177
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Genistein for glycolipid metabolism in postmenopausal women: a meta-analysis

, &
Pages 267-274 | Received 27 Jun 2020, Accepted 30 Nov 2020, Published online: 07 Jan 2021

References

  • American Heart Association. 2002. Heart diseases and stroke statistics-2003 update. http://www.americanheart.org/downloadable/heart/10590179711482003HDSStatsBookREV7-03.pdf
  • Golden SH, Dobs AS, Vaidya D, et al. Endogenous sex hormones and glucose tolerance status in postmenopausal women. J Clin Endocrinol Metab 2007;92:1289–95
  • Patel TP, Rawal K, Bagchi AK, et al. Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes. Heart Fail Rev 2016;21:11–23
  • Colditz GA, Hankinson SE, Hunter DJ, et al. The use of estrogen and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med 1995;332:1589–93
  • Grady D, Wenger NK, Herrington D, et al. Postmenopausal hormone therapy increases risk of venous thromboembolic disease: the Heart and Estrogen/progestin Replacement Study. Ann Intern Med 2000;132:689–96
  • Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–33
  • Manson JE, Hsia J, Johnson KC, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003;349:523–34
  • Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention on coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) research group. J Am Med Assoc 1998;280:605–13
  • Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 1998;139:4252–63
  • Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. Circulation 2007;116:2553–62
  • Saita E, Kondo K, Momiyama Y. Anti-Inflammatory diet for atherosclerosis and coronary artery disease: antioxidant foods. Clin Med Insights Cardiol 2015;8(Suppl 3):61–5
  • Altavilla D, Crisafulli A, Marini H, et al. Cardiovascular effects of the phytoestrogen genistein. Curr Med Chem-Cardiovas Hematol Agents 2004;2:179–86
  • Amanat S, Eftekhari MH, Fararouei M, Lankarani KB, Massoumi SJ. Genistein supplementation improves insulin resistance and inflammatory state in nonalcoholic fatty liver patients: a randomized, controlled trial. Clin Nutr 2018;37:1210–15
  • Gupta SK, Dongare S, Mathur R, et al. Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats. Mol Cell Biochem 2015;408:63–72
  • Guo TL, Wang Y, Xiong T, Ling X, Zheng J. Genistein modulation of streptozotocin diabetes in male B6C3F1 mice can be induced by diet. Toxicol Appl Pharmacol 2014;280:455–66
  • Marini H, Bitto A, Altavilla D, et al. Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab 2008;93:4787–96
  • Bitto A, Altavilla D, Bonaiuto A, et al. Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome. J Endocrinol 2009;200:367–76
  • Villa P, Costantini B, Suriano R, et al. The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status. J Clin Endocrinol Metab 2009;94:552–8
  • Liu ZM, Ho SC, Chen YM, Ho YP. The effects of isoflavones combined with soy protein on lipid profiles, C-reactive protein and cardiovascular risk among postmenopausal Chinese women. Nutr Metab Cardiovasc Dis 2012;22:712–19
  • Barrasa GRR, Gonzalez Canete N, Boasi LEV. Age of postmenopause women: effect of soy isoflavone in lipoprotein and inflammation markers. J Menopausal Med 2018;24:176–82
  • Dewell A, Hollenbeck CB, Bruce B. The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. J Clin Endocrinol Metab 2002;87:118–21
  • Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. Chichester, UK: John Wiley & Sons; 2011
  • Furukawa TA, Barbui C, Cipriani A, et al. Imputing missing standard deviations in meta-analyses can provide accurate results. J Clin Epidemiol 2006;59:7–10
  • Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327;557–60
  • Egger M, Davey SG, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315;629–34
  • Atteritano M, Marini H, Minutoli L, et al. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2007;92:3068–75
  • Braxas H, Rafraf M, Karimi Hasanabad S, Asghari Jafarabadi M. Effectiveness of genistein supplementation on metabolic factors and antioxidant status in postmenopausal women with type 2 diabetes mellitus. Can J Diabetes 2019;43:490–7
  • Crisafulli A, Altavilla D, Marini H, et al.. Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women. Menopause 2005;12:186–92
