Modern Rheumatology, Volume 31, Issue 1 (2021)

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Modern Rheumatology, Volume 31, Issue 1 (2021)

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Review Articles: Drug Approval Reports

Review Article
Anifrolumab, a monoclonal antibody to the type I interferon receptor subunit 1, for the treatment of systemic lupus erythematosus: an overview from clinical trials
Yoshiya Tanaka & Raj Tummala
Pages: 1-12
Published online: 17 Sep 2020
AbstractforAnifrolumab, a monoclonal antibody to the type I interferon receptor subunit 1, for the treatment of systemic lupus erythematosus: an overview from clinical trials | Full Text | References | PDF (1.2 MB) | EPUB
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Open Access
Article
Progressive fibrosing interstitial lung diseases: A new concept and indication of nintedanib
Shigeki Makino
Pages: 13-19
Published online: 21 Dec 2020
AbstractforProgressive fibrosing interstitial lung diseases: A new concept and indication of nintedanib | Full Text | References | PDF (699.1 KB) | EPUB
  • 6162 Views
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Open Access
Review Article
Which is the best SLE activity index for clinical trials?
Koichiro Ohmura
Pages: 20-28
Published online: 16 Jun 2020
AbstractforWhich is the best SLE activity index for clinical trials? | Full Text | References | PDF (979.6 KB) | EPUB
  • 16805 Views
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Open Access

Original Articles: Special Article

Article
2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases
Yoshiya Tanaka, Masataka Kuwana, Takao Fujii, Hideto Kameda, Yoshinao Muro, Keishi Fujio, Yasuhiko Itoh, Hidekata Yasuoka, Shusaku Fukaya, Konomi Ashihara, Daisuke Hirano, Koichiro Ohmura, Yuya Tabuchi, Hisanori Hasegawa, Ryo Matsumiya, Yuichiro Shirai, Takehisa Ogura, Yumi Tsuchida, Mariko Ogawa-Momohara, Hidehiko Narazaki, Yoshino Inoue, Ippei Miyagawa, Kazuhisa Nakano, Shintaro Hirata & Masaaki Mori
Pages: 29-33
Published online: 07 Jan 2020
Abstractfor2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases | Full Text | References | PDF (551.8 KB) | EPUB
  • 6792 Views
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Open Access

