Drug Design, Development and Therapy, Volume 5, Issue (2011)

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Drug Design, Development and Therapy, Volume 5, Issue (2011)

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Review

Review Article
The use of lorcaserin in the management of obesity: a critical appraisal
Bo Bai & Yu Wang
Pages: 1-7
Published online: 20 Dec 2010
AbstractforThe use of lorcaserin in the management of obesity: a critical appraisal | Full Text | References | PDF (147.5 KB)
  • 174 Views
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Open Access
Review Article
Current progress in the development of a prophylactic vaccine for HIV-1
Lena J Gamble & Qiana L Matthews
Pages: 9-26
Published online: 22 Dec 2010
AbstractforCurrent progress in the development of a prophylactic vaccine for HIV-1 | Full Text | References | PDF (254.3 KB)
  • 139 Views
  • 6 CrossRef citations
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Open Access
Review Article
Dronedarone: current evidence for its safety and efficacy in the management of atrial fibrillation
Patrick A Schweizer, Rüdiger Becker, Hugo A Katus & Dierk Thomas
Pages: 27-39
Published online: 06 Jan 2011
AbstractforDronedarone: current evidence for its safety and efficacy in the management of atrial fibrillation | Full Text | References | PDF (229.4 KB)
  • 117 Views
  • 6 CrossRef citations
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Review Article
Comparative assessment of biologics in treatment of psoriasis: drug design and clinical effectiveness of ustekinumab
Ignacio Garcia-Valladares, Raquel Cuchacovich & Luis R Espinoza
Pages: 41-49
Published online: 10 Jan 2011
AbstractforComparative assessment of biologics in treatment of psoriasis: drug design and clinical effectiveness of ustekinumab | Full Text | References | PDF (206.4 KB)
  • 98 Views
  • 4 CrossRef citations
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Review Article
When is high-dose intravenous iron repletion needed? Assessing new treatment options
David Gozzard
Pages: 51-60
Published online: 20 Jan 2011
AbstractforWhen is high-dose intravenous iron repletion needed? Assessing new treatment options | Full Text | References | PDF (183.8 KB)
  • 157 Views
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Open Access
Review Article
Abatacept in the treatment of polyarticular JIA: development, clinical utility, and place in therapy
Ofra Goldzweig & Philip J Hashkes
Pages: 61-70
Published online: 26 Jan 2011
AbstractforAbatacept in the treatment of polyarticular JIA: development, clinical utility, and place in therapy | Full Text | References | PDF (250.3 KB)
  • 106 Views
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Original Research

Article
Illicit methylphenidate use among Iranian medical students: prevalence and knowledge
Afshin Habibzadeh, Mahasti Alizadeh, Ayoub Malek, Leili Maghbooli, Mohammadali M Shoja & Kamyar Ghabili
Pages: 71-76
Published online: 03 Feb 2011
AbstractforIllicit methylphenidate use among Iranian medical students: prevalence and knowledge | Full Text | References | PDF (154.6 KB)
  • 259 Views
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Open Access
Article
Comparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis
Santa J Ono & Keith Lane
Pages: 77-84
Published online: 08 Feb 2011
AbstractforComparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis | Full Text | References | PDF (1.8 MB)
  • 128 Views
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Review

Review Article
Cefditoren in upper and lower community-acquired respiratory tract infections
Francisco Soriano, María-José Giménez & Lorenzo Aguilar
Pages: 85-94
Published online: 09 Feb 2011
AbstractforCefditoren in upper and lower community-acquired respiratory tract infections | Full Text | References | PDF (194.9 KB)
  • 143 Views
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Open Access
Review Article
The use of serotonergic drugs to treat obesity – is there any hope?
Nicholas T Bello & Nu-Chu Liang
Pages: 95-109
Published online: 10 Feb 2011
AbstractforThe use of serotonergic drugs to treat obesity – is there any hope? | Full Text | References | PDF (250.8 KB)
  • 138 Views
  • 36 CrossRef citations
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Open Access
Review Article
Maintaining remission in ulcerative colitis – role of once daily extended-release mesalamine
Lilliana Oliveira & Russell D Cohen
Pages: 111-116
Published online: 27 Feb 2011
AbstractforMaintaining remission in ulcerative colitis – role of once daily extended-release mesalamine | Full Text | References | PDF (211.5 KB)
  • 158 Views
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Open Access
Review Article
Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer
Channing J Paller & Emmanuel S Antonarakis
Pages: 117-124
Published online: 10 Mar 2011
AbstractforCabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer | Full Text | References | PDF (197.3 KB)
  • 601 Views
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Review Article
Paliperidone extended-release: does it have a place in antipsychotic therapy?
Maximilian Gahr, Markus A Kölle, Carlos Schönfeldt-Lecuona, Peter Lepping & Roland W Freudenmann
Pages: 125-146
Published online: 11 Mar 2011
AbstractforPaliperidone extended-release: does it have a place in antipsychotic therapy? | Full Text | References | PDF (296 KB)
  • 95 Views
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Case Report

