ILSI Brazil International Workshop on Functional Foods: a narrative review of the scientific evidence in the area of carbohydrates, microbiome, and health

References

• Carbohydrates in Human Nutrition. (1998). Report of a Joint FAO/WHO Expert Consultation. FAO Food and Nutrition Paper. 66: FAO. Rome., Italy. 1–140.
   Google Scholar
• Institute of Medicine of the National Academies. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. WashingtonDC: National Academies Press.2002, pp. 339–61.
   Google Scholar
• Health Canada. Policy for labelling and sdvertising of dietary fibre-containing food products. OttawaON: Health Canada, Bureau of Nutritional Sciences, Food Directorate, Health Products and Food Branch.2012.
   Google Scholar
• American Association of Cereal Chemists. (2001). Definition of dietary fiber: report of the dietary fiber definition committee to the board of directors of the American Association of Cereal Chemists. Cereal Foods World. 6: 112–26.
   Google Scholar
• European Commission. Commission Directive 2008/100/EC. Official Journal of the European Union. 2008; 51: L285–9.
   Google Scholar
• Codex Alimentarius Commission. (2008). Report of the 30th Session of the Codex Committee on Nutrition and Foods for Special Dietary Uses, Cape Town, South Africa, 3–7 November, 2008; ALINORM 09/32/26. RomeItaly: Codex Alimentarius Commission.
   Google Scholar
• Codex Alimentarius Commission. (2009). Report of the 31st Session of the Codex Committee on Nutrition and Foods for Special Dietary Uses, Düsseldorf, Germany, 2–6 November, 2009; ALINORM 09/32/26. RomeItaly: Codex Alimentarius Commission.
   Google Scholar
• Howlett JF, Betteridge VA, Champ M, Craig SA, Meheust A, Jones JM. The definition of dietary fiber – discussions at the Ninth Vahouny Fiber Symposium: building scientific agreement. Food Nutr Res. 2010; 54.5750. 10.3402/fnr.v57i0.19214.
   Web of Science ®Google Scholar
• Slavin JL. Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc. 2008; 108: 1716–31.
   PubMed Web of Science ®Google Scholar
• Institute of Medicine Food and Nutrition Board. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (Macronutrients). WashingtonDC: Institute of Medicine.2002.
   Google Scholar
• Grabitske HA, Slavin JL. Gastrointestinal effects of low-digestible carbohydrates. Crit Rev Food Sci Nutr. 2009; 49: 327–60.
   PubMed Web of Science ®Google Scholar
• Tucker LA, Thomas KS. Increasing total fiber intake reduces risk of weight and fat gains in women. J Nutr. 2009; 139: 576–81.
   PubMed Web of Science ®Google Scholar
• Du H, van der AD, Boshuizen HC, Forouhi NG, Wareham NJ, Halkjaer J, et al.. Dietary fiber and subsequent changes in body weight and waist circumference in European men and women. Am J Clin Nutr. 2010; 91: 329–36.
   PubMed Web of Science ®Google Scholar
• Pereira MA, Ludwig DS. Dietary fiber and body-weight regulation. Observations and mechanisms. Pediatr Clin North Am. 2001; 48: 969–80.
   PubMed Web of Science ®Google Scholar
• Flood-Obbagy JE, Rolls BJ. The effect of fruit in different forms on energy intake and satiety at a meal. Appetite. 2009; 52: 416–22.
   PubMed Web of Science ®Google Scholar
• Anne MS, Welch RW, Barbara M, Livingstone E, McCourt M, Burns AA, et al.. The effects of the fibre content and physical structure of carrots on satiety and subsequent intakes when eaten as part of a mixed meal. Br J Nutr. 2006; 96: 587–95.
   Web of Science ®Google Scholar
• Scholz-Ahrens KE, Ade P, Marten B, Weber P, Timm W, Acil Y, et al.. Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. J Nutr. 2007; 137: 838S–46S.
   PubMed Web of Science ®Google Scholar
• Macfarlane GT, Macfarlane S. Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebiotics. J Clin Gastroenterol. 2011; 45 Suppl: S120–7.
   Web of Science ®Google Scholar
• Wong JM, de SR, Kendall CW, Emam A, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006; 40: 235–43.
   PubMed Web of Science ®Google Scholar
• US Department of Agriculture. Dietary guidelines for Americans. WashingtonDC: US Government Printing Office.2010.
