Drug Delivery, Volume 25, Issue 1 (2018)

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Drug Delivery, Volume 25, Issue 1 (2018)

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Research Article

Article
Enhanced efficacy of curcumin with phosphatidylserine-decorated nanoparticles in the treatment of hepatic fibrosis
Ji Wang, Wen Pan, Ying Wang, Wan Lei, Bin Feng, Caigan Du & Xiao-juan Wang
Pages: 1-11
Published online: 07 Dec 2017
AbstractforEnhanced efficacy of curcumin with phosphatidylserine-decorated nanoparticles in the treatment of hepatic fibrosis | Full Text | References | PDF (2.7 MB) | Supplemental
  • 5203 Views
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Open Access
Article
Penetration enhancer-containing spanlastics (PECSs) for transdermal delivery of haloperidol: in vitro characterization, ex vivo permeation and in vivo biodistribution studies
Abdurrahman M. Fahmy, Doaa Ahmed El-Setouhy, Ahmed B. Ibrahim, Basant A. Habib, Saadia A. Tayel & Noha A. Bayoumi
Pages: 12-22
Published online: 08 Dec 2017
AbstractforPenetration enhancer-containing spanlastics (PECSs) for transdermal delivery of haloperidol: in vitro characterization, ex vivo permeation and in vivo biodistribution studies | Full Text | References | PDF (2.1 MB) | Supplemental
  • 4029 Views
  • 61 CrossRef citations
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Open Access
Article
Enteric-coated insulin microparticles delivered by lipopeptides of iturin and surfactin
Xiaoying Xing, Xiuyun Zhao, Jia Ding, Dongming Liu & Gaofu Qi
Pages: 23-34
Published online: 10 Dec 2017
AbstractforEnteric-coated insulin microparticles delivered by lipopeptides of iturin and surfactin | Full Text | References | PDF (1.9 MB) | Supplemental
  • 2323 Views
  • 7 CrossRef citations
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Open Access
Article
Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application
Gina S. El-Feky, Rania Farouk Abdulmaguid, Gamal M. Zayed & Rabab Kamel
Pages: 35-42
Published online: 10 Dec 2017
AbstractforMucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application | Full Text | References | PDF (1.6 MB)
  • 2459 Views
  • 22 CrossRef citations
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Open Access
Article
The efficacy and safety of riluzole for neurodegenerative movement disorders: a systematic review with meta-analysis
Jia Liu & Lu-Ning Wang
Pages: 43-48
Published online: 10 Dec 2017
AbstractforThe efficacy and safety of riluzole for neurodegenerative movement disorders: a systematic review with meta-analysis | Full Text | References | PDF (932.9 KB)
  • 4819 Views
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Open Access
Article
Electrostatic interaction of tumor-targeting adenoviruses with aminoclay acquires enhanced infectivity to tumor cells inside the bladder and has better cytotoxic activity
Soo-Yeon Kim, Whi-An Kwon, Seung-Pil Shin, Ho Kyung Seo, Soo-Jeong Lim, Yuh-Seog Jung, Hyo-Kyung Han, Kyung-Chae Jeong & Sang-Jin Lee
Pages: 49-58
Published online: 11 Dec 2017
AbstractforElectrostatic interaction of tumor-targeting adenoviruses with aminoclay acquires enhanced infectivity to tumor cells inside the bladder and has better cytotoxic activity | Full Text | References | PDF (2.5 MB)
  • 1654 Views
  • 8 CrossRef citations
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Open Access
Article
Synthesis, physicochemical properties and ocular pharmacokinetics of thermosensitive in situ hydrogels for ganciclovir in cytomegalovirus retinitis treatment
Qiyue Wang, Chunmeng Sun, Bohui Xu, Jiasheng Tu & Yan Shen
Pages: 59-69
Published online: 12 Dec 2017
AbstractforSynthesis, physicochemical properties and ocular pharmacokinetics of thermosensitive in situ hydrogels for ganciclovir in cytomegalovirus retinitis treatment | Full Text | References | PDF (2.4 MB) | Supplemental
  • 2933 Views
  • 19 CrossRef citations
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Open Access
Article
Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats
Rehab Abdelmonem, Mohamed el Nabarawi & Alshaimaa Attia
Pages: 70-77
Published online: 12 Dec 2017
AbstractforDevelopment of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats | Full Text | References | PDF (873.5 KB)
  • 2413 Views
  • 25 CrossRef citations
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Open Access
Article
Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study
Shaimaa El-Housiny, Maii Atef Shams Eldeen, Yasmina Ahmed El-Attar, Hoda A. Salem, Dalia Attia, Ehab R. Bendas & Mohamed A. El-Nabarawi
Pages: 78-90
Published online: 14 Dec 2017
AbstractforFluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study | Full Text | References | PDF (1.6 MB)
  • 9955 Views
  • 100 CrossRef citations
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Open Access
Article
Microencapsulated macrophages releases conditioned medium able to prevent epithelial to mesenchymal transition
Anna Sola, Laura Saenz del Burgo, Jesús Ciriza, Rosa Maria Hernandez, Gorka Orive, Jorge Martin Cordero, Priscila Calle, Jose Luis Pedraz & Georgina Hotter
Pages: 91-101
Published online: 17 Dec 2017
AbstractforMicroencapsulated macrophages releases conditioned medium able to prevent epithelial to mesenchymal transition | Full Text | References | PDF (3.2 MB)
  • 1786 Views
  • 3 CrossRef citations
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Open Access
Article
Intensive fibrosarcoma-binding capability of the reconstituted analog and its antitumor activity
Jian Xu, Yue Du, Wen-Juan Liu, Liang Li, Yi Li, Xiao-Fei Wang, Hong-Fei Yi, Chuan-Kun Shan, Gui-Min Xia, Xiu-Jun Liu & Yong-Su Zhen
Pages: 102-111
Published online: 17 Dec 2017
AbstractforIntensive fibrosarcoma-binding capability of the reconstituted analog and its antitumor activity | Full Text | References | PDF (3.9 MB)
  • 1498 Views
  • 5 CrossRef citations
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Open Access
Article
Improvement of chemosensitivity and inhibition of migration via targeting tumor epithelial-to-mesenchymal transition cells by ADH-1-modified liposomes
Zhaoming Guo, Wenqing Li, Yue Yuan, Kun Zheng, Yu Tang, Kun Ma, Changhao Cui, Li Wang, Bing He & Qiang Zhang
Pages: 112-121
Published online: 20 Dec 2017
AbstractforImprovement of chemosensitivity and inhibition of migration via targeting tumor epithelial-to-mesenchymal transition cells by ADH-1-modified liposomes | Full Text | References | PDF (2.7 MB) | Supplemental
  • 2689 Views
  • 11 CrossRef citations
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Open Access
Article
Novel polyethyleneimine-R8-heparin nanogel for high-efficiency gene delivery in vitro and in vivo
Linjiang Song, Xiuqi Liang, Suleixin Yang, Ning Wang, Tao He, Yan Wang, Lan Zhang, Qinjie Wu & Changyang Gong
Pages: 122-131
Published online: 21 Dec 2017
AbstractforNovel polyethyleneimine-R8-heparin nanogel for high-efficiency gene delivery in vitro and in vivo | Full Text | References | PDF (3.9 MB) | Supplemental
  • 2707 Views
  • 33 CrossRef citations
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Open Access
Article
Enhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study
Ahmed R. Fares, Aliaa N. ElMeshad & Mohamed A. A. Kassem
Pages: 132-142
Published online: 23 Dec 2017
AbstractforEnhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study | Full Text | References | PDF (2.3 MB)
  • 3878 Views
  • 65 CrossRef citations
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Open Access
Article
Preparation and evaluation of injectable Rasagiline mesylate dual-controlled drug delivery system for the treatment of Parkinson’s disease
Ying Jiang, Xuemei Zhang, Hongjie Mu, Hongchen Hua, Dongyu Duan, Xiuju Yan, Yiyun Wang, Qingqing Meng, Xiaoyan Lu, Aiping Wang, Wanhui Liu, Youxin Li & Kaoxiang Sun
Pages: 143-152
Published online: 23 Dec 2017
AbstractforPreparation and evaluation of injectable Rasagiline mesylate dual-controlled drug delivery system for the treatment of Parkinson’s disease | Full Text | References | PDF (2.3 MB) | Supplemental
  • 3200 Views
  • 14 CrossRef citations
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Open Access
Article
Enhanced anti-hepatocarcinoma efficacy by GLUT1 targeting and cellular microenvironment-responsive PAMAM–camptothecin conjugate
Pengkai Ma, Yi Sun, Jianhua Chen, Hongpin Li, Hongyu Zhu, Xing Gao, Xinning Bi & Yujie Zhang
Pages: 153-165
Published online: 28 Dec 2017
AbstractforEnhanced anti-hepatocarcinoma efficacy by GLUT1 targeting and cellular microenvironment-responsive PAMAM–camptothecin conjugate | Full Text | References | PDF (4.3 MB) | Supplemental
  • 2545 Views
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Open Access
Article
Development of a novel morphological paclitaxel-loaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations
Zongrui Zhang, Xinyu Wang, Binbin Li, Yuanjing Hou, Jing Yang & Li Yi
Pages: 166-177
Published online: 04 Jan 2018
AbstractforDevelopment of a novel morphological paclitaxel-loaded PLGA microspheres for effective cancer therapy: in vitro and in vivo evaluations | Full Text | References | PDF (3.8 MB) | Supplemental
  • 3371 Views
  • 45 CrossRef citations
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Open Access
Article
Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium
Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng, Mingwu Shen, Serge Mignani, Jean-Pierre Majoral & Xiangyang Shi
Pages: 178-186
Published online: 04 Jan 2018
AbstractforTargeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium | Full Text | References | PDF (2.5 MB) | Supplemental
  • 2097 Views
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Open Access
Article
Bone-targeted methotrexate–alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo
Zi’ang Xie, Guanxiong Liu, Pan Tang, Xuewu Sun, Shuai Chen, An Qin, Peizhi Zhu, Jianfeng Zhang & Shunwu Fan
Pages: 187-197
Published online: 05 Jan 2018
AbstractforBone-targeted methotrexate–alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo | Full Text | References | PDF (3.3 MB) | Supplemental
  • 2920 Views
  • 14 CrossRef citations
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Open Access
Article
Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry
Qihong Zhang, Nikolay E. Polyakov, Yulia S. Chistyachenko, Mikhail V. Khvostov, Tatjana S. Frolova, Tatjana G. Tolstikova, Alexandr V. Dushkin & Weike Su
Pages: 198-209
Published online: 05 Jan 2018
AbstractforPreparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry | Full Text | References | PDF (2.5 MB)
  • 4822 Views
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Open Access
Article
Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes
Xiaoyou Qu, Yang Zou, Chuyu He, Yuanhang Zhou, Yao Jin, Yunqiang Deng, Ziqi Wang, Xinru Li, Yanxia Zhou & Yan Liu
Pages: 210-225
Published online: 09 Jan 2018
AbstractforImproved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes | Full Text | References | PDF (3.9 MB) | Supplemental
  • 2402 Views
  • 29 CrossRef citations
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Open Access
Article
Ultrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2 aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer
Meng Wu, Hongyun Zhao, Liang Guo, Yiru Wang, Jiao Song, Xueli Zhao, Chongyan Li, Lan Hao, Dong Wang & Jie Tang
Pages: 226-240
Published online: 09 Jan 2018
AbstractforUltrasound-mediated nanobubble destruction (UMND) facilitates the delivery of A10-3.2 aptamer targeted and siRNA-loaded cationic nanobubbles for therapy of prostate cancer | Full Text | References | PDF (4.8 MB) | Supplemental
  • 3122 Views
  • 70 CrossRef citations
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Open Access
Article
Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds
Shi-Cong Tao, Bi-Yu Rui, Qi-Yang Wang, Ding Zhou, Yang Zhang & Shang-Chun Guo
Pages: 241-255
Published online: 15 Jan 2018
AbstractforExtracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds | Full Text | References | PDF (4.4 MB) | Supplemental
  • 4322 Views
  • 96 CrossRef citations
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Open Access
Article
Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide
Congcong Lin, Xue Zhang, Hubiao Chen, Zhaoxiang Bian, Ge Zhang, Muhammad Kashif Riaz, Deependra Tyagi, Ge Lin, Yanbo Zhang, Jinjin Wang, Aiping Lu & Zhijun Yang
Pages: 256-266
Published online: 15 Jan 2018
AbstractforDual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide | Full Text | References | PDF (3.3 MB) | Supplemental
  • 4348 Views
  • 85 CrossRef citations
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Open Access
Article
Delivery of radix ophiopogonis polysaccharide via sucrose acetate isobutyrate-based in situ forming systems alone or combined with its mono-PEGylation
LiNa Wang, Xiao Zheng, Fei Wu, Lan Shen, Xiao Lin & Yi Feng
Pages: 267-277
Published online: 15 Jan 2018
AbstractforDelivery of radix ophiopogonis polysaccharide via sucrose acetate isobutyrate-based in situ forming systems alone or combined with its mono-PEGylation | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1196 Views
  • 6 CrossRef citations
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Open Access

