Journal of Drug Assessment, Volume 2, Issue 1 (2013)

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Journal of Drug Assessment, Volume 2, Issue 1 (2013)

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Original Article

Article
Aliskiren/amlodipine as a single-pill combination in hypertensive patients: subgroup analysis of elderly patients, with metabolic risk factors or high body mass index
Christoph Axthelm, Christian Sieder, Franziska Meister, David Pittrow & Edelgard Kaiser
Pages: 1-10
Published online: 25 Dec 2012
AbstractforAliskiren/amlodipine as a single-pill combination in hypertensive patients: subgroup analysis of elderly patients, with metabolic risk factors or high body mass index | Full Text | References | PDF (836.1 KB)
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Open Access
Article
Delivery characteristics of a low-resistance dry-powder inhaler used to deliver the long-acting muscarinic antagonist glycopyrronium
Paul Colthorpe, Thomas Voshaar, Thomas Kieckbusch, Erika Cuoghi & Juergen Jauernig
Pages: 11-16
Published online: 01 Feb 2013
AbstractforDelivery characteristics of a low-resistance dry-powder inhaler used to deliver the long-acting muscarinic antagonist glycopyrronium | Full Text | References | PDF (206.2 KB)
  • 4887 Views
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Open Access
Article
Metabolism of the prodrug lisdexamfetamine dimesylate in human red blood cells from normal and sickle cell disease donors
Michael Pennick
Pages: 17-20
Published online: 13 Feb 2013
AbstractforMetabolism of the prodrug lisdexamfetamine dimesylate in human red blood cells from normal and sickle cell disease donors | Full Text | References | PDF (139.9 KB)
  • 2207 Views
  • 13 CrossRef citations
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Open Access
Article
Bioequivalence study of two subcutaneous formulations of dalteparin: randomized, single-dose, two-sequence, two-period, cross-over study in healthy volunteers
C. Gadiko, S. K. Tippabhotla, S. Thota, M. Nakkawar, R. Cheerla, M.R. Betha & V. Vobalaboina
Pages: 21-29
Published online: 04 Mar 2013
AbstractforBioequivalence study of two subcutaneous formulations of dalteparin: randomized, single-dose, two-sequence, two-period, cross-over study in healthy volunteers | Full Text | References | PDF (263.9 KB)
  • 2398 Views
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Open Access
Article
Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers
Renli Teng & Kathleen Butler
Pages: 30-39
Published online: 15 Mar 2013
AbstractforEffect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers | Full Text | References | PDF (291.9 KB)
  • 1898 Views
  • 27 CrossRef citations
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Open Access
Article
Safety, tolerability, pharmacokinetics and pharmacodynamics of belimumab in Japanese patients with mild-to-moderate systemic lupus erythematosus
Masanori Yamada, Mikio Akita, Tomofumi Nakagawa, Naoki Takahashi, Akira Endo & Pascal Yoshida
Pages: 40-48
Published online: 12 Apr 2013
AbstractforSafety, tolerability, pharmacokinetics and pharmacodynamics of belimumab in Japanese patients with mild-to-moderate systemic lupus erythematosus | Full Text | References | PDF (255.9 KB)
  • 1197 Views
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Open Access

Brief report

Brief Report
Effects of add-on montelukast on airway hyperresponsiveness in patients with well-controlled asthma – a pilot study
Nina Kononowa, Sandra Michel, David Miedinger, Christiane E. Pichler, Prashant N. Chhajed, Arthur Helbling & Jörg D. Leuppi
Pages: 49-57
Published online: 02 Apr 2013
AbstractforEffects of add-on montelukast on airway hyperresponsiveness in patients with well-controlled asthma – a pilot study | Full Text | References | PDF (111.1 KB)
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Open Access

Original Article

Article
Effects of dalfampridine and its metabolites on cloned human potassium channels Kv 1.1, Kv 1.2, and Kv 1.4 expressed in human embryonic kidney cells
Anthony Caggiano, Andrew Blight & Tom J. Parry
Pages: 58-66
Published online: 02 Apr 2013
AbstractforEffects of dalfampridine and its metabolites on cloned human potassium channels Kv 1.1, Kv 1.2, and Kv 1.4 expressed in human embryonic kidney cells | Full Text | References | PDF (258.8 KB)
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Open Access