   Google Scholar
• Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa de Orçamentos Familiares 2002/2003 (POF) – Aquisição alimentar domiciliar per capita, Brasil e grandes regiões. Rio de Janeiro: IBGE.2004.
   Google Scholar
• Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa de Orçamentos Familiares 2008/2009 (POF) – Aquisição alimentar domiciliar per capita, Brasil e grandes regiões. Rio de Janeiro: IBGE.2010.
   Google Scholar
• Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielden H, Baldwin JM, et al.. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr. 1981; 34: 362–6.
   PubMed Web of Science ®Google Scholar
• Livesey G, Taylor R, Hulshof T, Howlett J. Glycemic response and health–a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes. Am J Clin Nutr. 2008; 87: 258S–68S.
   PubMed Web of Science ®Google Scholar
• Livesey G, Taylor R, Hulshof T, Howlett J. Glycemic response and health–a systematic review and meta-analysis: the database, study characteristics, and macronutrient intakes. Am J Clin Nutr. 2008; 87: 223S–36S.
   Web of Science ®Google Scholar
• Sadler M. Food, glycaemic response and health. ILSI Europe Concise Monograph Series. ILSI Europe. BrusselsBelgium, 2011
   Google Scholar
• Wolever TM, Brand-Miller JC, Abernethy J, Astrup A, Atkinson F, Axelsen M, et al.. Measuring the glycemic index of foods: interlaboratory study. Am J Clin Nutr. 2008; 87: 247S–57S.
   PubMed Web of Science ®Google Scholar
• Atkinson FS, Foster-Powell K, Brand-Miller JC. International tables of glycemic index and glycemic load values: 2008. Diabetes Care. 2008; 31: 2281–3.
   PubMed Web of Science ®Google Scholar
• Hollenbeck CB, Coulston AM, Reaven GM. Comparison of plasma glucose and insulin responses to mixed meals of high-, intermediate-, and low-glycemic potential. Diabetes Care. 1988; 11: 323–9.
   PubMed Web of Science ®Google Scholar
• Monro JA, Shaw M. Glycemic impact, glycemic glucose equivalents, glycemic index, and glycemic load: definitions, distinctions, and implications. Am J Clin Nutr. 2008; 87: 237S–43S.
   PubMed Web of Science ®Google Scholar
• Jenkins DJ, Kendall CW, McKeown-Eyssen G, Josse RG, Silverberg J, Booth GL, et al.. Effect of a low-glycemic index or a high-cereal fiber diet on type 2 diabetes: a randomized trial. JAMA. 2008; 300: 2742–53.
   PubMed Web of Science ®Google Scholar
• Larsen TM, Dalskov S, van BM, Jebb S, Kafatos A, Pfeiffer A, et al.. The Diet, Obesity and Genes (Diogenes) Dietary Study in eight European countries – a comprehensive design for long-term intervention. Obes Rev. 2010; 11: 76–91.
   PubMed Web of Science ®Google Scholar
• Burkitt DP, Trowell HC. Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans. Refined carbohydrate foods and disease. Academic Press. New York, 1975
   Google Scholar
• Brand-Miller J, Hayne S, Petocz P, Colagiuri S. Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials. Diabetes Care. 2003; 26: 2261–7.
   PubMed Web of Science ®Google Scholar
• Sheard NF, Clark NG, Brand-Miller JC, Franz MJ, Pi-Sunyer FX, Mayer-Davis E, et al.. Dietary carbohydrate (amount and type) in the prevention and management of diabetes: a statement by the American Diabetes Association. Diabetes Care. 2004; 27: 2266–71.
   PubMed Web of Science ®Google Scholar
• Levitan EB, Song Y, Ford ES, Liu S. Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Arch Intern Med. 2004; 164: 2147–55.
   PubMed Web of Science ®Google Scholar
• Lawes CM, Parag V, Bennett DA, Suh I, Lam TH, Whitlock G, et al.. Blood glucose and risk of cardiovascular disease in the Asia Pacific region. Diabetes Care. 2004; 27: 2836–42.
   PubMed Web of Science ®Google Scholar
• Liu S, Manson JE, Buring JE, Stampfer MJ, Willett WC, Ridker PM. Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women. Am J Clin Nutr. 2002; 75: 492–8.