Review Article

Review
Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives
Tao Zhang, Ruyi Yang, Shengnan Yang, Jibin Guan, Dong Zhang, Yan Ma & Hongzhuo Liu
Pages: 278-292
Published online: 15 Jan 2018
AbstractforResearch progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives | Full Text | References | PDF (2.4 MB) | Supplemental
  • 5194 Views
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Open Access

Research Article

Article
Controlled synthesis and size effects of multifunctional mesoporous silica nanosystem for precise cancer therapy
Bin Ma, Lizhen He, Yuanyuan You, Jianbin Mo & Tianfeng Chen
Pages: 293-306
Published online: 15 Jan 2018
AbstractforControlled synthesis and size effects of multifunctional mesoporous silica nanosystem for precise cancer therapy | Full Text | References | PDF (5.3 MB) | Supplemental
  • 2535 Views
  • 37 CrossRef citations
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Open Access

Review Article

Review
Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease
Govindarajan Karthivashan, Palanivel Ganesan, Shin-Young Park, Joon-Soo Kim & Dong-Kug Choi
Pages: 307-320
Published online: 19 Jan 2018
AbstractforTherapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease | Full Text | References | PDF (2.3 MB)
  • 14870 Views
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Open Access

Research Article

Article
HSA-based multi-target combination therapy: regulating drugs’ release from HSA and overcoming single drug resistance in a breast cancer model
Yi Gou, Zhenlei Zhang, Dongyang Li, Lei Zhao, Meiling Cai, Zhewen Sun, Yongping Li, Yao Zhang, Hamid Khan, Hongbing Sun, Tao Wang, Hong Liang & Feng Yang
Pages: 321-329
Published online: 19 Jan 2018
AbstractforHSA-based multi-target combination therapy: regulating drugs’ release from HSA and overcoming single drug resistance in a breast cancer model | Full Text | References | PDF (2.8 MB) | Supplemental
  • 2367 Views
  • 30 CrossRef citations
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Open Access
Article
Comparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo
Jinling Wang, Ying Li, Lifang Wang, Xiaohui Wang & Pengfei Tu
Pages: 330-340
Published online: 19 Jan 2018
AbstractforComparison of hyaluronic acid-based micelles and polyethylene glycol-based micelles on reversal of multidrug resistance and enhanced anticancer efficacy in vitro and in vivo | Full Text | References | PDF (3.3 MB) | Supplemental
  • 2235 Views
  • 17 CrossRef citations
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Open Access
Article
Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles
Yue Zhao, Yanan Tan, Tingting Meng, Xuan Liu, Yun Zhu, Yun Hong, Xiqin Yang, Hong Yuan, Xuan Huang & Fuqiang Hu
Pages: 341-352
Published online: 22 Jan 2018
AbstractforSimultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles | Full Text | References | PDF (4.2 MB) | Supplemental
  • 1906 Views
  • 30 CrossRef citations
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Open Access
Article
Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle
Zuwu Wei, Ming Wu, Zuanfang Li, Zhan Lin, Jinhua Zeng, Haiyan Sun, Xiaolong Liu, Jingfeng Liu, Buhong Li & Yongyi Zeng
Pages: 353-363
Published online: 25 Jan 2018
AbstractforGadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle | Full Text | References | PDF (3.6 MB) | Supplemental
  • 1812 Views
  • 13 CrossRef citations
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Open Access
Article
Silk fibroin nanoparticles dyeing indocyanine green for imaging-guided photo-thermal therapy of glioblastoma
He-Lin Xu, De-Li ZhuGe, Pian-Pian Chen, Meng-Qi Tong, Meng-Ting Lin, Xue Jiang, Ya-Wen Zheng, Bin Chen, Xiao-Kun Li & Ying-Zheng Zhao
Pages: 364-375
Published online: 25 Jan 2018
AbstractforSilk fibroin nanoparticles dyeing indocyanine green for imaging-guided photo-thermal therapy of glioblastoma | Full Text | References | PDF (3.5 MB) | Supplemental
  • 20068 Views
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Open Access
Article
In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates
Alessandro Giuliani, Anna Giulia Balducci, Elisa Zironi, Gaia Colombo, Fabrizio Bortolotti, Luca Lorenzini, Viola Galligioni, Giampiero Pagliuca, Alessandra Scagliarini, Laura Calzà & Fabio Sonvico
Pages: 376-387
Published online: 30 Jan 2018
AbstractforIn vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates | Full Text | References | PDF (2 MB) | Supplemental
  • 3781 Views
  • 50 CrossRef citations
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Open Access
Article
Development a hyaluronic acid ion-pairing liposomal nanoparticle for enhancing anti-glioma efficacy by modulating glioma microenvironment
Liuqing Yang, Xu Song, Ting Gong, Kejun Jiang, Yingying Hou, Tijia Chen, Xun Sun, Zhirong Zhang & Tao Gong
Pages: 388-397
Published online: 29 Jan 2018
AbstractforDevelopment a hyaluronic acid ion-pairing liposomal nanoparticle for enhancing anti-glioma efficacy by modulating glioma microenvironment | Full Text | References | PDF (3.5 MB) | Supplemental
  • 2448 Views
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Review Article