Editorial

Editorial
Single-pill combinations: a therapeutic option or necessity for vascular risk treatment?
Niki Katsiki, Vasilios G. Athyros & Asterios Karagiannis
Pages: 67-71
Published online: 07 May 2013
First Page PreviewforSingle-pill combinations: a therapeutic option or necessity for vascular risk treatment? | Full Text | References | PDF (90.5 KB)
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Open Access

Original Article

Article
Identification of metabolites of dalfampridine (4-aminopyridine) in dog and rat
Anthony Caggiano, Andrew Blight & Tom J. Parry
Pages: 72-80
Published online: 12 Apr 2013
AbstractforIdentification of metabolites of dalfampridine (4-aminopyridine) in dog and rat | Full Text | References | PDF (452.9 KB)
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Open Access

Abbreviated research report

Article
Impact of clinical pharmacist collaboration in patients beginning insulin pump therapy: a retrospective and cross-sectional analysis
James L. Ledford, Rick Hess & Frank P. Johnson
Pages: 81-86
Published online: 19 Jun 2013
AbstractforImpact of clinical pharmacist collaboration in patients beginning insulin pump therapy: a retrospective and cross-sectional analysis | Full Text | References | PDF (135.4 KB)
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Open Access

Original Article

Article
Pharmacokinetics, safety, and tolerability following single-dose migalastat hydrochloride (GR181413A/AT1001) in healthy male Japanese subjects
Hiroko Ino, Naoki Takahashi, Takumi Terao, Paul N. Mudd Jr & Toshiyasu Hirama
Pages: 87-93
Published online: 24 Jul 2013
AbstractforPharmacokinetics, safety, and tolerability following single-dose migalastat hydrochloride (GR181413A/AT1001) in healthy male Japanese subjects | Full Text | References | PDF (157.3 KB)
  • 1005 Views
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Open Access
Article
Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber
Kazuhiro Hashiguchi, Sho Kanzaki, Ken-ichiro Wakabayashi, Nobuaki Tanaka, Kayoko Kawashima, Kiyochika Suematsu, Shoji Tokunaga, Kaoru Ogawa & Kimihiro Okubo
Pages: 94-105
Published online: 26 Jul 2013
AbstractforEfficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber | Full Text | References | PDF (420.9 KB)
  • 1689 Views
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Open Access
Article
In vitro evaluation of the effects of 4-aminopyridine on cytochrome P450 enzymes
Anthony Caggiano & Andrew Blight
Pages: 106-116
Published online: 26 Jun 2013
AbstractforIn vitro evaluation of the effects of 4-aminopyridine on cytochrome P450 enzymes | Full Text | References | PDF (428.7 KB)
  • 934 Views
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Open Access
Article
Identification of metabolites of dalfampridine (4-aminopyridine) in human subjects and reaction phenotyping of relevant cytochrome P450 pathways
Anthony Caggiano & Andrew Blight
Pages: 117-126
Published online: 14 Aug 2013
AbstractforIdentification of metabolites of dalfampridine (4-aminopyridine) in human subjects and reaction phenotyping of relevant cytochrome P450 pathways | Full Text | References | PDF (333.1 KB)
  • 1163 Views
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Open Access
Article
Randomized placebo-controlled study of intravenous methylnaltrexone in postoperative ileus
Eugene R. Viscusi, James P. Rathmell, Alessandro Fichera, Sander R. Binderow, Robert J. Israel, Frank L. Galasso, Darryl Penenberg & Tong J. Gan
Pages: 127-134
Published online: 27 Aug 2013
AbstractforRandomized placebo-controlled study of intravenous methylnaltrexone in postoperative ileus | Full Text | References | PDF (223.6 KB)
  • 1378 Views
  • 17 CrossRef citations
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Open Access
Article
Individual and population pharmacokinetic compartment analysis: a graphic procedure for quantification of predictive performance
Staffan Eksborg
Pages: 135-140
Published online: 03 Sep 2013
AbstractforIndividual and population pharmacokinetic compartment analysis: a graphic procedure for quantification of predictive performance | Full Text | References | PDF (177 KB)
  • 936 Views
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Open Access

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