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Volume 12, Issue 11

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 12, Issue 11 (2016)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 12, Issue 11 (2016)

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Editorial

Metabolomic profiling for early cancer detection: current status and future prospects

Vicki J. Hwang & Robert H. Weiss

Pages: 1263-1265

Published online: 23 Sep 2016

First Page PreviewforMetabolomic profiling for early cancer detection: current status and future prospects | Full Text | References | PDF (294.8 KB)

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Editorial

Effects of glucose-lowering drugs on cardiovascular outcomes in patients with type 2 diabetes

Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan & Zhong-Min Liu

Pages: 1267-1271

Published online: 19 Sep 2016

First Page PreviewforEffects of glucose-lowering drugs on cardiovascular outcomes in patients with type 2 diabetes | Full Text | References | PDF (553.7 KB)

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Original Research

Article

Simple physicochemical properties related with lipophilicity, polarity, molecular size and ionization status exert significant impact on the transfer of drugs and chemicals into human breast milk

George Vasios, Aggeliki Kosmidi, Olga-Ioanna Kalantzi, Anna Tsantili-Kakoulidou, Nikolaos Kavantzas, Stamatios Theocharis & Constantinos Giaginis

Pages: 1273-1278

Published online: 06 Sep 2016

AbstractforSimple physicochemical properties related with lipophilicity, polarity, molecular size and ionization status exert significant impact on the transfer of drugs and chemicals into human breast milk | Full Text | References | PDF (921.7 KB) | Supplemental

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Review

Ocular surface toxicity from glaucoma topical medications and associated preservatives such as benzalkonium chloride (BAK)

Alberto Aguayo Bonniard, Jacky Y. Yeung, Clara C. Chan & Catherine M. Birt

Pages: 1279-1289

Published online: 18 Jul 2016

AbstractforOcular surface toxicity from glaucoma topical medications and associated preservatives such as benzalkonium chloride (BAK) | Full Text | References | PDF (820.7 KB)

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Review

Autoimmune-like drug-induced liver injury: a review and update for the clinician

Jonathan G. Stine & Patrick G. Northup

Pages: 1291-1301

Published online: 21 Jul 2016

AbstractforAutoimmune-like drug-induced liver injury: a review and update for the clinician | Full Text | References | PDF (965.4 KB)

645 Views
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Review

The role of cytochrome P450 pharmacogenomics in chronic non-cancer pain patients

Tatiana Tverdohleb, Bora Dinc, Ivana Knezevic, Kenneth D. Candido & Nebojsa Nick Knezevic

Pages: 1303-1311

Published online: 15 Jul 2016

AbstractforThe role of cytochrome P450 pharmacogenomics in chronic non-cancer pain patients | Full Text | References | PDF (807.5 KB)

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Review

The use of pharmacokinetics in dose individualization of factor VIII in the treatment of hemophilia A

Alanna McEneny-King, Alfonso Iorio, Gary Foster & Andrea N. Edginton

Pages: 1313-1321

Published online: 19 Aug 2016

AbstractforThe use of pharmacokinetics in dose individualization of factor VIII in the treatment of hemophilia A | Full Text | References | PDF (894.1 KB)

877 Views
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Review

Therapeutic protein-drug interactions: plausible mechanisms and assessment strategies

Honghui Zhou & Amarnath Sharma

Pages: 1323-1331

Published online: 21 Jul 2016

AbstractforTherapeutic protein-drug interactions: plausible mechanisms and assessment strategies | Full Text | References | PDF (740.7 KB)

879 Views
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Review

Vonoprazan for treatment of gastroesophageal reflux: pharmacodynamic and pharmacokinetic considerations

Edoardo Savarino, Irene Martinucci, Manuele Furnari, Chiara Romana, Gaia Pellegatta, Alessandro Moscatelli, Giorgia Bodini, Elisa Marabotto, Vincenzo Savarino, Nicola de Bortoli & Corrado Blandizzi

Pages: 1333-1341

Published online: 08 Aug 2016

AbstractforVonoprazan for treatment of gastroesophageal reflux: pharmacodynamic and pharmacokinetic considerations | Full Text | References | PDF (714.2 KB)

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Review

Intravenous immunoglobulin: pharmacological properties and use in polyneuropathies

Livia Dézsi, Zoltán Horváth & László Vécsei

Pages: 1343-1358

Published online: 22 Aug 2016

AbstractforIntravenous immunoglobulin: pharmacological properties and use in polyneuropathies | Full Text | References | PDF (1.2 MB)

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Drug Evaluation

Article

Pharmacokinetic drug evaluation of albutrepenonacog alfa (CSL654) for the treatment of hemophilia

Massimo Morfini

Pages: 1359-1365

Published online: 02 Oct 2016

AbstractforPharmacokinetic drug evaluation of albutrepenonacog alfa (CSL654) for the treatment of hemophilia | Full Text | References | PDF (565.4 KB)

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Article

Pharmacokinetic and pharmacodynamic drug evaluation of tofogliflozin for the treatment of type 2 diabetes

Kalliopi Pafili, Efstratios Maltezos & Nikolaos Papanas

Pages: 1367-1380

Published online: 08 Sep 2016

AbstractforPharmacokinetic and pharmacodynamic drug evaluation of tofogliflozin for the treatment of type 2 diabetes | Full Text | References | PDF (1 MB)

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Article

Pharmacokinetic and pharmacodynamic evaluation of ibrutinib for the treatment of chronic lymphocytic leukemia: rationale for lower doses

Prithviraj Bose, Varsha V. Gandhi & Michael J. Keating

Pages: 1381-1392

Published online: 11 Oct 2016

AbstractforPharmacokinetic and pharmacodynamic evaluation of ibrutinib for the treatment of chronic lymphocytic leukemia: rationale for lower doses | Full Text | References | PDF (1.2 MB)

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