Review
Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine
Xiao Zheng, Fei Wu, Xiao Lin, Lan Shen & Yi Feng
Pages: 398-416
Published online: 29 Jan 2018
AbstractforDevelopments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine | Full Text | References | PDF (1.6 MB)
  • 4087 Views
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Research Article

Article
An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system
Mohamed Ali, Amira Abdel Motaal, Mohammed A. Ahmed, Abdulrhman Alsayari & Omaima N. El-Gazayerly
Pages: 417-425
Published online: 31 Jan 2018
AbstractforAn in vivo study of Hypericum perforatum in a niosomal topical drug delivery system | Full Text | References | PDF (1.8 MB) | Supplemental
  • 2802 Views
  • 18 CrossRef citations
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Open Access
Article
Dual-targeting for brain-specific drug delivery: synthesis and biological evaluation
Qiming Yue, Yao Peng, Yi Zhao, Runxin Lu, Qiuyi Fu, Yang Chen, Yang Yang, Li Hai, Li Guo & Yong Wu
Pages: 426-434
Published online: 31 Jan 2018
AbstractforDual-targeting for brain-specific drug delivery: synthesis and biological evaluation | Full Text | References | PDF (2.5 MB) | Supplemental
  • 2864 Views
  • 17 CrossRef citations
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Article
Nano-engineered microcapsules boost the treatment of persistent pain
Olga Kopach, Kayiu Zheng, Luo Dong, Andrei Sapelkin, Nana Voitenko, Gleb B. Sukhorukov & Dmitri A. Rusakov
Pages: 435-447
Published online: 31 Jan 2018
AbstractforNano-engineered microcapsules boost the treatment of persistent pain | Full Text | References | PDF (3.4 MB) | Supplemental
  • 1987 Views
  • 17 CrossRef citations
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Open Access
Article
Doxorubicin conjugated with a trastuzumab epitope and an MMP-2 sensitive peptide linker for the treatment of HER2-positive breast cancer
Yiwen You, Zhiyuan Xu & Yun Chen
Pages: 448-460
Published online: 06 Feb 2018
AbstractforDoxorubicin conjugated with a trastuzumab epitope and an MMP-2 sensitive peptide linker for the treatment of HER2-positive breast cancer | Full Text | References | PDF (2.6 MB) | Supplemental
  • 5113 Views
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Article
Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment
Baozhen Zhang, Guogang Cheng, Mingbin Zheng, Jinyu Han, Baobei Wang, Mengxia Li, Jie Chen, Tianxia Xiao, Jian Zhang, Lintao Cai, Shoujun Li & Xiujun Fan
Pages: 461-471
Published online: 09 Feb 2018
AbstractforTargeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment | Full Text | References | PDF (3.8 MB) | Supplemental
  • 3532 Views
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Article
Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas
Cristina Fornaguera, Miguel Ángel Lázaro, Pau Brugada-Vilà, Irene Porcar, Ingrid Morera, Marta Guerra-Rebollo, Cristina Garrido, Núria Rubio, Jerónimo Blanco, Anna Cascante & Salvador Borrós
Pages: 472-483
Published online: 07 Feb 2018
AbstractforApplication of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas | Full Text | References | PDF (2.1 MB) | Supplemental
  • 1722 Views
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Article
Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery
Wessam H. Abd-Elsalam, Sally A. El-Zahaby & Abdulaziz M. Al-Mahallawi
Pages: 484-492
Published online: 07 Feb 2018
AbstractforFormulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery | Full Text | References | PDF (1.3 MB)
  • 2357 Views
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Article
α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer
Dong Mei, Libo Zhao, Binlong Chen, Xiaoyan Zhang, Xiaoling Wang, Zhiying Yu, Xin Ni & Qiang Zhang
Pages: 493-503
Published online: 09 Feb 2018
Abstractforα-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer | Full Text | References | PDF (4.2 MB)
  • 2008 Views
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Article
Lipid-based nanocarrier efficiently delivers highly water soluble drug across the blood–brain barrier into brain
Lopamudra Dutta, Biswajit Mukherjee, Tapash Chakraborty, Malay Kumar Das, Laboni Mondal, Sanchari Bhattacharya, Raghuvir H. Gaonkar & Mita Chatterjee Debnath
Pages: 504-516
Published online: 09 Feb 2018
AbstractforLipid-based nanocarrier efficiently delivers highly water soluble drug across the blood–brain barrier into brain | Full Text | References | PDF (2.5 MB) | Supplemental
  • 2318 Views
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Article
Transferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer
Pranali Deshpande, Aditi Jhaveri, Bhushan Pattni, Swati Biswas & Vladimir Torchilin
Pages: 517-532
Published online: 12 Feb 2018
AbstractforTransferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer | Full Text | References | PDF (2.8 MB) | Supplemental
  • 3720 Views
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Article
Pulmonary delivery of influenza vaccine formulations in cotton rats: site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus
Yoshita Bhide, Jasmine Tomar, Wei Dong, Jacqueline de Vries-Idema, Henderik W. Frijlink, Anke Huckriede & Wouter L. J. Hinrichs
Pages: 533-545
Published online: 16 Feb 2018
AbstractforPulmonary delivery of influenza vaccine formulations in cotton rats: site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus | Full Text | References | PDF (2.1 MB) | Supplemental
  • 1837 Views
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Article
Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury
Meng Zhao, Yijie Zhou, Shuyun Liu, Lan Li, Younan Chen, Jingqiu Cheng, Yanrong Lu & Jingping Liu
Pages: 546-554
Published online: 16 Feb 2018
AbstractforControl release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury | Full Text | References | PDF (5.1 MB) | Supplemental
  • 3186 Views
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Article
Effect of finasteride particle size reduction on its pharmacokinetic, tissue distribution and cellular permeation
Tarek A. Ahmed & Ahmed M. Al-Abd
Pages: 555-563
Published online: 16 Feb 2018
AbstractforEffect of finasteride particle size reduction on its pharmacokinetic, tissue distribution and cellular permeation | Full Text | References | PDF (1.3 MB)
  • 2296 Views
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Article
Surface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy
Dongdong Bi, Lei Zhao, Runqi Yu, Haowen Li, Yifei Guo, Xiangtao Wang & Meihua Han
Pages: 564-575
Published online: 19 Feb 2018
AbstractforSurface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy | Full Text | References | PDF (3.1 MB) | Supplemental
  • 5209 Views
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Article
Follicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-α silencing and antitumor activity against ovarian cancer
Shan-Shan Hong, Ming-Xing Zhang, Meng Zhang, Yi Yu, Jun Chen, Xiao-Yan Zhang & Cong-Jian Xu
Pages: 576-584
Published online: 20 Feb 2018
AbstractforFollicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-α silencing and antitumor activity against ovarian cancer | Full Text | References | PDF (2.3 MB)
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Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy
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Pages: 585-599
Published online: 20 Feb 2018
AbstractforSynchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy | Full Text | References | PDF (5.1 MB) | Supplemental
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New model of proliferative vitreoretinopathy in rabbit for drug delivery and pharmacodynamic studies
Sang Woong Moon, Yaoyao Sun, David Warther, Kristyn Huffman, William R. Freeman, Michael J. Sailor & Lingyun Cheng
Pages: 600-610
Published online: 20 Feb 2018
AbstractforNew model of proliferative vitreoretinopathy in rabbit for drug delivery and pharmacodynamic studies | Full Text | References | PDF (3.4 MB) | Supplemental
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Wenli Zhang, Caibin Li, Ya Jin, Xinyue Liu, Zhiyu Wang, John P. Shaw, Bruce C. Baguley, Zimei Wu & Jianping Liu
Pages: 611-622
Published online: 01 Mar 2018
AbstractforMultiseed liposomal drug delivery system using micelle gradient as driving force to improve amphiphilic drug retention and its anti-tumor efficacy | Full Text | References | PDF (2.3 MB)
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Designed construction of tween 60@2β-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy
Yue Yuan, Qin Zhang, Yun Yan, Miaomiao Gong, Qi Zhao, Zhihong Bao, Kaerdun Liu & Siling Wang
