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In vitro and animal studies

Caffeine regulates osteogenic differentiation and mineralization of primary adipose-derived stem cells and a bone marrow stromal cell line

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Pages 429-436 | Published online: 09 Jan 2013

References

  • Backesjo CM, Li Y, Lindgren U, Haldosen LA. 2006. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. J Bone Miner Res. 21:993–1002.
  • Backesjo CM, Li Y, Lindgren U, Haldosen LA. 2009. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. Cells Tissues Organs. 189:93–97.
  • Baksh D, Song L, Tuan R. 2004. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med. 8:301–316.
  • Barone LM, Tassinari MS, Bortell R, Owen TA, Zerogian J, Gagne K, Stein GS, Lian JB. 1993. Inhibition of induced endochondral bone development in caffeine-treated rats. J Cell Biochem. 52:171–182.
  • Barrett-Connor E, Chang JC, Edelstein SL. 1994. Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study. JAMA. 271:280–283.
  • Burkhardt R, Kettner G, Bohm W, Schmidmeier M, Schlag R, Frisch B, . 1987. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone. 8:157–164.
  • Cartiser N, Bevalot F, Chatenay C, Le Meur C, Gaillard Y, Malicier D, Guitton J, . 2011. Postmortem measurement of caffeine in bone marrow: influence of sample location and correlation with blood concentration. Forensic Sci Int. 210:149–153.
  • Cooper C, Atkinson EJ, Wahner HW, O'Fallon WM, Riggs BL, Judd HL, Melton LJ3rd. 1992. Is caffeine consumption a risk factor for osteoporosis?. J Bone Miner Res. 7:465–471.
  • Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, . 1995. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 332:767–773.
  • Gimble J, Guilak F. 2003. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy. 5:362–369.
  • Hannan MT, Felson DT, Dawson-Hughes B, Tucker KL, Cupples LA, Wilson PW, Kiel DP. 2000. Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res. 15:710–720.
  • Jilka RL, Weinstein RS, Takahashi K, Parfitt AM, Manolagas SC. 1996. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest. 97:1732–1740.
  • Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J, . 1995. Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. J Bone Miner Res. 10:1802–1815.
  • Justesen J, Pedersen SB, Stenderup K, Kassem M. 2004. Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo. Tissue Eng. 10:381–391.
  • Justesen J, Stenderup K, Eriksen EF, Kassem M. 2002. Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures. Calcif Tissue Int. 71:36–44.
  • Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, . 1997. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res. 12:1772–1779.
  • Kamagata-Kiyoura Y, Ohta M, Cheuk G, Yazdani M, Saltzman MJ, Nakamoto T. 1999. Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells (UMR106-01). J Periodontol. 70:283–288.
  • Kaplan FS, Shore EM. 2000. Progressive osseous heteroplasia. J Bone Miner Res.. 15:2084–2094.
  • Kha HT, Basseri B, Shouhed D, Richardson J, Tetradis S, Hahn TJ, Parhami F. 2004. Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J Bone Miner Res. 19:830–840.
  • Khosla S. 2001. Minireview: the OPG/RANKL/RANK system. Endocrinology. 142:5050–5055.
  • Kilroy GE, Foster SJ, Wu X, Ruiz J, Sherwood S, Heifetz A, . 2007. Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors. J Cell Physiol. 212:702–709.
  • Kobayashi H, Gao Y, Ueta C, Yamaguchi A, Komori T. 2000. Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro. Biochem Biophys Res Commun. 273:630–636.
  • Komori T. 2010. Regulation of osteoblast differentiation by Runx2. Adv Exp Med Biol. 658:43–49.
  • Komori T. 2011. Signaling networks in RUNX2-dependent bone development. J Cell Biochem. 112:750–755.
  • Liu SH, Chen C, Yang RS, Yen YP, Yang YT, Tsai C. 2011. Caffeine enhances osteoclast differentiation from bone marrow hematopoietic cells and reduces bone mineral density in growing rats. J Orthop Res. 29:954–960.
  • Lloyd T, Rollings N, Eggli DF, Kieselhorst K, Chinchilli VM. 1997. Dietary caffeine intake and bone status of postmenopausal women. Am J Clin Nutr. 65:1826–1830.
  • Lu PZ, Lai CY, Chan WH. 2008. Caffeine induces cell death via activation of apoptotic signal and inactivation of survival signal in human osteoblasts. Int J Mol Sci. 9:698–718.
  • Massey LK. 2001. Is caffeine a risk factor for bone loss in the elderly?. Am J Clin Nutr. 74:569–570.
  • Meyer HE, Pedersen JI, Loken EB, Tverdal A. 1997. Dietary factors and the incidence of hip fracture in middle-aged Norwegians. A prospective study. Am J Epidemiol. 145:117–123.
  • Packard PT, Recker RR. 1996. Caffeine does not affect the rate of gain in spine bone in young women. Osteoporos Int. 6:149–152.
  • Polikeit A, Nolte LP, Ferguson SJ. 2004. Simulated influence of osteoporosis and disc degeneration on the load transfer in a lumbar functional spinal unit. J Biomech. 37:1061–1069.
  • Putnam SE, Scutt AM, Bicknell K, Priestley CM, Williamson EM. 2007. Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health. Phytother Res. 21:99–112.
  • Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. 2001. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr. 74:694–700.
  • Rapuri PB, Gallagher JC, Nawaz Z. 2007. Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. J Steroid Biochem Mol Biol. 103:368–371.
  • Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM. 2009. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr. 19:109–124.
  • Rosen CJ, Bouxsein ML. 2006. Mechanisms of disease: is osteoporosis the obesity of bone?. Nat Clin Pract Rheumatol. 2:35–43.
  • Serra A, Macia A, Romero MP, Pinol C, Motilva MJ. 2011. Rapid methods to determine procyanidins, anthocyanins, theobromine and caffeine in rat tissues by liquid chromatography–tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 879:1519–1528.
  • Stein GS, Lian JB, Owen TA. 1990. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 4:3111–3123.
  • Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Montecino M. 1996. Transcriptional control of osteoblast growth and differentiation. Physiol Rev. 76:593–629.
  • Tassinari MS, Gerstenfeld LC, Stein GS, Lian JB. 1991. Effect of caffeine on parameters of osteoblast growth and differentiation of a mineralized extracellular matrix in vitro. J Bone Miner Res. 6:1029–1036.
  • Tsuang YH, Sun JS, Chen LT, Sun SC, Chen SC. 2006. Direct effects of caffeine on osteoblastic cells metabolism: the possible causal effect of caffeine on the formation of osteoporosis. J Orthop Surg Res. 1:7.
  • Zhou Y, Guan XX, Zhu ZL, Guo J, Huang YC, Hou WW, Yu HY. 2010. Caffeine inhibits the viability and osteogenic differentiation of rat bone marrow-derived mesenchymal stromal cells. Br J Pharmacol. 161:1542–1552.

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