Genistein for glycolipid metabolism in postmenopausal women: a meta-analysis

Abstract

Objective

This study aimed to evaluate the effects of genistein on glycolipid metabolism in postmenopausal women.

Methods

Electronic databases were searched and relevant reports were hand-screened. We included only randomized controlled trials of isolated genistein for glycolipid metabolism. The primary outcome for lipid metabolism included a changed value of low-density lipoprotein cholesterol (LDL-C), and for glucose metabolism was a changed value of homeostasis model assessment for insulin resistance (HOMA-IR). Secondary outcomes included a changed value of total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), fasting blood insulin (INS), and body mass index (BMI).

Results

Ten trials with 11 articles were included. The level of LDL-C was not decreased in the genistein group compared with the placebo group (standardized mean difference [SMD] = −0.58; 95% confidence interval [CI] − 1.19, 0.02; p = 0.06). No statistical significance was found in subgroup analyses. HOMA-IR was obviously improved in the genistein group with SMD of −0.51 (95% CI −0.88, −0.14; p = 0.006). In subgroup analyses, HOMA-IR was improved more in women with BMI <30 kg/m² and without metabolic disorders (p < 0.0001). For secondary outcomes, there were significant differences in total cholesterol, HDL-C, FBG, and INS, but not triglyceride or BMI.

Conclusions

Genistein was effective in ameliorating glycolipid metabolism by increasing HDL-C levels and decreasing total cholesterol levels and improving insulin sensitivity.

摘要

目的：本研究旨在评估染料木黄酮对绝经后妇女糖脂代谢的影响。

方法：检索电子数据库, 手动筛选相关报告。我们只纳入了单独染料木黄酮对糖脂代谢影响的随机对照试验。脂质代谢的主要结局包括低密度脂蛋白胆固醇(LDL-C)的变化, 而糖代谢的主要结局是稳态模型评估的胰岛素抵抗(HOMA-IR)值的变化。次要结局包括总胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、空腹血胰岛素(INS)和体重指数(BMI)的变化。

结果：共纳入10项试验, 11篇文献。染料木黄酮组LDL-C水平与安慰剂组相比无明显降低(标化均数差[SMD]＝-0.58；95%可信区间[CI]-1.19, 0.02；p＝0.06)。亚组分析无统计学意义。染料木异黄酮组HOMA-IR明显改善, SMD为-0.51(95%CI为-0.88, -0.14；p＝0.006)。在亚组分析中, 体重指数<30 kg/m²且无代谢紊乱的女性其HOMA-IR改善更显著(p<0.0001)。对于次要结局, 总胆固醇、HDL-C、FBG和INS有显著差异, 但甘油三酯和BMI没有显著差异。

结论：染料木黄酮通过提高HDL-C水平、降低总胆固醇水平和改善胰岛素敏感性而有效地改善糖脂代谢。

Keywords:

• Genistein
• lipid
• glucose
• metabolism
• meta-analysis

Potential conflict of interest

The authors declare that there are no conflicts of interest.

Source of funding

Nil.