The regulatory network for the G1/S transition in Saccharomyces cerevisiae promotes the understanding of cancer developmental mechanisms

Abstract

The G1/S transition is crucial for regulating the initiation of cell division and is highly conserved across eukaryotes. This phase of the cell cycle involves intricate transcriptional controls that are essential for understanding cell proliferation dynamics. The G1/S transition integrates diverse intracellular and extracellular signals, including growth factors and cell sizes. Saccharomyces cerevisiae, an important model organism, plays an integral role in unveiling the regulatory mechanisms of the G1/S transition. Recent studies on the G1/S transition in both yeast and vertebrates have demonstrated a direct correlation between dysregulation of the G1/S transition and the development of cancer. This review explores the G1/S transition regulatory network and its association with cancer formation, providing a theoretical foundation for future research in fundamental cell cycle dynamics and cancer.

Keywords:

• Saccharomyces cerevisiae
• cell cycle
• G1/S transition
• cancer

Acknowledgments

The authors are grateful for the support provided by the Central Laboratory of the Affiliated Hospital of Hebei University for this work. The authors would like to thank A&L Scientific Editing (www.alpublish.com) for its linguistic assistance during the preparation of this manuscript.

Authors’ contributions

C.Z. and P.L. contributed equally to this work. Y.Q. and J.Z. conceptualized and organized the manuscript. Z.H. and T.L. reviewed and revised the manuscript. All authors have read and agreed to the published version of the manuscript.

Disclosure statement

The authors declare that they have no competing interests.

Data availability statement

The data that supports the findings of this study are available from the corresponding author upon reasonable request.

Additional information

Funding

This work was supported by the Hebei Provincial Government Funding for Specialist Capacity Building and Junior College Leaders Training Project (Grant number: 361007).