   PubMed Web of Science ®Google Scholar
• Frost G, Leeds AA, Dore CJ, Madeiros S, Brading S, Dornhorst A. Glycaemic index as a determinant of serum HDL-cholesterol concentration. Lancet. 1999; 353: 1045–8.
   PubMed Web of Science ®Google Scholar
• Franceschi S, Dal ML, Augustin L, Negri E, Parpinel M, Boyle P, et al.. Dietary glycemic load and colorectal cancer risk. Ann Oncol. 2001; 12: 173–8.
   PubMed Web of Science ®Google Scholar
• Augustin LS, Dal ML, La VC, Parpinel M, Negri E, Vaccarella S, et al.. Dietary glycemic index and glycemic load, and breast cancer risk: a case-control study. Ann Oncol. 2001; 12: 1533–8.
   PubMed Web of Science ®Google Scholar
• Augustin LS, Galeone C, Dal ML, Pelucchi C, Ramazzotti V, Jenkins DJ, et al.. Glycemic index, glycemic load and risk of prostate cancer. Int J Cancer. 2004; 112: 446–50.
   PubMed Web of Science ®Google Scholar
• Barclay AW, Petocz P, McMillan-Price J, Flood VM, Prvan T, Mitchell P, et al.. Glycemic index, glycemic load, and chronic disease risk–a meta-analysis of observational studies. Am J Clin Nutr. 2008; 87: 627–37.
   PubMed Web of Science ®Google Scholar
• Opperman AM, Venter CS, Oosthuizen W, Thompson RL, Vorster HH. Meta-analysis of the health effects of using the glycaemic index in meal-planning. Br J Nutr. 2004; 92: 367–81.
   PubMed Web of Science ®Google Scholar
• Bornet FR, Jardy-Gennetier AE, Jacquet N, Stowell J. Glycaemic response to foods: impact on satiety and long-term weight regulation. Appetite. 2007; 49: 535–53.
   PubMed Web of Science ®Google Scholar
• Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics. 1999; 103: E26.
   PubMed Web of Science ®Google Scholar
• Thomas DE, Elliott EJ, Baur L. Low glycaemic index or low glycaemic load diets for overweight and obesity. Cochrane Database Syst Rev. 2007; 18(3) CD005105.
   Google Scholar
• Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA. 2003; 290: 486–94.
   PubMed Web of Science ®Google Scholar
• The DECODE study group on behalf of the European Diabetes Epidemiology Group. Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. Lancet. 1999; 354: 617–21.
   PubMed Web of Science ®Google Scholar
• Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care. 1999; 22: 233–40.
   PubMed Web of Science ®Google Scholar
• Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA. beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab. 2005; 90: 493–500.
   PubMed Web of Science ®Google Scholar
• Chiu CJ, Milton RC, Gensler G, Taylor A. Association between dietary glycemic index and age-related macular degeneration in nondiabetic participants in the Age-Related Eye Disease Study. Am J Clin Nutr. 2007; 86: 180–8.
   Web of Science ®Google Scholar
• Chiu CJ, Morris MS, Rogers G, Jacques PF, Chylack LTJr, Tung W, et al.. Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities. Am J Clin Nutr. 2005; 81: 1411–6.
   Web of Science ®Google Scholar
• Chiu CJ, Hubbard LD, Armstrong J, Rogers G, Jacques PF, Chylack LTJr, et al.. Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration. Am J Clin Nutr. 2006; 83: 880–6.
   Web of Science ®Google Scholar
• Gilbertson HR, Brand-Miller JC, Thorburn AW, Evans S, Chondros P, Werther GA. The effect of flexible low glycemic index dietary advice versus measured carbohydrate exchange diets on glycemic control in children with type 1 diabetes. Diabetes Care. 2001; 24: 1137–43.
   PubMed Web of Science ®Google Scholar
• Blundell J, de GC, Hulshof T, Jebb S, Livingstone B, Lluch A, et al.. Appetite control: methodological aspects of the evaluation of foods. Obes Rev. 2010; 11: 251–70.
   PubMed Web of Science ®Google Scholar
• Hetherington MM, Regan MF. Effects of chewing gum on short-term appetite regulation in moderately restrained eaters. Appetite. 2011; 57: 475–82.