Case Report
Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel
Andrew S Bomback, James A Tumlin, Joel Baranski, James E Bourdeau, Anatole Besarab, Alice S Appel, Jai Radhakrishnan & Gerald B Appel
Pages: 147-153
Published online: 14 Mar 2011
AbstractforTreatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel | Full Text | References | PDF (195.1 KB)
  • 145 Views
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Review

Review Article
Update on role of agalsidase alfa in management of Fabry disease
Uma Ramaswami
Pages: 155-173
Published online: 14 Mar 2011
AbstractforUpdate on role of agalsidase alfa in management of Fabry disease | Full Text | References | PDF (294.8 KB)
  • 110 Views
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Open Access
Review Article
Drug discovery and development for neglected diseases: the DNDi model
Eric Chatelain & Jean-Robert Ioset
Pages: 175-181
Published online: 16 Mar 2011
AbstractforDrug discovery and development for neglected diseases: the DNDi model | Full Text | References | PDF (285 KB)
  • 658 Views
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Open Access

Corrigendum

Correction
Corrigendum
Page: 183
Published online: 21 Mar 2011
CitationforCorrigendum | Full Text | PDF (56.7 KB)
  • 61 Views
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Review

Review Article
Current and emerging drugs for the treatment of inflammatory bowel disease
John K Triantafillidis, Emmanuel Merikas & Filippos Georgopoulos
Pages: 185-210
Published online: 28 Sep 2022
AbstractforCurrent and emerging drugs for the treatment of inflammatory bowel disease | Full Text | References | PDF (318.6 KB)
  • 594 Views
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Open Access
Review Article
Targeting nicotine addiction: the possibility of a therapeutic vaccine
José Juan Escobar-Chávez, Clara Luisa Domínguez-Delgado & Isabel Marlen Rodríguez-Cruz
Pages: 211-224
Published online: 18 Apr 2011
AbstractforTargeting nicotine addiction: the possibility of a therapeutic vaccine | Full Text | References | PDF (234 KB)
  • 183 Views
  • 23 CrossRef citations
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Open Access
Review Article
Emerging strategies and therapies for treatment of Paget’s disease of bone
Laëtitia Michou & Jacques P Brown
Pages: 225-239
Published online: 26 Apr 2011
AbstractforEmerging strategies and therapies for treatment of Paget’s disease of bone | Full Text | References | PDF (1,020.9 KB)
  • 123 Views
  • 5 CrossRef citations
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Open Access
Review Article
Available and emerging treatments for Parkinson’s disease: a review
Patrick Hickey & Mark Stacy
Pages: 241-254
Published online: 02 May 2011
AbstractforAvailable and emerging treatments for Parkinson’s disease: a review | Full Text | References | PDF (243.6 KB)
  • 874 Views
  • 4 CrossRef citations
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Open Access
Review Article
Development of oral immunomodulatory agents in the management of multiple sclerosis
Richard Nicholas, Paolo Giannetti, Ali Alsanousi, Tim Friede & Paolo A Muraro
Pages: 255-274
Published online: 10 May 2011
AbstractforDevelopment of oral immunomodulatory agents in the management of multiple sclerosis | Full Text | References | PDF (648.6 KB)
  • 112 Views
  • 26 CrossRef citations
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Open Access
Review Article
Current difficulties and recent advances in bypass therapy for the management of hemophilia with inhibitors: a new and practical formulation of recombinant factor VIIa
Linda Butros, Koh Boayue & Prasad Mathew
Pages: 275-282
Published online: 12 May 2011
AbstractforCurrent difficulties and recent advances in bypass therapy for the management of hemophilia with inhibitors: a new and practical formulation of recombinant factor VIIa | Full Text | References | PDF (211.3 KB)
  • 83 Views
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Open Access
Review Article
Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus
Yasuyuki Kawai, Ryoko Sato-Ishida, Atsushi Motoyama & Kouji Kajinami
Pages: 283-297
Published online: 11 May 2011
AbstractforPlace of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus | Full Text | References | PDF (533.8 KB)
  • 153 Views
  • 7 CrossRef citations
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Open Access

Original Research

Article
Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells
Elizabeth Tahanian, Luis Arguello Sanchez, Tze Chieh Shiao, René Roy & Borhane Annabi
Pages: 299-309
Published online: 13 May 2011
AbstractforFlavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells | Full Text | References | PDF (909.6 KB)
  • 89 Views
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Open Access

Rapid Communication

Article
Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
Elrashid Saleh Mahdi, Mohamed HF Sakeena, Muthanna F Abdulkarim, Ghassan Z Abdullah, Munavvar Abdul Sattar & Azmin Mohd Noor
Pages: 311-323
Published online: 28 Sep 2022
AbstractforEffect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters | Full Text | References | PDF (396.9 KB)
  • 545 Views
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Review

Review Article
Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey
Richard Kones
Pages: 325-380
Published online: 13 Jun 2011
AbstractforPrimary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey | Full Text | References | PDF (625.5 KB)
  • 608 Views
  • 146 CrossRef citations
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Original Research