Rheumatoid Arthritis

Article
Predictors of new bone erosion in rheumatoid arthritis patients receiving conventional synthetic disease-modifying antirheumatic drugs: Analysis of data from the DRIVE and DESIRABLE studies
Tsutomu Takeuchi, Satoshi Soen, Naoki Ishiguro, Hisashi Yamanaka, Sakae Tanaka, Makiko Kobayashi, Naoki Okubo, Takaya Nitta & Yoshiya Tanaka
Pages: 34-41
Published online: 09 Jan 2020
AbstractforPredictors of new bone erosion in rheumatoid arthritis patients receiving conventional synthetic disease-modifying antirheumatic drugs: Analysis of data from the DRIVE and DESIRABLE studies | Full Text | References | PDF (1 MB) | EPUB
  • 2336 Views
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Open Access
Article
Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study
Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda & Hitoshi Kohsaka
Pages: 42-52
Published online: 20 Jan 2020
AbstractforResponse to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 459 Views
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Article
A phase 2a, randomized, double-blind, placebo-controlled trial of the efficacy and safety of the oral gonadotropin-releasing hormone antagonist, ASP1707, in postmenopausal female patients with rheumatoid arthritis taking methotrexate
Tsutomu Takeuchi, Yoshiya Tanaka, Chieri Higashitani, Megumi Iwai, Kanji Komatsu, Rio Akazawa & Christopher Lademacher
Pages: 53-60
Published online: 03 Mar 2020
AbstractforA phase 2a, randomized, double-blind, placebo-controlled trial of the efficacy and safety of the oral gonadotropin-releasing hormone antagonist, ASP1707, in postmenopausal female patients with rheumatoid arthritis taking methotrexate | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1294 Views
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Open Access
Article
Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis
Yuko Kaneko, Yutaka Kawahito, Masayo Kojima, Takeo Nakayama, Shintaro Hirata, Mitsumasa Kishimoto, Hirahito Endo, Yohei Seto, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Toshihisa Kojima, Naoyuki Kamatani, Kiichiro Tsutani, Ataru Igarashi, Mieko Hasegawa, Nobuyuki Miyasaka & Hisashi Yamanaka
Pages: 61-69
Published online: 30 Jan 2020
AbstractforEfficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 406 Views
  • 6 CrossRef citations
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Article
Tocilizumab, an anti-interleukin-6 receptor antibody, efficiently ameliorates persistent joint inflammation in rheumatoid arthritis
Yasuhiko Hirabayashi
Pages: 70-79
Published online: 18 May 2020
AbstractforTocilizumab, an anti-interleukin-6 receptor antibody, efficiently ameliorates persistent joint inflammation in rheumatoid arthritis | Full Text | References | PDF (1.1 MB) | EPUB
  • 1228 Views
  • 2 CrossRef citations
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Open Access
Article
Efficacy of add-on iguratimod in patients with rheumatoid arthritis who inadequately respond to either tocilizumab or tumor necrosis factor alpha inhibitors
Kyosuke Hattori, Yuji Hirano, Yasuhide Kanayama, Yosuke Hattori, Takefumi Kato, Nobunori Takahashi, Naoki Ishiguro & Toshihisa Kojima
Pages: 80-87
Published online: 19 Mar 2020
AbstractforEfficacy of add-on iguratimod in patients with rheumatoid arthritis who inadequately respond to either tocilizumab or tumor necrosis factor alpha inhibitors | Full Text | References | PDF (991.7 KB) | EPUB
  • 367 Views
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Article
Distinct decrease in peripheral lymphocytes in EBER-positive cases of MTX-LPD
Masahiro Kondo, Yohko Murakawa, Mayuko Moriyama, Manabu Honda, Tomoko Sugiura, Keiichi Onoda, Yohei Watanabe & Hiroyuki Kakimaru
Pages: 88-93
Published online: 03 Mar 2020
AbstractforDistinct decrease in peripheral lymphocytes in EBER-positive cases of MTX-LPD | Full Text | References | PDF (816.9 KB) | EPUB
  • 224 Views
  • 2 CrossRef citations
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Article
Clinical aspects in patients with rheumatoid arthritis complicated with lymphoproliferative disorders without regression after methotrexate withdrawal and treatment for arthritis after regression of lymphoproliferative disorders