   PubMed Web of Science ®Google Scholar
• Hogenkamp PS, Stafleu A, Mars M, Brunstrom JM, de GC. Texture, not flavor, determines expected satiation of dairy products. Appetite. 2011; 57: 635–41.
   PubMed Web of Science ®Google Scholar
• Marciani L, Gowland PA, Spiller RC, Manoj P, Moore RJ, Young P, et al.. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am J Physiol Gastrointest Liver Physiol. 2001; 280: G1227–33.
   PubMed Web of Science ®Google Scholar
• Samra RA, Anderson GH. Insoluble cereal fiber reduces appetite and short-term food intake and glycemic response to food consumed 75 min later by healthy men. Am J Clin Nutr. 2007; 86: 972–9.
   PubMed Web of Science ®Google Scholar
• Holt SH, Miller JC, Petocz P, Farmakalidis E. A satiety index of common foods. Eur J Clin Nutr. 1995; 49: 675–90.
   PubMed Web of Science ®Google Scholar
• Ranawana V, Henry CJ. Liquid and solid carbohydrate foods: comparative effects on glycemic and insulin responses, and satiety. Int J Food Sci Nutr. 2011; 62: 71–81.
   PubMed Web of Science ®Google Scholar
• de Graaf C. Texture and satiation: the role of oro-sensory exposure time. Physiol Behav. 2012; 107(4): 496–501.
   Web of Science ®Google Scholar
• Wanders AJ, van den Borne JJ, de GC, Hulshof T, Jonathan MC, Kristensen M, et al.. Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trials. Obes Rev. 2011; 12: 724–39.
   PubMed Web of Science ®Google Scholar
• European Food Safety Authority. Statement on the safety of synthetic zeaxanthin as an ingredient in food supplements. EFSA J. 2012; 10: 2891.
   Google Scholar
• European Food Safety Authority. Scientific opinion on the substantiation of health claims related to dietary fibre (ID 744, 745, 746, 748, 749, 753, 803, 810, 855, 1415, 1416, 4308, 4330) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J. 2010; 8: 1735.
   Google Scholar
• Benton D, Owens D. Is raised blood glucose associated with the relief of tension?. J Psychosom Res. 1993; 37: 723–35.
   PubMed Web of Science ®Google Scholar
• Nabb SL, Benton D. The effect of the interaction between glucose tolerance and breakfasts varying in carbohydrate and fibre on mood and cognition. Nutr Neurosci. 2006; 9: 161–8.
   PubMed Web of Science ®Google Scholar
• Benton D, Brock H. Mood and the macro-nutrient composition of breakfast and the mid-day meal. Appetite. 2010; 55: 436–40.
   PubMed Web of Science ®Google Scholar
• de Castro JM. Macronutrient relationships with meal patterns and mood in the spontaneous feeding behavior of humans. Physiol Behav. 1987; 39: 561–9.
   PubMed Web of Science ®Google Scholar
• Wolraich ML, Wilson DB, White JW. The effect of sugar on behavior or cognition in children. A meta-analysis. JAMA. 1995; 274: 1617–21.
   PubMed Web of Science ®Google Scholar
• Benton D. Sucrose and behavioral problems. Crit Rev Food Sci Nutr. 2008; 48: 385–401.
   PubMed Web of Science ®Google Scholar
• Benton D, Stevens MK. The influence of a glucose containing drink on the behavior of children in school. Biol Psychol. 2008; 78: 242–5.
   PubMed Web of Science ®Google Scholar
• Milazzo W, Fielder J, Bittel A, Coil J, McClure M, Tobin P, et al.. Oral sucrose to decrease pain associated with arterial puncture in infants 30 to 36 weeks’ gestation: a randomized clinical trial. Adv Neonatal Care. 2011; 11: 406–11.
   PubMedGoogle Scholar
• Willner P, Benton D, Brown E, Cheeta S, Davies G, Morgan J, et al.. Depression” increases “craving” for sweet rewards in animal and human models of depression and craving. Psychopharmacology (Berl). 1998; 136: 272–83.
   PubMed Web of Science ®Google Scholar
• Benton D, Maconie A, Williams C. The influence of the glycaemic load of breakfast on the behaviour of children in school. Physiol Behav. 2007; 92: 717–24.