Article
Five-day regimen of intramuscular or subcutaneous self-administered adrenocorticotropic hormone gel for acute exacerbations of multiple sclerosis: a prospective, randomized, open-label pilot trial
James P Simsarian, Carol Saunders & D Michelle Smith
Pages: 381-389
Published online: 11 Jul 2011
AbstractforFive-day regimen of intramuscular or subcutaneous self-administered adrenocorticotropic hormone gel for acute exacerbations of multiple sclerosis: a prospective, randomized, open-label pilot trial | Full Text | References | PDF (239.7 KB)
  • 89 Views
  • 28 CrossRef citations
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Open Access

Review

Review Article
Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis
Jennifer A Dickens & David A Lomas
Pages: 391-405
Published online: 17 Aug 2011
AbstractforWhy has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis | Full Text | References | PDF (2.4 MB)
  • 117 Views
  • 14 CrossRef citations
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Original Research

Article
Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil™) and granulocyte-colony stimulating factor
Boryana E Avramova, Maya N Yordanova, Dobrin N Konstantinov & Dragan G Bobev
Pages: 407-409
Published online: 26 Aug 2011
AbstractforSuccessful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil™) and granulocyte-colony stimulating factor | Full Text | References | PDF (132.6 KB)
  • 83 Views
  • 13 CrossRef citations
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Review

Review Article
Emerging options in growth hormone therapy: an update
Stephen F Kemp & J Paul Frindik
Pages: 411-419
Published online: 30 Aug 2011
AbstractforEmerging options in growth hormone therapy: an update | Full Text | References | PDF (181 KB)
  • 104 Views
  • 16 CrossRef citations
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Original Research

Article
Investigation of the antibacterial activity of pioglitazone
Majed M Masadeh, Nizar M Mhaidat, Sayer I Al-Azzam & Karem H Alzoubi
Pages: 421-425
Published online: 27 Sep 2011
AbstractforInvestigation of the antibacterial activity of pioglitazone | Full Text | References | PDF (182.7 KB)
  • 118 Views
  • 11 CrossRef citations
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Open Access
Article
Bioequivalence assessment of two formulations of ibuprofen
Zeyad A Al-Talla, Sabah H Akrawi, Luke T Tolley, Salim H Sioud, Mohammed F Zaater & Abdul-Hamid M Emwas
Pages: 427-433
Published online: 19 Oct 2011
AbstractforBioequivalence assessment of two formulations of ibuprofen | Full Text | References | PDF (211.9 KB)
  • 447 Views
  • 16 CrossRef citations
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Open Access

Review

Review Article
Future prospects in the treatment of erectile dysfunction: focus on avanafil
Amjad Alwaal, Raed Al-Mannie & Serge Carrier
Pages: 435-443
Published online: 18 Oct 2011
AbstractforFuture prospects in the treatment of erectile dysfunction: focus on avanafil | Full Text | References | PDF (174.9 KB)
  • 192 Views
  • 8 CrossRef citations
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Open Access
Review Article
Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates
Maurizio Muratore, Eugenio Quarta, Antonella Grimaldi, Fabio Calcagnile & Laura Quarta
Pages: 445-454
Published online: 19 Oct 2011
AbstractforClinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates | Full Text | References | PDF (205.8 KB)
  • 137 Views
  • 15 CrossRef citations
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Original Research

Article
Bioequivalence of oxymorphone extended release and crush-resistant oxymorphone extended release
Irma H Benedek, Janet Jobes, Qinfang Xiang & William D Fiske
Pages: 455-463
Published online: 31 Oct 2011
AbstractforBioequivalence of oxymorphone extended release and crush-resistant oxymorphone extended release | Full Text | References | PDF (252.6 KB)
  • 86 Views
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Short Report

Article
The influence of operational parameters and feed preparation in a convective batch ribbon powder mixer
Sin Tung Yeow, Asnawi Shahar, Norashikin Abdul Aziz, Mohd Shamsul Anuar, Yus Aniza Yusof & Farah Saleena Taip
Pages: 465-469
Published online: 14 Nov 2011
AbstractforThe influence of operational parameters and feed preparation in a convective batch ribbon powder mixer | Full Text | References | PDF (625.3 KB)
  • 131 Views
  • 4 CrossRef citations
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Review

Review Article
Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond
Sai-Hong Ignatius Ou
Pages: 471-485
Published online: 23 Nov 2011
AbstractforCrizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond | Full Text | References | PDF (1 MB)
  • 199 Views
  • 124 CrossRef citations
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Corrigendum

Correction
Corrigendum
Page: 487
Published online: 28 Nov 2011
CitationforCorrigendum | Full Text | PDF (67.6 KB)
  • 71 Views
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Review

Review Article
Profile of ipilimumab and its role in the treatment of metastatic melanoma
Sapna P Patel & Scott E Woodman
Pages: 489-495
Published online: 16 Dec 2011
AbstractforProfile of ipilimumab and its role in the treatment of metastatic melanoma | Full Text | References | PDF (330.3 KB)
  • 76 Views
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