Investigation of flurbiprofen genotoxicity and cytotoxicity in rat bone marrow cells

References

• Atienzar FA, Conradi M, Evenden AJ, et al. (1999). Qualitative assessment of genotoxicity using random amplified polymorphic DNA: comparison of genomic template stability with key fitness parameters in Daphnia magna exposed to benzo[a]pyrene. Environ Toxicol Chem 18:2275–2282
   PubMed Web of Science ®Google Scholar
• Atienzar FA, Jha AN. (2006). The random amplified polymorphic DNA (RAPD) assay and related techniques applied to genotoxicity and carcinogenesis studies: a critical review. Mutat Res 613:76–102
   PubMed Web of Science ®Google Scholar
• Burak Cimen MY, Cimen OB, Eskandari G, et al. (2003). In vivo effects of meloxicam, celecoxib, and ibuprofen on free radical metabolism in human erythrocytes. Drug Chem Toxicol 26:169–176
   PubMed Web of Science ®Google Scholar
• Contardo-Jara V, Lorenz C, Pflugmacher S, et al. (2011). Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha. Aquat Toxicol 105:428–437
   PubMed Web of Science ®Google Scholar
• Costa D, Moutinho L, Lima JL, Fernandes E. (2006). Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. Biol Pharm Bull 29:1659–1670
   PubMed Web of Science ®Google Scholar
• Doyle JJ, Doyle JL. (1987). A rapid DNA isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull 19:11–15
   Google Scholar
• Duncan K, Uwimpuhwe H, Czibere A, et al. (2012). NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo. IUBMB Life 64:636–643
   PubMed Web of Science ®Google Scholar
• Erel O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37:277–285
   PubMed Web of Science ®Google Scholar
• Erel O. (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38:1103–1111
   PubMed Web of Science ®Google Scholar
• Escárcega RO, Fuentes-Alexandro S, Garcia-Carrasco M, et al. (2007). The transcription factor nuclear factor-kappa B and cancer. Clin Oncol (R Coll Radiol) 19:154–161
   PubMed Web of Science ®Google Scholar
• Gonzalez-Mira E, Nikolic S, Garcia ML, et al. (2011). Potential use of nanostructured lipid carriers for topical delivery of flurbiprofen. J Pharm Sci 100:242–251
   PubMed Web of Science ®Google Scholar
• Harma M, Harma M, Erel O. (2003). Increased oxidative stress in patients with hydatidiform mole. Swiss Med Wkly 133:563–566
   PubMed Web of Science ®Google Scholar
• Ila HB, Topaktas M, Arslan M, Buyukleyla M. (2014). Signs of deferasirox genotoxicity. Cytotechnology 66:647–654
   PubMed Web of Science ®Google Scholar
• Jin H, Wang Z, Liu L, et al. (2010). R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75 (NTR) induction. Mol Pharm 7:156–168
   PubMed Web of Science ®Google Scholar
• Jurima-Romet M, Crawford K, Huang HS. (1994). Comparative cytotoxicity of non-steroidal anti-inflammatory drugs in primary cultures of rat hepatocytes. Toxicol In Vitro 8:55–66
   PubMed Web of Science ®Google Scholar
• Kim KS, Yoon JH, Kim JK, et al. (2004). Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem Biophys Res Commun 325:1298–1303
   PubMed Web of Science ®Google Scholar
• Knights KM, Mangoni AA, Miners JO. (2010). Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity. Expert Rev Clin Pharmacol 3:769–776
   PubMed Web of Science ®Google Scholar
• Kosecik M, Erel O, Sevinc E, Selek S. (2005). Increased oxidative stress in children exposed to passive smoking. Int J Cardiol 100:61–64
   PubMed Web of Science ®Google Scholar
• Koseoglu BG, Ozturk S, Kocak H, et al. (2008). The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery. Yonsei Med J 49:742–747
   PubMed Web of Science ®Google Scholar
• Kullich W, Klein G. (1986). Investigations of the influence of nonsteroidal antirheumatic drugs on the rates of sister-chromatid exchange. Mutat Res 174:131–134
   PubMed Web of Science ®Google Scholar
• Kusuhara H, Komatsu H, Sumichika H, Sugahara K. (1999). Reactive oxygen species are involved in the apoptosis induced by nonsteroidal anti-inflammatory drugs in cultured gastric cells. Eur J Pharmacol 383:331–337
   PubMed Web of Science ®Google Scholar
• Liu JK, Patel SK, Gillespie DL, et al. (2012). R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. J Neurooncol 106:561–569
   PubMed Web of Science ®Google Scholar
• Masubuchi Y, Saito H, Horie T. (1998). Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes. J Pharmacol Exp Ther 287:208–213
   PubMed Web of Science ®Google Scholar
• Mcanulty SR, Owens JT, Mcanulty LS, et al. (2007). Ibuprofen use during extreme exercise: effects on oxidative stress and PGE2. Med Sci Sports Exerc 39:1075–1079
   PubMed Web of Science ®Google Scholar
• Mcknight RE, Gleason AB, Keyes JA, Sahabi S. (2007). Binding mode and affinity studies of DNA-binding agents using topoisomerase I DNA unwinding assay. Bioorg Med Chem Lett 17:1013–1017
   PubMed Web of Science ®Google Scholar
• Nivsarkar M, Banerjee A, Padh H. (2008). Cyclooxygenase inhibitors: a novel direction for Alzheimer's management. Pharmacol Rep 60:692–698
   PubMed Web of Science ®Google Scholar