Pages: 623-631
Published online: 20 Feb 2018
AbstractforDesigned construction of tween 60@2β-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy | Full Text | References | PDF (2.5 MB) | Supplemental
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Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer
Chia-En Chang, Chien-Ming Hsieh, Ling-Chun Chen, Chia-Yu Su, Der-Zen Liu, Hua-Jing Jhan, Hsiu-O Ho & Ming-Thau Sheu
Pages: 632-643
Published online: 20 Feb 2018
AbstractforNovel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer | Full Text | References | PDF (1.4 MB) | Supplemental
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Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
Victoria Capel, Driton Vllasaliu, Peter Watts, Philip A. Clarke, Dominic Luxton, Anna M. Grabowska, Giuseppe Mantovani & Snjezana Stolnik
Pages: 644-653
Published online: 01 Mar 2018
AbstractforWater-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA | Full Text | References | PDF (2.3 MB) | Supplemental
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Multifunctional nanoemulsions for intraductal delivery as a new platform for local treatment of breast cancer
Amanda Migotto, Vanessa F. M. Carvalho, Giovanna C. Salata, Fernanda W. M. da Silva, Chao Yun Irene Yan, Kelly Ishida, Leticia V. Costa-Lotufo, Alexandre A. Steiner & Luciana B. Lopes
Pages: 654-667
Published online: 01 Mar 2018
AbstractforMultifunctional nanoemulsions for intraductal delivery as a new platform for local treatment of breast cancer | Full Text | References | PDF (3 MB) | Supplemental
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Antitumor efficacy of liposome-encapsulated NVP-BEZ 235 in combination with irreversible electroporation
Li Tian, Yang Qiao, Patrick Lee, Lucas Wang, Ashley Chang, Saisree Ravi, Thomas A. Rogers, Linfeng Lu, Burapol Singhana, Jun Zhao & Marites P. Melancon
Pages: 668-678
Published online: 27 Feb 2018
AbstractforAntitumor efficacy of liposome-encapsulated NVP-BEZ 235 in combination with irreversible electroporation | Full Text | References | PDF (2.8 MB) | Supplemental
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Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12
Najla Altwaijry, Sukrut Somani, John A. Parkinson, Rothwelle J. Tate, Patricia Keating, Monika Warzecha, Graeme R. Mackenzie, Hing Y. Leung & Christine Dufès
Pages: 679-689
Published online: 01 Mar 2018
AbstractforRegression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12 | Full Text | References | PDF (1.9 MB) | Supplemental
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Chitosan-based liposomal thermogels for the controlled delivery of pingyangmycin: design, optimization and in vitro and in vivo studies
Ling Zhang, Fen Chen, Jiatong Zheng, Hongwei Wang, Xingjun Qin & Weisan Pan
Pages: 690-702
Published online: 27 Feb 2018
AbstractforChitosan-based liposomal thermogels for the controlled delivery of pingyangmycin: design, optimization and in vitro and in vivo studies | Full Text | References | PDF (4 MB)
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On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation
Khawar Ali Shahzad, Xin Wan, Lei Zhang, Weiya Pei, Aifeng Zhang, Muhammad Younis, Wei Wang & Chuanlai Shen
Pages: 703-715
Published online: 06 Mar 2018
AbstractforOn-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation | Full Text | References | PDF (7.4 MB) | Supplemental
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Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy
Meiling Zhou, Jierong Hou, Zhirong Zhong, Na Hao, Yan Lin & Chunhong Li
Pages: 716-722
Published online: 08 Mar 2018
AbstractforTargeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy | Full Text | References | PDF (2.1 MB)
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Eph A10-modified pH-sensitive liposomes loaded with novel triphenylphosphine–docetaxel conjugate possess hierarchical targetability and sufficient antitumor effect both in vitro and in vivo
Jiulong Zhang, Chunrong Yang, Shuang Pan, Menghao Shi, Jie Li, Haiyang Hu, Mingxi Qiao, Dawei Chen & Xiuli Zhao
Pages: 723-737
Published online: 07 Mar 2018
AbstractforEph A10-modified pH-sensitive liposomes loaded with novel triphenylphosphine–docetaxel conjugate possess hierarchical targetability and sufficient antitumor effect both in vitro and in vivo | Full Text | References | PDF (3.3 MB) | Supplemental
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An α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy
Song Yi Lee & Hyun-Jong Cho
Pages: 738-749
Published online: 08 Mar 2018
AbstractforAn α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy | Full Text | References | PDF (2.7 MB) | Supplemental
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Ricardo Reyes, Jose Antonio Rodríguez, Josune Orbe, María Rosa Arnau, Carmen Évora & Araceli Delgado
Pages: 750-756
Published online: 08 Mar 2018
AbstractforCombined sustained release of BMP2 and MMP10 accelerates bone formation and mineralization of calvaria critical size defect in mice | Full Text | References | PDF (2.4 MB)
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Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment
Rui Huang, Jiawei Li, Dereje Kebebe, Yumei Wu, Bing Zhang & Zhidong Liu
Pages: 757-765
Published online: 12 Mar 2018
AbstractforCell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment | Full Text | References | PDF (2.7 MB) | Supplemental
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Review
Application of hyaluronic acid as carriers in drug delivery
Gangliang Huang & Hualiang Huang
Pages: 766-772
Published online: 14 Mar 2018
AbstractforApplication of hyaluronic acid as carriers in drug delivery | Full Text | References | PDF (751.8 KB)
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Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses
Weiping Cao, Margarita Mishina, Samuel Amoah, Wadzanai P. Mboko, Caitlin Bohannon, James McCoy, Suresh K. Mittal, Shivaprakash Gangappa & Suryaprakash Sambhara
Pages: 773-779
Published online: 15 Mar 2018
AbstractforNasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses | Full Text | References | PDF (929.9 KB) | Supplemental
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Xiaoye Yang, Xiaoqun Shi, Jianbo Ji & Guangxi Zhai
Pages: 780-796
Published online: 15 Mar 2018
AbstractforDevelopment of redox-responsive theranostic nanoparticles for near-infrared fluorescence imaging-guided photodynamic/chemotherapy of tumor | Full Text | References | PDF (4.8 MB) | Supplemental
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Transcriptional control of the MUC16 promoter facilitates follicle-stimulating hormone peptide-conjugated shRNA nanoparticle-mediated inhibition of ovarian carcinoma in vivo
Ming-Xing Zhang, Shan-Shan Hong, Qing-Qing Cai, Meng Zhang, Jun Chen, Xiao-Yan Zhang & Cong-Jian Xu
Pages: 797-806
Published online: 15 Mar 2018
AbstractforTranscriptional control of the MUC16 promoter facilitates follicle-stimulating hormone peptide-conjugated shRNA nanoparticle-mediated inhibition of ovarian carcinoma in vivo | Full Text | References | PDF (2.4 MB)
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Bioresponsive albumin-conjugated paclitaxel prodrugs for cancer therapy
Jincheng Yang, Qingzhi Lv, Wei Wei, Zhengtao Yang, Jiajun Dong, Ruoshi Zhang, Qiming Kan, Zhonggui He & Youjun Xu
Pages: 807-814
Published online: 19 Mar 2018
AbstractforBioresponsive albumin-conjugated paclitaxel prodrugs for cancer therapy | Full Text | References | PDF (2.3 MB) | Supplemental
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Diana E. Aziz, Aly A. Abdelbary & Abdelhalim I. Elassasy
Pages: 815-826
Published online: 20 Mar 2018
AbstractforFabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation | Full Text | References | PDF (1.9 MB)
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Puerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile
Wenqun Li, Junyong Wu, Jiang Zhang, Jingjing Wang, Daxiong Xiang, Shilin Luo, Jianhe Li & Xinyi Liu
Pages: 827-837
Published online: 28 Mar 2018
AbstractforPuerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile | Full Text | References | PDF (1.9 MB) | Supplemental
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Pages: 838-845
Published online: 28 Mar 2018
AbstractforUncovering the regional localization of inhaled salmeterol retention in the lung | Full Text | References | PDF (2.6 MB) | Supplemental
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Research Article

