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Clinical Focus: Cardiometabolic Conditions - Review

Can pleiotropic effects of eicosapentaenoic acid (EPA) impact residual cardiovascular risk?

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Pages 822-827 | Received 01 Sep 2017, Accepted 25 Sep 2017, Published online: 09 Oct 2017

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Manan Pareek, R. Preston Mason & Deepak L. Bhatt. (2022) Icosapent ethyl: safely reducing cardiovascular risk in adults with elevated triglycerides. Expert Opinion on Drug Safety 21:1, pages 31-42.
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John R. Nelson, Matthew J. Budoff, Omar R. Wani, Viet Le, Dhiren K. Patel, Ashley Nelson & Richard L. Nemiroff. (2021) EPA’s pleiotropic mechanisms of action: a narrative review. Postgraduate Medicine 133:6, pages 651-664.
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Kamini Trivedi, Viet Le & John R. Nelson. (2021) The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention. Postgraduate Medicine 133:1, pages 28-41.
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Articles from other publishers (19)

Jing Liu, Qingshu Meng, Liang Zheng, Ping Yu, Hao Hu, Rulin Zhuang, Xinyu Ge, Zhongmin Liu, Xiaoting Liang & Xiaohui Zhou. (2022) Effect of n -3 PUFA on left ventricular remodelling in chronic heart failure: a systematic review and meta-analysis . British Journal of Nutrition 129:9, pages 1500-1509.
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Juan Pedro-Botet, Vivencio Barrios, Víctor Sánchez-Margalet, Juan Tamargo, Francisco Arrieta, José Mª Gámez, José Antonio Gimeno-Orna, Carlos Escobar, Juan José Gómez-Doblas & Antonio Pérez. (2023) Tratamiento de la hipertrigliceridemia con icosapento de etilo en pacientes de alto/muy alto riesgo cardiovascular. Documento de consenso de la Sociedad Española de Cardiología y Sociedad Española de Diabetes. Endocrinología, Diabetes y Nutrición 70, pages 51-62.
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Juan Pedro-Botet, Vivencio Barrios, Víctor Sánchez-Margalet, Juan Tamargo, Francisco Arrieta, José Mª Gámez, José Antonio Gimeno-Orna, Carlos Escobar, Juan José Gómez-Doblas & Antonio Pérez. (2023) Treatment of hypertriglyceridaemia with icosapent ethyl in patients with high/very high cardiovascular risk. Consensus document of the Sociedad Española de Cardiología [Spanish Society of Cardiology] and the Sociedad Española de Diabetes [Spanish Diabetes Society]. Endocrinología, Diabetes y Nutrición (English ed.) 70, pages 51-62.
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Arden R. Barry & Dave L. Dixon. (2021) Omega‐3 fatty acids for the prevention of atherosclerotic cardiovascular disease. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 41:12, pages 1056-1065.
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Ram D. Bhatt, Peter Libby, Subodh Verma, R. Preston Mason & Deepak L. Bhatt. (2021) The role of eicosapentaenoic acid in reducing important cardiovascular events, including coronary revascularization. Progress in Cardiovascular Diseases 69, pages 3-10.
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Karan Kapoor, Abdulhamied Alfaddagh, Neil J. Stone & Roger S. Blumenthal. (2021) Update on the omega-3 fatty acid trial landscape: A narrative review with implications for primary prevention. Journal of Clinical Lipidology 15:4, pages 545-555.
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Lu Zeng, Lan Luo, Qi Xue, Qiong He, Xingyu Chen, Jiang Meng, Shumei Wang & Shengwang Liang. (2021) LC–MS based plasma metabolomics study of the intervention effect of different polar parts of Hawthorn on hyperlipidemia rats. Journal of Separation Science 44:5, pages 963-972.
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William E Boden, Seth Baum, Peter P Toth, Sergio Fazio & Deepak L Bhatt. (2021) Impact of expanded FDA indication for icosapent ethyl on enhanced cardiovascular residual risk reduction. Future Cardiology 17:1, pages 155-174.
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Bimmer E. Claessen, Paul Guedeney, C. Michael Gibson, Dominick J. Angiolillo, Davide Cao, Norman Lepor & Roxana Mehran. (2020) Lipid Management in Patients Presenting With Acute Coronary Syndromes: A Review. Journal of the American Heart Association 9:24.
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Garima Sharma, Seth S. Martin & Roger S. Blumenthal. (2020) Effects of Omega-3 Fatty Acids on Major Adverse Cardiovascular Events. JAMA 324:22, pages 2262.
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Nobuaki Suzuki, Kaori Sawada, Ippei Takahashi, Motoko Matsuda, Shinji Fukui, Hidemasa Tokuyasu, Hiroyasu Shimizu, Junichi Yokoyama, Arata Akaike & Shigeyuki Nakaji. (2020) Association between Polyunsaturated Fatty Acid and Reactive Oxygen Species Production of Neutrophils in the General Population. Nutrients 12:11, pages 3222.
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Matthew J Budoff, Deepak L Bhatt, April Kinninger, Suvasini Lakshmanan, Joseph B Muhlestein, Viet T Le, Heidi T May, Kashif Shaikh, Chandana Shekar, Sion K Roy, John Tayek & John R Nelson. (2020) Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial. European Heart Journal 41:40, pages 3925-3932.
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Brian Olshansky, Mina K Chung, Matthew J Budoff, Sephy Philip, Lixia Jiao, Ralph T Doyle, Jr., Christina Copland, Alex Giaquinto, Rebecca A Juliano & Deepak L Bhatt. (2020) Mineral oil: safety and use as placebo in REDUCE-IT and other clinical studies. European Heart Journal Supplements 22:Supplement_J, pages J34-J48.
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Suvasini Lakshmanan, Chandana Shekar, April Kinninger, Suraj Dahal, Afiachukwu Onuegbu, Andrew N. Cai, Sajad Hamal, Divya Birudaraju, Lavanya Cherukuri, Ferdinand Flores, Christopher Dailing, Sion K. Roy, Deepak L. Bhatt, John R. Nelson & Matthew J. Budoff. (2020) Association of high-density lipoprotein levels with baseline coronary plaque volumes by coronary CTA in the EVAPORATE trial. Atherosclerosis 305, pages 34-41.
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Julieta Lazarte & Robert A. Hegele. (2020) Dyslipidemia Management in Adults With Diabetes. Canadian Journal of Diabetes 44:1, pages 53-60.
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Daniel E. Hilleman, Barbara S. Wiggins & Michael B. Bottorff. (2020) Critical Differences Between Dietary Supplement and Prescription Omega-3 Fatty Acids: A Narrative Review. Advances in Therapy 37:2, pages 656-670.
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William S. Harris. (2019) Understanding why REDUCE-IT was positive – Mechanistic overview of eicosapentaenoic acid. Progress in Cardiovascular Diseases 62:5, pages 401-405.
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Seth J. Baum & Kenneth P. Scholz. (2019) Rounding the corner on residual risk: Implications of REDUCE‐IT for omega‐3 polyunsaturated fatty acids treatment in secondary prevention of atherosclerotic cardiovascular disease. Clinical Cardiology 42:9, pages 829-838.
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Patrizia Carità, Andrea Igoren Guaricci, Giuseppe Muscogiuri, Nazario Carrabba & Gianluca Pontone. (2018) Prognostic Value and Therapeutic Perspectives of Coronary CT Angiography: A Literature Review. BioMed Research International 2018, pages 1-13.
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