   PubMed Web of Science ®Google Scholar
• Wolever TM, Vuksan V, Eshuis H, Spadafora P, Peterson RD, Chao ES, et al.. Effect of method of administration of psyllium on glycemic response and carbohydrate digestibility. J Am Coll Nutr. 1991; 10: 364–71.
   PubMed Web of Science ®Google Scholar
• Bjorck I, Elmstahl HL. The glycaemic index: importance of dietary fibre and other food properties. Proc Nutr Soc. 2003; 62: 201–6.
   PubMed Web of Science ®Google Scholar
• Pineiro M, Asp NG, Reid G, Macfarlane S, Morelli L, Brunser O, et al.. FAO Technical meeting on prebiotics. J Clin Gastroenterol. 2008; 42(Suppl 3): S156–9.
   Google Scholar
• Food and Agriculture Organization of the United Nations WHO. (2001). Report of a joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. RomeItaly: FAO/WHO.
   Google Scholar
• Guarner F, Malagelada JR. Gut flora in health and disease. Lancet. 2003; 361: 512–9.
   PubMed Web of Science ®Google Scholar
• Gibson GR, Scott KP, Rastall RA, Tuohy KM, Hotchkiss A, Dubert-Ferrandon A. Dietary prebiotics: current status and new definition. Food Sci Technol Bull: Functional Foods. 2010; 7: 1–19.
   Google Scholar
• Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995; 125: 1401–12.
   PubMed Web of Science ®Google Scholar
• Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, et al.. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010; 104(Suppl 2): S1–63.
   PubMed Web of Science ®Google Scholar
• Sela DA, Mills DA. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends Microbiol. 2010; 18: 298–307.
   PubMed Web of Science ®Google Scholar
• Bode L. Human milk oligosaccharides: prebiotics and beyond. Nutr Rev. 2009; 67(Suppl 2): S183–91.
   PubMedGoogle Scholar
• de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol. 2008; 111: 1–66.
   PubMed Web of Science ®Google Scholar
• Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 2004; 79: 537–43.
   PubMed Web of Science ®Google Scholar
• Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ, et al.. Nutrition recommendations and interventions for diabetes– 2006: a position statement of the American Diabetes Association. Diabetes Care. 2006; 29: 2140–57.
   PubMed Web of Science ®Google Scholar
• Johnson RK, Appel LJ, Brands M, Howard BV, Lefevre M, Lustig RH, et al.. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2009; 120: 1011–20.
   PubMed Web of Science ®Google Scholar
• Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from: http://www.cochrane-handbook.org.
   Google Scholar
• Lewis GF, Uffelman K, Naples M, Szeto L, Haidari M, Adeli K. Intestinal lipoprotein overproduction, a newly recognized component of insulin resistance, is ameliorated by the insulin sensitizer rosiglitazone: studies in the fructose-fed Syrian golden hamster. Endocrinology. 2005; 146: 247–55.
   PubMed Web of Science ®Google Scholar
• Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999–2000. JAMA. 2002; 288: 1723–7.
   PubMed Web of Science ®Google Scholar
• Vuilleumier S. Worldwide production of high-fructose syrup and crystalline fructose. Am J Clin Nutr. 1993; 58: 733S–6S.
   Web of Science ®Google Scholar
• Swarbrick MM, Stanhope KL, Elliott SS, Graham JL, Krauss RM, Christiansen MP, et al.. Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women. Br J Nutr. 2008; 100: 947–52.
   PubMed Web of Science ®Google Scholar
• Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, et al.. Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab. 2011; 96: E1596–605.
   PubMed Web of Science ®Google Scholar
• Stanhope KL, Havel PJ. Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup. Am J Clin Nutr. 2008; 88: 1733S–7S.
   PubMed Web of Science ®Google Scholar
• Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, et al.. Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women. Eur J Clin Nutr. 2012; 66: 201–8.
   PubMed Web of Science ®Google Scholar
• Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper's illustrated biochemistry. McGraw-Hill. New York, 2006
   Google Scholar
• Brunengraber DZ, McCabe BJ, Kasumov T, Alexander JC, Chandramouli V, Previs SF. Influence of diet on the modeling of adipose tissue triglycerides during growth. Am J Physiol Endocrinol Metab. 2003; 285: E917–25.
   PubMed Web of Science ®Google Scholar
• Lee WN, Bassilian S, Ajie HO, Schoeller DA, Edmond J, Bergner EA, et al.. In vivo measurement of fatty acids and cholesterol synthesis using D2O and mass isotopomer analysis. Am J Physiol. 1994; 266: E699–708.