Kazuhisa Nakano, Kazuyoshi Saito, Aya Nawata, Kentaro Hanami, Satoshi Kubo, Ippei Miyagawa, Yoshihisa Fujino, Shingo Nakayamada & Yoshiya Tanaka
Pages: 94-100
Published online: 27 Mar 2020
AbstractforClinical aspects in patients with rheumatoid arthritis complicated with lymphoproliferative disorders without regression after methotrexate withdrawal and treatment for arthritis after regression of lymphoproliferative disorders | Full Text | References | PDF (894.1 KB) | EPUB | Supplemental
  • 551 Views
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Article
Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study
Yasumori Sobue, Toshihisa Kojima, Koji Funahashi, Nobuyuki Okui, Nobunori Takahashi, Shuji Asai, Kenya Terabe, Tsuyoshi Nishiume, Mochihito Suzuki, Yutaka Yokota, Yoshifumi Ohashi & Naoki Ishiguro
Pages: 101-107
Published online: 30 Mar 2020
AbstractforRelationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study | Full Text | References | PDF (995.1 KB) | EPUB
  • 182 Views
  • 4 CrossRef citations
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Article
Usefulness of daily folic acid supplementation during methotrexate treatment of Japanese patients with rheumatoid arthritis
Keiichi Sasaki, Toshikazu Tsuji, Yasutaka Kimoto, Yuki Yanagihara, Ken Masuguchi, Ayako Chikamori, Hiroyuki Watanabe, Tesshin Murakami, Daisuke Oryoji, Masafumi Hashimoto, Takahiko Horiuchi & Nobuaki Egashira
Pages: 108-113
Published online: 30 Mar 2020
AbstractforUsefulness of daily folic acid supplementation during methotrexate treatment of Japanese patients with rheumatoid arthritis | Full Text | References | PDF (818.4 KB) | EPUB
  • 353 Views
  • 4 CrossRef citations
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Article
Arthrodesis of the digital joint using intraosseous wiring in patients with rheumatoid arthritis
Yumi Nomura, Hajime Ishikawa, Asami Abe, Hiroshi Otani, Satoshi Ito, Kiyoshi Nakazono & Akira Murasawa
Pages: 114-118
Published online: 30 Mar 2020
AbstractforArthrodesis of the digital joint using intraosseous wiring in patients with rheumatoid arthritis | Full Text | References | PDF (883.9 KB) | EPUB
  • 152 Views
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Article
Renin–angiotensin system molecules are associated with subclinical atherosclerosis and disease activity in rheumatoid arthritis
Nayara Felicidade Tomaz Braz, Maria Raquel C. Pinto, Érica Leandro Marciano Vieira, Adriano J. Souza, Antonio Lucio Teixeira, Ana C. Simões-e-Silva & Adriana Maria Kakehasi
Pages: 119-126
Published online: 30 Mar 2020
AbstractforRenin–angiotensin system molecules are associated with subclinical atherosclerosis and disease activity in rheumatoid arthritis | Full Text | References | PDF (995.4 KB) | EPUB
  • 132 Views
  • 14 CrossRef citations
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Article
Decreased peripheral blood memory B cells are associated with the presence of interstitial lung disease in rheumatoid arthritis: a case-control study
Toshiaki Shimizu, Yasuo Nagafuchi, Hiroaki Harada, Yumi Tsuchida, Haruka Tsuchiya, Norio Hanata, Shoko Tateishi, Hiroko Kanda, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto & Keishi Fujio
Pages: 127-132
Published online: 05 Feb 2020
AbstractforDecreased peripheral blood memory B cells are associated with the presence of interstitial lung disease in rheumatoid arthritis: a case-control study | Full Text | References | PDF (869.6 KB) | EPUB
  • 210 Views
  • 4 CrossRef citations
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Article
Comparative study of HO-1 expressing synovial lining cells between RA and OA
Suran Yang, Rintaro Ohe, Naing Ye Aung, Tomoya Kato, Takanobu Kabasawa, Aya Utsunomiya, Yuya Takakubo, Michiaki Takagi & Mitsunori Yamakawa
Pages: 133-140
Published online: 22 Jan 2020
AbstractforComparative study of HO-1 expressing synovial lining cells between RA and OA | Full Text | References | PDF (1.9 MB) | EPUB
  • 111 Views
  • 3 CrossRef citations
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Connective Tissue Diseases and Related Disorders