  • Irace C, Marini H, Bitto A, et al. Genistein and endothelial function in postmenopausal women with metabolic syndrome. Eur J Clin Invest 2013;43:1025–31
  • Kaygusuz I, Turhan NO, Duvan CI, Koca C, Aydin M. Effect of genistein therapy on plasma levels of asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study. Fertil Steril 2010;94:764–6
  • Squadrito F, Altavilla D, Morabito N, et al. The Effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002;163:339–47
  • Squadrito F, Marini H, Bitto A, et al. Genistein in the metabolic syndrome: results of a randomized clinical trial. J Clin Endocrinol Metab 2013;98:3366–74
  • Usategui-Martín R, Pérez-Alonso M, Socorro-Briongos L, et al. Estrogen receptor genes polymorphisms determine serum lipid profile in healthy postmenopausal women treated with calcium, vitamin D, and genistein. J Cell Biochem 2019;120:13115–20
  • Yildiz MF, Kumru S, Godekmerdan A, Kutlu S. Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women. Int J Gynaecol Obstet 2005;90:128–133
  • Zhang T, Chi XX. The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia. Diabetol Metab Syndr 2019;11:111
  • Lethaby A, Marjoribanks J, Kronenberg F, et al. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev 2013;12:CD001395
  • Abdi F, Alimoradi Z, Haqi P, Mahdizad F. Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials. Climacteric 2016;19:535–45
  • Si H, Liu D. Phytochemical genistein in the regulation of vascular function: new insights. Curr Med Chem 2007;14:2581–9
  • Pöss J, Custodis F, Werner C, et al. Cardiovascular disease and dyslipidemia: beyond LDL. Curr Pharm Des 2011;17:861–70
  • Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005;366:1267–78
  • Li J, Liu Y, Wang T, Zhao L, Feng W. Does genistein lower plasma lipids and homocysteine levels in postmenopausal women? A meta-analysis. Climacteric 2016;19:440–7
  • Sanders T, Dean T, Grainger D, Miller G, Wiseman H. Moderate intakes of intact soy protein rich in isoflavones compared with ethanol-extracted soy protein increase HDL but do not influence transforming growth factor beta(1) concentrations and hemostatic risk factors for coronary heart disease in healthy subjects. Am J Clin Nutr 2002;76:373–7
  • Jakobsson T, Treuter E, Gustafsson JA, Steffensen KR. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol Sci 2012;33:394–404
  • Yousefinejad A, Siassi F, Mirshafiey A, et al. Effect of genistein and L-carnitine and their combination on gene expression of hepatocyte HMG-COA reductase and LDL receptor in experimental nephrotic syndrome. Iran J Public Health 2015;44:1339–347
  • Notarnicola M, Messa C, Orlando A, et al. Effect of genistein on cholesterol metabolism-related genes in a colon cancer cell line. Genes Nutr 2008;3:35–40
  • Sacks F, Lichtenstein A, Van Horn L, et al. Soy protein, isoflavones, and cardiovascular health: a summary of a statement for professionals from the American Heart Association Nutrition committee. Arterioscler Thromb Vasc Biol 2006;26:1689–92
  • Weggemans RM, Trautwein EA. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. Eur J Clin Nutr 2003;57:940–6
  • Liu Y, Li J, Wang T, et al. The effect of genistein on glucose control and insulin sensitivity in postmenopausal women: a meta-analysis. Maturitas 2017;97:44–52
  • Ricci E, Cipriani S, Chiaffarino F, Malvezzi M, Parazzini F. Effects of soy isoflavones and genistein on glucose metabolism in perimenopausal and postmenopausal non-Asian women: a meta-analysis of randomized controlled trials. Menopause 2010;17:1080–6
  • Villegas R, Gao YT, Yang G, et al. Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women’s Health Study. Am J Clin Nutr 2008;87:162–7
  • Yang B, Chen Y, Xu T, et al. Systematic review and meta-analysis of soy products consumption in patients with type 2 diabetes mellitus. Asia Pacific J Clin Nutr 2011;20:593–602
  • Ko KP, Kim CS, Ahn Y, et al. Plasma isoflavone concentration is associated with decreased risk of type 2 diabetes in Korean women but not men: results from the Korean Genome and Epidemiology study. Diabetologia 2015;58:726–35
  • Dang ZC, Audinot V, Papapoulos SE, Boutin JA, Lowik CW. Peroxisome proliferator-activated receptor (PPAR) as a molecular target for the soy phytoestrogen genistein. J Biol Chem 2003;278:962–7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.