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AbstractforMagnetically assisted intraperitoneal drug delivery for cancer chemotherapy | Full Text | References | PDF (3.3 MB) | Supplemental
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AbstractforModified mixed nanomicelles with collagen peptides enhanced oral absorption of Cucurbitacin B: preparation and evaluation | Full Text | References | PDF (2.2 MB)
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AbstractforPeri-tumor administration of 5-fluorouracil sol-gel using a hollow microneedle for treatment of gastric cancer | Full Text | References | PDF (2.6 MB)
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AbstractforFolate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice | Full Text | References | PDF (1.9 MB) | Supplemental
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AbstractforImproving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation, in vitro and in vivo studies | Full Text | References | PDF (2.1 MB) | Supplemental
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AbstractforCell penetrating peptides: a comparative transport analysis for 474 sequence motifs | Full Text | References | PDF (2.3 MB) | Supplemental
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AbstractforFabrication of a drug delivery system that enhances antifungal drug corneal penetration | Full Text | References | PDF (2.7 MB) | Supplemental
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AbstractforPreparation of poly-l-lysine-based nanoparticles with pH-sensitive release of curcumin for targeted imaging and therapy of liver cancer in vitro and in vivo | Full Text | References | PDF (3.6 MB) | Supplemental
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AbstractforAKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells | Full Text | References | PDF (3.7 MB) | Supplemental
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AbstractforLocalized delivery of therapeutic doxorubicin dose across the canine blood–brain barrier with hyperthermia and temperature sensitive liposomes | Full Text | References | PDF (2.7 MB)
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AbstractforRetro-inverso follicle-stimulating hormone peptide-mediated polyethylenimine complexes for targeted ovarian cancer gene therapy | Full Text | References | PDF (2.1 MB) | Supplemental
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AbstractforIntra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis | Full Text | References | PDF (3.2 MB)
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AbstractforGlioma targeting peptide modified apoferritin nanocage | Full Text | References | PDF (4.4 MB) | Supplemental
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Published online: 24 Apr 2018
AbstractforModification of translationally controlled tumor protein-derived protein transduction domain for improved intranasal delivery of insulin | Full Text | References | PDF (1.2 MB) | Supplemental
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Published online: 24 Apr 2018
AbstractforNovel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2 | Full Text | References | PDF (5.4 MB)
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AbstractforPreparation of psoralen polymer–lipid hybrid nanoparticles and their reversal of multidrug resistance in MCF-7/ADR cells | Full Text | References | PDF (4.3 MB)
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AbstractforDevelopment of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions | Full Text | References | PDF (1.7 MB) | Supplemental
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AbstractforBispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors | Full Text | References | PDF (1.8 MB) | Supplemental
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AbstractforCurcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease | Full Text | References | PDF (2.9 MB) | Supplemental
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Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance
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AbstractforSericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance | Full Text | References | PDF (2.3 MB) | Supplemental
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Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery
Maria C. Llinàs, Gabriel Martínez-Edo, Anna Cascante, Irene Porcar, Salvador Borrós & David Sánchez-García
Pages: 1137-1146
Published online: 19 May 2018
AbstractforPreparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery | Full Text | References | PDF (2.7 MB) | Supplemental
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Article
Graphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response
Jesús Ciriza, Laura Saenz del Burgo, Haritz Gurruchaga, Francesc E. Borras, Marcella Franquesa, Gorka Orive, Rosa Maria Hernández & José Luis Pedraz
Pages: 1147-1160
Published online: 19 May 2018
AbstractforGraphene oxide enhances alginate encapsulated cells viability and functionality while not affecting the foreign body response | Full Text | References | PDF (4.5 MB) | Supplemental
  • 1747 Views
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Article
Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug
Samar M. Abouelatta, Ahmed A. Aboelwafa & Omaima N. El-Gazayerly
Pages: 1161-1174
Published online: 24 May 2018
AbstractforGastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug | Full Text | References | PDF (5 MB) | Supplemental
  • 2717 Views
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Article
Plateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine
Juanhong Zhang, Yuyan Chen, Yuemei Sun, Rong Wang, Junmin Zhang & Zhengping Jia
Pages: 1175-1181
Published online: 23 May 2018
AbstractforPlateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine | Full Text | References | PDF (1.5 MB)
  • 2167 Views
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Article
Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: in vitro and in vivo evaluation
Nan Zhang, Chunyu Xu, Na Li, Shasha Zhang, Lingling Fu, Xiao Chu, Haiying Hua, Xianghui Zeng & Yongxing Zhao
Pages: 1182-1191
Published online: 23 May 2018
AbstractforFolate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: in vitro and in vivo evaluation | Full Text | References | PDF (2.8 MB) | Supplemental
  • 2109 Views
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Article
Hybrid liposomes showing enhanced accumulation in tumors as theranostic agents in the orthotopic graft model mouse of colorectal cancer
Masaki Okumura, Hideaki Ichihara & Yoko Matsumoto
Pages: 1192-1199
Published online: 23 May 2018
AbstractforHybrid liposomes showing enhanced accumulation in tumors as theranostic agents in the orthotopic graft model mouse of colorectal cancer | Full Text | References | PDF (1.9 MB)
  • 1158 Views
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Article
Neutrophil-mediated delivery of pixantrone-loaded liposomes decorated with poly(sialic acid)–octadecylamine conjugate for lung cancer treatment
Xiang Luo, Ling Hu, Huangliang Zheng, Mingqi Liu, Xinrong Liu, Cong Li, Qiujun Qiu, Zitong Zhao, Xiaobo Cheng, Chaoyang Lai, Yuqing Su, Yihui Deng & Yanzhi Song
Pages: 1200-1212
Published online: 23 May 2018
AbstractforNeutrophil-mediated delivery of pixantrone-loaded liposomes decorated with poly(sialic acid)–octadecylamine conjugate for lung cancer treatment | Full Text | References | PDF (2.7 MB) | Supplemental
  • 2738 Views
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Article
Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway
Qin-You Tan, Qian Hu, Sheng-Nan Zhu, Lu-Lu Jia, Juan Xiao, Hua-Zhen Su, Shao-Yuan Huang, Jing Zhang & Junfei Jin
Pages: 1213-1223
Published online: 23 May 2018
AbstractforLicorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway | Full Text | References | PDF (2.4 MB) | Supplemental
  • 3107 Views
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Article
Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids
Zhe Zhang, Hongxiang Li, Guangrui Xu & Ping Yao
Pages: 1224-1233
Published online: 23 May 2018
AbstractforLiver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids | Full Text | References | PDF (2.1 MB) | Supplemental
  • 3288 Views
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Review Article

Review
Delivering CRISPR: a review of the challenges and approaches
Christopher A. Lino, Jason C. Harper, James P. Carney & Jerilyn A. Timlin
Pages: 1234-1257
Published online: 25 May 2018
AbstractforDelivering CRISPR: a review of the challenges and approaches | Full Text | References | PDF (4.6 MB)
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Research Article