• Noel S, Rath SK. (2006). Randomly amplified polymorphic DNA as a tool for genotoxicity: an assessment. Toxicol Ind Health 22:267–275
   PubMed Web of Science ®Google Scholar
• OECD. (1997). Test No. 475: mammalian bone marrow chromosome aberration test, OECD guidelines for the testing of chemicals, Section 4. Paris: OECD
   Google Scholar
• Oldham JW, Preston RF, Paulson JD. (1986). Mutagenicity testing of selected analgesics in Ames Salmonella strains. J Appl Toxicol 6:237–243
   PubMed Web of Science ®Google Scholar
• Parolini M, Binelli A, Cogni D, et al. (2009). An in vitro biomarker approach for the evaluation of the ecotoxicity of non-steroidal anti-inflammatory drugs (NSAIDs). Toxicol In Vitro 23:935–942
   PubMed Web of Science ®Google Scholar
• Parolini M, Binelli A. (2012). Sub-lethal effects induced by a mixture of three non-steroidal anti-inflammatory drugs (NSAIDs) on the freshwater bivalve Dreissena polymorpha. Ecotoxicology 21:379–392
   PubMed Web of Science ®Google Scholar
• Quann EJ, Khwaja F, Zavitz KH, Djakiew D. (2007). The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Res 67:3254–3262
   PubMed Web of Science ®Google Scholar
• Repine JE, Fox RB, Berger EM. (1981). Dimethyl sulfoxide inhibits killing of Staphylococcus aureus by polymorphonuclear leukocytes. Infect Immun 31:510–513
   PubMed Web of Science ®Google Scholar
• Rocco L, Frenzilli G, Fusco D, Peluso C, Stingo V. (2010). Evaluation of zebrafish DNA integrity after exposure to pharmacological agents present in aquatic environments. Ecotoxicol Environ Saf 73:1530–1536
   PubMed Web of Science ®Google Scholar
• Rosenblum W. (1983). Dimethyl sulfoxide effects on platelet aggregation and vascular reactivity in pial microcirculation. Ann N Y Acad Sci 411:110–119
   PubMed Web of Science ®Google Scholar
• Sanmartin-Suarez C, Soto-Otero R, Sanchez-Sellero I, Mendez-Alvarez E. (2011). Antioxidant properties of dimethyl sulfoxide and its viability as a solvent in the evaluation of neuroprotective antioxidants. J Pharmacol Toxicol Methods 63:209–215
   PubMed Web of Science ®Google Scholar
• Schweitzer C, Scaiano JC. (2003). Selective binding and local photophysics of the fluorescent cyanine dye PicoGreen in double-stranded and single-stranded DNA. Phys Chem Chem Phys 5:4911–4917
   Web of Science ®Google Scholar
• Sheikh MS, Huang Y. (2003). Death receptor activation complexes: it takes two to activate TNF receptor 1. Cell Cycle 2:550–552
   PubMedGoogle Scholar
• Sigma – Material Safety Data Sheet. Available from: www.sigmaaldrich.com/catalog/product/sigma/f8514. Accessed on February 1, 2013
   Google Scholar
• Sun Y, Huang L, Mackenzie GG, Rigas B. (2011). Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents. J Pharmacol Exp Ther 338:775–783
   PubMed Web of Science ®Google Scholar
• Sun Y, Rowehl LM, Huang L, et al. (2012). Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system. Breast Cancer Res 14:R20
   PubMed Web of Science ®Google Scholar
• Tegeder I, Niederberger E, Israr E, et al. (2001). Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. FASEB J 15:2–4
   PubMed Web of Science ®Google Scholar
• Tomisato W, Tsutsumi S, Hoshino T, et al. (2004). Role of direct cytotoxic effects of NSAIDs in the induction of gastric lesions. Biochem Pharmacol 67:575–585
   PubMed Web of Science ®Google Scholar
• Tracy TS, Rosenbluth BW, Wrighton SA, et al. (1995). Role of cytochrome P450 2C9 and an allelic variant in the 4′-hydroxylation of (R)- and (S)-flurbiprofen. Biochem Pharmacol 49:1269–1275
   PubMed Web of Science ®Google Scholar
• Tuzun S, Uzun H, Aydin S, et al. (2005). Effects of flurbiprofen and tiaprofenic acid on oxidative stress markers in osteoarthritis: a prospective, randomized, open-label, active- and placebo-controlled trial. Curr Ther Res Clin Exp 66:335–344
   PubMed Web of Science ®Google Scholar
• Wechter WJ, Leipold DD, Quiggle DD, et al. (2000). R-Flurbiprofen (E-7869), a chemopreventive and treatment of cancer. InflammoPharmacology 8:189–206
   Google Scholar
• WHOCC. Available from: http://www.whocc.no/atc_ddd_index/?code=M01AE09. Accessed on April 15, 2014
   Google Scholar
• Williams GM, Mori H, Mcqueen CA. (1989). Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals. Mutat Res 221:263–286
   PubMed Web of Science ®Google Scholar
• Yumru M, Savas HA, Kalenderoglu A, et al. (2009). Oxidative imbalance in bipolar disorder subtypes: a comparative study. Prog Neuropsychopharmacol Biol Psychiatry 33:1070–1074
   PubMed Web of Science ®Google Scholar
• Zhao X, Rebeck GW, Hoe HS, Andrews PM. (2008). Tarenflurbil protection from cytotoxicity is associated with an upregulation of neurotrophins. J Alzheimers Dis 15:397–407
   PubMed Web of Science ®Google Scholar
• Zhou Y, Cho KJ, Plowman SJ, Hancock JF. (2012). Nonsteroidal anti-inflammatory drugs alter the spatiotemporal organization of Ras proteins on the plasma membrane. J Biol Chem 287:16586–16595
   PubMed Web of Science ®Google Scholar
• Zielinska-Przyjemska M, Glowka FK, Klaczynska J. (2008). Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils. Chirality 20:159–165
   PubMed Web of Science ®Google Scholar