Cellular Choreography: Decoding Life, Death, and Plasticity in the Integrative Systems Biology Era, through Advanced Techniques and Models
Multicellular organisms are a complex tapestry where cellular fate and adaptability are shaped by epigenomic programming and intricate interactions, reflecting both external and internal cues. This adaptability, while offering potential advantages, presents challenges in maintaining cellular fidelity and balancing cell death with pro-survival mechanisms, emphasizing the importance of understanding cellular evolution for therapeutic advancements. Advanced systems biology approaches, using relevant physiological models, are pivotal in unravelling this intricate cellular interplay.
This Article collection presents research articles, and reviews that delve into the intricate world of molecular, cell, and systems biology. The focus is on the holistic approach that integrates single-cell sequencing, long-read sequencing techniques, advanced micro-physiological systems, and cutting-edge imaging.
Guest advisors
Professor Soren Hayrabedyan(Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences)
Dr. Soren Hayrabedyan earned his PhD in Immunology from the Institute of Biology and Immunology of Reproduction (IBIR), BAS, Sofia. He serves as the Director at IBIR and Full Professor in Immunology. His research interests lie in the intersections of reproductive and cancer immunology, particularly focusing on innate immunity signalling and inflammasome dynamics, enhanced by his exploration in multi-dimensional data analysis, imaging, and nanopore sequencing.
Associate Professor Milena Mourdjeva(Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences)
Associate Professor Milena Mourdjeva is a leading scientist in the field of stem cells in Bulgaria. She is a lecturer at the Department of Biology at Sofia University and at the Institute of Biology and Immunology of Reproduction. She has extensive experience in studying mesenchymal stem cells (MSC) and their role in various cellular and biological processes. Her research group has focused on studying the role of MSC in inflammation and regeneration of bones and joint surfaces.