Article
Hyaluronic acid modified MPEG-b-PAE block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein
Cong Li, Rui Chen, Mengzhen Xu, Jiyan Qiao, Liang Yan & Xin Dong Guo
Pages: 1258-1265
Published online: 30 May 2018
AbstractforHyaluronic acid modified MPEG-b-PAE block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein | Full Text | References | PDF (1.8 MB) | Supplemental
  • 2525 Views
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Article
Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity
Kazuaki Taguchi, Saori Nagao, Hitoshi Maeda, Hiroki Yanagisawa, Hiromi Sakai, Keishi Yamasaki, Tomohiko Wakayama, Hiroshi Watanabe, Masaki Otagiri & Toru Maruyama
Pages: 1266-1274
Published online: 30 May 2018
AbstractforBiomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity | Full Text | References | PDF (1.8 MB)
  • 2197 Views
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Article
l-Peptide functionalized dual-responsive nanoparticles for controlled paclitaxel release and enhanced apoptosis in breast cancer cells
Shiwei Niu, David H. Bremner, Junzi Wu, Jianrong Wu, Haijun Wang, Heyu Li, Qianqian Qian, Hong Zheng & Limin Zhu
Pages: 1275-1288
Published online: 30 May 2018
Abstractforl-Peptide functionalized dual-responsive nanoparticles for controlled paclitaxel release and enhanced apoptosis in breast cancer cells | Full Text | References | PDF (3 MB)
  • 1812 Views
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Article
Temporary suppression the sequestrated function of host macrophages for better nanoparticles tumor delivery
Jifu Hao, Te Han, Meixiang Wang, Qiannan Zhuang, Xiaodan Wang, Jianguo Liu, Yongan Wang & Hua Tang
Pages: 1289-1301
Published online: 05 Jun 2018
AbstractforTemporary suppression the sequestrated function of host macrophages for better nanoparticles tumor delivery | Full Text | References | PDF (3.7 MB)
  • 1407 Views
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Article
Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core–shell nanoparticles targeting the heterogeneous tumor cells of glioma
He-Lin Xu, Zi-Liang Fan, De-Li ZhuGe, Meng-Qi Tong, Bi-Xin Shen, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Yasin Sohawon, Qing Yao & Ying-Zheng Zhao
Pages: 1302-1318
Published online: 05 Jun 2018
AbstractforRatiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core–shell nanoparticles targeting the heterogeneous tumor cells of glioma | Full Text | References | PDF (2.3 MB) | Supplemental
  • 1646 Views
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Article
Nanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines
Jiemin Wang, Xiongbin Hu & Daxiong Xiang
Pages: 1319-1327
Published online: 05 Jun 2018
AbstractforNanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines | Full Text | References | PDF (1,010.3 KB)
  • 11284 Views
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Article
Novel in situ gelling vaginal sponges of sildenafil citrate-based cubosomes for uterine targeting
Heba M. Aboud, Amira H. Hassan, Adel A. Ali & Abdel-Razik H. Abdel-Razik
Pages: 1328-1339
Published online: 05 Jun 2018
AbstractforNovel in situ gelling vaginal sponges of sildenafil citrate-based cubosomes for uterine targeting | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2190 Views
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Article
Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits
Nagwa Hussein Fouda, Randa Tag Abdelrehim, Doaa Abdelmagid Hegazy & Basant Ahmed Habib
Pages: 1340-1349
Published online: 05 Jun 2018
AbstractforSustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2388 Views
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Article
Cancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to achieve precise cancer therapy
Yuanwei Liang, Wei Huang, Delong Zeng, Xiaoting Huang, Leung Chan, Chaoming Mei, Pengju Feng, Choon-Hong Tan & Tianfeng Chen
Pages: 1350-1361
Published online: 05 Jun 2018
AbstractforCancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to achieve precise cancer therapy | Full Text | References | PDF (1.9 MB) | Supplemental
  • 2375 Views
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Article
Development of a docetaxel micellar formulation using poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery
Taehoon Sim, Jae Eun Kim, Ngoc Ha Hoang, Jin Kook Kang, Chaemin Lim, Dong Shik Kim, Eun Seong Lee, Yu Seok Youn, Han-Gon Choi, Hyo-Kyung Han, Kwon-Yeon Weon & Kyung Taek Oh
Pages: 1362-1371
Published online: 05 Jun 2018
AbstractforDevelopment of a docetaxel micellar formulation using poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery | Full Text | References | PDF (2.6 MB) | Supplemental
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Article
Multivesicular liposomes for sustained release of bevacizumab in treating laser-induced choroidal neovascularization
Hongjie Mu, Yiyun Wang, Yongchao Chu, Ying Jiang, Hongchen Hua, Liuxiang Chu, Kaili Wang, Aiping Wang, Wanhui Liu, Youxin Li, Fenghua Fu & Kaoxiang Sun
Pages: 1372-1383
Published online: 05 Jun 2018
AbstractforMultivesicular liposomes for sustained release of bevacizumab in treating laser-induced choroidal neovascularization | Full Text | References | PDF (1.6 MB)
  • 3190 Views
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Article
SPECT/CT imaging of chemotherapy-induced tumor apoptosis using 99mTc-labeled dendrimer-entrapped gold nanoparticles
Yan Xing, Jingyi Zhu, Lingzhou Zhao, Zhijuan Xiong, Yujie Li, San Wu, Gitasha Chand, Xiangyang Shi & Jinhua Zhao
Pages: 1384-1393
Published online: 05 Jun 2018
AbstractforSPECT/CT imaging of chemotherapy-induced tumor apoptosis using 99mTc-labeled dendrimer-entrapped gold nanoparticles | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2123 Views
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Article
Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer
Ga Hee Kim, Ji Eun Won, Yeongseon Byeon, Min Gi Kim, Tae In Wi, Jae Myeong Lee, Yun-Yong Park, Jeong-Won Lee, Tae Heung Kang, In Duk Jung, Byung Cheol Shin, Hyung Jun Ahn, Young Joo Lee, Anil K. Sood, Hee Dong Han & Yeong-Min Park
Pages: 1394-1402
Published online: 11 Jun 2018
AbstractforSelective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer | Full Text | References | PDF (1.8 MB) | Supplemental
  • 2864 Views
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Article
Dipeptide-modified nanoparticles to facilitate oral docetaxel delivery: new insights into PepT1-mediated targeting strategy
Yuqian Du, Chutong Tian, Menglin Wang, Di Huang, Wei Wei, Yan Liu, Lin Li, Bingjun Sun, Longfa Kou, Qiming Kan, Kexin Liu, Cong Luo, Jin Sun & Zhonggui He
Pages: 1403-1413
Published online: 12 Jun 2018
AbstractforDipeptide-modified nanoparticles to facilitate oral docetaxel delivery: new insights into PepT1-mediated targeting strategy | Full Text | References | PDF (1.6 MB) | Supplemental
  • 2273 Views
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Article

Article
A nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides
Maryam A. Shetab Boushehri, Mona M. A. Abdel-Mottaleb, Arnaud Béduneau, Yann Pellequer & Alf Lamprecht
Pages: 1414-1425
Published online: 14 Jun 2018
AbstractforA nanoparticle-based approach to improve the outcome of cancer active immunotherapy with lipopolysaccharides | Full Text | References | PDF (1.5 MB)
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Research Article

Article
Improved delivery of natural alkaloids into lung cancer through woody oil-based emulsive nanosystems
Jing Zhao, Shan Liu, Xueyuan Hu, Yunmei Zhang, Shenglei Yan, Hua Zhao, Mei Zeng, Yao Li, Lan Yang & Jingqing Zhang
Pages: 1426-1437
Published online: 11 Jun 2018
AbstractforImproved delivery of natural alkaloids into lung cancer through woody oil-based emulsive nanosystems | Full Text | References | PDF (2.2 MB)
  • 1658 Views
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Article
Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis
A. R. Tellegen, I. Rudnik-Jansen, B. Pouran, H. M. de Visser, H. H. Weinans, R. E. Thomas, M. J. L. Kik, G. C. M. Grinwis, J. C. Thies, N. Woike, G. Mihov, P. J. Emans, B. P. Meij, L. B. Creemers & M. A. Tryfonidou
Pages: 1438-1447
Published online: 12 Jun 2018
AbstractforControlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis | Full Text | References | PDF (1.5 MB) | Supplemental
  • 3074 Views
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Article
Ultrahigh verapamil-loaded controlled release polymeric beads using superamphiphobic substrate: D-optimal statistical design, in vitro and in vivo performance
Carol Yousry, Maha M. Amin, Ahmed H. Elshafeey & Omaima N. El Gazayerly
Pages: 1448-1460
Published online: 14 Jun 2018
AbstractforUltrahigh verapamil-loaded controlled release polymeric beads using superamphiphobic substrate: D-optimal statistical design, in vitro and in vivo performance | Full Text | References | PDF (1.6 MB)
  • 1427 Views
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Article
Improved lymphatic targeting: effect and mechanism of synthetic borneol on lymph node uptake of 7-ethyl-10-hydroxycamptothecin nanoliposomes following subcutaneous administration
Tiantian Ye, Yue Wu, Lei Shang, Xueqing Deng & Shujun Wang
Pages: 1461-1471
Published online: 14 Jun 2018
AbstractforImproved lymphatic targeting: effect and mechanism of synthetic borneol on lymph node uptake of 7-ethyl-10-hydroxycamptothecin nanoliposomes following subcutaneous administration | Full Text | References | PDF (1.4 MB)
  • 1367 Views
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Article
Hyaluronic acid/doxorubicin nanoassembly-releasing microspheres for the transarterial chemoembolization of a liver tumor
Song Yi Lee, Jin Woo Choi, Jae-Young Lee, Dae-Duk Kim, Hyo-Cheol Kim & Hyun-Jong Cho
Pages: 1472-1483
Published online: 17 Jun 2018
AbstractforHyaluronic acid/doxorubicin nanoassembly-releasing microspheres for the transarterial chemoembolization of a liver tumor | Full Text | References | PDF (2.1 MB) | Supplemental
  • 2635 Views
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Article
Anti-GPC3 antibody-modified sorafenib-loaded nanoparticles significantly inhibited HepG2 hepatocellular carcinoma
Xiaolong Tang, Longzhou Chen, Amin Li, Shiyu Cai, Yinci Zhang, Xueke Liu, Zhenyou Jiang, Xinkuang Liu, Yong Liang & Dong Ma
Pages: 1484-1494
Published online: 19 Jun 2018
AbstractforAnti-GPC3 antibody-modified sorafenib-loaded nanoparticles significantly inhibited HepG2 hepatocellular carcinoma | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2803 Views
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Article
Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft
Anni Pan, Zhaoyang Wang, Binlong Chen, Wenbing Dai, Hua Zhang, Bing He, Xueqing Wang, Yiguang Wang & Qiang Zhang
Pages: 1495-1503
Published online: 26 Jun 2018
AbstractforLocalized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft | Full Text | References | PDF (1.7 MB) | Supplemental
  • 2817 Views
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Review Article

