Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Issue 1 (2009)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Issue 1 (2009)

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Research Article

Article
Efavirenz Mannich bases: Synthesis, anti-HIV and antitubercular activities
Dharmarajan Sriram, Debjani Banerjee & Perumal Yogeeswari
Pages: 1-5
Published online: 01 Feb 2009
AbstractforEfavirenz Mannich bases: Synthesis, anti-HIV and antitubercular activities | Full Text | References | PDF (84.7 KB)
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Article
QSAR study of substituted 2-pyridinyl guanidines as selective urokinase-type plasminogen activator (uPA) inhibitors
C. Karthikeyan, N.S. Hari Narayana Moorthy & Piyush Trivedi
Pages: 6-13
Published online: 01 Feb 2009
AbstractforQSAR study of substituted 2-pyridinyl guanidines as selective urokinase-type plasminogen activator (uPA) inhibitors | Full Text | References | PDF (93.6 KB)
  • 931 Views
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Article
Inhibitory effects of flavonoids on aldehyde oxidase activity
Saeed Pirouzpanah, Jalal Hanaee, Seyed-Vali Razavieh & Mohammad-Reza Rashidi
Pages: 14-21
Published online: 20 Oct 2008
AbstractforInhibitory effects of flavonoids on aldehyde oxidase activity | Full Text | References | PDF (112.1 KB)
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Article
Alkaline phosphatase inhibition by vanadyl-β-diketone complexes: electron density effects
Amanda J. Ziegler, Jan Florián, Miguel A. Ballicora & Albert W. Herlinger
Pages: 22-28
Published online: 20 Oct 2008
AbstractforAlkaline phosphatase inhibition by vanadyl-β-diketone complexes: electron density effects | Full Text | References | PDF (138.9 KB)
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Article
Synthesis and characterization of some new 2(3H)-benzoxazolones with analgesic and antiinflammatory activities
Nesrin Gökhan-Kelekçi, Meriç Köksal, Songül Ünüvar, Göknur Aktay & Hakki Erdoğan
Pages: 29-37
Published online: 20 Oct 2008
AbstractforSynthesis and characterization of some new 2(3H)-benzoxazolones with analgesic and antiinflammatory activities | Full Text | References | PDF (321.2 KB)
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Article
His22 of TLXI plays a critical role in the inhibition of glycoside hydrolase family 11 xylanases
Sigrid Rombouts, Ellen Fierens, Elien Vandermarliere, Arnout Voet, Kurt Gebruers, Johnny Beaugrand, Christophe M. Courtin, Jan A. Delcour, Marc de Maeyer, Anja Rabijns, Steven Van Campenhout & Guido Volckaert
Pages: 38-46
Published online: 20 Oct 2008
AbstractforHis22 of TLXI plays a critical role in the inhibition of glycoside hydrolase family 11 xylanases | Full Text | References | PDF (2.4 MB)
  • 577 Views
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Article
New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors
Muhammad Nisar, Obaidullah, Manzoor Ahmad, Noreen Wadood, Muhammad Arif Lodhi, Farzana Shaheen & M. Iqbal Choudhary
Pages: 47-51
Published online: 20 Oct 2008
AbstractforNew diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors | Full Text | References | PDF (107.6 KB)
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Article
Unexpected formation of 3-chloro-1-hydroxy-2,6-diarylpiperidin-4-ones: Synthesis, antibacterial and antifungal activities
M. Gopalakrishnan, J. Thanusu, V. Kanagarajan & R. Govindaraju
Pages: 52-58
Published online: 20 Oct 2008
AbstractforUnexpected formation of 3-chloro-1-hydroxy-2,6-diarylpiperidin-4-ones: Synthesis, antibacterial and antifungal activities | Full Text | References | PDF (95.8 KB)
  • 422 Views
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Article
Isolation and characterization of a novel adenosine deaminase inhibitor, IADA-7, from Bacillus sp. J-89
Gwang Lee, Sang Seop Lee, Kwang Yol Kay, Dong Wan Kim, Sangdun Choi & Hong Ki Jun
Pages: 59-64
Published online: 20 Oct 2008
AbstractforIsolation and characterization of a novel adenosine deaminase inhibitor, IADA-7, from Bacillus sp. J-89 | Full Text | References | PDF (206.3 KB)
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Article
α-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose
Sirichai Adisakwattana, Piyawan Charoenlertkul & Sirintorn Yibchok-anun
Pages: 65-69
Published online: 20 Oct 2008
Abstractforα-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose | Full Text | References | PDF (157.6 KB)
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Article
Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions
Isao Nishimori, Tomoko Minakuchi, Saburo Onishi, Daniela Vullo, Alessandro Cecchi, Andrea Scozzafava & Claudiu T. Supuran
Pages: 70-76
Published online: 20 Oct 2008
AbstractforCarbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions | Full Text | References | PDF (368.9 KB)
  • 726 Views
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Article
Topological descriptors in modeling malonyl coenzyme A decarboxylase inhibitory activity: N-Alkyl-N-(1,1,1,3,3,3-hexafluoro-2-hydroxypropylphenyl)amide derivatives
P. Singh, R. Kumar, B. K. Sharma & Y. S. Prabhakar
Pages: 77-85
Published online: 20 Oct 2008
AbstractforTopological descriptors in modeling malonyl coenzyme A decarboxylase inhibitory activity: N-Alkyl-N-(1,1,1,3,3,3-hexafluoro-2-hydroxypropylphenyl)amide derivatives | Full Text | References | PDF (113.1 KB)
  • 873 Views
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Article
Modeling of vascular endothelial growth factor receptor 2 (VEGFR2) kinase inhibitory activity of 2-anilino-5-aryloxazoles using chemometric tools
B. K. Sharma, S. K. Sharma, P. Singh, Susheela Sharma & Y. S. Prabhakar
Pages: 86-93
Published online: 20 Oct 2008
AbstractforModeling of vascular endothelial growth factor receptor 2 (VEGFR2) kinase inhibitory activity of 2-anilino-5-aryloxazoles using chemometric tools | Full Text | References | PDF (96.1 KB)
  • 409 Views
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Article
Topological descriptors in modelling antimalarial activity: N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype
Shreekant Deshpande, V. Raja Solomon, Setu B. Katti & Yenamandra S. Prabhakar
Pages: 94-104
Published online: 20 Oct 2008
AbstractforTopological descriptors in modelling antimalarial activity: N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype | Full Text | References | PDF (136.5 KB)
  • 583 Views
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Article
Aluminium(III), chromium(III) and iron(III) complexes with 5-iodouracil and 5-iodouracil-histidine and their antitumour activity
Vinod P. Singh, Shweta Singh, K. K. Narang & D. Bhattacharya
Pages: 105-110
Published online: 20 Oct 2008
AbstractforAluminium(III), chromium(III) and iron(III) complexes with 5-iodouracil and 5-iodouracil-histidine and their antitumour activity | Full Text | References | PDF (87 KB)
  • 527 Views
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Article
Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni
Juan A. Musso-Buendía, Antonio E. Vidal, Ganasan Kasinthan, Corinne Nguyen, Juana Carrero-Lérida, Luis M. Ruiz-pérez, Keith Wilson, Nils Gunnar Johansson, Ian H. Gilbert & Dolores González-Pacanowska
Pages: 111-116
Published online: 20 Oct 2008
AbstractforKinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni | Full Text | References | PDF (94.3 KB)
  • 861 Views
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Article
Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes
Vijayakumar N. Sonar & Peter A. Crooks
Pages: 117-124
Published online: 20 Oct 2008
AbstractforSynthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes | Full Text | References | PDF (112.6 KB)
  • 852 Views
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Article
A new Schiff base copper (II) complex derived from estrone and d-glucosamine: Synthesis, characterization and its interaction with DNA
Xin-Bin Yang, Li Wang, Ji Zhang, Zhong-Wei Zhang, Hong-Hui Lin, Li-Hong Zhou & Xiao-Qi Yu
Pages: 125-130
Published online: 20 Oct 2008
AbstractforA new Schiff base copper (II) complex derived from estrone and d-glucosamine: Synthesis, characterization and its interaction with DNA | Full Text | References | PDF (216.7 KB)
  • 762 Views
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Article
Antiplasmodial activities of sesquiterpene lactone from Carpesium cernum
Ill-Min Chung & Hyung-In Moon
Pages: 131-135
Published online: 20 Oct 2008
AbstractforAntiplasmodial activities of sesquiterpene lactone from Carpesium cernum | Full Text | References | PDF (85.6 KB)
  • 667 Views
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Article
Antidiabetic Effect of an Active Fraction Extracted from Dragon's Blood (Dracaena Cochinchinensis)
Hui-Juan Gu, Jing-Ci Lv, Ke-Lan Yong, Xu Chen, Pei-Pei Liu & Xia-Bing Zhang
Pages: 136-139
Published online: 20 Oct 2008
AbstractforAntidiabetic Effect of an Active Fraction Extracted from Dragon's Blood (Dracaena Cochinchinensis) | Full Text | References | PDF (150.8 KB)
  • 1073 Views
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Article
Synthesis, spectral characterization and microbiological studies of Co(II), Ni(II) and Cu(II) complexes with some novel 20-membered macrocyclic hydrazino-1,2,4-triazole Schiff bases
Prakash Gouda Avaji & Sangamesh Amarappa Patil
Pages: 140-150
Published online: 01 Feb 2009
AbstractforSynthesis, spectral characterization and microbiological studies of Co(II), Ni(II) and Cu(II) complexes with some novel 20-membered macrocyclic hydrazino-1,2,4-triazole Schiff bases | Full Text | References | PDF (400.6 KB)
