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Volume 11, Issue 2

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 2 (2015)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 2 (2015)

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Editorial

The therapeutic armamentarium in migraine is quite elderly

Paolo Martelletti

Pages: 175-177

Published online: 01 Dec 2014

AbstractforThe therapeutic armamentarium in migraine is quite elderly | Full Text | References | PDF (128.4 KB)

2058 Views
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Free Access

Original Research

Article

Ethnic sensitivity assessment – pharmacokinetic comparability between Japanese and non-Japanese healthy subjects on selected mAbs

Soichiro Matsushima PhD, Yue Huang PhD, Hikoe Suzuki, Junichi Nishino & Peter Lloyd PhD

Pages: 179-191

Published online: 18 Dec 2014

AbstractforEthnic sensitivity assessment – pharmacokinetic comparability between Japanese and non-Japanese healthy subjects on selected mAbs | Full Text | References | PDF (353.6 KB)

1841 Views
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Review

Review Article

Abuse-deterrent formulations: part 1 – development of a formulation-based classification system

David J Mastropietro & Hossein Omidian PhD

Pages: 193-204

Published online: 06 Nov 2014

AbstractforAbuse-deterrent formulations: part 1 – development of a formulation-based classification system | Full Text | References | PDF (310 KB)

424 Views
21 CrossRef citations
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Clinical pharmacokinetics and pharmacodynamics of ganciclovir and valganciclovir in children with cytomegalovirus infection

Chris Stockmann, Jessica K Roberts, Elizabeth D Knackstedt, Michael G Spigarelli & Catherine MT Sherwin

Pages: 205-219

Published online: 27 Nov 2014

AbstractforClinical pharmacokinetics and pharmacodynamics of ganciclovir and valganciclovir in children with cytomegalovirus infection | Full Text | References | PDF (554.1 KB)

1298 Views
30 CrossRef citations
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Animal models for exploring the pharmacokinetics of breast cancer therapies

Omar M Rashid MD JD & Kazuaki Takabe MD PhD FACS

Pages: 221-230

Published online: 21 Nov 2014

AbstractforAnimal models for exploring the pharmacokinetics of breast cancer therapies | Full Text | References | PDF (257.7 KB)

596 Views
42 CrossRef citations
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Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review

Yi Ling Teo, Han Kiat Ho & Alexandre Chan

Pages: 231-242

Published online: 15 Nov 2014

AbstractforFormation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review | Full Text | References | PDF (762.4 KB)

950 Views
48 CrossRef citations
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Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis

Alexander Johnston & Jack Uetrecht

Pages: 243-257

Published online: 26 Nov 2014

AbstractforCurrent understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis | Full Text | References | PDF (587.8 KB)

1334 Views
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Applying machine learning techniques for ADME-Tox prediction: a review

Vinícius Gonçalves Maltarollo, Jadson Castro Gertrudes, Patrícia Rufino Oliveira & Kathia Maria Honorio

Pages: 259-271

Published online: 02 Dec 2014

AbstractforApplying machine learning techniques for ADME-Tox prediction: a review | Full Text | References | PDF (489.5 KB)

1393 Views
117 CrossRef citations
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New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition

Lori WE van der Schoor, Henkjan J Verkade, Folkert Kuipers & Johan W Jonker

Pages: 273-293

Published online: 07 Nov 2014

AbstractforNew insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition | Full Text | References | PDF (593.3 KB)

921 Views
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Drug Evaluation

Pharmacology and clinical efficacy of dalfampridine for treating multiple sclerosis

Alessandra Lugaresi MD PhD

Pages: 295-306

Published online: 16 Dec 2014

AbstractforPharmacology and clinical efficacy of dalfampridine for treating multiple sclerosis | Full Text | References | PDF (502.7 KB)

275 Views
7 CrossRef citations
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Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy

Soken-Nakazawa J Song MD PhD & Kazuyuki Yoshizaki (Professor) MD PhD

Pages: 307-316

Published online: 10 Dec 2014

AbstractforTocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy | Full Text | References | PDF (266.8 KB)

1067 Views
31 CrossRef citations
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Evaluation of pharmacokinetics and pharmacodynamics and clinical efficacy of certolizumab pegol for Crohn’s disease

Gloria SZ Tun & Alan J Lobo (Professor)

Pages: 317-327

Published online: 14 Jan 2015

AbstractforEvaluation of pharmacokinetics and pharmacodynamics and clinical efficacy of certolizumab pegol for Crohn’s disease | Full Text | References | PDF (547.6 KB)

664 Views
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Expert Opinion on Drug Metabolism & Toxicology (Vol.11, Iss.2, 2015)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 2 (2015)

Expert Opinion on Drug Metabolism & Toxicology, Volume 11, Issue 2 (2015)

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