Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 4 (2014)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 4 (2014)

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Original Article

Article
New spiroindolinones bearing 5-chlorobenzothiazole moiety
Görkem Ermut, Nilgün Karalı, Nurten Özsoy & Ayşe Can
Pages: 457-468
Published online: 05 Jun 2013
AbstractforNew spiroindolinones bearing 5-chlorobenzothiazole moiety | Full Text | References | PDF (1.8 MB)
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Research Article

Article
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies
Serdar Durdagi, Gabriele Scozzafava, Daniela Vullo, Hüseyin Sahin, Sevgi Kolayli & Claudiu T. Supuran
Pages: 469-475
Published online: 05 Aug 2013
AbstractforInhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies | Full Text | References | PDF (1.4 MB)
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Article
Dual evaluation of some novel 2-amino-substituted coumarinylthiazoles as anti-inflammatory–antimicrobial agents and their docking studies with COX-1/COX-2 active sites
Navneet Chandak, Pawan Kumar, Pawan Kaushik, Parul Varshney, Chetan Sharma, Dhirender Kaushik, Sudha Jain, Kamal R. Aneja & Pawan K. Sharma
Pages: 476-484
Published online: 19 Jun 2013
AbstractforDual evaluation of some novel 2-amino-substituted coumarinylthiazoles as anti-inflammatory–antimicrobial agents and their docking studies with COX-1/COX-2 active sites | Full Text | References | PDF (1 MB) | Supplemental
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Article
A thermostable trypsin inhibitor with antiproliferative activity from small pinto beans
Yau Sang Chan, Yanbo Zhang, Stephen Cho Wing Sze & Tzi Bun Ng
Pages: 485-490
Published online: 16 Jul 2013
AbstractforA thermostable trypsin inhibitor with antiproliferative activity from small pinto beans | Full Text | References | PDF (431.1 KB)
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Article
Glutathione reductase activity with an oxidized methylated glutathione analog
Brant L. Kedrowski, Jonathan H. Gutow, Gorman Stock, Maureen Smith, Chondrea Jordan & Douglas S. Masterson
Pages: 491-494
Published online: 01 Jul 2013
AbstractforGlutathione reductase activity with an oxidized methylated glutathione analog | Full Text | References | PDF (659.2 KB)
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Article
Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase
Sinan Bilginer, Elif Unluer, Halise Inci Gul, Ebru Mete, Semra Isik, Daniela Vullo, Ozen Ozensoy-Guler, Serap Beyaztas, Clemente Capasso & Claudiu T. Supuran
Pages: 495-499
Published online: 01 Jul 2013
AbstractforCarbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase | Full Text | References | PDF (405.8 KB)
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Article
Biochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) “Kuntze”
Nina A. Dathan, Vincenzo Alterio, Elisa Troiano, Daniela Vullo, Martha Ludwig, Giuseppina De Simone, Claudiu T. Supuran & Simona M. Monti
Pages: 500-504
Published online: 29 Jul 2013
AbstractforBiochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) “Kuntze” | Full Text | References | PDF (685.6 KB)
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Article
Design and synthesis of (5-amino-1, 2, 4-triazin-6-yl)(2-(benzo[d] isoxazol-3-yl) pyrrolidin-1-yl)methanone derivatives as sodium channel blocker and anticonvulsant agents
Sachin Malik & Suroor A. Khan
Pages: 505-516
Published online: 05 Aug 2013
AbstractforDesign and synthesis of (5-amino-1, 2, 4-triazin-6-yl)(2-(benzo[d] isoxazol-3-yl) pyrrolidin-1-yl)methanone derivatives as sodium channel blocker and anticonvulsant agents | Full Text | References | PDF (461 KB)
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Article
Metal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity
Muhammad Hanif, Zahid H. Chohan, Jean-Yves Winum & Javeed Akhtar
Pages: 517-526
Published online: 05 Aug 2013
AbstractforMetal-based carboxamide-derived compounds endowed with antibacterial and antifungal activity | Full Text | References | PDF (659.7 KB)
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Article
Human thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel
Plínio Cunha Sathler, Marcos Santana, André Luiz Lourenço, Carlos Rangel Rodrigues, Paula Abreu, Lúcio Mendes Cabral & Helena Carla Castro
Pages: 527-531
Published online: 05 Aug 2013
AbstractforHuman thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel | Full Text | References | PDF (674.3 KB)
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Article
Biochemical characterization of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA
Sonia Del Prete, Viviana De Luca, Daniela Vullo, Andrea Scozzafava, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso
Pages: 532-537
Published online: 05 Aug 2013
AbstractforBiochemical characterization of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA | Full Text | References | PDF (344.1 KB)
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Article
Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells
Ju-Ying Tsai, Mon-Juan Lee, Margaret Dah-Tsyr Chang, Hsin-Chieh Wang, Chun-Cheng Lin & Haimei Huang
Pages: 538-546
Published online: 01 Oct 2013
AbstractforEffects of novel human cathepsin S inhibitors on cell migration in human cancer cells | Full Text | References | PDF (1.6 MB) | Supplemental
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Short Communication