Article
Nintedanib in patients with systemic sclerosis-associated interstitial lung disease: A Japanese population analysis of the SENSCIS trial
Masataka Kuwana, Takashi Ogura, Shigeki Makino, Sakae Homma, Yasuhiro Kondoh, Aiko Saito, Hiroyuki Ugai, Martina Gahlemann, Kazuhiko Takehara & Arata Azuma
Pages: 141-150
Published online: 23 Apr 2020
AbstractforNintedanib in patients with systemic sclerosis-associated interstitial lung disease: A Japanese population analysis of the SENSCIS trial | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 4192 Views
  • 12 CrossRef citations
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Open Access
Article
The effects of oral treatment for systemic sclerosis related pulmonary arterial hypertension: A systematic review and meta-analysis
Yunxia Lei, Xiao Zhang, Haobo Lin, Yuan Feng, Jieying Wang & Riqiang Luo
Pages: 151-161
Published online: 04 Jan 2020
AbstractforThe effects of oral treatment for systemic sclerosis related pulmonary arterial hypertension: A systematic review and meta-analysis | Full Text | References | PDF (2.7 MB) | EPUB
  • 289 Views
  • 5 CrossRef citations
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Article
Clinical course of Japanese patients with early systemic sclerosis: A multicenter, prospective, observational study
Akira Utsunomiya, Minoru Hasegawa, Noritaka Oyama, Yoshihide Asano, Hirahito Endo, Manabu Fujimoto, Daisuke Goto, Osamu Ishikawa, Yasushi Kawaguchi, Masataka Kuwana, Fumihide Ogawa, Hiroki Takahashi, Sumiaki Tanaka, Shinichi Sato, Kazuhiko Takehara & Hironobu Ihn
Pages: 162-170
Published online: 21 Apr 2020
AbstractforClinical course of Japanese patients with early systemic sclerosis: A multicenter, prospective, observational study | Full Text | References | PDF (2 MB) | EPUB
  • 340 Views
  • 3 CrossRef citations
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Article
Up-regulation of IGF-1, RANTES and VEGF in patients with anti-centromere antibody-positive early/mild systemic sclerosis
Kayoko Tabata, Naoya Mikita, Misaki Yasutake, Ryo Matsumiya, Katsunori Tanaka, Sayaka Tani, Hisako Okuhira, Masatoshi Jinnin & Takao Fujii
Pages: 171-176
Published online: 17 Feb 2020
AbstractforUp-regulation of IGF-1, RANTES and VEGF in patients with anti-centromere antibody-positive early/mild systemic sclerosis | Full Text | References | PDF (1.1 MB) | EPUB
  • 208 Views
  • 4 CrossRef citations
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Article
Clinical features of dermatomyositis associated with anti-MDA5 antibodies by age
Koichi Yamaguchi, Aya Yamaguchi, Yuji Onuki, Miki Itai, Chiharu Kashiwagi, Kazutaka Takehara, Shuhei Aoki, Azusa Kanaya, Kohei Taguchi, Kazue Umetsu, Kazuma Oshima, Megumi Uchida, Hayato Kimura, Morimitsu Kasahara, Masao Takemura, Kenichiro Hara, Akiko Sekiguchi, Sei-ichiro Motegi, Yoshinao Muro, Masao Nakasatomi, Rena Motohashi, Toru Sakairi, Junichi Nakagawa, Keiju Hiromura, Masaru Obokata, Masahiko Kurabayashi & Toshitaka Maeno
Pages: 177-185
Published online: 30 Mar 2020
AbstractforClinical features of dermatomyositis associated with anti-MDA5 antibodies by age | Full Text | References | PDF (808.4 KB) | EPUB
  • 433 Views
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Article
Human umbilical cord mesenchymal stem cells confer potent immunosuppressive effects in Sjögren’s syndrome by inducing regulatory T cells
Yanying Liu, Chunlei Li, Shiyao Wang, Jing Guo, Jianping Guo, Jiangnan Fu, Limin Ren, Yuan An, Jing He & Zhanguo Li
Pages: 186-196
Published online: 07 Jan 2020
AbstractforHuman umbilical cord mesenchymal stem cells confer potent immunosuppressive effects in Sjögren’s syndrome by inducing regulatory T cells | Full Text | References | PDF (2.3 MB) | EPUB
  • 252 Views
  • 20 CrossRef citations
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Article
Efficacy and safety of tocilizumab in treatment of Takayasu arteritis: A systematic review of randomized controlled trials
Ambrish Singh, Debashish Danda, Salman Hussain, Abul Kalam Najmi, Ashish Mathew, Ruchika Goel, Shaheen E. Lakhan, Belzik Tajudheen & Benny Antony
Pages: 197-204
Published online: 13 Feb 2020
AbstractforEfficacy and safety of tocilizumab in treatment of Takayasu arteritis: A systematic review of randomized controlled trials | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 629 Views
  • 10 CrossRef citations
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Article
Rationale of concomitant cyclophosphamide for remission-induction in patients with antineutrophil cytoplasmic antibody-associated vasculitis: A propensity score-matched analysis of two nationwide prospective cohort studies
Haruki Watanabe, Ken-Ei Sada, Yoshinori Matsumoto, Masayoshi Harigai, Koichi Amano, Shouichi Fujimoto, Hiroaki Dobashi, Yukio Yuzawa, Kunihiro Yamagata, Eri Muso, Yoshihiro Arimura, Hirofumi Makino & on behalf of Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis Syndrome (JPVAS)
Pages: 205-213
Published online: 06 Jan 2020
AbstractforRationale of concomitant cyclophosphamide for remission-induction in patients with antineutrophil cytoplasmic antibody-associated vasculitis: A propensity score-matched analysis of two nationwide prospective cohort studies | Full Text | References | PDF (1.3 MB) | EPUB
  • 210 Views
  • 3 CrossRef citations
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Article
HLA-A26 is a risk factor for Behçet’s disease ocular lesions
