Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 24, Issue 5-6 (2023)

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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 24, Issue 5-6 (2023)

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Editorial

Review
Why is nutrition vital for advancing ALS care and clinical research?
Edward J. Kasarskis & Rup Tandan
Pages: 359-361
Published online: 21 Feb 2023
AbstractforWhy is nutrition vital for advancing ALS care and clinical research? | Full Text | References | PDF (165.4 KB) | EPUB
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Review

Review Article
Transcranial magnetic stimulation to monitor disease progression in ALS: a review
Mamede De Carvalho & Michael Swash
Pages: 362-368
Published online: 27 Dec 2022
AbstractforTranscranial magnetic stimulation to monitor disease progression in ALS: a review | Full Text | References | PDF (257.9 KB) | EPUB
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Clinical

Article
Clinical and demographical characteristics in a cohort of MND patients treated with riluzole. Differences between tablets and oral suspension
Elisabet Romero-Gangonells, M. Núria Virgili-Casas, Mònica Povedano & Maria A Barceló
Pages: 369-382
Published online: 03 Apr 2023
AbstractforClinical and demographical characteristics in a cohort of MND patients treated with riluzole. Differences between tablets and oral suspension | Full Text | References | PDF (834.3 KB) | EPUB | Supplemental
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Article
The flail-arm syndrome: the influence of phenotypic features
Marta Gromicho, Miguel Oliveira Santos, Susana Pinto, Michael Swash & Mamede De Carvalho
Pages: 383-388
Published online: 04 Jan 2023
AbstractforThe flail-arm syndrome: the influence of phenotypic features | Full Text | References | PDF (473.1 KB) | EPUB
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Multicentered Studies

Article
PRECISION ALS—an integrated pan European patient data platform for ALS
Robert McFarlane, Miriam Galvin, Mark Heverin, Éanna Mac Domhnaill, Deirdre Murray, Dara Meldrum, Peter Bede, Anthony Bolger, Lucy Hederman, Sinéad Impey, Gaye Stephens, Ciara O’Meara, Vincent Wade, Ammar Al-Chalabi, Adriano Chiò, Phillippe Corcia, Philip van Damme, Caroline Ingre, Christopher McDermott, Monica Povedanos, Leonard van den Berg & Orla Hardiman
Pages: 389-393
Published online: 23 May 2023
AbstractforPRECISION ALS—an integrated pan European patient data platform for ALS | Full Text | References | PDF (429.2 KB) | EPUB
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Open Access
Article
Primary lateral sclerosis natural history study – planning, designing, and early enrollment
Hiroshi Mitsumoto, Grace Jang, Ikjae Lee, Zachary Simmons, Alexander V. Sherman, Daragh Heitzman, Eric Sorenson, Ken Cheung, Jinsy Andrews, Matthew Harms, Neil A. Shneider, Regina Santella, Sabrina Paganoni, Senda Ajroud-Driss, J. Americo M. Fernandes, Katherine M. Burke, Kelly Gwathmey, Ali A. Habib, Nicholas J. Maragakis, David Walk, Christina Fournier, Terry Heiman-Patterson, James Wymer, Frank Diaz, Stephen N. Scelsa, Lauren Elman, Angela Genge, Stephen A. Goutman, Ghazala Hayat, Omar Jawdat, Wendy S. Johnston, Nanette C. Joyce, Edward J. Kasarskis, Yaz Y. Kisanuki, Catherine Lomen-Hoerth, Michael T. Pulley, Jaimin S. Shah, Christen Shoesmith, Lorne Zinman & The PLS Natural History Study Group.
Pages: 394-404
Published online: 28 Dec 2022
AbstractforPrimary lateral sclerosis natural history study – planning, designing, and early enrollment | Full Text | References | PDF (467.2 KB) | EPUB | Supplemental
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Genetics

Article
A survey of current practice in genetic testing in amyotrophic lateral sclerosis in the UK and Republic of Ireland: implications for future planning
Hugo M. De Oliveira, Arunachalam Soma, Mark R. Baker, Martin R. Turner, Kevin Talbot & Timothy L. Williams
Pages: 405-413
Published online: 02 Dec 2022
AbstractforA survey of current practice in genetic testing in amyotrophic lateral sclerosis in the UK and Republic of Ireland: implications for future planning | Full Text | References | PDF (1,022.2 KB) | EPUB | Supplemental
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Open Access
Article
Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers
Rüstem Yilmaz, Torsten Grehl, Lukas Eckrich, Ines Marschalkowski, Kanchi Weishaupt, Ivan Valkadinov, Melita Simic, David Brenner, Peter M. Andersen, Joachim Wolf & Jochen H. Weishaupt
Pages: 414-419
Published online: 17 Jan 2023
AbstractforFrequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers | Full Text | References | PDF (249.6 KB) | EPUB | Supplemental
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Open Access
Article
Clinical testing panels for ALS: global distribution, consistency, and challenges
Allison A. Dilliott, Ahmad Al Nasser, Marwa Elnagheeb, Jennifer Fifita, Lyndal Henden, Ingrid M. Keseler, Steven Lenz, Heather Marriott, Emily Mccann, Maysen Mesaros, Sarah Opie-Martin, Emma Owens, Brooke Palus, Justyne Ross, Zhanjun Wang, Hannah White, Ammar Al-Chalabi, Peter M. Andersen, Michael Benatar, Ian Blair, Johnathan Cooper-Knock, Elizabeth A. Harrington, Jeannine Heckmann, John Landers, Cristiane Moreno, Melissa Nel, Evadnie Rampersaud, Jennifer Roggenbuck, Guy Rouleau, Bryan Traynor, Marka Van Blitterswijk, Wouter Van Rheenen, Jan Veldink, Jochen Weishaupt, Luke Drury, Matthew B. Harms, Sali M. K. Farhan & On behalf of the Amyotrophic lateral sclerosis spectrum disorders Gene Curation Expert Panel
Pages: 420-435
Published online: 10 Mar 2023
AbstractforClinical testing panels for ALS: global distribution, consistency, and challenges | Full Text | References | PDF (1.9 MB) | EPUB
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Open Access