Review
The paradigm shift for drug delivery systems for oral and maxillofacial implants
Rafal Pokrowiecki
Pages: 1504-1515
Published online: 03 Jul 2018
AbstractforThe paradigm shift for drug delivery systems for oral and maxillofacial implants | Full Text | References | PDF (1.2 MB)
  • 2552 Views
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Review Article
Advanced physical techniques for gene delivery based on membrane perforation
Xiaofan Du, Jing Wang, Quan Zhou, Luwei Zhang, Sijia Wang, Zhenxi Zhang & Cuiping Yao
Pages: 1516-1525
Published online: 03 Jul 2018
AbstractforAdvanced physical techniques for gene delivery based on membrane perforation | Full Text | References | PDF (964 KB)
  • 5963 Views
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Research Article

Article
Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy
Gihan Mahmoud, Jarmila Jedelská, Samia Mohamed Omar, Boris Strehlow, Marc Schneider & Udo Bakowsky
Pages: 1526-1536
Published online: 11 Jul 2018
AbstractforStabilized tetraether lipids based particles guided prophyrins photodynamic therapy | Full Text | References | PDF (1.4 MB)
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Article
Porous silicon based intravitreal platform for dual-drug loading and controlled release towards synergistic therapy
David Warther, Ying Xiao, Fangting Li, Yuqin Wang, Kristyn Huffman, William R. Freeman, Michael Sailor & Lingyun Cheng
Pages: 1537-1545
Published online: 11 Jul 2018
AbstractforPorous silicon based intravitreal platform for dual-drug loading and controlled release towards synergistic therapy | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1598 Views
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Article
Superior anti-neoplastic activities of triacontanol-PEG conjugate: synthesis, characterization and biological evaluations
Yimeng Zhou, Ning Li, Zhixia Qiu, Xiaoyu Lu, Min Fang, Xijing Chen, Lili Ren, Guangji Wang & Pingkai Ouyang
Pages: 1546-1559
Published online: 19 Jul 2018
AbstractforSuperior anti-neoplastic activities of triacontanol-PEG conjugate: synthesis, characterization and biological evaluations | Full Text | References | PDF (1.9 MB) | Supplemental
  • 1416 Views
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Article
Efficient treatment of Parkinson’s disease using ultrasonography-guided rhFGF20 proteoliposomes
Jianlou Niu, Junjun Xie, Kaiwen Guo, Xiaomin Zhang, Feng Xia, Xinyu Zhao, Lintao Song, Deli Zhuge, Xiaokun Li, Yingzheng Zhao & Zhifeng Huang
Pages: 1560-1569
Published online: 25 Jul 2018
AbstractforEfficient treatment of Parkinson’s disease using ultrasonography-guided rhFGF20 proteoliposomes | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2015 Views
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Article
Self-assembled PEGylated albumin nanoparticles (SPAN) as a platform for cancer chemotherapy and imaging
Jung Eun Lee, Myung Goo Kim, Yeon Lim Jang, Min Sang Lee, Nak Won Kim, Yue Yin, Jong Han Lee, Su Yeon Lim, Ji Won Park, Jaeyun Kim, Doo Sung Lee, Sun Hwa Kim & Ji Hoon Jeong
Pages: 1570-1578
Published online: 25 Jul 2018
AbstractforSelf-assembled PEGylated albumin nanoparticles (SPAN) as a platform for cancer chemotherapy and imaging | Full Text | References | PDF (1.5 MB) | Supplemental
  • 3107 Views
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Article
Modified translationally controlled tumor protein-derived protein transduction domain enhances nasal delivery of exendin-4 as shown with insulin
Hae-Duck Bae, Moonhee Kim, Joohyun Lee & Kyunglim Lee
Pages: 1579-1584
Published online: 25 Jul 2018
AbstractforModified translationally controlled tumor protein-derived protein transduction domain enhances nasal delivery of exendin-4 as shown with insulin | Full Text | References | PDF (749.1 KB)
  • 886 Views
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Article
Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity
Danillo F. M. C. Veloso, Naiara I. G. M. Benedetti, Renato I. Ávila, Thiago S. A. Bastos, Thaísa C. Silva, Maria R. R. Silva, Aline C. Batista, Marize C. Valadares & Eliana M. Lima
Pages: 1585-1594
Published online: 25 Jul 2018
AbstractforIntravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity | Full Text | References | PDF (2.1 MB) | Supplemental
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Article
Sodium stibogluconate loaded nano-deformable liposomes for topical treatment of leishmaniasis: macrophage as a target cell
M. Junaid Dar, Fakhar Ud Din & Gul Majid Khan
Pages: 1595-1606
Published online: 14 Aug 2018
AbstractforSodium stibogluconate loaded nano-deformable liposomes for topical treatment of leishmaniasis: macrophage as a target cell | Full Text | References | PDF (1.7 MB) | Supplemental
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Article
Stacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors
Yan Yan, Ruizhi Wang, Yong Hu, Rongyue Sun, Tian Song, Xiangyang Shi & Shimeng Yin
Pages: 1607-1616
Published online: 22 Oct 2018
AbstractforStacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1969 Views
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Article
Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis
Qun Zheng, Zi-Xian Chen, Meng-Bei Xu, Xiao-Li Zhou, Yue-Yue Huang, Guo-Qing Zheng & Yan Wang
Pages: 1617-1633
Published online: 18 Oct 2018
AbstractforBorneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis | Full Text | References | PDF (1.6 MB) | Supplemental
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Articles

Article
Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting
Liuxiang Chu, Aiping Wang, Ling Ni, Xiuju Yan, Yina Song, Mingyu Zhao, Kaoxiang Sun, Hongjie Mu, Sha Liu, Zimei Wu & Chunyan Zhang
Pages: 1634-1641
Published online: 03 Sep 2018
AbstractforNose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting | Full Text | References | PDF (1.2 MB)
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Research Article