   Google Scholar
• Leveille GA. In vivo fatty acid synthesis in adipose tissue and liver of meal-fed rats. Proc Soc Exp Biol Med. 1967; 125: 85–8.
   PubMed Web of Science ®Google Scholar
• Sievenpiper JL, de Souza RJ, Kendall CW, Jenkins DJ. Is fructose a story of mice but not men?. J Am Diet Assoc. 2011; 111: 219–20.
   Google Scholar
• Petersen KF, Laurent D, Yu C, Cline GW, Shulman GI. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. Diabetes. 2001; 50: 1263–8.
   PubMed Web of Science ®Google Scholar
• Hawkins M, Gabriely I, Wozniak R, Vilcu C, Shamoon H, Rossetti L. Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes. Diabetes. 2002; 51: 606–14.
   PubMed Web of Science ®Google Scholar
• Marriott BP, Cole N, Lee E. National estimates of dietary fructose intake increased from 1977 to 2004 in the United States. J Nutr. 2009; 139: 1228S–35S.
   PubMed Web of Science ®Google Scholar
• Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN, et al.. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011; 123: 2292–333.
   PubMed Web of Science ®Google Scholar
• Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ, et al.. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2008; 31(Suppl 1): S61–78.
   PubMed Web of Science ®Google Scholar
• Sievenpiper JL, Carleton AJ, Chatha S, Jiang HY, de Souza RJ, Beyene J, et al.. Heterogeneous effects of fructose on blood lipids in individuals with type 2 diabetes: systematic review and meta-analysis of experimental trials in humans. Diabetes Care. 2009; 32: 1930–7.
   PubMed Web of Science ®Google Scholar
• Ha V, Sievenpiper JL, de Souza RJ, Chiavaroli L, Wang DD, Cozma AI, et al.. Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials. Hypertension. 2012; 59: 787–95.
   PubMed Web of Science ®Google Scholar
• Wang DD, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Cozma AI, et al.. The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr. 2012; 142: 916–23.
   PubMed Web of Science ®Google Scholar
• Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, et al.. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med. 2012; 156: 291–304.
   PubMed Web of Science ®Google Scholar
• Cozma AI, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Wang DD, et al.. Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials. Diabetes Care. 2012; 35: 1611–20.
   PubMed Web of Science ®Google Scholar
• Livesey G, Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr. 2008; 88: 1419–37.
   PubMed Web of Science ®Google Scholar
• Perez-Pozo SE, Schold J, Nakagawa T, Sanchez-Lozada LG, Johnson RJ, Lillo JL. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes (Lond). 2010; 34: 454–61.
   PubMed Web of Science ®Google Scholar
• Scientific concepts of functional foods in Europe. Consensus document. Br J Nutr. 1999; 81(Suppl 1): S1–27.
   Google Scholar
• Aggett PJ, Antoine JM, Asp NG, Bellisle F, Contor L, Cummings JH, et al.. PASSCLAIM: consensus on criteria. Eur J Nutr. 2005; 44(Suppl 1): i5–30.
   PubMed Web of Science ®Google Scholar
• Regulation (EC) No 1924/2006 of the European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods. OJ L 404, 2006; 30.12.2006. 9.
   Google Scholar
• Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69: 89–95.
   PubMed Web of Science ®Google Scholar
• Micheel C. Evaluation of biomarkers and surrogate endpoints in chronic disease. National Academy Press. Washington DC, 2010
   Google Scholar
• Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol. 2008; 8: 411–20.
   PubMed Web of Science ®Google Scholar
• Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012; 148: 1258–70.
   PubMed Web of Science ®Google Scholar
• Galdeano CM, Perdigon G. The probiotic bacterium Lactobacillus casei induces activation of the gut mucosal immune system through innate immunity. Clin Vaccine Immunol. 2006; 13: 219–26.
   PubMed Web of Science ®Google Scholar
• Galdeano CM, de Moreno de LA, Vinderola G, Bonet ME, Perdigon G. Proposed model: mechanisms of immunomodulation induced by probiotic bacteria. Clin Vaccine Immunol. 2007; 14: 485–92.