Epidemiology

Article
Epidemiology and economic burden of amyotrophic lateral sclerosis in the United States: a literature review
James D. Berry, Marie Blanchard, Kerina Bonar, Emma Drane, Molly Murton, Uffe Ploug, Kristen Ricchetti-Masterson, Natasa Savic, Emma Worthington & Terry Heiman-Patterson
Pages: 436-448
Published online: 07 Feb 2023
AbstractforEpidemiology and economic burden of amyotrophic lateral sclerosis in the United States: a literature review | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Open Access
Article
Association of the practice of contact sports with the development of amyotrophic lateral sclerosis
Ana Rita Henriques, Marta Gromicho, Julian Grosskreutz, Magdalena Kuzma-Kozakiewicz, Susanne Petri, Hilmi Uysal, Susana Pinto, Marília Antunes, Mamede De Carvalho & Ruy M. Ribeiro
Pages: 449-456
Published online: 29 Mar 2023
AbstractforAssociation of the practice of contact sports with the development of amyotrophic lateral sclerosis | Full Text | References | PDF (1.1 MB) | EPUB
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Cognition

Article
Italian reference values and brain correlates of verbal fluency index – vs standard verbal fluency test – to assess executive dysfunction in ALS
Elisa Canu, Veronica Castelnovo, Paola MV Rancoita, Michela Leocadi, Alessandra Lamanuzzi, Edoardo Gioele Spinelli, Silvia Basaia, Nilo Riva, Barbara Poletti, Federica Solca, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Sharon Abrahams, Massimo Filippi & Federica Agosta
Pages: 457-465
Published online: 18 Jan 2023
AbstractforItalian reference values and brain correlates of verbal fluency index – vs standard verbal fluency test – to assess executive dysfunction in ALS | Full Text | References | PDF (849.1 KB) | EPUB | Supplemental
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Open Access
Article
Sensitivity and specificity of the ECAS in identifying executive function and social cognition deficits in MND
Priscilla Tjokrowijoto, Mia Phillips, Amelia Ceslis, Robert D. Henderson, Pamela A. McCombe & Gail A. Robinson
Pages: 466-474
Published online: 27 Mar 2023
AbstractforSensitivity and specificity of the ECAS in identifying executive function and social cognition deficits in MND | Full Text | References | PDF (314.4 KB) | EPUB
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Open Access
Article
Determining impairment in the Swedish, Polish and German ECAS: the importance of adjusting for age and education
Julia Finsel, Ivar Winroth, Katarzyna Ciećwierska, Olga Helczyk, Erica A. Stenberg, Ann-Christin Häggström, Albert C. Ludolph, Ingo Uttner, Olof Semb, Beata Pilczuk, Natalia Szejko, Simona Rosentul, Dorothée Lulé, Magdalena Kuźma-Kozakiewicz & Peter M. Andersen
Pages: 475-484
Published online: 30 Mar 2023
AbstractforDetermining impairment in the Swedish, Polish and German ECAS: the importance of adjusting for age and education | Full Text | References | PDF (1.2 MB) | EPUB
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Biomarkers

Article
FDG-PET shows weak correlation between focal motor weakness and brain metabolic alterations in ALS
Stefan Sennfält, Marco Pagani, Fang Fang, Irina Savitcheva, Ulrika Estenberg & Caroline Ingre
Pages: 485-494
Published online: 08 Feb 2023
AbstractforFDG-PET shows weak correlation between focal motor weakness and brain metabolic alterations in ALS | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Open Access
Article
Correlation between oculometric measures and clinical assessment in ALS patients participating in a phase IIb clinical drug trial
Eitan Raveh, Assaf Ben-Shimon, Vova Anisimov, Rivka Kreitman, Edmund Ben-Ami, Elisheva Nechushtan, Nurit Birman & Vivian E Drory
Pages: 495-501
Published online: 07 Apr 2023
AbstractforCorrelation between oculometric measures and clinical assessment in ALS patients participating in a phase IIb clinical drug trial | Full Text | References | PDF (724.7 KB) | EPUB
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Open Access

