Sorghum extract exerts cholesterol-lowering effects through the regulation of hepatic cholesterol metabolism in hypercholesterolemic mice

References

• Ando H, Tsuruoka S, Yamamoto H, Takamura T, Kaneko S, Fujimura A. 2005. Regulation of cholesterol 7-α hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet. Atherosclerosis 178:265–269
   PubMed Web of Science ®Google Scholar
• Awika JM, Rooney LW. 2004. Sorghum phytochemicals and their potential impact on human health. Phytochemistry 65:1199–1221
   PubMed Web of Science ®Google Scholar
• Bloomfield DK. 1963. Dynamics of cholesterol metabolism, I. Factors regulating total sterol biosynthesis and accumulation in the rat. Proc Natl Acad Sci 50:117–124
   Google Scholar
• Bursill CA, Abbey M, Roach PD. 2007. A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit. Atherosclerosis 193:86–93
   PubMed Web of Science ®Google Scholar
• Carling D. 2004. The AMP-activated protein kinase cascade – a unifying system for energy control. Trends Biochem Sci 29:18–24
   PubMed Web of Science ®Google Scholar
• Carr TP, Weller CL, Schlegel VL, Cuppett SL, Guderian DM, Johnson KR. 2005. Grain sorghum lipid extract reduces cholesterol absorption and plasma non-HDL cholesterol concentration in hamsters. J Nutr 135:2236–2240
   PubMed Web of Science ®Google Scholar
• Chiang JY. 2002. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 23:443–463
   PubMed Web of Science ®Google Scholar
• Chiang JY. 2004. Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J Hepatol 40:539–551
   PubMed Web of Science ®Google Scholar
• Chung IM, Kim EH, Yeo MA, Kim SJ, Seo MC, Moon HI. 2011. Antidiabetic effects of three Korean sorghum phenolic extracts in normal and streptozotocin-induced diabetic rats. Food Res Int 44:127–132
   Web of Science ®Google Scholar
• Chung IM, Yeo MA, Kim SJ, Kim MJ, Park DS, Moon HI. 2010. Antilipidemic activity of organic solvent extract from Sorghum bicolor on rats with diet-induced obesity. Hum Exp Toxicol 30:1865–1868
   Google Scholar
• Folch J, Lees M, Stanley GHS. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502
   PubMed Web of Science ®Google Scholar
• Goedeke L, Fernández-Hernando C. 2012. Regulation of cholesterol homeostasis. Cell Mol Life Sci 69:915–930
   PubMed Web of Science ®Google Scholar
• Guo J, Bei W, Hu Y, Tang C, He W, Liu X, Huang L, et al. 2011. A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats. J Ethnopharmacol 135:299–307
   Google Scholar
• Gupta S, Pandak WM, Hylemon PB. 2002. LXRα is the dominant regulator of CYP7A1 transcription. Biochem Biophys Res Commun 293:338–343
   PubMed Web of Science ®Google Scholar
• Hoi JT, Weller CL, Schlegel VL, Cuppett SL, Lee JY. 2009. Sorghum distillers dried grain lipid extract increases cholesterol excretion and decreases plasma and liver cholesterol concentration in hamsters. J Funct Foods 1:381–386
   Web of Science ®Google Scholar
• Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, Pang G, Cho KY, Song CH. 2010. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nurt Res 30:49–56
   Google Scholar
• Kemp BE, Stapleton D, Campbell DJ, Chen Z-P, Murthy S, Walter M, Gupta A, et al. 2003. AMP-activated protein kinase, super metabolic regulator. Biochem Soc Trans 31:162–168
   PubMed Web of Science ®Google Scholar
• Kim J, Park Y. 2012. Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats. Nutr Metab 9:106
   Google Scholar
• Li Y, Xu S, Mihaylova M, Zheng B, Hou X, Jiang B, Park O, et al. 2011. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin resistant mice. Cell Metab 13:376–388
   PubMed Web of Science ®Google Scholar
• Lin CL, Huang HC, Lin JK. 2007. The aflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J Lipid Res 48:2334–2343
   PubMed Web of Science ®Google Scholar
• Osada K, Suzuki T, Kawakami Y, Senda M, Kasai A, Sami M, Ohta Y, et al. 2006. Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol. Lipids 41:133–139
   PubMed Web of Science ®Google Scholar
• Pandak WM, Bohdan P, Franklund C, Mallonee DH, Eggertsen G, Björkhem I, Gil G, et al. 2001. Expression of sterol 12-α hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo. Gastroenterology 120:1801–1809
   Google Scholar
• Park JH, Lee SH, Chung IM, Park Y. 2012. Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-γ in mice fed a high-fat diet. Nutr Res Pract 6:322–327
   PubMed Web of Science ®Google Scholar
• Rader DJ, Davidson MH, Caplan RJ, Pears JS. 2003. Lipid and apolipoprotein ratios: association with coronary artery disease and effects of rosuvastatin compared with atorvastatin, pravastatin, and simvastatin. Am J Cardiol 91:20C–24C
   PubMed Web of Science ®Google Scholar
• Roopchand DE, Kuhn P, Rojo LE, Lila MA, Raskin I. 2013. Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice. Pharmacol Res 68:59–67
   PubMed Web of Science ®Google Scholar
• Rosenson RS. 2004. Current overview of statin-induced myopathy. Am J Med 116:408–416
   PubMed Web of Science ®Google Scholar
• Sanclemente T, Marques-Lopes I, Fajó-Pascual M, Cofán M, Jarauta E, Ros E, Puzo J, García-Otín AL. 2012. Naturally-occurring phytosterols in the usual diet influence cholesterol metabolism in healthy subjects. Nutr Metab Cardiovasc Dis 22:849–855
   Google Scholar
• Shefer S, Hauser S, Lapar V, Mosbach EH. 1972. HMG CoA reductase of intestinal mucosa and liver of the rat. J Lipid Res 13:402–412
   PubMed Web of Science ®Google Scholar
• Sikwese FE, Doudu KG. 2007. Antioxidant effect of a crude phenolic extract from sorghum bran in sunflower oil in the presence of ferric ions. Food Chem 104:324–331
   Web of Science ®Google Scholar
• Smith JR, Osborne TF, Brown MS, Goldstein JL, Gil G. 1988. Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Biol Chem 263:18480–18487
   PubMed Web of Science ®Google Scholar
• Suganyadevi P, Saravanakumar KM, Mohandas S. 2013. The antiproliferative activity of 3-deoxyanthocyanins extracted from red sorghum (Sorghum bicolor) bran through P53-dependent and Bcl-2 gene expression in breast cancer cell line. Life Sci 92:379–382
   PubMed Web of Science ®Google Scholar
• Vlahcevic ZR, Eggertsen G, Björkhem I, Hylemon PB, Redford K, Pandak WM. 2000. Regulation of sterol 12-α hydroxylase and cholic acid biosynthesis in the rat. Gastroenterology 118:599–607
   PubMedGoogle Scholar
• Wierzbicki AS, Mikhailidis DP, Wary R. 2001. Drug treatment of combined hyperlipidemia. Am J Cardiovasc Drugs 1:327–336
   PubMedGoogle Scholar
• Yokozawa T, Cho EJ, Sasaki S, Satho A, Okamoto T, Sei Y. 2006. The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats. Biol Pharm Bull 29:760–765
   PubMed Web of Science ®Google Scholar
• Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, et al. 2006. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55:2180–2191
   PubMed Web of Science ®Google Scholar