   PubMed Web of Science ®Google Scholar
• Galdeano CM, Perdigon G. Role of viability of probiotic strains in their persistence in the gut and in mucosal immune stimulation. J Appl Microbiol. 2004; 97: 673–81.
   PubMed Web of Science ®Google Scholar
• Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science. 2001; 292: 1115–8.
   PubMed Web of Science ®Google Scholar
• Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell. 2006; 124: 837–48.
   PubMed Web of Science ®Google Scholar
• Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009; 326: 1694–7.
   PubMed Web of Science ®Google Scholar
• Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008; 134: 577–94.
   PubMed Web of Science ®Google Scholar
• Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA. 2005; 102: 11070–5.
   PubMed Web of Science ®Google Scholar
• Scanlan PD, Shanahan F, Clune Y, Collins JK, O'Sullivan GC, O'Riordan M, et al.. Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis. Environ Microbiol. 2008; 10: 789–98.
   PubMed Web of Science ®Google Scholar
• Macpherson AJ, Harris NL. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol. 2004; 4: 478–85.
   PubMed Web of Science ®Google Scholar
• Faith JJ, McNulty NP, Rey FE, Gordon JI. Predicting a human gut microbiota's response to diet in gnotobiotic mice. Science. 2011; 333: 101–4.
   PubMed Web of Science ®Google Scholar
• Arumugam M, Raes J, Pelletier E, Le PD, Yamada T, Mende DR, et al.. Enterotypes of the human gut microbiome. Nature. 2011; 473: 174–80.
   PubMed Web of Science ®Google Scholar
• Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, et al.. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011; 334: 105–8.
   PubMed Web of Science ®Google Scholar
• Sanz ML, Gibson GR, Rastall RA. Influence of disaccharide structure on prebiotic selectivity in vitro. J Agric Food Chem. 2005; 53: 5192–9.
   PubMed Web of Science ®Google Scholar
• Sarbini SR, Kolida S, Naeye T, Einerhand A, Brison Y, Remaud-Simeon M, et al.. In vitro fermentation of linear and alpha-1,2-branched dextrans by the human fecal microbiota. Appl Environ Microbiol. 2011; 77: 5307–15.
   PubMed Web of Science ®Google Scholar
• Onumpai C, Kolida S, Bonnin E, Rastall RA. Microbial utilization and selectivity of pectin fractions with various structures. Appl Environ Microbiol. 2011; 77: 5747–54.
   PubMed Web of Science ®Google Scholar
• Rastall RA. Functional oligosaccharides: application and manufacture. Annu Rev Food Sci Technol. 2010; 1: 305–39.
   PubMed Web of Science ®Google Scholar
• Rhoades J, Manderson K, Wells A, Hotchkiss ATJr, Gibson GR, Formentin K, et al.. Oligosaccharide-mediated inhibition of the adhesion of pathogenic Escherichia coli strains to human gut epithelial cells in vitro. J Food Prot. 2008; 71: 2272–7.
   Web of Science ®Google Scholar
• Shoaf K, Mulvey GL, Armstrong GD, Hutkins RW. Prebiotic galactooligosaccharides reduce adherence of enteropathogenic Escherichia coli to tissue culture cells. Infect Immun. 2006; 74: 6920–8.
   PubMed Web of Science ®Google Scholar
• Sinclair HR, de SJ, Gibson GR, Rastall RA. Galactooligosaccharides (GOS) inhibit Vibrio cholerae toxin binding to its GM1 receptor. J Agric Food Chem. 2009; 57: 3113–9.
   Web of Science ®Google Scholar
• Al-Lahham SH, Roelofsen H, Priebe M, Weening D, Dijkstra M, Hoek A, et al.. Regulation of adipokine production in human adipose tissue by propionic acid. Eur J Clin Invest. 2010; 40: 401–7.
   PubMed Web of Science ®Google Scholar
• Cani PD, Osto M, Geurts L, Everard A. Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes. 2012;3: 279–288.
   PubMed Web of Science ®Google Scholar
• Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, et al.. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr. 2011; 94: 58–65.
   PubMed Web of Science ®Google Scholar
• Tasse L, Bercovici J, Pizzut-Serin S, Robe P, Tap J, Klopp C, et al.. Functional metagenomics to mine the human gut microbiome for dietary fiber catabolic enzymes. Genome Res. 2010; 20: 1605–12.