Health Economics

Article
The economic evaluation of ALS care: quality and cost
Mustafa Çoban, Uğur Bilge, Hale Balseven, Hilmi Uysal & Betül Artut
Pages: 502-513
Published online: 16 Feb 2023
AbstractforThe economic evaluation of ALS care: quality and cost | Full Text | References | PDF (1.1 MB) | EPUB
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Article
The amyotrophic lateral sclerosis-health index (ALS-HI): development and evaluation of a novel outcome measure
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Christine Zizzi, Danae Alexandrou, Ellen Wagner, Nuran Dilek, John Heatwole, Joanne Wuu, James Caress, Richard Bedlack, Volkan Granit, Jeffrey Statland, Paul Mehta, Michael Benatar, Aaron Kaat & Chad Heatwole
Pages: 514-522
Published online: 15 May 2023
AbstractforThe amyotrophic lateral sclerosis-health index (ALS-HI): development and evaluation of a novel outcome measure | Full Text | References | PDF (726.3 KB) | EPUB | Supplemental
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Clinical Trial

Article
COURAGE-ALS: a randomized, double-blind phase 3 study designed to improve participant experience and increase the probability of success
Jeremy M. Shefner, Ammar Al-Chalabi, Jinsy A. Andrews, Adriano Chio, Mamede De Carvalho, Bettina M. Cockroft, Philippe Corcia, Philippe Couratier, Merit E. Cudkowicz, Angela Genge, Orla Hardiman, Terry Heiman-Patterson, Robert D. Henderson, Caroline Ingre, Carlayne E. Jackson, Wendy Johnston, Noah Lechtzin, Albert Ludolph, Nicholas J. Maragakis, Timothy M. Miller, Jesus S. Mora Pardina, Susanne Petri, Zachary Simmons, Leonard H. Van Den Berg, Lorne Zinman, Stuart Kupfer, Fady I. Malik, Lisa Meng, Tyrell J. Simkins, Jenny Wei, Andrew A. Wolff & Stacy A. Rudnicki
Pages: 523-534
Published online: 30 May 2023
AbstractforCOURAGE-ALS: a randomized, double-blind phase 3 study designed to improve participant experience and increase the probability of success | Full Text | References | PDF (3.2 MB) | EPUB
  • 1469 Views
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Open Access

Brief Report

Report
A novel homozygous loss-of-function variant in SOD1 causing progressive spastic tetraplegia and axial hypotonia
Arman Çakar, Emre Pekbilir, Serdar Ceylaner, Hacer Durmuş, Esra Battaloğlu, Umut Şahin & Yeşim Parman
Pages: 535-538
Published online: 19 Mar 2023
AbstractforA novel homozygous loss-of-function variant in SOD1 causing progressive spastic tetraplegia and axial hypotonia | Full Text | References | PDF (579.6 KB) | EPUB
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ALS Untangled

Review Article
ALSUntangled #66: antimycobacterial antibiotics.
Ellen S. Pierce, Paul Barkhaus, Morgan Beauchamp, Mark Bromberg, Gregory T. Carter, Jill Goslinga, David Greeley, Sky Kihuwa-Mani, Gleb Levitsky, Isaac Lund, Christopher McDermott, Gary Pattee, Kaitlyn Pierce, Meraida Polak, Dylan Ratner, Paul Wicks & Richard Bedlack
Pages: 539-543
Published online: 01 Aug 2022
AbstractforALSUntangled #66: antimycobacterial antibiotics. | Full Text | References | PDF (506 KB) | EPUB | Supplemental
  • 1672 Views
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Free Access
Case Report
ALSUntangled #67: rituximab
Xiaoyan Li, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. Feldman, Jonathan Glass, Jill Goslinga, Terry Heiman-Patterson, Sartaj Jhooty, Rachel Lichtenstein, Isaac Lund, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Kristiana Salmon, Paul Wicks & Richard Bedlack
Pages: 544-547
Published online: 15 Sep 2022
AbstractforALSUntangled #67: rituximab | Full Text | References | PDF (458.7 KB) | EPUB
  • 1805 Views
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Case Report
ALSUntangled #68: ozone therapy
Yuyao Sun, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. Feldman, Timothy Fullam, Terry Heiman-Patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Paul Wicks & Richard Bedlack
Pages: 548-552
Published online: 18 Nov 2022
AbstractforALSUntangled #68: ozone therapy | Full Text | References | PDF (451.4 KB) | EPUB
  • 2037 Views
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Case Report
ALSUntangled # 69: astaxanthin
Timothy Fullam, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Javier Mascias Cadavid, Gregory T. Carter, Mazen Dimachkie, Dave Ennist, Eva L. Feldman, Terry Heiman-patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Dylan Ratner, Paul Wicks & Richard Bedlack
Pages: 553-557
Published online: 24 Jan 2023
AbstractforALSUntangled # 69: astaxanthin | Full Text | References | PDF (572.9 KB) | EPUB
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Correction

Correction
Correction
Page: 558
Published online: 16 Feb 2023
CitationforCorrection | Full Text | PDF (96.6 KB) | EPUB
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