Article
Local release of gemcitabine via in situ UV-crosslinked lipid-strengthened hydrogel for inhibiting osteosarcoma
Wei Wu, Yong Dai, Han Liu, Ruoyu Cheng, Qing Ni, Tingjun Ye & Wenguo Cui
Pages: 1642-1651
Published online: 27 Aug 2018
AbstractforLocal release of gemcitabine via in situ UV-crosslinked lipid-strengthened hydrogel for inhibiting osteosarcoma | Full Text | References | PDF (1.6 MB)
  • 2414 Views
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Article
Enhanced blood–brain barrier penetration and glioma therapy mediated by T7 peptide-modified low-density lipoprotein particles
Meng Liang, Chunhong Gao, Yuli Wang, Wei Gong, Shiyao Fu, Lin Cui, Zhenhan Zhou, Xiaoyang Chu, Yue Zhang, Qianqian Liu, Xiong Zhao, Baoquan Zhao, Meiyan Yang, Zhiping Li, Chunrong Yang, Xiangyang Xie, Yang Yang & Chunsheng Gao
Pages: 1652-1663
Published online: 03 Nov 2018
AbstractforEnhanced blood–brain barrier penetration and glioma therapy mediated by T7 peptide-modified low-density lipoprotein particles | Full Text | References | PDF (1.6 MB) | Supplemental
  • 2912 Views
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Article
A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin⋅hydrochloride for thyroid cancer treatment in vitro and in vivo
Youngbum Yoo, Sun-Jung Yoon, So Yeon Kim, Deok-Won Lee, Sewook Um, Hoon Hyun, Sung Ok Hong & Dae Hyeok Yang
Pages: 1664-1671
Published online: 05 Sep 2018
AbstractforA local drug delivery system based on visible light-cured glycol chitosan and doxorubicin⋅hydrochloride for thyroid cancer treatment in vitro and in vivo | Full Text | References | PDF (1.1 MB)
  • 1843 Views
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Article
Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†
Amgad E. Salem, Elham A. Mohamed, Hosam M. Elghadban & Galal M. Abdelghani
Pages: 1672-1682
Published online: 15 Nov 2018
AbstractforPotential combination topical therapy of anal fissure: development, evaluation, and clinical study† | Full Text | References | PDF (1.6 MB)
  • 5288 Views
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Article
Dual-mode imaging and therapeutic effects of drug-loaded phase-transition nanoparticles combined with near-infrared laser and low-intensity ultrasound on ovarian cancer
Shuning Chen, Yujiao Liu, Shenyin Zhu, Chunyan Chen, Wan Xie, Linlin Xiao, Yi Zhu, Lan Hao, Zhigang Wang, Jiangchuan Sun & Shufang Chang
Pages: 1683-1693
Published online: 20 Oct 2018
AbstractforDual-mode imaging and therapeutic effects of drug-loaded phase-transition nanoparticles combined with near-infrared laser and low-intensity ultrasound on ovarian cancer | Full Text | References | PDF (2.8 MB) | Supplemental
  • 1891 Views
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Critical Review

Review
The challenges of oral drug delivery via nanocarriers
Jonas Reinholz, Katharina Landfester & Volker Mailänder
Pages: 1694-1705
Published online: 03 Nov 2018
AbstractforThe challenges of oral drug delivery via nanocarriers | Full Text | References | PDF (2.3 MB)
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Research Article

Article
Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization, in vitro, ex vivo and in vivo characterization
Nihal Farid Younes, Sally Adel Abdel-Halim & Abdelhalim I. Elassasy
Pages: 1706-1717
Published online: 15 Nov 2018
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Published online: 01 Oct 2018
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Pages: 1728-1739
Published online: 05 Sep 2018
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Hui Zhang, Zhiyi Chen, Meng Du, Yue Li & Yuhao Chen
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Published online: 21 Sep 2018
AbstractforEnhanced gene transfection efficiency by low-dose 25 kDa polyethylenimine by the assistance of 1.8 kDa polyethylenimine | Full Text | References | PDF (1.2 MB) | Supplemental
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Pages: 1746-1755
Published online: 03 Nov 2018
AbstractforPD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer | Full Text | References | PDF (2.7 MB)
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Published online: 19 Oct 2018
AbstractforDevelopment and characterization of sorafenib-loaded lipid nanocapsules for the treatment of glioblastoma | Full Text | References | PDF (1.8 MB) | Supplemental
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Published online: 12 Oct 2018
AbstractforA journey from the endothelium to the tumor tissue: distinct behavior between PEO-PCL micelles and polymersomes nanocarriers | Full Text | References | PDF (2.4 MB) | Supplemental
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Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis
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Pages: 1779-1789
Published online: 19 Oct 2018
AbstractforCo-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis | Full Text | References | PDF (3.9 MB) | Supplemental
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Pages: 1790-1801
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Pages: 1802-1810
Published online: 20 Oct 2018
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Published online: 20 Nov 2018
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Published online: 26 Dec 2018
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Pages: 1858-1864
Published online: 19 Oct 2018
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Pages: 1865-1876
Published online: 26 Nov 2018
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Published online: 26 Nov 2018
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Published online: 07 Nov 2018
AbstractforBrain-targeted delivery of PEGylated nano-bacitracin A against Penicillin-sensitive and -resistant Pneumococcal meningitis: formulated with RVG29 and Pluronic® P85 unimers | Full Text | References | PDF (2.5 MB) | Supplemental
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A Bayesian network meta-analysis on the efficacy and safety of eighteen targeted drugs or drug combinations for pulmonary arterial hypertension
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Pages: 1898-1909
Published online: 15 Nov 2018
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Marzia Cirri, Lavinia Maestrini, Francesca Maestrelli, Natascia Mennini, Paola Mura, Carla Ghelardini & Lorenzo Di Cesare Mannelli
Pages: 1910-1921
Published online: 19 Nov 2018
AbstractforDesign, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy | Full Text | References | PDF (1.2 MB) | Supplemental
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Primary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy
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Published online: 22 Nov 2018
AbstractforPrimary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy | Full Text | References | PDF (2.8 MB)
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Development of dual-drug-loaded stealth nanocarriers for targeted and synergistic anti-lung cancer efficacy
Juan Chen, Xiaobing Yang, Liuqing Huang, Huixian Lai, Chuanhai Gan & Xuetao Luo
Pages: 1932-1942
Published online: 24 Nov 2018
AbstractforDevelopment of dual-drug-loaded stealth nanocarriers for targeted and synergistic anti-lung cancer efficacy | Full Text | References | PDF (2.8 MB)
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Anika Haq & Bozena Michniak-Kohn
Pages: 1943-1949
Published online: 21 Nov 2018
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Review Article

Review Article
Oncolytic herpes simplex virus tumor targeting and neutralization escape by engineering viral envelope glycoproteins
Xiao-Qin Liu, Hong-Yi Xin, Yan-Ning Lyu, Zhao-Wu Ma, Xiao-Chun Peng, Ying Xiang, Ying-Ying Wang, Zi-Jun Wu, Jun-Ting Cheng, Jia-Fu Ji, Ji-Xin Zhong, Bo-Xu Ren, Xian-Wang Wang & Hong-Wu Xin
Pages: 1950-1962
Published online: 04 Dec 2018
AbstractforOncolytic herpes simplex virus tumor targeting and neutralization escape by engineering viral envelope glycoproteins | Full Text | References | PDF (1.9 MB)
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Delivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy
Mohammad K. D. Manshadi, Mahsa Saadat, Mehdi Mohammadi, Milad Shamsi, Morteza Dejam, Reza Kamali & Amir Sanati-Nezhad
Pages: 1963-1973
Published online: 06 Dec 2018
AbstractforDelivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy | Full Text | References | PDF (2.9 MB) | Supplemental
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Article
Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles
Hai-Zhen Zhu, Jing Hou, Yi Guo, Xin Liu, Fei-Long Jiang, Guang-Peng Chen, Xiu-Feng Pang, Jian-Guo Sun & Zheng-Tang Chen
Pages: 1974-1983
Published online: 09 Jan 2019
AbstractforIdentification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles | Full Text | References | PDF (3.8 MB) | Supplemental
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Research Article

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Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice
Mingxiang Chang, Meimei Wu & Hanmin Li
Pages: 1984-1995
Published online: 30 Nov 2018
AbstractforAntitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice | Full Text | References | PDF (2 MB) | Supplemental
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Review

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Versatility of cell-penetrating peptides for intracellular delivery of siRNA
Tejinder Singh, Akula S. N. Murthy, Hye-Jin Yang & Jungkyun Im
Pages: 1996-2006
Published online: 31 Dec 2018
AbstractforVersatility of cell-penetrating peptides for intracellular delivery of siRNA | Full Text | References | PDF (1.6 MB)
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Research Article

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Low-density lipoprotein decorated silica nanoparticles co-delivering sorafenib and doxorubicin for effective treatment of hepatocellular carcinoma
Junfeng Ye, Ruoyan Zhang, Wengang Chai & Xiaohong Du
Pages: 2007-2014
Published online: 27 Dec 2018
AbstractforLow-density lipoprotein decorated silica nanoparticles co-delivering sorafenib and doxorubicin for effective treatment of hepatocellular carcinoma | Full Text | References | PDF (1.4 MB)
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Corrigendum

Correction
Correction to: El-Housiny et al., Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study
Page: 2015
Published online: 20 Dec 2017
CitationforCorrection to: El-Housiny et al., Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study | Full Text | PDF (137.4 KB)
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Correction
Correction to: Ma et al., Controlled synthesis and size effects of multifunctional mesoporous silica nanosystem for precise cancer therapy
Page: 2016
Published online: 12 Feb 2018
CitationforCorrection to: Ma et al., Controlled synthesis and size effects of multifunctional mesoporous silica nanosystem for precise cancer therapy | Full Text | PDF (135.3 KB)
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