   PubMed Web of Science ®Google Scholar
• Musso G, Gambino R, Cassader M. Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders. Curr Opin Lipidol. 2010; 21: 76–83.
   PubMed Web of Science ®Google Scholar
• Clarke S, Murphy E, Nilaweera K, Ross P, Shanahan F, O'Toole PW, et al.. The gut microbiota and its relationship to diet and obesity: new insights. Gut Microbes. 2012; 3: 186–202.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, et al.. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci USA. 2004; 101: 1045–50.
   PubMed Web of Science ®Google Scholar
• Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, et al.. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia. 2007; 50: 2374–83.
   PubMed Web of Science ®Google Scholar
• Membrez M, Blancher F, Jaquet M, Bibiloni R, Cani PD, Burcelin RG, et al.. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J. 2008; 22: 2416–26.
   PubMed Web of Science ®Google Scholar
• Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y, et al.. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA. 2009; 106: 2365–70.
   PubMed Web of Science ®Google Scholar
• Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?. Gastroenterology. 2002; 122: 1140–56.
   PubMed Web of Science ®Google Scholar
• Mittermaier C, Dejaco C, Waldhoer T, Oefferlbauer-Ernst A, Miehsler W, Beier M, et al.. Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study. Psychosom Med. 2004; 66: 79–84.
   PubMed Web of Science ®Google Scholar
• Addolorato G, Capristo E, Stefanini GF, Gasbarrini G. Inflammatory bowel disease: a study of the association between anxiety and depression, physical morbidity, and nutritional status. Scand J Gastroenterol. 1997; 32: 1013–21.
   PubMed Web of Science ®Google Scholar
• Andrews H, Barczak P, Allan RN. Psychiatric illness in patients with inflammatory bowel disease. Gut. 1987; 28: 1600–4.
   PubMed Web of Science ®Google Scholar
• Renault PF, Hoofnagle JH, Park Y, Mullen KD, Peters M, Jones DB, et al.. Psychiatric complications of long-term interferon alfa therapy. Arch Intern Med. 1987; 147: 1577–80.
   PubMed Web of Science ®Google Scholar
• Dantzer R, Kelley KW. Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun. 2007; 21: 153–60.
   PubMed Web of Science ®Google Scholar
• Denicoff KD, Rubinow DR, Papa MZ, Simpson C, Seipp CA, Lotze MT, et al.. The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med. 1987; 107: 293–300.
   PubMed Web of Science ®Google Scholar
• DuPont AW, DuPont HL. The intestinal microbiota and chronic disorders of the gut. Nat Rev Gastroenterol Hepatol. 2011; 8: 523–31.
   PubMed Web of Science ®Google Scholar
• Gaykema RP, Goehler LE, Lyte M. Brain response to cecal infection with Campylobacter jejuni: analysis with Fos immunohistochemistry. Brain Behav Immun. 2004; 18: 238–45.
   Web of Science ®Google Scholar
• Lyte M, Varcoe JJ, Bailey MT. Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation. Physiol Behav. 1998; 65: 63–8.
   PubMed Web of Science ®Google Scholar
• Bercik P, Verdu EF, Foster JA, Lu J, Scharringa A, Kean I, et al.. Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection. Am J Physiol Regul Integr Comp Physiol. 2009; 296: R587–94.
   PubMed Web of Science ®Google Scholar
• Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang X, et al.. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology. 2010; 139: 2102–12.
   PubMed Web of Science ®Google Scholar
• Heijtz RD, Wang S, Anuar F, Qian Y, Bjorkholm B, Samuelsson A, et al.. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA. 2011; 108: 3047–52.
   PubMed Web of Science ®Google Scholar
• Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil. 2011; 23: 255–64, e119.
   PubMed Web of Science ®Google Scholar
• Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, et al.. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology. 2011; 141: 599–609.
   PubMed Web of Science ®Google Scholar
• McCleary BV, DeVries JW, Rader JI, Cohen G, Prosky L, Mugford DC, et al.. Determination of total dietary fiber (CODEX definition) by enzymatic-gravimetric method and liquid chromatography: collaborative study. J AOAC Int. 2010; 93: 221–33.
   PubMed Web of Science ®Google Scholar
• Giuntini EB, Menezes EW. Dietary fiber. Nutrient recognized functions. ILSI Brasil. Sao PauloBrazil, 2011
   Google Scholar