Article
Identification and structure–activity relationship study of carvacrol derivatives as Mycobacterium tuberculosis chorismate mutase inhibitors
Reshma Alokam, Variam Ullas Jeankumar, Jonnalagadda Padma Sridevi, Siddharth Sai Matikonda, Santosh Peddi, Mallika Alvala, Perumal Yogeeswari & Dharmarajan Sriram
Pages: 547-554
Published online: 03 Oct 2013
AbstractforIdentification and structure–activity relationship study of carvacrol derivatives as Mycobacterium tuberculosis chorismate mutase inhibitors | Full Text | References | PDF (1.3 MB)
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Original Article

Article
Quinolone-based HDAC inhibitors
Gopalan Balasubramanian, Narasimhan Kilambi, Suresh Rathinasamy, Praveen Rajendran, Shridhar Narayanan & Sridharan Rajagopal
Pages: 555-562
Published online: 09 Sep 2013
AbstractforQuinolone-based HDAC inhibitors | Full Text | References | PDF (1.9 MB)
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Research Article

Article
Sarcoplasmic reticulum Ca2+-ATPase from rabbit skeletal muscle modified by peroxynitrite
Petronela Žižková, Jana Viskupičová, Dušan Blaškovič, Miriam K. Štrosová, Neven Žarkovič & Ľubica Horáková
Pages: 563-570
Published online: 03 Oct 2013
AbstractforSarcoplasmic reticulum Ca2+-ATPase from rabbit skeletal muscle modified by peroxynitrite | Full Text | References | PDF (709.1 KB)
  • 693 Views
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Article
A systematic quantitative approach to rational drug design and discovery of novel human carbonic anhydrase IX inhibitors
Kalyan K. Sethi & Saurabh M. Verma
Pages: 571-581
Published online: 03 Oct 2013
AbstractforA systematic quantitative approach to rational drug design and discovery of novel human carbonic anhydrase IX inhibitors | Full Text | References | PDF (2.5 MB)
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Article
Discovery of a series of hydroximic acid derivatives as potent histone deacetylase inhibitors
Lei Zhang, Xuejian Wang, Xiaoguang Li, Lihui Zhang & Wenfang Xu
Pages: 582-589
Published online: 23 Sep 2013
AbstractforDiscovery of a series of hydroximic acid derivatives as potent histone deacetylase inhibitors | Full Text | References | PDF (1.9 MB)
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Article
Quantitative insights towards the design of potent deazaxanthine antagonists of adenosine 2B receptors
Odailson Santos Paz, Camila Carane Bitencourt Brito & Marcelo Santos Castilho
Pages: 590-598
Published online: 03 Oct 2013
AbstractforQuantitative insights towards the design of potent deazaxanthine antagonists of adenosine 2B receptors | Full Text | References | PDF (925.5 KB) | Supplemental
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Article
PLS and shape-based similarity analysis of maleimides – GSK-3 inhibitors
Luminita Crisan, Liliana Pacureanu, Sorin Avram, Alina Bora, Speranta Avram & Ludovic Kurunczi
Pages: 599-610
Published online: 19 Sep 2013
AbstractforPLS and shape-based similarity analysis of maleimides – GSK-3 inhibitors | Full Text | References | PDF (1.9 MB) | Supplemental
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