Hiroaki Kato, Masaki Takeuchi, Nobuyuki Horita, Takehito Ishido, Ryuta Mizuki, Tatsukata Kawagoe, Etsuko Shibuya, Kentaro Yuda, Mizuho Ishido, Yuki Mizuki, Takahiko Hayashi, Akira Meguro, Yohei Kirino, Kaoru Minegishi, Hiroto Nakano, Ryusuke Yoshimi, Michiko Kurosawa, Takeshi Fukumoto, Mitsuhiro Takeno, Kazuki Hotta, Takeshi Kaneko & Nobuhisa Mizuki
Pages: 214-218
Published online: 04 Jan 2020
AbstractforHLA-A26 is a risk factor for Behçet’s disease ocular lesions | Full Text | References | PDF (765.3 KB) | EPUB
  • 244 Views
  • 7 CrossRef citations
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Article
Age of onset as an influencing factor for disease severity in children with familial Mediterranean fever
Ayşe Tanatar, Şerife Gül Karadağ, Mustafa Çakan, Hafize Emine Sönmez & Nuray Aktay Ayaz
Pages: 219-222
Published online: 30 Jan 2020
AbstractforAge of onset as an influencing factor for disease severity in children with familial Mediterranean fever | Full Text | References | PDF (445.9 KB) | EPUB
  • 148 Views
  • 9 CrossRef citations
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Article
The assessment of tocilizumab therapy on recurrent attacks of patients with familial Mediterranean fever: A retrospective study of 15 patients
Seda Colak, Emre Tekgoz, Muhammet Cinar & Sedat Yilmaz
Pages: 223-225
Published online: 10 Jan 2020
AbstractforThe assessment of tocilizumab therapy on recurrent attacks of patients with familial Mediterranean fever: A retrospective study of 15 patients | Full Text | References | PDF (802.2 KB) | EPUB
  • 217 Views
  • 7 CrossRef citations
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Article
Efficacy and safety of canakinumab in systemic juvenile idiopathic arthritis: 48-week results from an open-label phase III study in Japanese patients
Kenichi Nishimura, Ryoki Hara, Hiroaki Umebayashi, Syuji Takei, Naomi Iwata, Tomoyuki Imagawa, Masaki Shimizu, Minako Tomiita, Noriko Seko, Tetsuji Kitawaki & Shumpei Yokota
Pages: 226-234
Published online: 29 Jul 2020
AbstractforEfficacy and safety of canakinumab in systemic juvenile idiopathic arthritis: 48-week results from an open-label phase III study in Japanese patients | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2024 Views
  • 13 CrossRef citations
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Open Access
Article
Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis
Takafumi Niwamoto, Tomohiro Handa, Shoko Matsui, Hiroshi Yamamoto, Hajime Yoshifuji, Hiroyasu Abe, Hisako Matsumoto, Yuzo Kodama, Tsutomu Chiba, Hiroshi Seno, Tsuneyo Mimori & Toyohiro Hirai
Pages: 235-240
Published online: 04 Jan 2020
AbstractforPhenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis | Full Text | References | PDF (737.1 KB) | EPUB | Supplemental
  • 281 Views
  • 12 CrossRef citations
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Article
Hypocomplementemia is related to elevated serum levels of IgG subclasses other than IgG4 in IgG4-related kidney disease
Yuhei Fujisawa, Ichiro Mizushima, Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Shoko Matsui, Syunsuke Tsuge, Satoshi Hara, Kiyoaki Ito, Hiroshi Fujii, Hiroki Takahashi, Hideki Nomura, Shigeyuki Kawa & Mitsuhiro Kawano
Pages: 241-248
Published online: 13 Jan 2020
AbstractforHypocomplementemia is related to elevated serum levels of IgG subclasses other than IgG4 in IgG4-related kidney disease | Full Text | References | PDF (895.8 KB) | EPUB
  • 215 Views
  • 10 CrossRef citations
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Article
Cytotoxic Tph-like cells are involved in persistent tissue damage in IgG4-related disease
Hayato Yabe, Ryuta Kamekura, Motohisa Yamamoto, Kosuke Murayama, Shiori Kamiya, Ippei Ikegami, Katsunori Shigehara, Hiromi Takaki, Hirofumi Chiba, Hiroki Takahashi, Kenichi Takano, Hiroki Takahashi & Shingo Ichimiya
Pages: 249-260
Published online: 05 Feb 2020
AbstractforCytotoxic Tph-like cells are involved in persistent tissue damage in IgG4-related disease | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 308 Views
  • 14 CrossRef citations
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Article
Real-world treatment of gout and asymptomatic hyperuricemia: A cross-sectional study of Japanese health insurance claims data
Ruriko Koto, Akihiro Nakajima, Hideki Horiuchi & Hisashi Yamanaka
Pages: 261-269
Published online: 20 Jul 2020
AbstractforReal-world treatment of gout and asymptomatic hyperuricemia: A cross-sectional study of Japanese health insurance claims data | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 6203 Views
  • 35 CrossRef citations
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Open Access
Article
Uric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib
Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Takeshi Urano, Makiko Yashiro Furuya, Tomoyuki Asano, Shuzo Sato, Haruki Matsumoto, Hiroshi Watanabe, Hideko Kozuru, Hiroshi Yatsuhashi, Atsushi Kawakami & Kiyoshi Migita
Pages: 270-275
Published online: 30 Mar 2020
AbstractforUric acid-mediated inflammasome activation in IL-6 primed innate immune cells is regulated by baricitinib | Full Text | References | PDF (970.6 KB) | EPUB
  • 199 Views
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Correction

Correction
Correction
Page: 276
Published online: 23 Nov 2020
CitationforCorrection | Full Text | PDF (221.9 KB) | EPUB
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