Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 25, Issue 2 (2010)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 25, Issue 2 (2010)

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Editorial

Editorial
Proceedings of the 17th annual conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A) and the 22nd “Journées Franco-Belges de Pharmacochimie”
Page: 151
Published online: 11 Mar 2010
CitationforProceedings of the 17th annual conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A) and the 22nd “Journées Franco-Belges de Pharmacochimie” | Full Text | PDF (493.3 KB)
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Research Articles (GP2A Conference)

Article
Description and assessment of a model for GSK-3β database virtual screening
Nadege Ventimila, Pierre-Yves Dupont, Michel Laguerre & Jean Dessolin
Pages: 152-157
Published online: 19 Feb 2010
AbstractforDescription and assessment of a model for GSK-3β database virtual screening | Full Text | References | PDF (741.5 KB)
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Article
Quinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer
Antonio Garofalo, Laurence Goossens, Amelie Lemoine, Amaury Farce, Yannick Arlot & Patrick Depreux
Pages: 158-171
Published online: 11 Mar 2010
AbstractforQuinazoline-urea, new protein kinase inhibitors in treatment of prostate cancer | Full Text | References | PDF (1.1 MB)
  • 1062 Views
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Article
Semisynthesis of α-methyl-γ-lactones and in vitro evaluation of their activity on protein farnesyltransferase
Benoit Pinel, Joëlle Dubois, Denis Séraphin & Pascal Richomme
Pages: 172-179
Published online: 11 Mar 2010
AbstractforSemisynthesis of α-methyl-γ-lactones and in vitro evaluation of their activity on protein farnesyltransferase | Full Text | References | PDF (768.9 KB)
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Article
Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects
Irene Barrett, Miriam Carr, Niamh O’Boyle, Lisa M. Greene, Andrew J. S. Knox, David G. Lloyd, Daniela M. Zisterer & Mary J. Meegan
Pages: 180-194
Published online: 11 Mar 2010
AbstractforLead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects | Full Text | References | PDF (960 KB)
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Article
Prediction of acute toxicity in fish by using QSAR methods and chemical modes of action
Sylvain Lozano, Elodie Lescot, Marie-Pierre Halm, Alban Lepailleur, Ronan Bureau & Sylvain Rault
Pages: 195-203
Published online: 29 Oct 2009
AbstractforPrediction of acute toxicity in fish by using QSAR methods and chemical modes of action | Full Text | References | PDF (1.6 MB)
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Article
Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II
Vanessa Desplat, Stephane Moreau, Aurore Gay, Solene Belisle Fabre, Denis Thiolat, Stephane Massip, Gregory Macky, Frederic Godde, Djavad Mossalayi, Christian Jarry & Jean Guillon
Pages: 204-215
Published online: 11 Mar 2010
AbstractforSynthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II | Full Text | References | PDF (850.7 KB)
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Article
Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes
Pascal Rouge, Viviane Silva Pires, François Gaboriau, Alexandra Dassonville-Klimpt, Jean Guillon, Sophie Da Nascimento, Jean-Michel Leger, Gerard Lescoat & Pascal Sonnet
Pages: 216-227
Published online: 02 Nov 2009
AbstractforAntiproliferative effect on HepaRG cell cultures of new calix[4]arenes | Full Text | References | PDF (1 MB)
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Article
Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells
Ruben F. Tchokouaha, Xanthippi Alexi, Elizabeth Chosson, Thierry Besson, Alexios-Leandros Skaltsounis, Elisabeth Seguin, Michael N. Alexis & Jean Wandji
Pages: 228-233
Published online: 29 Oct 2009
AbstractforErymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells | Full Text | References | PDF (623 KB)
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Article
A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease
Andreas Gratz, Claudia Götz & Joachim Jose
Pages: 234-239
Published online: 29 Oct 2009
AbstractforA FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease | Full Text | References | PDF (726.4 KB)
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Research Articles (Regular)

Article
3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors
Xiaoyun Lu, Yadong Chen & Qidong You
Pages: 240-249
Published online: 07 Dec 2009
Abstractfor3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors | Full Text | References | PDF (1.3 MB)
  • 610 Views
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Article
Human polymerase α inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives
Monika Höltje, Anja Richartz, Barbara Zdrazil, Anja Schwanke, Branislav Dugovic, Caterina Murruzzu, Hans-Ulrich Reißig, Hans Christian Korting, Burkhard Kleuser, Hans-Dieter Höltje & Monika Schäfer-Korting
Pages: 250-265
Published online: 11 Mar 2010
AbstractforHuman polymerase α inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives | Full Text | References | PDF (1.3 MB)
  • 591 Views
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Article
Synthesis and biological evaluation of some novel 6-aryl-2-(p-sulfamylphenyl)-4,5-dihydropyridazin-3(2H)-ones as anti-cancer, antimicrobial, and anti-inflammatory agents
Shamim Ahmad, I. G. Rathish, Sameena Bano, M. S. Alam & Kalim Javed
Pages: 266-271
Published online: 29 Dec 2009
AbstractforSynthesis and biological evaluation of some novel 6-aryl-2-(p-sulfamylphenyl)-4,5-dihydropyridazin-3(2H)-ones as anti-cancer, antimicrobial, and anti-inflammatory agents | Full Text | References | PDF (659.8 KB)
  • 714 Views
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Article
Potent inhibitory effects of benzyl and p-xylidine-bis dithiocarbamate sodium salts on activities of mushroom tyrosinase
E. Amin, A. A. Saboury, H. Mansuri-Torshizi & A. A. Moosavi-Movahedi
Pages: 272-281
Published online: 11 Mar 2010
AbstractforPotent inhibitory effects of benzyl and p-xylidine-bis dithiocarbamate sodium salts on activities of mushroom tyrosinase | Full Text | References | PDF (1.2 MB)
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Article
The effect of substituted thiophene and benzothiophene derivates on PPARγ expression and glucose metabolism
Huayi Shao, Dong Li, Yi Yang, Hui-Fang Guo, Zong-Ying Liu, Shu-Yi Si, Ze Yang & Zhuo-Rong Li
Pages: 282-289
Published online: 11 Mar 2010
AbstractforThe effect of substituted thiophene and benzothiophene derivates on PPARγ expression and glucose metabolism | Full Text | References | PDF (1.7 MB)
  • 679 Views
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Article
Inhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells
Xue-Bing Sun, Jiong Zhao, Xiao-Feng Ma & Wei-Xi Tian
Pages: 290-295
Published online: 29 Oct 2009
AbstractforInhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells | Full Text | References | PDF (1,019.9 KB)
  • 537 Views
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Article
Urease inhibitors from Hypericum oblongifolium WALL.
Mohammad Arfan, Mumtaz Ali, Habib Ahmad, Itrat Anis, Ajmal Khan, M. Iqbal Choudhary & Muhammad Raza Shah
Pages: 296-299
Published online: 11 Mar 2010
AbstractforUrease inhibitors from Hypericum oblongifolium WALL. | Full Text | References | PDF (654.5 KB)
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