  • 986 Views
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Article
In silico studies of urease inhibitors to explore ligand-enzyme interactions
Farzana Latif Ansari, Abdul Wadood, Ahsan Ullah, Fatima Iftikhar & Zaheer Ul-Haq
Pages: 151-156
Published online: 20 Oct 2008
AbstractforIn silico studies of urease inhibitors to explore ligand-enzyme interactions | Full Text | References | PDF (256.7 KB)
  • 1130 Views
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Article
Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the α4β2* nicotinic acetylcholine receptor
Fang Zheng, Guangrong Zheng, A. Gabriela Deaciuc, Chang-Guo Zhan, Linda P. Dwoskin & Peter A. Crooks
Pages: 157-168
Published online: 20 Oct 2008
AbstractforComputational neural network analysis of the affinity of N-n-alkylnicotinium salts for the α4β2* nicotinic acetylcholine receptor | Full Text | References | PDF (135 KB)
  • 431 Views
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Article
Synthesis of organometallic-based biologically active compounds: In vitro antibacterial, antifungal and cytotoxic properties of some sulfonamide incorporated ferrocences
Zahid H. Chohan
Pages: 169-175
Published online: 20 Oct 2008
AbstractforSynthesis of organometallic-based biologically active compounds: In vitro antibacterial, antifungal and cytotoxic properties of some sulfonamide incorporated ferrocences | Full Text | References | PDF (348.7 KB)
  • 700 Views
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Article
4-phenyldiazenyl 2-(phenylimino methyl) phenols; synthesis and in-vitro biological evaluation as potential antibacterial agents
Anand K. Halve, Pushp Kant Dubey, Amit Kankoriya & Kiran Tiwari
Pages: 176-180
Published online: 20 Oct 2008
Abstractfor4-phenyldiazenyl 2-(phenylimino methyl) phenols; synthesis and in-vitro biological evaluation as potential antibacterial agents | Full Text | References | PDF (89.7 KB)
  • 1081 Views
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Article
New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors
Y. Laras, C. Garino, J. Dessolin, C. Weck, V. Moret, A. Rolland & J.-L. Kraus
Pages: 181-187
Published online: 01 Feb 2009
AbstractforNew N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors | Full Text | References | PDF (102.8 KB)
  • 514 Views
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Article
Quinic acid derivatives from Saussurea triangulata attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells
Ill-Min Chung, Min-Young Kim, Won-Hwan Park & Hyung-In Moon
Pages: 188-191
Published online: 20 Oct 2008
AbstractforQuinic acid derivatives from Saussurea triangulata attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells | Full Text | References | PDF (67.9 KB)
  • 561 Views
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Article
In vitro antifungal and antibacterial activities of extracts of Galium tricornutum subsp. longipedunculatum
Abdul Khaliq Jan, Muhammad Raza Shah, Itrat Anis & Inamullah Khan Marwat
Pages: 192-196
Published online: 20 Oct 2008
AbstractforIn vitro antifungal and antibacterial activities of extracts of Galium tricornutum subsp. longipedunculatum | Full Text | References | PDF (70.4 KB)
  • 1104 Views
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Article
Synthesis, characterization and antimicrobial activities of some mixed ligand complexes of Co(II) with thiosemicarbazones and N-protected amino acids
Renu Sharma, Meena Nagar, Manoj Agarwal & Hemant Sharma
Pages: 197-204
Published online: 01 Feb 2009
AbstractforSynthesis, characterization and antimicrobial activities of some mixed ligand complexes of Co(II) with thiosemicarbazones and N-protected amino acids | Full Text | References | PDF (244.4 KB)
  • 1171 Views
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Article
Predictive QSAR modeling of CCR5 antagonist piperidine derivatives using chemometric tools
Kunal Roy & Asim Sattwa Mandal
Pages: 205-223
Published online: 20 Oct 2008
AbstractforPredictive QSAR modeling of CCR5 antagonist piperidine derivatives using chemometric tools | Full Text | References | PDF (434.6 KB)
  • 700 Views
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Article
Antibacterial, antifungal, insecticidal, cytotoxicity and phytotoxicity studies on Indigofera gerardiana
Muhammad Nisar, Shafiq Ahmad Tariq, Inamullah Khan Marwat, Muhammad Raza Shah & Ihsan Ali Khan
Pages: 224-229
Published online: 01 Feb 2009
AbstractforAntibacterial, antifungal, insecticidal, cytotoxicity and phytotoxicity studies on Indigofera gerardiana | Full Text | References | PDF (177.5 KB)
  • 1664 Views
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Article
Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro
Seung Hyun Kim, Sin-Duk Jang, Ki Yong Lee, Sang Hyun Sung & Young Choong Kim
Pages: 230-233
Published online: 01 Feb 2009
AbstractforChemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro | Full Text | References | PDF (123 KB)
  • 913 Views
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Article
The leaf extract of Siberian Crabapple (Malus baccata (Linn.) Borkh) contains potential fatty acid synthase inhibitors
Xiang Wei, Ran Zhao, Ying-Hui Sun, Jian-Ping Cong, Fan-Guo Meng & Hai-Meng Zhou
Pages: 234-240
Published online: 20 Oct 2008
AbstractforThe leaf extract of Siberian Crabapple (Malus baccata (Linn.) Borkh) contains potential fatty acid synthase inhibitors | Full Text | References | PDF (260.2 KB)
  • 542 Views
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Article
The strand transfer oligonucleotide inhibitors of HIV-integrase
Jan Snášel, Ivan Rosenberg, Ondřej Pačes & Iva Pichová
Pages: 241-246
Published online: 20 Oct 2008
AbstractforThe strand transfer oligonucleotide inhibitors of HIV-integrase | Full Text | References | PDF (428.2 KB)
  • 337 Views
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Article
In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum
Jong-Jin Kim, Ill-Min Chung, Jae-Chul Jung, Min-Young Kim & Hyung-In Moon
Pages: 247-250
Published online: 20 Oct 2008
AbstractforIn vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum | Full Text | References | PDF (61.5 KB)
  • 697 Views
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Article
Inhibitory effects of Cefazolin and Cefodizime on the activity of mushroom tyrosinase
Jiang-Xing Zhuang, Wen-Gang Li, Ling Qiu, Xue Zhong, Jing-Jing Zhou & Qing-Xi Chen
Pages: 251-256
Published online: 01 Feb 2009
AbstractforInhibitory effects of Cefazolin and Cefodizime on the activity of mushroom tyrosinase | Full Text | References | PDF (165.6 KB)
  • 693 Views
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Article
Protein glycation inhibitory activities of Lawsonia inermis and its active principles
Nighat Sultana, Muhammed Iqbal Choudhary & Ambrin Khan
Pages: 257-261
Published online: 01 Feb 2009
AbstractforProtein glycation inhibitory activities of Lawsonia inermis and its active principles | Full Text | References | PDF (83.7 KB)
  • 1799 Views
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Article
QSAR study on dual SET and NET reuptake inhibitors: An insight into the structural requirement for antidepressant activity
Nigus Dessalew
Pages: 262-271
Published online: 20 Oct 2008
AbstractforQSAR study on dual SET and NET reuptake inhibitors: An insight into the structural requirement for antidepressant activity | Full Text | References | PDF (110.8 KB)
  • 663 Views
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Article
CoMFA and CoMSIA 3D-QSAR analysis on hydroxamic acid derivatives as urease inhibitors
Zaheer- Ul-Haq, Abdul Wadood & Reaz Uddin
Pages: 272-278
Published online: 20 Oct 2008
AbstractforCoMFA and CoMSIA 3D-QSAR analysis on hydroxamic acid derivatives as urease inhibitors | Full Text | References | PDF (194.2 KB)
  • 1498 Views
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Article
Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues
Hisashi Ito, Masafumi Watanabe, Yong-Tae Kim & Kenji Takahashi
Pages: 279-286
Published online: 01 Feb 2009
AbstractforInhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues | Full Text | References | PDF (885 KB)
  • 540 Views
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Article
Green tea catechins in chemoprevention of cancer: A molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1)
Roberto Artali, Giangiacomo Beretta, Paolo Morazzoni, Ezio Bombardelli & Fiorella Meneghetti
Pages: 287-295
Published online: 01 Feb 2009
AbstractforGreen tea catechins in chemoprevention of cancer: A molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1) | Full Text | References | PDF (546.7 KB)
  • 1272 Views
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Article
Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents
Adnan A. Bekhit, Hayam M. A. Ashour, Alaa El-Din A. Bekhit, Hamdy M. Abdel-Rahman & Salma A. Bekhit
Pages: 296-309
Published online: 01 Feb 2009
AbstractforSynthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents | Full Text | References | PDF (285.3 KB)
  • 1319 Views
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Corrigendum

Corrigendum
Adnan A. Bekhit, Hayam M.A. Ashour, Alaa El-Din A. Bekhit, Hamdy M. Abdel-Rahman & Salma A. Bekhit
Pages: 310-314
Published online: 01 Feb 2009
First Page PreviewforCorrigendum | Full Text | PDF (54.8 KB)
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