2007; 31(S3):4S–12S.
   PubMed Web of Science ®Google Scholar
• McLellan AT, Kemp J, Brooks A, Carise D. Improving public addiction treatment through performance contracting: The Delaware experiment. Health Pol 2008; 87(3):296–308.
   PubMed Web of Science ®Google Scholar
• McHugh RK, Barlow DH. The dissemination and implementation of evidence-based psychological treatments. A review of current efforts. Am Psychol 2010; 65(2):73–84.
   PubMed Web of Science ®Google Scholar
• Proctor EK, Landsverk J, Aarons G, Chambers D, Glisson C, Mittman B. Implementation research in mental health services: An emerging science with conceptual, methodological, and training challenges. Adm Policy Ment Health 2009; 36(1):24–34.
   PubMed Web of Science ®Google Scholar
• Norquist G, Regier DA. The epidemiology of psychiatric disorders and the de facto mental health care system. Annu Rev Med 1996; 47:473–479.
   PubMed Web of Science ®Google Scholar
• Regier DA, Narrow WE, Rae DS, Manderscheid RW, Locke BZ, Goodwin FK. The de facto US mental health and addictive disorders service system: Epidemiological catchment area prospective one-year prevalence rates of disorders and services. Arch Gen Psychiatry 1993; 50:85–91.
   PubMed Web of Science ®Google Scholar
• McLellan AT, Carise D, Kleber HD. Can the national addiction treatment infrastructure support the public’s demand for quality care? J Subst Abuse Treat 2003; 25:117–121.
   PubMed Web of Science ®Google Scholar
• McCarty D, McConnell KJ, Schmidt LA. Priorities for policy research on treatments for alcohol and drug use disorders. J Subst Abuse Treat 2010; 39(2):87–95.
   PubMed Web of Science ®Google Scholar
• Babor TF, McKee BG, Kassenbaum PA, Grimaldi PL, Ahmed K, Bray J. Screening, brief intervention, and referral to treatment (SBIRT): Toward a public health approach to the management of substance abuse. Subst Abus 2007; 28:7–30.
   PubMedGoogle Scholar
• Carroll KM, Rounsaville BJ. Computer-assisted therapy in psychiatry: Be brave-it’s a new world. Curr Psychiatry Rep 2010; 12:426–432.
   PubMed Web of Science ®Google Scholar
• Bickel WK, Christensen DR, Marsch LA. A review of computer-based interventions used in the assessment, treatment, and research of drug addiction. Subst Use Misuse 2011; 46(1):4–9.
   PubMed Web of Science ®Google Scholar
• Bickel WK, Marsch LA, Buchhalter AR, Badger GJ. Computerized behavior therapy for opioid-dependent outpatients: A randomized controlled trial. Exp Clin Psychopharmacol 2008; 16(2):132–143.
   PubMed Web of Science ®Google Scholar
• Institute of Medicine. Improving the Quality of Health Care for Mental and Substance Use Conditions. Washington, DC: The National Academies Press, 2006.
   Google Scholar
• McLellan AT, Lewis DC, O’Brien CP, Kleber HD. Drug dependence, a chronic medical illness: Implications for treatment, insurance, and outcomes evaluation. J Am Med Assoc 2000; 284:1689–1695.
   Google Scholar
• McKay JR. Continuing care in the treatment of addictive disorders. Curr Psychiatry Rep 2006; 8(5The Clinical Trials Network: A Decade of Progress (Guest Editor: Edward Nunes)):355–362.
   PubMedGoogle Scholar
• McLellan AT. Congratulations on the 10-year anniversary of the National Drug Abuse Treatment Clinical Trial Network – now, what’s new for the coming decade? J Subst Abuse Treat 2010; 38(Suppl. 1):S1–S3.
   PubMed Web of Science ®Google Scholar
• Carroll KM, Rounsaville BJ. A perfect platform: Combining contingency management with medications for drug abuse. Am J Drug Alcohol Abuse 2007; 33(3):343–365, PMCID: PMC2367002.
   PubMed Web of Science ®Google Scholar